Cooperative human robot interaction systems: IV. Communication of shared plans with Naïve humans using gaze and speech

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Changes in lower limb rotation after soft tissue surgery in spastic diplegia: 3-dimensional gait analysis in 28 children

Background and purpose Rotational osteotomies are usually necessary to correct pronounced rotational deformities in ambulant children with cerebral palsy. The effects of soft tissue surgery on such deformities are unclear. In this retrospective study, we determined whether multilevel soft tissue surgery, performed to correct deformities in the sagittal plane, would also have an effect on rotational parameters

Red-giant and main-sequence solar-like oscillators in binary systems revealed by ESA Gaia Data Release 3 -- Reconstructing stellar and orbital evolution from binary-star ensemble seismology

Binary systems constitute a valuable astrophysics tool for testing our understanding of stellar structure and evolution. Systems containing a oscillating component are interesting as asteroseismology offers independent parameters for the oscillating component that aid the analysis. About 150 of such systems are known in the literature. To enlarge the sample of these benchmark objects, we crossmatch the Two-Body-Orbit Catalogue (TBO) of Gaia DR3, with catalogs of confirmed solar-like oscillators on the main-sequence and red-giant phase from NASA Kepler and TESS. We obtain 954 new binary system candidates hosting solar-like oscillators, of which 45 and 909 stars are on the main sequence and red-giant, resp., including 2 new red giants in eclipsing systems. 918 oscillators in potentially long-periodic systems are reported. We increase the sample size of known solar-like oscillators in binary systems by an order of magnitude. We present the seismic properties of the full sample and conclude that the grand majority of the orbital elements in the TBO is physically reasonable. 82% of all TBO binary candidates with multiple times with APOGEE are confirmed from radial-velocity measurement. However, we suggest that due to instrumental noise of the TESS satellite the seismically inferred masses and radii of stars with $\nu_\textrm{max}$$\lesssim$30$\mu$Hz could be significantly overestimated. For 146 giants the seismically inferred evolutionary state has been determined and shows clear differences in their distribution in the orbital parameters, which are accounted the accumulative effect of the equilibrium tide acting in these evolved binary systems. For other 146 systems hosting oscillating stars values for the orbital inclination were found in the TBO. From testing the TBO on the SB9 catalogue, we obtain a completeness factor of 1/3.Comment: under review for publication in A&A (22 pages + 4 pages of appendix, 21 figures, 33 pages of tables in the Appendix

Action observation can prime visual object recognition

Observing an action activates action representations in the motor system. Moreover, the representations of manipulable objects are closely linked to the motor systems at a functional and neuroanatomical level. Here, we investigated whether action observation can facilitate object recognition using an action priming paradigm. As prime stimuli we presented short video movies showing hands performing an action in interaction with an object (where the object itself was always removed from the video). The prime movie was followed by a (briefly presented) target object affording motor interactions that are either similar (congruent condition) or dissimilar (incongruent condition) to the prime action. Participants had to decide whether an object name shown after the target picture corresponds with the picture or not (picture–word matching task). We found superior accuracy for prime–target pairs with congruent as compared to incongruent actions across two experiments. Thus, action observation can facilitate recognition of a manipulable object typically involving a similar action. This action priming effect supports the notion that action representations play a functional role in object recognition

Palearctic predator invades North American Great Lakes

Bythotrephes cederstroemii Schoedler, a predatory freshwater zooplankter (Crustacea: Cladocera), was first found in the Laurentian Great Lakes in December 1984. The first individuals were from Lake Huron, followed in 1985 with records from Lakes Erie and Ontario. By late August, 1986 the species had spread to southern Lake Michigan (43°N). Bythotrephes has not previously been reported from North America, but has been restricted to a northern and central Palearctic distribution. Its dramatic and widespread rise in abundance in Lake Michigan was greatest in offshore regions. Bythotrephes appears to be invading aggressively, but avoiding habitats presently occupied by glacio-marine relict species that became established in deep oligotrophic North American lakes after the Wisconsin glaciation. Because it is a voracious predator its invasion may lead to alterations in the native zooplankton fauna of the Great Lakes. It offers the chance to study how invading plankton species join an existing community. Judging from its persistence and success in deep European lakes, Bythotrephes may now become a permanent member of zooplankton communities in the Nearctic.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47771/1/442_2004_Article_BF00378947.pd

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007