The soup that is not too hot

The exploration of the QCD phase diagram is the goal of many experiments in the world. The low net baryon density region is relatively well studied, while the one corresponding to higher net densities still contains multiple unrevealed puzzles getting significant attention. In multiple experimental complexes such as STAR or HADES, the heavy ions collide at relatively lower energies than those obtained at LHC, creating "not the hottest soup" of nuclear matter. The examination of it provides unique insights into understanding the properties of matter production and its transitions. In this paper, several of the significant experimental discoveries are reviewed.Comment: 5 pages

Examination of heavy-ion collisions using EPOS model in the frame of BES program

EPOS is a generator which allows one to simulatevarious types of collisions of divers systems with different initialparameters. It considers the parton-based Gribov-Regge theory.So far the EPOS model has been used to describe highercollision energies obtained with RHIC or LHC data. Onthe other hand, there is another program under investigation:Beam Energy Scan conducted at Brookhaven National Laboratory.The beams of gold ions are collided at energies such as psN

Event-by-event investigation of the two-particle source function in heavy-ion collisions with EPOS

Exploring the shape of the pair-source function for particles such as pions or kaons has been an important goal of heavy-ion physics, and substantial effort has been made in order to understand the underlying physics behind the experimental observations of non-Gaussian behavior. In experiments, since no direct measurement of the source function is possible, quantum-statistical momentum correlations are utilized to gain information about the space-time geometry of the particle emitting source. Event generators, such as EPOS, however, provide direct access to the freeze-out coordinates of final state particles, and thus the source function can be constructed and investigated. The EPOS model is a sophisticated hybrid model where the initial stage evolution of the system is governed by Parton-Based Gribov-Regge theory, and subsequently a hydrodynamic evolution is utilized, followed by hadronization and hadron dynamics. EPOS has already proven to be successful in describing several different experimental observations for systems characterized by baryon chemical potential close to zero, but so far the source shape has not been explored in detail. In this paper we discuss an event-by-event analysis of the two-particle source function in $\sqrt{s_{NN}}$ = 200 GeV Au+Au collisions generated by the EPOS model. We find that when utilizing all stages of the model, L\'evy-shaped distributions (unlike Gaussian distributions) provide a good description of the source shape in the individual events. Hence it is clear that it is not the event averaging that creates the non-Gaussian features in the pair distributions. Based on this observation, we determine L\'evy-parameters of the source as a function of event centrality and particle momentum.Comment: 13 pages, 6 figure

SolidarCity Policy Group – Policies affecting employment and entrepreneurship in towns and cities

National and European employment objectives cannot be achieved without the active involvement of actors at the regional and local level. The idea of the project SolidarCity has been developed in continuity of 3 EQUAL Projects implemented during the period 2001 – 2006 by EFXINI POLI / Network of 30 Local Authorities and in collaboration with multidimensional partnerships all having experience in working within the existing employment policy framework and tailoring programs to local needs, influencing the employment development policy itself by becoming an integral part of policy design and appliance. SolidarCity as a decisive intervention from all local actors (regional & local authorities, civil society) for employment rate increase at local level appears as a need to contribute to the economic modernization and increased competitiveness of Europe. Main objective of the SolidarCity project is to improve the effectiveness of regional development policies by enhancing the role and involvement of local & regional authorities and civil society in employment rate increase through exploring the parameters which burden the active participation into the local labour market and finding ways to create more and better. This paper will present the outputs of SolidarCity project concerning policies affecting employment and entrepreneurship in towns and cities from several countries as: Greece, Bulgaria, United Kingdom, Finland, Italy and Romania. This project was financed by European Union, European Regional Development Fund through INTERREG IVC (www.i4c.eu) program

Confronting experimental data with heavy-ion models: Rivet for heavy ions

The Rivet library is an important toolkit in particle physics, and serves as a repository for analysis data and code. It allows for comparisons between data and theoretical calculations of the final state of collision events. This paper outlines several recent additions and improvements to the framework to include support for analysis of heavy ion collision simulated data. The paper also presents examples of these recent developments and their applicability in implementing concrete physics analyses

Comparison of clofarabine activity in childhood and adult acute leukemia : individual tumor response study

Background: Clofarabine is a second-generation nucleoside analogue. The aim of the study was the analysis of ex vivo activity of clofarabine and 14 other anticancer drugs in pediatric and adult acute lymphoblastic (ALL) and myeloid (AML) leukemia. Patients and Methods: The ex vivo drug resistance profile was analyzed in 282 patients, including 201 children with ALL de novo, 24 children with relapsed ALL, 25 children with AML de novo and 32 adults with AML. Cellular ex vivo drug resistance was tested by means of the MTT assay. Results: Clofarabine had comparable ex vivo activity against lymphoblasts and myeloblasts, both on initial diagnosis and at relapse, both in children and in adults. Its activity in acute myeloid leukemia was independent of patient age. No significant differences in drug resistance to clofarabine between pediatric age-based subgroups of ALL were detected, while it was observed for most of other drugs. An activity of clofarabine in relapsed pediatric ALL patients was as good as in newly-diagnosed ones. Conclusion: In comparison to childhood acute lymphoblastic leukemia, lack of differences in ex vivo activity gives rationale for use of clofarabine in refractory and relapsed pediatric and adult patients with acute myeloid leukemia

Prognostic impact of combined fludarabine, treosulfan and mitoxantrone resistance profile in childhood acute myeloid leukemia

Background: The role of cellular drug resistance in childhood acute myeloid leukemia (AML) has not yet been established. The aim of the study was the analysis of the clinical value of ex vivo drug resistance in pediatric AML. Patients and Methods: A cohort of 90 children with de novo AML were assayed for drug resistance profile by the 3-4,5- dimethylthiazol-2-yl-2,5-difenyl tetrazolium bromide (MTT) assay and prognostic model of in vitro drug sensitivity was analyzed. Results: Children who relapsed during follow-up showed higher in vitro resistance of leukemic blasts to most of the drugs tested, except for cytarabine, cladribine, vincristine, mercaptopurine and thioguanine. A combined in vitro drug resistance profile to fludarabine, treosulfan and mitoxantrone (FTM score) was defined and it had an independent prognostic significance for disease free survival in pediatric AML. Conclusion: The combined fludarabine, treosulfan and mitoxantrone resistance profile to possibly may be used for better stratification of children with AML or indicate the necessity for additional therapy

CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.

BACKGROUND: Markers of cerebrovascular disease are common in dementia, and may be present before dementia onset. However, their clinical relevance in midlife adults at risk of future dementia remains unclear. We investigated whether the Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score was associated with markers of cerebral small vessel disease (SVD), and if it predicted future progression of SVD. We also determined its relationship to systemic inflammation, which has been additionally implicated in dementia and SVD. METHODS: Cognitively healthy midlife participants were assessed at baseline (n=185) and 2-year follow-up (n=158). To assess SVD, we quantified white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), microbleeds and lacunes. We derived composite scores of SVD burden, and subtypes of hypertensive arteriopathy and cerebral amyloid angiopathy. Inflammation was quantified using serum C-reactive protein (CRP) and fibrinogen. RESULTS: At baseline, higher CAIDE scores were associated with all markers of SVD and inflammation. Longitudinally, CAIDE scores predicted greater total (p<0.001), periventricular (p<0.001) and deep (p=0.012) WMH progression, and increased CRP (p=0.017). Assessment of individual CAIDE components suggested that markers were driven by different risk factors (WMH/EPVS: age/hypertension, lacunes/deep microbleeds: hypertension/obesity). Interaction analyses demonstrated that higher CAIDE scores amplified the effect of age on SVD, and the effect of WMH on poorer memory. CONCLUSION: Higher CAIDE scores, indicating greater risk of dementia, predicts future progression of both WMH and systemic inflammation. Findings highlight the CAIDE score's potential as both a prognostic and predictive marker in the context of cerebrovascular disease, identifying at-risk individuals who might benefit most from managing modifiable risk.Research grants from the UK Alzheimer's Society, the US Alzheimer’s Association and philanthropic donations. This work was funded by a grant for the PREVENT-Dementia programme from the UK Alzheimer’s Society (grant numbers 178 and 264), and the PREVENT-Dementia study is also supported by the US Alzheimer’s Association (grant number TriBEKa-17–519007) and philanthropic donations. AL is supported by the Lee Kuan Yew Fitzwilliam PhD Scholarship and the Tan Kah Kee Postgraduate Scholarship. JDS is a Wellcome clinical PhD fellow funded on grant 203914/Z/16/Z to the Universities of Manchester, Leeds, Newcastle and Sheffield. EM is supported by Alzheimer’s Society Junior Research Fellowship (RG 9611). LS is supported by the Cambridge NIHR Biomedical Research Centre (BRC) and Alzheimer’s Research UK (ARUK-SRF2017B-1). HSM is supported by an NIHR Senior Investigator award. JOB and HSM receive infrastructural support from the Cambridge NIHR Biomedical Research Centre (BRC). This research was supported by the NIHR Cambridge BRC (BRC-1215-20014). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care