1,727 research outputs found

    Organizational justice perceptions in Virginia high schools: A study of its relationship to school climate and faculty trust

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    In the private sector, organizational justice has consistently demonstrated a strong correlation with trust in management, employee commitment, and performance. The purpose of this study was to investigate whether organizational justice had a similar relationship with social processes in the educational arena. This study examined the relationship between organizational justice and school climate and it sought to replicate earlier findings of a significant link between perceptions of justice and faculty trust. The Organizational Justice Scale (OJS), School Climate Index (SCI), and Omnibus T-Scale were used to survey 988 licensed, professional staff members in 30 public high schools in Virginia.;A significant positive relationship was found between organizational justice and school climate. Additional analysis revealed a significant positive correlation between justice and each school climate factor: collegial leadership, teacher professionalism, academic press, and community engagement. When regressed with the other climate factors, collegial leadership alone demonstrated a significant independent effect on organizational justice. A significant positive correlation was also found between organizational justice and all three faculty trust factors: trust in principal, trust in colleagues, and trust in clients. However, only trust in the principal demonstrated a significant and independent effect on organizational justice when regressed with the other trust factors

    From Bilingual to Biliteracy: Learning from Families

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    This study examined the home literacy practices of bilingual families. We were specifically interested in the literacy practices families developed to answer the challenge of biliteracy. Through the home visits and supplying high quality bilingual books, we listened, observed, and gained a deeper understanding of the children and their families which allowed us and educators reading this piece to make connections between children’s home literacy practices and literacy practices in the classroom. After discussing the use of bilingual books, the following four themes emerged from the data: families negotiating biliteracy using bilingual books, the role of Spanish, siblings and literacy learning, families negotiating resources for literacy and interacting with schools

    Chronic smoke exposure is associated with autophagy in murine Peyer's patches

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    INTRODUCTION: Cigarette smoke causes oxidative stress, leading to smoke-induced autophagy in several organs. Autophagy is a homeostatic process regulating the turnover of proteins and cytoplasmatic organelles. However, recently it has also been associated with many autoimmune and inflammatory disorders, among which Crohn’s disease. The purpose of the present study was to investigate whether cigarette smoke exposure is associated with increased autophagy in Peyer’s patches and its epithelium. AIMS & METHODS: C57BL/6 mice were exposed to cigarette smoke or air. After 24 weeks, the animals were sacrificied and Peyer’s patches were collected. m RNA expression of autophagy-related genes was determined by RT-PCR. Transmission electron microscopy (TEM) was used to evaluate the presence of autophagic vesicles in the follicleassociated epithelium of Peyer’s patches. RESULTS: Expression of Beclin-1, a protein involved in the nucleation of autophagosomes, and of Atg5 and Atg7, which both play a role in the autophagosome vesicle elongation and completion, increased after chronic smoke exposure. Furthermore, electron microscopy of the follicle-associated epithelium demonstrated that the mean area of autophagic vesicles per epithelial cell increased considerably from 1.1 μm2 ± 0.4 μm2 in the air group to 2.4 μm2 ± 0.4 μm2 in the smoke group (p < 0.05). Epithelial cells had a significantly higher number of autophagic vesicles after smoke exposure (1.1 ± 0.1 after smoke exposure versus 0.5 ± 0.1 vesicles per cell after air exposure, p < 0.05), but the size of the vesicles did not differ between both groups. CONCLUSION: Here we provide the first evidence that chronic exposure to cigarette smoke is associated with autophagy in murine Peyer’s patches, and more in particular in the follicle-associated epithelium covering Peyer’s patches. Our findings can help to understand the role of smoking in the pathogenesis of inflammatory bowel disease, such as Crohn’s disease

    Cigarette smoking alters intestinal barrier function and Peyer's Patch composition

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    Smokers have a two-fold increased risk to develop Crohn’s disease (CD). However, little is known about the mechanisms through which smoking affects CD pathogenesis. Interestingly, the Peyer’s patches in the terminal ileum are the sites where the first CD lesions develop. To investigate whether smoke exposure causes alterations in Peyer’s patches, we studied C57BL/6 mice after exposure to air or cigarette smoke for 24 weeks. First, barrier function of the follicle-associated epithelium overlying Peyer’s patches was evaluated. We demonstrate that chronic smoke exposure is associated with increased apoptosis in the follicle-associated epithelium. Furthermore, immune cell numbers and differentiation along with chemokine expression were determined in the ileal Peyer’s patches. We observed significant increases in total dendritic cells (DC), CD4+ T-cells (including regulatory T-cells) and CD8+ T-cells after smoke exposure compared with air-exposed animals. The CD11b+ DC subset almost doubled. Interestingly, these changes were accompanied by an up-regulated mRNA expression of the chemokines CCL9 and CCL20, which are known to attract CD11b+ DC towards the subepithelial dome of Peyer’s patches. Our results demonstrate that cigarette smoke exposure induces apoptosis in follicle-associated epithelium and is associated with immune cell accumulation in Peyer’s patches, changes which can predispose to the development of CD

    Cigarette smoke induces apoptosis in the follicle-associated epithelium of murine Peyer's patches

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    Background: Recently, cigarette smoking has been associated with the development of several auto-immune diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). The cellular and molecular mechanisms through which cigarette smoking predisposes to IBD are unknown. Cigarette smoke-induced apoptosis is described in several in vivo and in vitro experiments, and might play a role in the pathogenesis of several smoke-associated diseases. The aim of this study was to quantify apoptosis in normal murine Follicle-Associated Epithelium (FAE) and compare this to apoptosis in FAE of smoking mice. Methods: 8 C57BL/6 male mice were exposed to cigarette smoke for 24 weeks (chronic exposure); a control group of 8 mice was exposed to air during the same period. After 24 weeks the mice were sacrificed and Peyer’s patches of each mouse were dissected for histology. Immunohistochemistry for caspase-3 was performed on paraffin-embedded tissue sections of 11 Peyer’s patches of smoking animals and 11 Peyer’s patches of controls. To compare apoptotic activities between smokers and controls, the apoptotic index (percentage of apoptotic cells per 100 cells) in the FAE was calculated. An unpaired student T-test was applied. Results: A statistically significant increase in apoptosis of FAE cells was observed in smoking mice compared to air-exposed mice (P=0.002). In the FAE of smoking animals, the mean apoptotic index was 1.82 with a range of 1.11 to 3.00, whereas the mean apoptotic index in non-smoking animals was 0.92 (range 0.24 -2.06). Most apoptotic cells in both groups were seen at the apex of the FAE. Conclusion: We quantified rates of apoptosis in the FAE of murine Peyer’s patches. Furthermore we compared apoptosis in the FAE of smoking mice versus non-smoking siblings and observed an increased apoptotic index in the FAE of smoking animals. Our results demonstrate that cigarette smoke induces a significant increase of apoptosis in the FAE of murine Peyer’s patches and may point to a role for smoking in the pathogenesis of intestinal inflammation. Further investigation needs to clarify whether this increase in apoptosis influences normal function of the FAE

    SPP and the Way Forward for North American Integration

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    During the past year, relations among the NAFTA partners took on an increasingly two-tier structure. More visible were a widening array of disagreements over issues including BMD, Iraq, US demands on passports, the Senate’s vote to keep the border shut to Canadian cattle, alleged American gun trafficking and, above all, Washington’s efforts to evade the NAFTA ruling on softwood lumber. Yet, despite this mix of genuine grievances and political posturing, we saw substantial movement toward a more efficient North American economic system. Reports from the Security and Prosperity Partnership Working Groups set up after the Bush-Fox-Martin meeting in Waco, Texas, illustrated a wide array of activities under the politico-journalistic radar. Perhaps more important are the myriad of business- and community-driven initiatives underway to expand and improve cross-border links. How much of all of this will actually lead to concrete results is unclear. But several conclusions are evident. One is that this movement is driven by deepening interdependence. The second is that the current two-tier process in which national leaders kick each other in the shins while businesses and bureaucrats in federal, state, and municipal governments and community groups squirrel away to repair problems in the North American system will not work. Third is that integration-by-stealth is also unacceptable. The time has come to examine carefully what is happening in North America, to explore what our interests are in this emerging continental system, and to open a dialogue about different, even competing, visions of North America. The dialogue should involve perspectives from different regions, different economic and social sectors, and those who oppose as well as support integration. The process must get outside of the beltways—it must give voice to community and economic leaders who are most deeply involved in this new system

    Staying Alive: North American Competitiveness and the Challenge of Asia

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    While analyses of North American integration after NAFTA continue to stress outdated notions of country-to-country trade and the exchange of finished products across national borders, our paper starts from the premise that what we have now is a single, integrated regional economic system whose expansion has followed the pace and contours of business strategies emphasizing continentally-integrated supply chains, but whose management via regulatory and policy coordination has lagged dangerously behind. Most dangerous of all has been the massive gap between our region\u27s infrastructure needs – ports, transportation, and borders – and what has been coordinated and facilitated by the public sector. In this paper we investigate this current impasse from the point of view of reframing the competition with Asia\u27s export giants – in particular China – as an impetus to enhance the competitive edge not of our national economies but rather of the regional economic system as a whole. We highlight the potential for synergy between the dynamism of cross-border regions such as the Pacific Northwest and their gateway strategies of coping with booming trade with Asia, on the one hand, and the aim of enhancing North American regional competitiveness via a more rationalized and effective continental transportation and infrastructure strategy. For example, British Columbia\u27s plans to expand the Prince Rupert port facility, or the West Coast Corridor Coalition\u27s plans for transportation links from B.C. [British Columbia] to B.C. [Baja California] would do well to explore their potential to connect with developing transportation networks and trade corridors in the center of the continent, as well as emerging export centers on the Eastern seaboard (Halifax/Atlantica), and on Mexico\u27s Pacific coast. In keeping with North America\u27s unique integration pattern – decentralized and business-driven – this focus on cross-border regions and public-private partnerships could bridge the infrastructure gap, linking local concerns with greater continental prosperity

    Regard(less) as a Feminist Pedagogical Practice

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    In 2020, COVID-19 became a global pandemic that shifted everyday life, spatially, temporally, and affectively. As teachers who care(d) for students simultaneously navigating uncertain pandemic terrain, we found ourselves changing our practices to accommodate the varied complexities we all faced, and how those complex identities were already embedded in a socio-political landscape within a pandemic. With regard to these students, we adapted our teaching. Regard(less), we carried on. In this article, we think with regard(less) as a pedagogical concept and practice that playfully, though necessarily, shifts between regardless and regard. Though regardless we kept teaching, we did so with regard to and for students in our classes. We narrate regard(less) as a feminist practice within two qualitative inquiry courses Stephanie and Kelly co-taught with Kelsey in 2020

    Epilepsy, identity, and the experience of the body

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    © 2018 Elsevier Inc. Living with a chronic condition can challenge a person\u27s identity, yet there is a paucity of research exploring this experience for people with epilepsy and particularly for those diagnosed in adulthood. Consequently, through an interpretative phenomenological approach, the current study aimed to explore what the experience of adult-onset epilepsy meant for a person\u27s identity. Thirty-nine people with adult-onset epilepsy from across the UK took part in up to two semi-structured interviews. A modified form of interpretative phenomenological analysis was conducted and identified three themes: 1) disarming the impact of seizures considered strategies used to control seizure occurrence and regain a sense of control over the body; 2) distinguishing the self from the body highlighted participants’ attempts to separate their sense of self from the unpredictability of their bodies; 3) separating epilepsy from themselves demonstrated how participants externalized epilepsy from themselves in order to reject it as part of their identity. The findings highlighted that living with adult-onset epilepsy can challenge a person\u27s sense of self and trust in their body, resulting in the adoption of various strategies to manage the threat to their identity. As such, practitioners must pay attention to the impact that adult-onset epilepsy can have on a person\u27s identity and faith in their body
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