Sustainable business solutions through lean product lifecycle management

In today\u27s process manufacturing environment, innovation is viewed as critical to sustainable growth and business profitability. While open innovation is regarded as the answer, the companies can effectively measure the return on R&D investment, have acceptable product success rates, achieve acceptable promotional effectiveness, or have visibility into their compliance risks or operational readiness for new product launches. While open innovation is an actual topic, capitalizing on the opportunity requires holistic strategy, not just increased collaboration. Companies must have repeatable, compliant and responsive business processes, global information infrastructure that provides a single source of the truth, alignment across departments and solutions that evolve without coding. With holistic strategy and supporting infrastructure, companies can consistently minimize the time to scale, improve product success rates and promotional effectiveness, and enjoy sustainable and profitable growth. With open innovation providing unlimited opportunities, the company should start to identify the best open innovation opportunity and deliver top and bottom line of the company\u27s benefits. The companies must first focus on the needs of their customer, continually minimize time to scale, eliminate waste, drive out costs and improve. These are core concepts of a Lean strategy. This paper will describe how Lean concept with PLM business strategy can leverage Lean with integrated compliance, continual improvement and other PLM best practices to increase the return on R&D investments and provide sustainable and profitable growth for business processes mainly manufacturing processes. The purpose of this paper is to review PLM approach linked to Lean concepts in order to achieve sustainable and innovative business processes with sustainable and profitable growth

A Geometric Derivation of the Irwin-Hall Distribution

The Irwin-Hall distribution is the distribution of the sum of a finite number of independent identically distributed uniform random variables on the unit interval. Many applications arise since round-off errors have a transformed Irwin-Hall distribution and the distribution supplies spline approximations to normal distributions. We review some of the distribution’s history. The present derivation is very transparent, since it is geometric and explicitly uses the inclusion-exclusion principle. In certain special cases, the derivation can be extended to linear combinations of independent uniform random variables on other intervals of finite length.The derivation adds to the literature about methodologies for finding distributions of sums of random variables, especially distributions that have domains with boundaries so that the inclusion-exclusion principle might be employed

Results of surgical treatment of patients with aortoiliac atherosclerosis

АТЕРОСКЛЕРОЗАРТЕРИОСКЛЕРОЗАТЕРОСКЛЕРОЗАОРТЫ АНЕВРИЗМААОРТЫ АНЕВРИЗМЫ РАЗРЫВАОРТЫ РАЗРЫВАОРТО-ПОДВЗДОШНАЯ РЕКОНСТРУКЦИЯ /ХИРКРИТИЧЕСКАЯ ИШЕМИЯ КОНЕЧНОСТИ /ДИАГНЦель. Изучить результаты хирургического лечения пациентов с аорто-подвздошной патологией в раннем послеоперационном периоде. Материал и методы. В исследование включено 103 пациента с аортальной патологией, которые были направлены в клинику сосудистой хирургии с 2015 по 2017 гг. Прооперировано 53 пациента с аорто-подвздошным атеросклерозом и 50 пациентов с аневризмой абдоминальной аорты. Показанием к операции были перемежающаяся хромота, критическая ишемия конечности или острый тромбоз аорты у пациентов с аорто-подвздошным атеросклерозом. Показанием к операции у пациентов с аневризмой абдоминальной аорты была аневризма более 5,5 см в поперечном диаметре или разрыв аневризмы. Ранние результаты хирургического лечения пациентов оценивали по частоте послеоперационных осложнений и летальных исходов. Результаты. Из 53 пациентов с аорто-подвздошным атеросклерозом 49 (92,5%) пациентов были прооперированы в плановом порядке и 4 (7,5%) пациента были прооперированы ургентно. Выполнено 52 (98,2%) аорто-бифеморальных шунтирования и один (1,8%) аорто-феморальный (односторонний) шунт. Три осложнения (6,1%) наблюдались у пациентов, которые были прооперированы в плановом порядке, и одно осложнение (25%) у пациента, которого оперировали в ургентном порядке. Среди ургентных пациентов смертность составила 25%, среди плановых – 2,0%. Прооперированы 28 пациентов с бессимптомной аневризмой абдоминальной аорты и 22 пациента с разрывом аневризмы абдоминальной аорты. Смертность после плановой операции составила 3,6%. У пациентов с разрывом аневризмы абдоминальной аорты смертность составила 40,9%. Заключение. Хорошие и удовлетворительные результаты планового хирургического лечения симптоматического аорто-подвздошного атеросклероза в раннем послеоперационном периоде составили 98%, асимптоматической аневризмы аорты – 96,4%. Смертность после ургентной операции при разрыве аневризмы составила 40,9%. Хирургическое лечение аневризмы аорты показано у пациентов с низким и средним хирургическим риском.Objective. To investigate the results of surgical treatment of patients with aortoiliac pathology in the early postoperative period. Methods. In the study 103 patients with aortoiliac pathology were included, who were referred to the Clinic of Vascular Surgery from 2015 to 2017 years. 53 patients were operated on because of aortoiliac atherosclerosis and 50 patients – because of abdominal aortic aneurysm. The indications for surgery were limiting claudication, critical limb ischemia or acute thrombosis of the aorta in patients with aortoiliac atherosclerosis. The indication for surgery in patients with abdominal aortic aneurysm was the aneurysm over 5.5 cm in the transverse diameter or the ruptured aneurysm. Early results of patients’ surgical treatment were assessed by the frequency of postoperative complications and deaths. Results. 49 (92.5%) out of 53 patients with aortoiliac atherosclerosis were operated on as planned and 4 (7.5%) patients were operated on urgently. 52 (98.2%) aortobifemoral bypasses and one (1.8%) aortofemoral (unilateral) bypass were performed. Three complications (6.1%) occurred postoperatively in patients operated on according to plan and one complication (25%) – in patients operated urgently. The mortality rate was 25% in urgent patients and 2.0% in planned patients. 28 patients with asymptomatic abdominal aortic aneurysm and 22 with the ruptured abdominal aortic aneurysm were operated on. The mortality in the planned patients was 3.6%. 40.9% mortality rate was registered in the ruptured abdominal aortic aneurysm patients. Conclusions. Early good and satisfactory results of the routine surgical treatment of symptomatic aortoiliac atherosclerosis in the early postoperative period accounted 98%, asymptomatic aortic aneurysm – 96.4%. Mortality after urgent surgery with aneurysm rupture made up 40.9%. Surgical treatment of aortic aneurysm is indicated in patients with low and moderate surgical risk

Factores socioculturales y uso de métodos anticonceptivos en adolescentes del Centro Poblado Pampa Grande –Tumbes, 2023

Se realizó un estudio de tipo descriptivo y diseño no experimental con un enfoque metodológico cuantitativo. Objetivo: Determinar los factores socioculturales que se relacionan con el uso de métodos anticonceptivos en adolescentes del Centro Poblado de Pampa Grande, Tumbes, 2023, en una muestra de 75 adolescentes delCentro Poblado de Pampa Grande. Método: La encuesta y la técnica fue la entrevista inherente a los objetivos de investigación. Resultados: Han permitido identificar que el 65.3% adolescentes no utilizan métodos anticonceptivos. Los factores sociales que se relacionaron fueron: la edad, estado civil, ocupación y la creencia de que la ocupación influye en el uso de dichos métodos (p< 0,05) y los factores culturales que se relacionaron fueron: grado de instrucción y conocimiento sobre si los métodos anticonceptivos naturales son menos efectivos (p<0,05). Conclusión: Existe relación entre los factores socioculturales y el uso de métodosanticonceptivos

Multifocal Assessment Reveals Anemia-related Program Gaps and Implementation Challenges in Ghana (P10-088-19)

Objectives: Despite existing program efforts in Ghana, incidence of childhood anemia remain high. This study describes existing childhood anemia prevention and treatment strategies and assessed implementation gaps. Methods: A cross-sectional study using purposive sampling/snowballing technique identified organizations implementing childhood anemia prevention and treatment programs. Interview guides constructed around UNICEF\u27s conceptual framework of malnutrition identified programs addressing each cause of anemia. Interviews were administered via in-person and phone in August 2018. Interviews were audio-recorded, transcribed, and coded/analyzed using Dedoose software version 8.1.8. Results: Twenty-five officials from Universities (n = 2), local non-governmental (n = 4), government departments (n = 6) and international (n = 2) agencies completed interviews. Reported contextual immediate causes of anemia were malaria, diarrhea, worm infestation and inadequate dietary intake. All organizations implemented programs addressing ≥1 of the immediate causes, with many overlapping programs from different organizations addressing inadequate dietary intake in the same district. Government-assisted programs and Universities reported national scope; non-governmental/private organizations had regional/district focus. The contextual underlying causes reported were inadequate nutrition knowledge, food safety and environmental hygiene, food insecurity and health services. All organizations were implementing programs addressing ≥1 of these underlying causes. Few programs addressed the reported basic causes namely, inadequate human resources (n = 5) and housing/water/toilet facilities (n = 3) and poverty/financial resources (n = 2). Reported program gaps included inadequate human resources and scarce funding for projects. The main observed gap was insufficient communication and integration between programs implementer. Conclusions: Multiple programs, sometimes with overlapping focus in the same region were addressing anemia. Re-designing programs to prioritize communication between current program may result in efficient use of limited funding and human resources. New programs may focus on improving financial investment in programs and more personnel

Educational and vocational goal disruption in adolescent and young adult cancer survivors

ObjectiveCancer in adolescents and young adults (AYAs) can interrupt important developmental milestones. Absence from school and time lost from work, together with the physical impacts of treatment on energy and cognition, can disrupt educational and vocational goals. The purpose of this paper is to report on AYA cancer survivors’ experiences of reintegration into school and/or work and to describe perceived changes in their educational and vocational goals.MethodsAdolescents and young adults recruited from 7 hospitals in Australia, aged 15 to 26 years and â ¤24 months posttreatment, were interviewed using the psychosocial adjustment to illness scale. Responses were analysed to determine the extent of, and explanations for, cancer’s effect on school/work.ResultsFortyâ two AYA cancer survivors (50% female) participated. Compared with their previous vocational functioning, 12 (28.6%) were scored as experiencing mild impairment, 14 (33.3%) moderate impairment, and 3 (7.1%) marked impairment. Adolescents and young adults described difficulties reintegrating to school/work as a result of cognitive impacts such as concentration problems and physical impacts of their treatment, including fatigue. Despite these reported difficulties, the majority indicated that their vocation goals were of equal or greater importance than before diagnosis (26/42; 62%), and most AYAs did not see their performance as compromised (23/42; 55%). Many survivors described a positive shift in life goals and priorities. The theme of goal conflict emerged where AYAs reported compromised abilities to achieve their goals.ConclusionsThe physical and cognitive impacts of treatment can make returning to school/work challenging for AYA cancer survivors. Adolescents and young adults experiencing difficulties may benefit from additional supports to facilitate meaningful engagement with their chosen educational/vocational goals.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142495/1/pon4525_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142495/2/pon4525.pd

Результаты симультанных операций у пациентов с атеросклеротическим поражением сонных и коронарных артерий

СОННЫЕ АРТЕРИИАТЕРОСКЛЕРОЗАРТЕРИОСКЛЕРОЗКОРОНАРНЫХ АРТЕРИЙ СТЕНОЗКАРОТИДНАЯ ЭНДАРТЕРЭКТОМИЯСОННОЙ АРТЕРИИ ЭНДАРТЕРЭКТОМИЯСТЕНОКАРДИЯАОРТОКОРОНАРНОЕ ШУНТИРОВАНИЕКОРОНАРНОЙ АРТЕРИИ ШУНТИРОВАНИ

The ComX Quorum Sensing Peptide of Bacillus subtilis Affects Biofilm Formation Negatively and Sporulation Positively

Quorum sensing (QS) is often required for the formation of bacterial biofilms and is a popular target of biofilm control strategies. Previous studies implicate the ComQXPA quorum sensing system of Bacillus subtilis as a promoter of biofilm formation. Here, we report that ComX signaling peptide deficient mutants form thicker and more robust pellicle biofilms that contain chains of cells. We confirm that ComX positively affects the transcriptional activity of the P$_{epsA}$ promoter, which controls the synthesis of the major matrix polysaccharide. In contrast, ComX negatively controls the P$_{tapA}$ promoter, which drives the production of TasA, a fibrous matrix protein. Overall, the biomass of the mutant biofilm lacking ComX accumulates more monosaccharide and protein content than the wild type. We conclude that this QS phenotype might be due to extended investment into growth rather than spore development. Consistent with this, the ComX deficient mutant shows a delayed activation of the pre-spore specific promoter, P$_{spoIIQ}$, and a delayed, more synchronous commitment to sporulation. We conclude that ComX mediated early commitment to sporulation of the wild type slows down biofilm formation and modulates the coexistence of multiple biological states during the early stages of biofilm development

The variation of actinobacteria species from a vicia sativa cultivated soil microhabitat

Actinobacteria is a fairly complex group, intermediate between bacteria and filamentous fungi involved in producing some infection, in the case of pathogenic strains and recycling of organic matter, as in the case of nonpathogenic actinobacteria. Literature data have surprised many plant-microorganism interaction, on the one hand making reference to the mineralization processes involving microorganisms by whom plants necessary nutrients are released, and on the other hand underlines the influence of plants on the quantity and quality of microbial population in root area as a result of exudates removed in the natural environment. Actinobacteria from Frankia genus are counted among bacteria being able to fix nitrogen, and those from the genus Streptomyces are major producers of antibiotics and numerous secondary metabolites. This paper presents the study of the composition of Streptomyces genus actinobacteria community from a moderately gleyed eutricambosoil, grown with vetch (Vicia sativa). The soil is located in the western part of Romania. Biological material sampling was conducted in October, the depth of 0-20 cm. Isolation and studies of this bacterial group were performed "in vitro", on Gause 1 culture media. Actinobacteria were collected from four areas (biotopes): the plot uncultivated with Vicia sativa (control variant), the far rhizospheric area, the hairy root and root areas of vetch plant. Based on effectuated observations, it was noticed that soil microhabitats contain a variety of actinobacteria and S. albosporeus, S. aureus, S. griseus, S.albus, S. nigrescens, S. lavenduleroseus, S. helvolus. Numerically dominant species in tested soil samples are: S. griseus, S. albus and S. albosporeus

Performance of the Human Quantifiler, the Investigator Quantiplex and the Investigator ESSplex Plus kit for quantification and nuclear DNA typing of old skeletal remains

Abstract: Aim. We tested the performance of two real-time polymerase chain reaction (PCR) human quantification kits (Human Quantifiler (Applied Biosystems) and Investigator Quantiplex kit (Qiagen)) and forensic identification short tandem repeat (STR) Investigator ESSplex Plus (Qiagen) kit on approximately 70 years old skeletal remains. Methods. We analysed 54 bones and teeth excavated from Second World War mass graves in Slovenia. Genomic DNA was obtained from 0.5 g of bone or tooth powder after total demineralization. The DNA was purified in a Biorobot EZ1 (Qiagen) device. The same extract was used for quantification and STR typing with all three kits using the amplification conditions recommended by the manufacturers. Results. In almost two thirds of the samples the results of quantification were up to 6 times higher using the Human Quantifiler than using the Investigator Quantiplex kit, because of the degradation of DNA in old skeletal remains and amplification of shorter DNA fragment with the Human Quantifiler kit. The autosomal STR typing with the Investigator ESSplex Plus kit was successful in 52 out of the 54 samples, which represent a 96% success rate. Conclusion. The commercially available Investigator ESSplex Plus kit can be used for STR typing of old skeletal remains with the DNA extraction method optimised in our laboratory and without any changes to the manufacturers&apos; PCR amplification protocols. The Human Quantifiler kit and Investigator Quantiplex kit together can be used for estimation of the degree of DNA degradation in compromised old bone samples. n skeletonised human remains bones and teeth are the only accessible source of DNA which can be preserved for a long time. In them binding of DNA to hydroxyapatite provides stability of DNA and its preservation In addition, the chemistry and methods used for DNA extraction and amplification may have a strong effect on the amplification succes