High-Intensity Discharge Lamp and Duffing Oscillator - Similarities and Differences

The processes inside the arc tube of high-intensity discharge lamps are investigated by finite element simulations. The behavior of the gas mixture inside the arc tube is governed by differential equations describing mass, energy and charge conservation as well as the Helmholtz equation for the acoustic pressure and the Navier-Stokes equation for the flow driven by the buoyancy and the acoustic streaming force. The model is highly nonlinear and requires a recursion procedure to account for the impact of acoustic streaming on the temperature and other fields. The investigations reveal the presence of a hysteresis and the corresponding jump phenomenon, quite similar to a Duffing oscillator. The similarities and, in particular, the differences of the nonlinear behavior of the high-intensity discharge lamp to that of a Duffing oscillator are discussed. For large amplitudes the high-intensity discharge lamp exhibits a stiffening effect in contrast to the Duffing oscillator.Comment: 14 pages, 8 figure

Implementation, demonstration and validation of a user-defined wall-function for direct precipitation fouling in ANSYS Fluent

In a previous paper (Johnsen et al., 2015) and presentation (Johnsen et al., 2016), we developed and demonstrated a generic modelling framework for the modelling of direct precipitation fouling from multi-component fluid mixtures that become super-saturated at the wall. The modelling concept involves the 1-dimensional transport of the fluid species through the turbulent boundary layer close to the wall. The governing equations include the Reynolds-averaged (RANS) advection-diffusion equations for each fluid species, and the axial momentum and energy equations for the fluid mixture. The driving force for the diffusive transport is the local gradient in the species' chemical potential. Adsorption mechanisms are not modelled per se, but the time-scale of adsorption is reflected in the choice of Dirichlet boundary conditions for the depositing species, at the fluid-solid interface. In this paper, the modelling framework is implemented as a user-defined function (UDF) for the CFD software ANSYS Fluent, to act as a wall boundary condition for mass-transfer to the wall. The subgrid, 1-dimensional formulation of the model reduces the computational cost associated with resolving the fine length-scales at which the boundary-layer mass transfer is determined, and allows for efficient modelling of industry-scale heat exchangers suffering from fouling. The current paper describes the modelling framework, and demonstrates and validates its applicability in a simplified 2D heat exchanger geometry (experimental and detailed CFD modelling data by P\"a\"akk\"onen et al. (2012, 2016)). By tuning the diffusivity, only, good agreement with the experimental data and the detailed CFD model was obtained, in terms of area-averaged deposition rates.Comment: 12th International Conference on CFD in Oil & Gas, Metallurgical and Process Industries, SINTEF, Trondheim, NORWAY, May 30th - June 1st, 2017, 9 pages, 9 figure

Verfügbarkeit und vergleichende Bewertung der Anwendungssicherheit von Pflanzenschutzmitteln und Biozidprodukten

Availability and comparative evaluation of the application security of plant protection products and biocide

Stride-to-Stride Variability of the Center of Mass in Male Trained Runners After an Exhaustive Run: A Three Dimensional Movement Variability Analysis With a Subject-Specific Anthropometric Model

The motion of the human body can be described by the motion of its center of mass (CoM). Since the trajectory of the CoM is a crucial variable during running, one can assume that trained runners would try to keep their CoM trajectory constant from stride to stride. However, when exposed to fatigue, runners might have to adapt certain biomechanical parameters. The Uncontrolled Manifold approach (UCM) and the Tolerance, Noise, and Covariation (TNC) approach are used to analyze changes in movement variability while considering the overall task of keeping a certain task relevant variable constant. The purpose of this study was to investigate if and how runners adjust their CoM trajectory during a run to fatigue at a constant speed on a treadmill and how fatigue affects the variability of the CoM trajectory. Additionally, the results obtained with the TNC approach were compared to the results obtained with the UCM analysis in an earlier study on the same dataset. Therefore, two TNC analyses were conducted to assess effects of fatigue on the CoM trajectory from two viewpoints: one analyzing the CoM with respect to a lab coordinate system (PV$_{lab}$) and another one analyzing the CoM with respect to the right foot (PV$_{foot}$). Full body kinematics of 13 healthy young athletes were captured in a rested and in a fatigued state and an anthropometric model was used to calculate the CoM based on the joint angles. Variability was quantified by the coefficient of variation of the length of the position vector of the CoM and by the components Tolerance, Noise, and Covariation which were analyzed both in 3D and the projections in the vertical, anterior-posterior and medio-lateral coordinate axes. Concerning PV$_{lab}$ we found that runners increased their stride-to-stride variability in medio-lateral direction (1%). Concerning PV$_{foot}$ we found that runners lowered their CoM (4 mm) and increased their stride-to-stride variability in the absorption phase in both 3D and in the vertical direction. Although we identified statistically relevant differences between the two running states, we have to point out that the effects were small (CV ≤ 1%) and must be interpreted cautiously

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the development of small molecule inhibitors. Thus, to exploit fully the potential of the Human Genome Project to advance human medicine, there is a need to develop generic methods of inhibiting protein activity that do not rely on the target protein’s function. We previously demonstrated that a normally stable protein, methionine aminopeptidase-2 or MetAP-2, could be artificially targeted to an Skp1-Cullin-F-box (SCF) ubiquitin ligase complex for ubiquitination and degradation through a chimeric bridging molecule or Protac (proteolysis targeting chimeric molecule). This Protac consisted of an SCFß-TRCP-binding phosphopeptide derived from I{kappa}B{alpha} linked to ovalicin, which covalently binds MetAP-2. In this study, we employed this approach to target two different proteins, the estrogen (ER) and androgen (AR) receptors, which have been implicated in the progression of breast and prostate cancer, respectively. We show here that an estradiol-based Protac can enforce the ubiquitination and degradation of the {alpha} isoform of ER in vitro, and a dihydroxytestosterone-based Protac introduced into cells promotes the rapid disappearance of AR in a proteasome-dependent manner. Future improvements to this technology may yield a general approach to treat a number of human diseases, including cancer

Effects of Hip Bracing on Gait Biomechanics, Pain and Function in Subjects With Mild to Moderate Hip Osteoarthritis

Hip Osteoarthritis (HOA) is a common joint disease with serious impact on the quality of life of the affected persons. Additionally, persons with HOA often show alterations in gait biomechanics. Developing effective conservative treatment strategies is of paramount importance, as joint replacement is only indicated for end-stage HOA. In contrast to knee osteoarthritis, little is known about the effectiveness of hip bracing for the management of HOA. Studies analysing mechanically unloading hip braces partly showed beneficial results. However, methodological limitations of these studies, such as small sample sizes or lack of control groups, limit the applicability of the results. Additionally, mechanically unloading braces might impose restrictions on motion and comfort and thus, might not be suitable for people with only mild or moderate symptoms. The aim of this study was to comprehensively quantify the effects of unilateral HOA as well as functional hip bracing on gait biomechanics, pain, proprioception and functional capacity in people with mild to moderate HOA. Hip and pelvis biomechanics during walking were analysed in 21 subjects with mild to moderate HOA under three bracing conditions: unbraced, immediately after brace application and after 1 week of brace usage. Additionally, pain, hip proprioception and functional capacity were assessed. A matched group of 21 healthy subjects was included as reference. Kinematic and kinetic data were collected using a 16-camera infrared motion capturing system and two force plates. Visual analogue scales, an angle reproduction test and a 6-min walking test were applied to measure pain, hip proprioception and functional capacity, respectively. Subjects with HOA walked slower, with reduced step length, sagittal hip range of motion and peak extension angle and had a reduced functional capacity. After 1 week of brace application step length, walking speed and functional capacity were significantly increased. Additionally, pain perception was significantly lower in the intervention period. These results encourage the application of functional hip braces in the management of mild to moderate HOA. However, as key parameters of HOA gait such as a reduced peak extension angle remained unchanged, the underlying mechanisms remain partly unclear and have to be considered in the future

IDENTIFICATION OF FATIGUE-RELATED KINEMATIC CHANGES IN ELITE RUNNERS USING A SUPPORT VECTOR MACHINE APPROACH

Understanding the kinematic changes underlying fatigue is essential in running biomechanics. The aim of this study was to identify fatigue-related kinematic changes in elite runners using a support vector machine approach. Full-body kinematics of thirteen trained runners were recorded in a non-fatigued and a fatigued state during treadmill running at their individual fatigue-speed. A support vector machine was trained and used to identify kinematic differences between the non-fatigued and fatigued state based on principal component scores. Strides during non-fatigued and fatigued running could be separated with 99.4% classification accuracy. Four upper limb (two shoulder and two elbow), four lower limb (one ankle, two knee and one hip) and two trunk (one thoracic and one lumbar spine) principal component scores were identified as most discriminative kinematic features between non-fatigued and fatigued running. The findings of the study suggest the feasibility of a support vector machine approach to identify subtle fatigue-related kinematic changes in elite runners