Language Reform by Lebanese Lexicographers in the Nahḍa: The case of Saʻīd al-Ḫūrī aš-Šartūnī

This article provides an overview of the social and literary revival and linguistic regeneration of the nineteenth century in Arab countries, especially in the Syro-Lebanese region. After outlining the work of the most important Lebanese lexicographers, this research focuses on the author Saʻīd al-Ḫūrī aš-Šartūnī and his multiple interests. The aim of this paper is to understand the role of this author in a reform carried out by two groups of intellectuals, one conservative and one reformist, in the period called Nahḍa

Promozione della partecipazione, della salute e del ben-essere sociale con le comunità educanti territoriali: persone, famiglie, istituzioni in una prospettiva di interezza delle politiche pubbliche

The research thesis Promotion of participation, health and social well-being with educating local communities. Persons, Families, Insitutions in the context of public policies presents the results of a wide range of socio-pedagogical activities with communities. Data concerning the social context of reference of this study shows that services, professions, disciplinary gestures are often self-referential and that quite narrow and deterministic interpretations of socio-educational dynamics are not adequate to deal with nonlinear inconveniences,needs and desires of the people. Therefore, social actions and educational interventations in Sardinia appear often fragmented, dis-combined and the public policies disorganized and disconnected. The research has been inspired by a pedagogy of dialogue, by Freire’s action-praxis posture and by the action-research approach. On such premises, this work presented promoted and co-activated in the Sardinian territory a process aimed at co-construction of educating local communities as places of pro-life engines of dialogic processes and relationships among persons, families, communities, institutions and territories. Health promotion combined with the promotion of social participation,culture,active citizenship and the entirety of public policies have given life to local educational alliances aimed at co-generated responses of the whole community which are strictly connected with perceived needs of local populations, in order to activate an “Inclusive Welfare”

Synthesis and sar study of 2-substituted imidazo[2,1-b] [1,3]benzothiazoles and related compounds endowed with affinity for dopamine D₂ receptors as potential antipsychotics

Typical antipsychotic agents such as chlorpromazine and haloperidol block the D2 subtype of dopamine receptors in a direct relation to their clinical potency. In this context we have developed a series of (1,2-diphenyl-imidazolyl)piperazine derivatives (1) that are endowed with substantial affinities for both dopamine D2 receptors as well as 5-HT1A and 5-HT2A serotonin receptors, compound 1a (R = o-OCH3) of which is representative. We have extended our study on other series of compounds derived from 1 both modifying the 1,2-diphenyl motif attached to the imidazole core, and the phenyl-piperazine moiety

Cadmium Yellow Pigments in Oil Paintings: Optical Degradation Studies Utilizing 3D Fluorescence Mapping Supported by Raman Spectroscopy and Colorimetry

The degradation of cadmium yellow in paintings is influenced by various factors, primarily environmental conditions and light exposure. Applying a thin protective layer of linseed oil on the surface could help mitigate these processes. Linseed oil, being a natural material, acts as a barrier against harmful atmospheric agents like moisture and oxygen, which contribute to the degradation of pigments including cadmium yellow. Additionally, linseed oil reduces direct light exposure, thereby lowering the risk of fading and color alteration. In this study, we explored the degradation of cadmium pigments mixed with oil and applied on canvas. We elucidated how the use of a binder prevents the direct oxidation of the pigment, inducing artificial degradation by irradiating samples with UVA (365 nm) and UVC (250 nm) sources. By employing various spectroscopic techniques such as three-dimensional fluorescence mapping (PLE) and Raman, along with colorimetric analysis, we gained a comprehensive understanding of the degradation process, particularly when linseed oil serves as a protective layer

Promising Molecular Architectures for Two-Photon Probes in the Diagnosis of α-Synuclein Aggregates

The abnormal deposition of protein in the brain is the central factor in neurodegenerative disorders (NDs). These detrimental aggregates, stemming from the misfolding and subsequent irregular aggregation of α-synuclein protein, are primarily accountable for conditions such as Parkinson’s disease, Alzheimer’s disease, and dementia. Two-photon-excited (TPE) probes are a promising tool for the early-stage diagnosis of these pathologies as they provide accurate spatial resolution, minimal intrusion, and the ability for prolonged observation. To identify compounds with the potential to function as diagnostic probes using two-photon techniques, we explore three distinct categories of compounds: Hydroxyl azobenzene (AZO-OH); Dicyano-vinyl bithiophene (DCVBT); and Tetra-amino phthalocyanine (PcZnNH2). The molecules were structurally and optically characterized using a multi-technique approach via UV-vis absorption, Raman spectroscopy, three-dimensional fluorescence mapping (PLE), time-resolved photoluminescence (TRPL), and pump and probe measurements. Furthermore, quantum chemical and molecular docking calculations were performed to provide insights into the photophysical properties of the compounds as well as to assess their affinity with the α-synuclein protein. This innovative approach seeks to enhance the accuracy of in vivo probing, contributing to early Parkinson’s disease (PD) detection and ultimately allowing for targeted intervention strategies

Optimizing the Mechanoluminescent Properties of CaZnOS:Tb via Microwave-Assisted Synthesis: A Comparative Study with Conventional Thermal Methods

Recent developments in lighting and display technologies have led to an increased focus on materials and phosphors with high efficiency, chemical stability, and eco-friendliness. Mechanoluminescence (ML) is a promising technology for new lighting devices, specifically in pressure sensors and displays. CaZnOS has been identified as an efficient ML material, with potential applications as a stress sensor. This study focuses on optimizing the mechanoluminescent properties of CaZnOS:Tb through microwave-assisted synthesis. We successfully synthesized CaZnOS doped with Tb3+ using this method and compared it with samples obtained through conventional solid-state methods. We analyzed the material's characteristics using various techniques to investigate their structural, morphological, and optical properties. We then studied the material's mechanoluminescent properties through single impacts with varying energies. Our results show that materials synthesized through microwave methods exhibit similar optical and, primarily, mechanoluminescent properties, making them suitable for use in photonics applications. The comparison of the microwave and conventional solid-state synthesis methods highlights the potential of microwave-assisted methods to optimize the properties of mechanoluminescent materials for practical applications

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease

Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis, than in lesions induced in resistant BN rats. In BN rats, highest increase in Yap1-tyr357, p73 phosphorylation and Caspase 3 cleavage occurred. In human HCCs with poorer prognosis ( 3 years survival; HCCB). In the latter, higher levels of phosphorylated YAP1-ser127, YAP1-tyr357 and p73, YAP1 ubiquitination, and Caspase 3 cleavage occurred. Expression of stemness markers NANOG, OCT-3/4, and CD133 were highest in HCCP and correlated with YAP1 and YAP1-TEAD levels. In HepG2, Huh7, and Hep3B cells, forced YAP1 over-expression led to stem cell markers expression and increased cell viability, whereas inhibition of YAP1 expression by specific siRNA, or transfection of mutant YAP1 which does not bind to TEAD, induced opposite alterations. These changes were associated, in Huh7 cells transfected with YAP1 or YAP1 siRNA, with stimulation or inhibition of cell migration and invasivity, respectively. Furthermore, transcriptome analysis showed that YAP1 transfection in Huh7 cells induces over-expression of genes involved in tumor stemness. In conclusion, Yap1 post-translational modifications favoring its ubiquitination and apoptosis characterize HCC with better prognosis, whereas conditions favoring the formation of YAP1-TEAD complexes are associated with aggressiveness and acquisition of stemness features by HCC cells

a multidisciplinary approach in the diagnosis of allergic and non allergic respiratory diseases nasal cytology and feno

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Copper chloro-complexes concentrated solutions: An electrochemical study

Basic studies on concentrated solutions are becoming more and more important due to the practical industrial and geological applications. The use in redox flow batteries is one of the most important applications of these solutions. Specifically, in this paper we investigated high-concentrated copper chloro-complexes solutions with different additives. The concentration of ligands and additives affects the physicochemical and electrochemical properties of 2 M solutions of Cu(I) and Cu(II). Solutions with calcium chloride and HCl as Cl- source were investigated with Cu:Cl ratios of 1:5 and 1:7, the 1:5 Cu:Cl ratio being the best performing. The substitution of calcium chloride with ammonium chloride increased the conductivity. However, while the effect on the positive electrode process was not very evident, the reversibility of the copper deposition-stripping process was greatly improved. Orthophosphoric acid could be a viable additive to decrease the complexation of calcium with chloride anions and to improve the stability of Cu(II) chloro-complexes. Absorption spectroscopy demonstrated that phosphate ions do not coordinate copper(II) but lead to a shift in the distribution of copper chloro-complexes toward more coordinated species. Electrochemically, the increased availability of chloride anions in solution stabilized the Cu(II)-rich solution and led to increased reversibility of the Cu(II)/Cu(I) redox process

Selecting molecular or surface centers in carbon dots-silica hybrids to tune the optical emission: A photo-physics study down to the atomistic level

In this work, we unveil the fluorescence features of citric acid and urea-based Carbon Dots (CDs) through a photo-physical characterization of nanoparticles synthesized, under solvent-free and open-air condi-tions, within silica-ordered mesoporous silica, as a potential host for solid-state emitting hybrids. Compared to CDs synthesized without silica matrices and dispersed in water, silica-CD hybrids display a broader emission in the green range whose contribution can be increased by UV and blue laser irradi-ation. The analysis of hybrids synthesized within different silica (MCM-48 and SBA-15) calls for an active role of the matrix in directing the synthesis toward the formation of CDs with a larger content of graphitic N and imidic groups at the expense of N-pyridinic molecules. As a result, CDs tuned in size and with a larger green emission are obtained in the hybrids and are retained once extracted from the silica matrix and dispersed in water. The kinetics of the photo-physics under UV and blue irradiation of hybrid samples show a photo-assisted formation process leading to a further increase of the relative contribution of the green emission, not observed in the water-dispersed reference samples, suggesting that the porous matrix is involved also in the photo-activated process. Finally, we carried out DFT and TD-DFT calcula-tions on the interaction of silica with selected models of CD emitting centers, like surface functional groups (OH and COOH), dopants (graphitic N), and citric acid-based molecules. The combined experimen-tal and theoretical results clearly indicate the presence of molecular species and surface centers both emitting in the blue and green spectral range, whose relative contribution is tuned by the interaction with the surrounding media