The QCD equation of state and the effects of the charm

We present an update on the QCD equation of state of the Wuppertal-Budapest Collaboration, extending our previous studies [JHEP 0601 (2006) 089, JHEP 1011 (2010) 077]. A Symanzik improved gauge and a stout-link improved staggered fermion action is utilized. We discuss partial quenching and present preliminary results for the fully dynamical charmed equation of state.Comment: Talk presented at the XXIX International Symposium on Lattice Field Theory, July 10-16, 2011, Lake Tahoe, Californi

N_f=2+1 flavour equation of state

We conclude our investigation on the QCD equation of state (EoS) with 2+1 staggered flavors and one-link stout improvement. We extend our previous study [JHEP 0601:089 (2006)] by choosing even finer lattices. These new results [for details see arXiv:1007.2580] support our earlier findings. Lattices with N_t=6,8 and 10 are used, and the continuum limit is approached by checking the results at N_t=12. A Symanzik improved gauge and a stout-link improved staggered fermion action is taken; the light and strange quark masses are set to their physical values. Various observables are calculated in the temperature (T) interval of 100 to 1000~MeV. We compare our data to the equation of state obtained by the "hotQCD" collaboration.Comment: presented at the XXVIII. International Symposium on Lattice Field Theory, June 14-19,2010, Villasimius, Sardinia Ital

Transition temperature and the equation of state from lattice QCD, Wuppertal-Budapest results

The QCD transition is studied on lattices up to $N_t=16$. The chiral condensate is presented as a function of the temperature, and the corresponding transition temperature is extracted. The equation of state is determined on lattices with $N_t=6,8,10$ and at some temperature values with $N_t=12$. The pressure and the trace anomaly are presented as functions of the temperature in the range 100 ...1000 MeV . Using the same configurations we determine the continuum extrapolated phase diagram of QCD on the $\mu-T$ plane for small to moderate chemical potentials. Two transition lines are defined with two quantities, the chiral condensate and the strange quark number susceptibility.Comment: 4 pages, 2 figures, Proceedings for Quark Matter 201

Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.

Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality to give rise to the underlying disease. Using X-ray crystallography, we show that the ciliopathy-associated centriolar protein CEP120 contains three C2 domains. The point mutations V194A and A199P, which cause Joubert syndrome (JS) and Jeune asphyxiating thoracic dystrophy (JATD), respectively, both reduce the thermostability of the second C2 domain by targeting residues that point toward its hydrophobic core. Genome-engineered cells homozygous for these mutations have largely normal centriole numbers but show reduced CEP120 levels, compromised recruitment of distal centriole markers, and deficient cilia formation. Our results provide insight into the disease mechanism of two ciliopathic mutations in CEP120, identify putative binding partners of CEP120 C2B, and suggest a complex genotype-phenotype relation of the CEP120 ciliopathy alleles

Object Affordances Tune Observers' Prior Expectations about Tool-Use Behaviors

Learning about the function and use of tools through observation requires the ability to exploit one's own knowledge derived from past experience. It also depends on the detection of low-level local cues that are rooted in the tool's perceptual properties. Best known as ‘affordances’, these cues generate biomechanical priors that constrain the number of possible motor acts that are likely to be performed on tools. The contribution of these biomechanical priors to the learning of tool-use behaviors is well supported. However, it is not yet clear if, and how, affordances interact with higher-order expectations that are generated from past experience – i.e. probabilistic exposure – to enable observational learning of tool use. To address this question we designed an action observation task in which participants were required to infer, under various conditions of visual uncertainty, the intentions of a demonstrator performing tool-use behaviors. Both the probability of observing the demonstrator achieving a particular tool function and the biomechanical optimality of the observed movement were varied. We demonstrate that biomechanical priors modulate the extent to which participants' predictions are influenced by probabilistically-induced prior expectations. Biomechanical and probabilistic priors have a cumulative effect when they ‘converge’ (in the case of a probabilistic bias assigned to optimal behaviors), or a mutually inhibitory effect when they actively ‘diverge’ (in the case of probabilistic bias assigned to suboptimal behaviors)

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.

Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated structures, such as the striated fibers in Chlamydomonas that are important for ciliary function. The conserved protein CCDC61/VFL3 is involved in this process, but its exact role is unclear. Here, we show that CCDC61 is a paralog of SAS6. Crystal structures of CCDC61 demonstrate that it contains two homodimerization interfaces that are similar to those found in SAS6, but result in the formation of linear filaments rather than rings. Furthermore, we show that CCDC61 binds microtubules and that residues involved in CCDC61 microtubule binding are important for ciliary function in Chlamydomonas. Together, our findings suggest that CCDC61 and SAS6 functionally diverged from a common ancestor while retaining the ability to scaffold the assembly of basal body-associated structures or centrioles, respectively