AN ANALYSIS OF THE COMMERCIALITY DETERMINATION FOR UNITED STATES SPACE FORCE SPACE LAUNCH SERVICES

The Orbital Service Program-4 (OSP-4) acquires launch missions as commercial items in accordance with FAR Part 12 to comply with 51 USC §50132, “Acquisition of commercial space transportation services,” which requires space transportation to be considered a commercial item under acquisition laws. As a result, acquisition professionals must opt for contract structures that only allow for Firm Fixed Price contract types and consequently are prohibited from utilizing cost reimbursement contract types. The National Security Space Launch program (NSSL) and the Orbital Service Program (as part of the Rocket Systems Launch Program) share a common commercial item determination and operated under the same Launch Enterprise Division of Space Systems Command until March 2022. As of March 2022, the two programs were realigned under different Deltas within Space Systems Command. This Capstone Applied Project analyzes the current policy for the acquisition of commercial space transportation services as it applies to both the NSSL and OSP-4 programs. Furthermore, the research seeks to address difficulties in determining fair and reasonable prices for space launch services due to the commercial contracts for space launch services containing noncommercial requirements.Civilian, DARPACivilian, Department of the Air ForceApproved for public release. Distribution is unlimited

Hear my voice: a community-based participatory study gathering the lived experiences of people with disabilities and older people in Tanzania

This is the final version of the article. Available from the publisher via the URL in this record.This study provides evidence on the specific nature and experiences of people with disabilities and older people from their own perspectives in rural and urban settings in Tanzania. Its aim was to better inform efforts to provide services for and improve the lives of people living in those regions. A community-based participatory approach was used, involving collaboration with the community. Peer researchers and research partners collected and analysed interviews with people with disabilities and older people, leading to policy and advocacy recommendations and early stage plans. Findings were framed in terms of experiences of participation and inclusion as impacted by physical, social and attitudinal factors, as well presented at individual, interpersonal and societal levels. They demonstrate how lack of access to healthcare and education, social limitations and powerful community attitudes were interwoven and exacerbated poverty in these contexts. Policy recommendations cover issues such as halting persecution and killings of people with albinism, support and guidance for families of children with disabilities, national policy on ageing legislation, and implementing and monitoring the UN Convention on the Rights of Persons with Disabilities

Perancangan Robot Pengikut Garis Berbasis Microcontroller

Currently the development of robot technology is growing rapidly. The technology is utilized and developed to assist people in doing their activities more easily and efficiently. One application of the robotic technology is the line follower robot that is widely used in transportation in industrial field. The purpose of this thesis was to determine the working principle and reliability of the line follower robot with its main components that are power supply, sensors, microcontrollers, and motor drivers. The methodology of the research is to design and to assamble a line follower robot and perform direct testing of the reliability on the on 6,5m “Ϩ” - shaped tracked. The results show that the stages of the assembling of the line follower robot consist of the installation of each circuit and the installation of the drive system in robot frame. The test results show that the line follower robot is able to pass through the track well with average speed of 0,22 m/sec

Improving the Segmentation of Scanning Probe Microscope Images using Convolutional Neural Networks

A wide range of techniques can be considered for segmentation of images of nanostructured surfaces. Manually segmenting these images is time-consuming and results in a user-dependent segmentation bias, while there is currently no consensus on the best automated segmentation methods for particular techniques, image classes, and samples. Any image segmentation approach must minimise the noise in the images to ensure accurate and meaningful statistical analysis can be carried out. Here we develop protocols for the segmentation of images of 2D assemblies of gold nanoparticles formed on silicon surfaces via deposition from an organic solvent. The evaporation of the solvent drives far-from-equilibrium self-organisation of the particles, producing a wide variety of nano- and micro-structured patterns. We show that a segmentation strategy using the U-Net convolutional neural network outperforms traditional automated approaches and has particular potential in the processing of images of nanostructured systems.Comment: 21 pages, 10 figure

GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery

Background: Patients who have severe narrowing at or near the origin of the internal carotid artery as a result of atherosclerosis have a high risk of ischaemic stroke ipsilateral to the arterial lesion. Previous trials have shown that carotid endarterectomy improves long-term outcomes, particularly when performed soon after a prior transient ischaemic attack or mild ischaemic stroke. However, complications may occur during or soon after surgery, the most serious of which is stroke, which can be fatal. It has been suggested that performing the operation under local anaesthesia, rather than general anaesthesia, may be safer. Therefore, a prospective, randomised trial of local versus general anaesthesia for carotid endarterectomy was proposed to determine whether type of anaesthesia influences peri-operative morbidity and mortality, quality of life and longer term outcome in terms of stroke-free survival. Methods/design: A two-arm, parallel group, multicentre randomised controlled trial with a recruitment target of 5000 patients. For entry into the study, in the opinion of the responsible clinician, the patient requiring an endarterectomy must be suitable for either local or general anaesthesia, and have no clear indication for either type. All patients with symptomatic or asymptomatic internal carotid stenosis for whom open surgery is advised are eligible. There is no upper age limit. Exclusion criteria are: no informed consent; definite preference for local or general anaesthetic by the clinician or patient; patient unlikely to be able to co-operate with awake testing during local anaesthesia; patient requiring simultaneous bilateral carotid endarterectomy; carotid endarterectomy combined with another operation such as coronary bypass surgery; and, the patient has been randomised into the trial previously. Patients are randomised to local or general anaesthesia by the central trial office. The primary outcome is the proportion of patients alive, stroke free ( including retinal infarction) and without myocardial infarction 30 days post-surgery. Secondary outcomes include the proportion of patients alive and stroke free at one year; health related quality of life at 30 days; surgical adverse events, re-operation and re-admission rates; the relative cost of the two methods of anaesthesia; length of stay and intensive and high dependency bed occupancy

Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3):a multicentre randomised controlled trial

Acknowledgments The study was jointly sponsored by University of Edinburgh and NHS Lothian. The start up phase of the trial (December, 2008–March, 2010) was funded by Chief Scientist Office of the Scottish Government (ref CZH/4/417). The main phase of the trial was funded by the National Institute of Health Research (NIHR) Health Technology Assessment (HTA) programme (ref 08/14/03). Covidien (MA, USA) lent their Kendall SCD Express Sequential Compression System Controllers to our 105 centres and donated supplies of their sleeves. They also provided logistical help in keeping our centres supplied with sleeves and training materials relevant to the use of their devices. Recruitment and follow-up was supported by the NIHR funded UK Stroke research network and the Scottish Stroke Research network which was supported by NHS Research Scotland (NRS). A full description of the trial will be published in the Health Technology Assessment journal series. Visit the HTA programme website for more details. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the Department of Health or Chief Scientist Office of the Scottish Government. Open Access funded by Department of Health UKPeer reviewedPublisher PD

Automated Searching and Identification of Self-Organized Nanostructures

Currently, researchers spend significant time manually searching through large volumes of data produced during scanning probe imaging to identify specific patterns and motifs formed via self-assembly and self-organisation. Here, we use a combination of Monte Carlo simulations, general statistics and machine learning to automatically distinguish several spatially-correlated patterns in a mixed, highly varied dataset of real AFM images of self-organised nanoparticles. We do this regardless of feature-scale and without the need for manually labelled training data. Provided that the structures of interest can be simulated, the strategy and protocols we describe can be easily adapted to other self-organised systems and datasets

Hearing aid review appointments : attendance and effectiveness

PURPOSE : This study aimed to (a) identify participant factors associated with Xappointment attendance, (b) investigate whether the completion of self-report survey identifying hearing aid-related problems affects HAR appointment attendance, and (c) investigate whether hearing aid problems and hearing aid management deficiencies are adequately addressed during HAR appointments. METHOD : A prospective cohort study of adult hearing aid owners recruited from a single hearing clinic in Western Australia. Potential participants were invited to an annual HAR appointment via postal letter. The invitation included a paper-based self-report survey evaluating either (a) hearing aid problems, (b) hearing aid management skills, or (c) hearing aid outcomes, depending on which intervention/control group the potential participants were assigned to, and a reply paid addressed envelope. Two months later, potential participants were sent all three paper-based self-report surveys, irrespective of whether they had attended or not attended an HAR appointment. RESULTS : (a) There was no significant difference in gender or source of funding for hearing services between HAR appointment attendees and nonattendees. HAR nonattendees lived a greater distance from their clinic and were younger than attendees. (b) Survey completion did not influence HAR appointment attendance rates. (c) A significant reduction in individuals' self-reported hearing aid problems was recorded following the attendance at the HAR appointment. No significant changes in hearing aid management skills or overall hearing aid outcomes were detected. CONCLUSIONS : Long travel distances may be a barrier to attendance at review appointments. HAR appointments appear to be effective in improving hearing aid problems.PURPOSE : This study aimed to (a) identify participant factors associated with hearing aid review (HAR) appointment attendance, (b) investigate whether the completion of self-report survey identifying hearing aid-related problems affects HAR appointment attendance, and (c) investigate whether hearing aid problems and hearing aid management deficiencies are adequately addressed during HAR appointments. METHOD : A prospective cohort study of adult hearing aid owners recruited from a single hearing clinic in Western Australia. Potential participants were invited to an annual HAR appointment via postal letter. The invitation included a paper-based self-report survey evaluating either (a) hearing aid problems, (b) hearing aid management skills, or (c) hearing aid outcomes, depending on which intervention/control group the potential participants were assigned to, and a reply paid addressed envelope. Two months later, potential participants were sent all three paper-based self-report surveys, irrespective of whether they had attended or not attended an HAR appointment. RESULTS : (a) There was no significant difference in gender or source of funding for hearing services between HAR appointment attendees and nonattendees. HAR nonattendees lived a greater distance from their clinic and were younger than attendees. (b) Survey completion did not influence HAR appointment attendance rates. (c) A significant reduction in individuals' self-reported hearing aid problems was recorded following the attendance at the HAR appointment. No significant changes in hearing aid management skills or overall hearing aid outcomes were detected. CONCLUSIONS : Long travel distances may be a barrier to attendance at review appointments. HAR appointments appear to be effective in improving hearing aid problems.https://pubs.asha.org/journal/ajahj2022Speech-Language Pathology and Audiolog

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage:Extended Follow-up of the RESTART Randomized Clinical Trial

Importance: The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage (ICH) that had occurred during antithrombotic (antiplatelet or anticoagulant) therapy. Objectives: To monitor adherence, increase duration of follow-up, and improve precision of estimates of the effects of antiplatelet therapy on recurrent ICH and major vascular events. Design, setting and participants: From May 22, 2013, through May 31, 2018, this prospective, open, blinded end point, parallel-group randomized clinical trial studied 537 participants at 122 hospitals in the UK. Participants were individuals 18 years or older who had taken antithrombotic therapy for the prevention of occlusive vascular disease when they developed ICH, discontinued antithrombotic therapy, and survived for 24 hours. After initial follow-up ended on November 30, 2018, annual follow-up was extended until November 30, 2020, for a median of 3.0 years (interquartile range [IQR], 2.0-5.0 years) for the trial cohort. Interventions: Computerized randomization that incorporated minimization allocated participants (1:1) to start or avoid antiplatelet therapy. Main outcomes and measures: Participants were followed up for the primary outcome (recurrent symptomatic ICH) and secondary outcomes (all major vascular events) for up to 7 years. Data from all randomized participants were analyzed using Cox proportional hazards regression, adjusted for minimization covariates. Results: A total of 537 patients (median age, 76.0 years; IQR, 69.0-82.0 years; 360 [67.0%] male; median time after ICH onset, 76.0 days; IQR, 29.0-146.0 days) were randomly allocated to start (n = 268) or avoid (n = 269 [1 withdrew]) antiplatelet therapy. The primary outcome of recurrent ICH affected 22 of 268 participants (8.2%) allocated to antiplatelet therapy compared with 25 of 268 participants (9.3%) allocated to avoid antiplatelet therapy (adjusted hazard ratio, 0.87; 95% CI, 0.49-1.55; P = .64). A major vascular event affected 72 participants (26.8%) allocated to antiplatelet therapy compared with 87 participants (32.5%) allocated to avoid antiplatelet therapy (hazard ratio, 0.79; 95% CI, 0.58-1.08; P = .14). Conclusions and relevance: Among patients with ICH who had previously taken antithrombotic therapy, this study found no statistically significant effect of antiplatelet therapy on recurrent ICH or all major vascular events. These findings provide physicians with some reassurance about the use of antiplatelet therapy after ICH if indicated for secondary prevention of major vascular events. Trial registration: isrctn.org Identifier: ISRCTN71907627