Examining Migration Flows Across Kentucky\u27s Counties

The state of Kentucky is home to many rural counties which experience high levels of outward migration due to their relatively unfavorable economic conditions. While migration trends nationally have begun to plateau, migration flows from county to county show a much more volatile story. This study will examine the relationship between economic opportunity and migration flow estimates in Kentucky’s counties through a multiple regression approach with the response variable being annual migration flow estimates, with multiple predictor variables showing the economic composition of the county. Variables used in this regression include annual unemployment rates, educational attainment levels, county poverty rates, and the percentage of a county’s population that is of the prime working age, 25-54. Based on the results of this regression, it was determined that there are a few counties in Kentucky that despite relatively unfavorable economic conditions, have been able to stem the flow of outward migration and either maintain their existing working population, or attract new citizens to their county. At the heart of this research is the question of why some of these counties have been more successful than others in retaining their young people despite these existing economic hardships. Due to this finding, interviews with public officials, organizations, and agencies associated with these “bright spot” counties were conducted and the results of these interviews were used to highlight the strategies used by these counties to stem the flow of outward migration, while also providing other county, state, and national leaders with recommendations based on the success stories of these few Kentucky counties

Pure braid subgroups of braided Thompson's groups

We describe pure braided versions of Thompson's group F. These groups, $BF$ and $\hat{BF}$, are subgroups of the braided versions of Thompson's group V, introduced by Brin and Dehornoy. Unlike V, elements of F are order-preserving self-maps of the interval and we use pure braids together with elements of F thus preserving order. We define these groups and give normal forms for elements and describe infinite and finite presentations of these groups.Comment: 26 pages, 6 figures, with updated bibliograph

The 2011 February superoutburst of the dwarf nova SDSS J112003.40+663632.4

We report unfiltered photometry of SDSS J112003.40+663632.4 during the 2011 February outburst which revealed the presence of superhumps with peak-to-peak amplitude of up to 0.22 magnitudes showing this to be an SU UMa type dwarf nova. The outburst amplitude was 5.4 magnitudes above mean quiescence and it lasted at least 12 days. The mean superhump period during the plateau phase was Psh = 0.07057(19) d.Comment: Accepted for publication in the Journal of the British Astronomical Association. 12 pages, 5 figure

Pure braid subgroups of braided Thompson's groups

We describe some properties of braided generalizations of Thompson's groups, introduced by Brin and Dehornoy. We give slightly different characterizations of the braided Thompson's groups BV and BVd which lead to natural presentations which emphasize one of their subgroup-containment properties. We consider pure braided versions of Thompson's group F. These groups, BF and BFd, are subgroups of the braided versions of Thompson's group V . Unlike V , elements of F are order-preserving self-maps of the interval and we use pure braids together with elements of F thus again preserving order. We define these pure braided groups, give normal forms for elements, and construct infinite and finite presentations of these groups

Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms

We previously found that gender influenced the JAK2 V617F allele burden, but it is unknown whether this gender difference in molecular epidemiology influences complications in the myeloproliferative neoplasms (MPNs). Historically, vascular complications represented the most common cause of mortality in polycythemia vera and essential thrombocytosis and contributed to morbidity in primary myelofibrosis. To determine the influence of gender on vascular complications, we retrospectively analyzed associations between gender and vascular complications. Despite their younger age, less prevalent dyslipidemia or smoking history, lower white blood counts, and lower JAK2 V617F allele burden, women had higher rates of abdominal venous thrombosis and comparable rates of all vascular complications. Vascular risk is currently not easily stratified by MPN-disease burden or traditional risk factors. Our analysis contributes to growing literature emphasizing gender differences in the MPN and further supports the important impact of individual and host variation on MPN clinical manifestations, and especially vascular risk

Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative Neoplasms

AbstractDespite the emergence of JAK inhibitors, there is a need for disease-modifying treatments for Philadelphia-negative myeloproliferative neoplasms (MPNs). JAK inhibitors ameliorate symptoms and address splenomegaly, but because of the heterogeneous contributors to the disease process, JAK inhibitor monotherapy incompletely addresses the burden of disease. The ever-growing understanding of MPN pathogenesis has provided the rationale for testing novel and targeted therapeutic agents, as monotherapies or in combination, in preclinical and clinical settings. A number of intriguing options have emerged, and it is hoped that further progress will lead to significant changes in the natural history of MPNs

Pure braid subgroups of braided Thompson's groups

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Radiotherapy in the treatment of gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GISTs) are uncommon mesenchymal tumors of the gastrointestinal tract. Up to one-third of GISTs are malignant with a high rate of metastasis. Surgical resection is the mainstay of care for patients with resectable disease. Imatinib mesylate, a selective tyrosine kinase inhibitor, is the current standard of care for GISTs that cannot be completely resected or in cases of metastatic GIST. Although often overlooked, radiation therapy is a viable option for select patients with GIST. We report the case of a patient with unresectable GIST who was treated with local radiotherapy and achieved long-term response. We also present a review of the literature regarding the use of radiotherapy in the treatment of GIST. GIST has been shown to be a radiosensitive tumor. Radiotherapy can offer long-term local control and should be considered in the adjuvant or palliative setting. The role of radiotherapy delivered concurrently with imatinib in the treatment of GIST may warrant further investigation