A Novel Secure NFC-based Approach for BMS Monitoring and Diagnostic Readout

In modern systems that rely on the use of Battery Management Systems (BMS), longevity and the re-use of battery packs have always been important topics of discussion. These battery packs would be stored inside warehouses where they would need to be properly monitored and configured before their re-integration into the new systems. Traditional use of wired connections can be very cumbersome, and sometimes even impossible, due to the outer layers and packaging. To circumvent these issues, we propose an extension to the conventional BMS design that incorporates the use of Near Field Communication (NFC) for the purpose of wireless battery pack status readout. Additionally, to ensure that these packs are only managed by authenticated devices and that the data that is communicated with is protected against outside eavesdropping and tampering, we present a solution in the form of a lightweight security layer on top of the NFC protocol. To show the feasibility of our design, an accompanying prototype has been implemented and evaluated.Comment: Accepted copy for Publication at the 16th IEEE International Conference on RFID, 202

Ultrastructure of the Membrana Limitans Interna after Dye-Assisted Membrane Peeling

The purpose of this study was to investigate the ultrastructure of the membrana limitans interna (internal limiting membrane, ILM) and to evaluate alterations to the retinal cell layers after membrane peeling with vital dyes. Twenty-five patients (25 eyes) who underwent macular hole surgery were included, whereby 12 indocyanine green (ICG)- and 13 brilliant blue G (BBG)-stained ILM were analyzed using light, transmission electron and scanning electron microscopy. Retinal cell fragments on the ILM were identified in both groups using immunohistochemistry. Comparing ICG- and BBG-stained membranes, larger cellular fragments were observed at a higher frequency in the BBG group. Thereby, the findings indicate that ICG permits an enhanced separation of the ILM from the underlying retina with less mechanical destruction. A possible explanation might be seen in the known photosensitivity of ICG, which induces a stiffening and shrinkage of the ILM but also generates retinal toxic metabolite

Die Einflussfaktoren eines Sozialdienstes für nachhaltige Ablösung

Womit gelingt es Sozialdiensten, dass ihre Klientinnen und Klienten nicht mehr auf Sozialhilfe angewiesen sind – und es auf Dauer bleiben? Eine Studie hat die relevanten Faktoren eingehend untersucht. Sie fand zehn Einflussgrössen, mit denen Sozialdienste die Chance einer mittel- bis langfristigen Ablösung erhöhen können. Eine davon ist die Ziel- und Handlungsplanung

Die Einflussfaktoren eines Sozialdienstes für nachhaltige Integration

Wie gelingt es Sozialdiensten, dass ihre Klientinnen und Klienten nicht mehr auf Sozialhilfe angewiesen sind? Und es auf Dauer bleiben? Eine Studie der BFH hat die relevanten Faktoren eingehend untersucht. Sie fand zehn Einflussgrössen, mit denen Sozialdienste die Chance einer mittel- bis langfristigen Ablösung erhöhen können

A Novel Approach Based on a Hierarchical Multiresolution Analysis of Optical Time Series to Reconstruct the Daily High-Resolution Snow Cover Area

High-resolution (HR) snow cover maps derived by remotely sensed images are an asset for data assimilation in hydrological models. However, the current satellite missions do not provide daily HR multispectral observations suitable for an accurate snow monitoring in alpine environments. On the contrary, low-resolution (LR) sensors acquire daily information of snow cover fraction (SCF) but at an inappropriate spatial scale. This article proposes a novel approach that combines multisource and multiscale acquisitions to infer the daily HR snow cover area (SCA) for mountainous basins. The approach builds on the assumption that interannual snow patterns are both affected by the local geomorphometry and meteorology. We derive these patterns through a hierarchical multistep approach based on historical statistical analyses on a long and sparse HR time-series. At each step, we obtain HR snow cover maps with higher number of reconstructed pixels but decreasing level of confidence. Historical data are used to estimate the probability that a HR pixel is covered by snow according to two possible multiscale strategies: 1) HR gap-filling, or 2) LR downscaling. These analyses lead to the identification of the patterns that regularly appear given certain conditions. When no systematic patterns are observed, we reinforce the inference of the pixel class by a generalized additive model that exploits not only the historical data, but also explicit geomorphometric, global snow, and multitemporal properties. The proposed approach has been validated on a catchment in the Sierra Nevada, USA, for three hydrological years (2017–2019) showing an average overall accuracy of 92%

A systematic review of participatory scenario planning to envision mountain social-ecological systems futures

Mountain social-ecological systems (MtSES) provide crucial ecosystem services to over half of humanity. However, populations living in these highly varied regions are now confronted by global change. It is critical that they are able to anticipate change to strategically manage resources and avoid potential conflict. Yet, planning for sustainable, equitable transitions for the future is a daunting task, considering the range of uncertainties and the unique character of MtSES. Participatory scenario planning (PSP) can help MtSES communities by critically reflecting on a wider array of innovative pathways for adaptive transformation. Although the design of effective approaches has been widely discussed, how PSP has been employed in MtSES has yet to be examined. Here, we present the first systematic global review of single- and multiscalar, multisectoral PSP undertaken in MtSES, in which we characterize the process, identify strengths and gaps, and suggest effective ways to apply PSP in MtSES. We used a nine-step process to help guide the analysis of 42 studies from 1989 screened articles. Our results indicate a steady increase in relevant studies since 2006, with 43% published between 2015 and 2017. These studies encompass 39 countries, with over 50% in Europe. PSP in MtSES is used predominantly to build cooperation, social learning, collaboration, and decision support, yet meeting these objectives is hindered by insufficient engagement with intended end users. MtSES PSP has focused largely on envisioning themes of governance, economy, land use change, and biodiversity, but has overlooked themes such as gender equality, public health, and sanitation. There are many avenues to expand and improve PSP in MtSES: to other regions, sectors, across a greater diversity of stakeholders, and with a specific focus on MtSES paradoxes. Communicating uncertainty, monitoring and evaluating impacts, and engendering more comparative approaches can further increase the utility of PSP for addressing MtSES challenges, with lessons for other complex social-ecological systems

A systematic review of participatory scenario planning to envision mountain social-ecological systems futures

Mountain social-ecological systems (MtSES) provide crucial ecosystem services to over half of humanity. However, populations living in these highly varied regions are now confronted by global change. It is critical that they are able to anticipate change to strategically manage resources and avoid potential conflict. Yet, planning for sustainable, equitable transitions for the future is a daunting task, considering the range of uncertainties and the unique character of MtSES. Participatory scenario planning (PSP) can help MtSES communities by critically reflecting on a wider array of innovative pathways for adaptive transformation. Although the design of effective approaches has been widely discussed, how PSP has been employed in MtSES has yet to be examined. Here, we present the first systematic global review of single- and multiscalar, multisectoral PSP undertaken in MtSES, in which we characterize the process, identify strengths and gaps, and suggest effective ways to apply PSP in MtSES. We used a nine-step process to help guide the analysis of 42 studies from 1989 screened articles. Our results indicate a steady increase in relevant studies since 2006, with 43% published between 2015 and 2017. These studies encompass 39 countries, with over 50% in Europe. PSP in MtSES is used predominantly to build cooperation, social learning, collaboration, and decision support, yet meeting these objectives is hindered by insufficient engagement with intended end users. MtSES PSP has focused largely on envisioning themes of governance, economy, land use change, and biodiversity, but has overlooked themes such as gender equality, public health, and sanitation. There are many avenues to expand and improve PSP in MtSES: to other regions, sectors, across a greater diversity of stakeholders, and with a specific focus on MtSES paradoxes. Communicating uncertainty, monitoring and evaluating impacts, and engendering more comparative approaches can further increase the utility of PSP for addressing MtSES challenges, with lessons for other complex social-ecological systems. © 2020 by the author(s)

PAK6 phosphorylates 14-3-3γ to regulate steady state phosphorylation of LRRK2

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in health and disease are incompletely understood, robust evidence indicates that PD-associated mutations alter LRRK2 kinase and GTPase activities with consequent deregulation of the downstream signaling pathways. We have previously demonstrated that one LRRK2 binding partner is P21 (RAC1) Activated Kinase 6 (PAK6). Here, we interrogate the PAK6 interactome and find that PAK6 binds a subset of 14-3-3 proteins in a kinase dependent manner. Furthermore, PAK6 efficiently phosphorylates 14-3-3γ at Ser59 and this phosphorylation serves as a switch to dissociate the chaperone from client proteins including LRRK2, a well-established 14-3-3 binding partner. We found that 14-3-3γ phosphorylated by PAK6 is no longer competent to bind LRRK2 at phospho-Ser935, causing LRRK2 dephosphorylation. To address whether these interactions are relevant in a neuronal context, we demonstrate that a constitutively active form of PAK6 rescues the G2019S LRRK2-associated neurite shortening through phosphorylation of 14-3-3γ. Our results identify PAK6 as the kinase for 14-3-3γ and reveal a novel regulatory mechanism of 14-3-3/LRRK2 complex in the brain