A new species of Phyllophaga Harris from the island of Navassa in the Caribbean (Coleoptera: Scarabaeidae: Melolonthinae)

The small Caribbean island of Navassa (U.S. possession) is unoccupied by humans, but recent surveys have detected a surprising number of endemic (precinctive) invertebrates. A new species of May beetle, Phyllophaga navassa, is here described and compared to the Hispaniolan Phyllophaga fauna

Measuring Black Hole Spin by the Continuum-Fitting Method: Effect of Deviations from the Novikov-Thorne Disc Model

The X-ray spectra of accretion discs of eight stellar-mass black holes have been analyzed to date using the thermal continuum fitting method, and the spectral fits have been used to estimate the spin parameters of the black holes. However, the underlying model used in this method of estimating spin is the general relativistic thin-disc model of Novikov & Thorne, which is only valid for razor-thin discs. We therefore expect errors in the measured values of spin due to inadequacies in the theoretical model. We investigate this issue by computing spectra of numerically calculated models of thin accretion discs around black holes, obtained via three-dimensional general relativistic magnetohydrodynamic (GRMHD) simulations. We apply the continuum fitting method to these computed spectra to estimate the black hole spins and check how closely the values match the actual spin used in the GRMHD simulations. We find that the error in the dimensionless spin parameter is up to about 0.2 for a non-spinning black hole, depending on the inclination. For black holes with spins of 0.7, 0.9 and 0.98, the errors are up to about 0.1, 0.03 and 0.01 respectively. These errors are comparable to or smaller than those arising from current levels of observational uncertainty. Furthermore, we estimate that the GRMHD simulated discs from which these error estimates are obtained correspond to effective disc luminosities of about 0.4-0.7 Eddington, and that the errors will be smaller for discs with luminosities of 0.3 Eddington or less, which are used in the continuum-fitting method. We thus conclude that use of the Novikov-Thorne thin-disc model does not presently limit the accuracy of the continuum-fitting method of measuring black hole spin.Comment: 13 pages, 7 figures, accepted for publication in MNRAS. v2: fixed typo in author name, updated acknowledgment

On the accuracy of ion measurements using a neutral cluster and air ion spectrometer

Here, we present a calibration of the Neutral cluster and Air Ion Spectrometer (NAIS, Airel Ltd.) for the size and concentration of ions in the mobility-diameter size-range 0.98-29.1 nm. Previous studies raised accuracy issues in size and concentration determination and highlighted the importance of used data inversion algorithm. Therefore, we investigated the performance of the NAIS by using five inversion methods. The presented results illustrate that the size information given by the NAIS is very accurate, regardless of the version of the data inversion. The number concentrations determined by the NAIS were 15%-30% too low especially at the lower end of the measurement size range (<5 nm), whereas concentrations at diameters 19.6 nm and larger were overestimated by up to 8%. With the correction presented in this study, the uncertainty of the ion concentration measurement of the NAIS can be reduced to less than 10%, allowing the NAIS to be used in quantitative ion cluster studies and more accurate determination of formation and growth rates.Peer reviewe

Return to drug use and overdose after release from prison: a qualitative study of risk and protective factors

BACKGROUND: Former inmates are at high risk for death from drug overdose, especially in the immediate post-release period. The purpose of the study is to understand the drug use experiences, perceptions of overdose risk, and experiences with overdose among former prisoners. METHODS: This qualitative study included former prison inmates (N = 29) who were recruited within two months after their release. Interviewers conducted in-person, semi-structured interviews which explored participants' experiences and perceptions. Transcripts were analyzed utilizing a team-based method of inductive analysis. RESULTS: The following themes emerged: 1) Relapse to drugs and alcohol occurred in a context of poor social support, medical co-morbidity and inadequate economic resources; 2) former inmates experienced ubiquitous exposure to drugs in their living environments; 3) intentional overdose was considered "a way out" given situational stressors, and accidental overdose was perceived as related to decreased tolerance; and 4) protective factors included structured drug treatment programs, spirituality/religion, community-based resources (including self-help groups), and family. CONCLUSIONS: Former inmates return to environments that strongly trigger relapse to drug use and put them at risk for overdose. Interventions to prevent overdose after release from prison may benefit from including structured treatment with gradual transition to the community, enhanced protective factors, and reductions of environmental triggers to use drugs

Profiling Sterols in Cerebrotendinous Xanthomatosis: Utility of Girard Derivatization and High Resolution Exact Mass LC-ESI-MSn Analysis

In this study we profile free 3-oxo sterols present in plasma from patients affected with the neurodegenerative disorder of sterol and bile acid metabolism cerebrotendinous xanthomatosis (CTX), utilizing a combination of charge-tagging and LC-ESI-MSn performed with an LTQ-Orbitrap Discovery instrument. In addition, we profile sterols in plasma from 24-month-old cyp27A1 gene knockout mice lacking the enzyme defective in CTX. Charge-tagging was accomplished by reaction with cationic Girard\u27s P (GP) reagent 1-(carboxymethyl) pyridinium chloride hydrazide, an approach uniquely suited to studying the 3-oxo sterols that accumulate in CTX, as Girard\u27s reagent reacts with the sterol oxo moiety to form charged hydrazone derivatives. The ability to selectively generate GP-tagged 3-oxo-4-ene and 3-oxo-5(H) saturated plasma sterols enabled ESI-MSn analysis of these sterols in the presence of a large excess (3 orders of magnitude) of cholesterol. Often cholesterol detected in biological samples makes it challenging to quantify minor sterols, with cholesterol frequently removed prior to analysis. We derivatized plasma (10μl) without SPE removal of cholesterol to ensure detection of all sterols present in plasma. We were able to measure 4-cholesten-3-one in plasma from untreated CTX patients (1207±302ng/ml, mean±SD, n=4), as well as other intermediates in a proposed pathway to 5α-cholestanol. In addition, a number of bile acid precursors were identified in plasma using this technique. GP-tagged sterols were identified utilizing high resolution exact mass spectra (±5ppm), as well as MS2 ([M]+→) spectra that possessed characteristic neutral loss of 79Da (pyridine) fragment ions, and MS3 ([M]+→[M-79]+→) spectra that provided additional structurally informative fragment ions. © 2010 Elsevier B.V

Measuring the Spins of Accreting Black Holes

A typical galaxy is thought to contain tens of millions of stellar-mass black holes, the collapsed remnants of once massive stars, and a single nuclear supermassive black hole. Both classes of black holes accrete gas from their environments. The accreting gas forms a flattened orbiting structure known as an accretion disk. During the past several years, it has become possible to obtain measurements of the spins of the two classes of black holes by modeling the X-ray emission from their accretion disks. Two methods are employed, both of which depend upon identifying the inner radius of the accretion disk with the innermost stable circular orbit (ISCO), whose radius depends only on the mass and spin of the black hole. In the Fe K method, which applies to both classes of black holes, one models the profile of the relativistically-broadened iron line with a special focus on the gravitationally redshifted red wing of the line. In the continuum-fitting method, which has so far only been applied to stellar-mass black holes, one models the thermal X-ray continuum spectrum of the accretion disk. We discuss both methods, with a strong emphasis on the continuum-fitting method and its application to stellar-mass black holes. Spin results for eight stellar-mass black holes are summarized. These data are used to argue that the high spins of at least some of these black holes are natal, and that the presence or absence of relativistic jets in accreting black holes is not entirely determined by the spin of the black hole.Comment: To appear in Classical and Quantum Gravity; Special volume for GR19, eds. D. Marolf and D. Sudarsky; 28 pages, 6 figures; Includes corrections made to proofs, which are significant only for Section

Neuronal correlates of cognitive control are altered in women with endometriosis and chronic pelvic pain

Endometriosis is a debilitating women's health condition and is the most common cause of chronic pelvic pain. Impaired cognitive control is common in chronic pain conditions, however, it has not yet been investigated in endometriosis. The aim of this study was to explore the neuronal correlates of cognitive control in women with endometriosis. Using a cross-sectional study design with data collected at a single time-point, event-related potentials were elicited during a cued continuous performance test from 20 women with endometriosis (mean age = 28.5 ± 5.2 years) and 20 age- and gender-matched controls (mean age = 28.5 ± 5.2 years). Event-related potential components were extracted and P3 component amplitudes were derived with temporal principal components analysis. Behavioral and ERP outcomes were compared between groups and subjective pain severity was correlated with ERP component amplitudes. No significant behavioral differences were seen in task performance between the groups (all p > 0.094). Target P3b (all p < 0.034) and SW (all p < 0.040), and non-target early P3a (eP3a; all p < 0.023) and late P3a (lP3a; all p < 0.035) amplitudes were smaller for the endometriosis compared to the healthy control group. Lower non-target eP3a (p < 0.001), lP3a (p = 0.013), and SW (p = 0.019) amplitudes were correlated with higher pain severity scores. Findings suggest that endometriosis-associated chronic pelvic pain is linked to alterations in stimulus-response processing and inhibitory control networks, but not impaired behavioral performance, due to compensatory neuroplastic changes in overlapping cognitive control and pain networks