Swift/XRT follow-up observations of unidentified INTEGRAL/IBIS sources

Many sources listed in the 4th IBIS/ISGRI survey are still unidentified, i.e. lacking an X-ray counterpart or simply not studied at lower energies (< 10 keV). The cross-correlation between the list of IBIS sources in the 4th catalogue and the Swift/XRT data archive is of key importance to search for the X-ray counterparts; in fact, the positional accuracy of few arcseconds obtained with XRT allows us to perform more efficient and reliable follow-up observations at other wavelengths (optical, UV, radio). In this work, we present the results of the XRT observations for four new gamma-ray sources: IGR J12123-5802, IGR J1248.2-5828, IGR J13107-5626 and IGR J14080-3023. For IGR J12123-5802 we find a likely counterpart, but further information are needed to classified this object, IGR J1248.2-5828 is found to be a Seyfert 1.9, for IGR J13107-5626 we suggest a possible AGN nature, while IGR J14080-3023 is classified as a Seyfert 1.5 galaxy.Comment: 6 pages, 4 figure and 2 tables. Accepted for publication on PoS (contribution PoS(extremesky2009)018), proceedings of "The Extreme sky: Sampling the Universe above 10 keV", held in Otranto (Italy), 13-17 October 200

Exposure Keratopathy in the Intensive Care Unit: Do Not Neglect the Unseen

Exposure keratopathy (EK) is a frequently overlooked complication seen in nearly 60% of sedated or intubated intensive care unit (ICU) patients. Signs and symptoms of EK often start as mild subjective complaints of eye pain and irritation, but can progress to vision loss in the most severe cases. For many critically ill patients, the presence of sedation effectively precludes their ability to communicate clinical complaints typically associated with EK. This, combined with the potentially severe sequelae, makes EK a potentially preventable complication and a patient safety issue. Clinical management of EK can be challenging for both providers and patients due to the nature of treatment with eye drops and ointments as well as the burden and expense of associated procedural interventions. Risk factors for EK have been extensively described in the literature, and wider dissemination of this knowledge should facilitate education of physicians and nurses regarding EK prevention. The most common risk factors include lagophthalmos, chemosis, Bell’s palsy, and congenital deformities. Additionally, critically ill patients are less likely to be promptly diagnosed due to the focus of staff on life-threatening problems over ocular prophylaxis. However, the potential severity of complications associated with EK mandates that prevention remains a crucial component of the care of at-risk patients. The reader will explore the broad category of adverse medical occurrences included under the umbrella term, “errors of omission” (EOO): an error category that is most likely to culminate in EK. The most critical preventive measure is education of health care providers, although this may not be enough by itself. To this end, universal precautions against EK in combination with education may be used to help combat the relatively high incidence of this easily preventable ocular pathology

Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas

Background: Voltage-gated sodium channels Nav1.8 and Nav1.9 are expressed preferentially in small diameter sensory neurons, and are thought to play a role in the generation of ectopic activity in neuronal cell bodies and/or their axons following peripheral nerve injury. The expression of Nav1.8 and Nav1.9 has been quantified in human lingual nerves that have been previously injured inadvertently during lower third molar removal, and any correlation between the expression of these ion channels and the presence or absence of dysaesthesia investigated. Results: Immunohistochemical processing and quantitative image analysis revealed that Nav1.8 and Nav1.9 were expressed in human lingual nerve neuromas from patients with or without symptoms of dysaesthesia. The level of Nav1.8 expression was significantly higher in patients reporting pain compared with no pain, and a significant positive correlation was observed between levels of Nav1.8 expression and VAS scores for the symptom of tingling. No significant differences were recorded in the level of expression of Nav1.9 between patients with or without pain. Conclusions: These results demonstrate that Nav1.8 and Nav1.9 are present in human lingual nerve neuromas, with significant correlations between the level of expression of Nav1.8 and symptoms of pain. These data provide further evidence that changes in expression of Nav1.8 are important in the development and/or maintenance of nerve injury-induced pain, and suggest that Nav1.8 may be a potential therapeutic target

Using the Rosat Catalogue to find Counterparts for Unidentified Objects in the 1st Fermi/LAT Catalogue

There are a total of 1451 gamma-ray emitting objects in the Fermi Large Area Telescope First Source Catalogue. The point source location accuracy of typically a few arcminutes has allowed the counterparts for many of these sources to be found at other wavelengths, but even so there are 630 which are described as having no plausible counterpart at 80% confidence. In order to help identify the unknown objects, we have cross-correlated the positions of these sources with the Rosat All Sky Survey Bright Source Catalogue. In this way, for Fermi sources which have a possible counterpart in soft X-rays, we can use the, much smaller, Rosat error box to search for identifications. We find a strong correlation between the two samples and calculate that there are about 60 sources with a Rosat counterpart. Using the Rosat error boxes we provide tentative associations for half of them, demonstrate that the majority of these are either blazars or blazar candidates and give evidence that most belong to the BL Lac class. Given that they are X-ray selected and most are high synchrotron peaked objects, which indicates the presence of high energy electrons, these sources are also good candidates for TeV emission, and therefore good probes of the extragalactic background light.Comment: 9 pages, 1 figure; Accepted for publication in MNRA

Performance optimisation of inertial confinement fusion codes using mini-applications

Despite the recent successes of nuclear energy researchers, the scientific community still remains some distance from being able to create controlled, self-sustaining fusion reactions. Inertial Confinement Fusion (ICF) techniques represent one possible option to surpass this barrier, with scientific simulation playing a leading role in guiding and supporting their development. The simulation of such techniques allows for safe and efficient investigation of laser design and pulse shaping, as well as providing insight into the reaction as a whole. The research presented here focuses on the simulation code EPOCH, a fully relativistic particle-in-cell plasma physics code concerned with faithfully recreating laser-plasma interactions at scale. A significant challenge in developing large codes like EPOCH is maintaining effective scientific delivery on successive generations of high-performance computing architecture. To support this process, we adopt the use of mini-applications -- small code proxies that encapsulate important computational properties of their larger parent counterparts. Through the development of a mini-application for EPOCH (called miniEPOCH), we investigate a variety of the performance features exhibited in EPOCH, expose opportunities for optimisation and increased scientific capability, and offer our conclusions to guide future changes to similar ICF codes

Unveiling the nature of INTEGRAL objects through optical spectroscopy. IV. A study of six new hard X-ray sources

We present further results from our ongoing optical spectrophotometric campaign at the Astronomical Observatory of Bologna in Loiano (Italy) on unidentified hard X-ray sources detected by INTEGRAL. We observed spectroscopically the putative optical counterparts of the INTEGRAL sources IGR J00234+6141, IGR J01583+6713, IGR J06074+2205, IGR J13091+1137 and IGR J20286+2544. We find that the first two are Galactic objects, namely a Cataclysmic Variable at a distance of about 300 pc and a Be/X transient High-Mass X-ray Binary (HMXB) located at about 6.4 kpc, respectively, whereas the last one is identified with MCG +04-48-002, a Starburst/HII galaxy at redshift z = 0.013 hiding a Seyfert 2 nucleus. We identify IGR J13091+1137 as the (likely Seyfert 2 type) active nucleus of galaxy NGC 4992, which we classify as an X-ray Bright, Optically Normal Galaxy; this is the first example of this type of object to be detected by INTEGRAL, and one of the closest of this class. We moreover confirm the possible Be/X nature of IGR J06074+2205, and we estimate it to be at a distance of about 1 kpc. We also reexamine the spectrum of the z = 0.087 elliptical radio galaxy PKS 0352-686, the possible counterpart of the INTEGRAL source IGR J03532-6829, and we find that it is a BL Lac. Physical parameters for these sources are also evaluated by discussing our findings in the context of the available multiwavelength information. These identifications further stress the importance of INTEGRAL in the study of the hard X-ray spectrum of Active Galactic Nuclei, HMXBs and Cataclysmic Variables.Comment: 11 pages, 3 figures, 2 tables, accepted for publication on A&A, main journal. The quality of Fig. 1 was degraded to fit the arXiv uploads size limits. Revised version matches the A&A corrected proof

The shear-driven Rayleigh problem for generalised Newtonian fluids

We consider a variant of the classical ‘Rayleigh problem’ (‘Stokes’s first problem’) in which a semi-infinite region of initially quiescent fluid is mobilised by a shear stress applied suddenly to its boundary. We show that self-similar solutions for the fluid velocity are available for any generalised Newtonian fluid, regardless of its constitutive law. We demonstrate how these solutions may be used to provide insight into some generic questions about the behaviour of unsteady, non-Newtonian boundary layers, and in particular the effect of shear thinning or thickening on the thickness of a boundary layer

Mini-app driven optimisation of inertial confinement fusion codes

In September 2013, the large laser-based inertial confinement fusion device housed in the National Ignition Facility at Lawrence Livermore National Laboratory, was widely acclaimed to have achieved a milestone in controlled fusion – successfully initiating a reaction that resulted in the release of more energy than the fuel absorbed. Despite this success, we remain some distance from being able to create controlled, self-sustaining fusion reactions. Inertial Confinement Fusion (ICF) represents one leading design for the generation of energy by nuclear fusion. Since the 1950s, ICF has been supported by computing simulations, providing the mathematical foundations for pulse shaping, lasers, and material shells needed to ensure effective and efficient implosion. The research presented here focuses on one such simulation code, EPOCH, a fully relativistic particle-in-cell plasma physics code, developed by a leading network of over 30 UK researchers. A significant challenge in developing large codes like EPOCH is maintaining effective scientific delivery on successive generations of high-performance computing architecture. To support this process, we adopt the use of mini-applications – small code proxies that encapsulate important computational properties of their larger parent counterparts. Through the development of a miniapp for EPOCH (called miniEPOCH), we investigate known timestep scaling issues within EPOCH and explore possible optimisations: (i) Employing loop fission to increase levels of vectorisation; (ii) Enforcing particle ordering to allow the exploitation of domain specific knowledge and, (iii) Changing underlying data storage to improve memory locality. When applied to EPOCH, these improvements represent a 2.02× speed-up in the core algorithm and a 1.55× speed-up to the overall application runtime, when executed on EPCC’s Cray XC30 ARCHER platform