127 research outputs found
Amused, accepted, and used? Attitudes and emotions towards automated vehicles, their relationships, and predictive value for usage intention
Automated vehicles (AVs) have left the laboratories and can be experienced in several projects, e.g. at the premises of a clinic in Germany. With this transition, research on AV attitudes no longer needs to rely on questionnaires with hypothetical scenarios and simulations. Previous research â limited by the unavailability of AVs â has provided ambivalent results regarding age and gender differences in attitudes towards AVs. We present research results about the role of age and gender in connection with attitudes such as acceptance, perceived safety, and trust, as well as intention to use. We additionally demonstrate relationships between those constructs and emotions such as amusement, fear, and surprise. Data were collected from participants (nâŻ=âŻ125) after having experienced an AV ride with level 4 automation on two campuses of a clinic in Berlin, Germany. Results reveal strong correlations between all attitudes (0.55âŻâ€âŻrâŻâ€âŻ0.71; pâŻ<âŻ0.01) and show acceptance and perceived safety to be solid predictors of intention to use AVs. We also found age to be a significant predictor for usage intention even when other attitudes are considered (ÎČâŻ=âŻâ0.22; pâŻ<âŻ0.01). MANOVA results point to gender differences in all constructs, but with limited confidence (5.40âŻâ€âŻFâŻâ€âŻ18.34; pâŻâ€âŻ0.02). However, we reject our hypothesis that young men are highly accepting, trusting, and intending to use AVs compared to other combinations of age and gender. We recommend using a mix of attitude, emotion, and behavioural (intention) measures in future research on AVs together with more transparency regarding construct definitions and study materials
Iâm curious, Iâm open to it, I test it, I trust it! A focus groups study to understand a-priori trust in automated buses
Trust is regarded as one of the main predictors for adopting automated buses (ABs). However, theories about trust (development) in technology generally vary and an in-depths study about trust in ABs specifically is still outstanding. The present study fills this gap by presenting results from focus group interviews to trust (development) in shared automated buses prior to exposure. The objectives of this study are to contrast participantsâ naĂŻve concepts of trust with theory and to identify underlying factors influencing a-priori trust in ABs. Results show that the N = 21 focus group participants use different strategies to familiarise themselves with the new technology of ABs, e.g., comparisons with familiar technologies, fundamental tendencies to approach or avoid, additional information seeking, or anthropomorphisation. These strategies largely support existing theories on trust (development) in technology. Differences between naĂŻve interpretations of trust and its theoretical assumptions were found in focus group debates where more control over technology limited uncertainty and led to more trust. While theories suggest control and trust to be incompatible opposites, participants see control as a way to enhance trust. We provide starting points for further theory development and expansion and stress the importance of explanations in emerging technologies for trust and acceptance building
Potenziale und Herausforderungen von sozialen Robotern fĂŒr Beziehungen Ă€lterer Menschen: eine Bestandsaufnahme mittels ârapid reviewâ
BACKGROUND: Social relationships are essential resources for psychological well-being and physical health. In old age, increased vulnerability and loss of functions are accompanied by diminishing social networks reinforcing a vicious circle. This decrease of social cohesion presents risks for health and well-being that might be cushioned by introducing social robots. OBJECTIVE: What potentials and challenges for older people result from their interaction with social robots? MATERIAL UND METHODS: The objectives are approached via a rapid review. The systematic search resulted in 433 unique articles. Of these 11 articles were included in the analysis. RESULTS: Social robots have the potential to reduce loneliness, reinforce (interpersonal) communication, enhance the mood while reducing stress. Challenges lie in the social embedding of the interaction with robots. Authors suggest principles such as charity, autonomy, and privacy as helpful guidelines for the design and use of social robots to prevent a loss of social relationships. CONCLUSION: The results present corridors for the viable use of social robots for older adults offering to exploit existing potentials. At the core lies a view on the individual case with its unique circumstances and predispositions, because social robots bear positive and negative outcomes regarding social relationships. The identified studies focused on deficient settings (e.g., particular disorders within care facilities). Thus, research on the use of social robots by healthy adults should add to the existing literature
Is there an association between social determinants and care dependency risk? A multiâstate model analysis of a longitudinal study
Despite a growing body of knowledge about the morbidities and functional impairment that frequently lead to care dependency, the role of social determinants is not yet well understood. The purpose of this study was to examine the effect of social determinants on care dependency onset and progression. We used data from the Berlin Initiative Study, a prospective, population-based cohort study including 2,069 older participants living in Berlin. Care dependency was defined as requiring substantial assistance in at least two activities of daily living for 90 min daily (level 1) or 3+ hours daily (level 2). Multi-state time to event regression modeling was used to estimate the effects of social determinants (partnership status, education, income, and sex), morbidities, and health behaviors, characteristics, and conditions. During the study period, 556 participants (27.5%) changed their status of care dependency. Participants without a partner at baseline were at a higher risk to become care-dependent than participants with a partner (hazard ratio [HR], 95% confidence interval [CI]: 1.24 (1.02-1.51)). After adjustment for other social determinants, morbidities and health behaviors, characteristics, and conditions the risk decreased to a HR of 1.19 (95% CI: 0.79-1.79). Results indicate that older people without a partner may tend to be at higher risk of care dependency onset but not at higher risk of care dependency progression. Clinicians should inquire about and consider patients' partnership status as they evaluate care needs
High leptin/adiponectin ratio and serum triglycerides are associated with an "at-risk" phenotype in young severely obese patients.
Modernizing persistenceâbioaccumulationâtoxicity (PBT) assessment with high throughput animal-free methods
The assessment of persistence (P), bioaccumulation (B), and toxicity (T) of a chemical is a crucial first step at ensuring chemical safety and is a cornerstone of the European Unionâs chemicals regulation REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals). Existing methods for PBT assessment are overly complex and cumbersome, have produced incorrect conclusions, and rely heavily on animal-intensive testing. We explore how new-approach methodologies (NAMs) can overcome the limitations of current PBT assessment. We propose two innovative hazard indicators, termed cumulative toxicity equivalents (CTE) and persistent toxicity equivalents (PTE). Together they are intended to replace existing PBT indicators and can also accommodate the emerging concept of PMT (where M stands for mobility). The proposed âtoxicity equivalentsâ can be measured with high throughput in vitro bioassays. CTE refers to the toxic effects measured directly in any given sample, including single chemicals, substitution products, or mixtures. PTE is the equivalent measure of cumulative toxicity equivalents measured after simulated environmental degradation of the sample. With an appropriate panel of animal-free or alternative in vitro bioassays, CTE and PTE comprise key environmental and human health hazard indicators. CTE and PTE do not require analytical identification of transformation products and mixture components but instead prompt two key questions: is the chemical or mixture toxic, and is this toxicity persistent or can it be attenuated by environmental degradation? Taken together, the proposed hazard indicators CTE and PTE have the potential to integrate P, B/M and T assessment into one high-throughput experimental workflow that sidesteps the need for analytical measurements and will support the Chemicals Strategy for Sustainability of the European Union.ISSN:0340-5761ISSN:1432-073
Modernizing persistenceâbioaccumulationâtoxicity (PBT) assessment with high throughput animal-free methods
The assessment of persistence (P), bioaccumulation (B), and toxicity (T) of a chemical is a crucial first step at ensuring chemical safety and is a cornerstone of the European Unionâs chemicals regulation REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals). Existing methods for PBT assessment are overly complex and cumbersome, have produced incorrect conclusions, and rely heavily on animal-intensive testing. We explore how new-approach methodologies (NAMs) can overcome the limitations of current PBT assessment. We propose two innovative hazard indicators, termed cumulative toxicity equivalents (CTE) and persistent toxicity equivalents (PTE). Together they are intended to replace existing PBT indicators and can also accommodate the emerging concept of PMT (where M stands for mobility). The proposed âtoxicity equivalentsâ can be measured with high throughput in vitro bioassays. CTE refers to the toxic effects measured directly in any given sample, including single chemicals, substitution products, or mixtures. PTE is the equivalent measure of cumulative toxicity equivalents measured after simulated environmental degradation of the sample. With an appropriate panel of animal-free or alternative in vitro bioassays, CTE and PTE comprise key environmental and human health hazard indicators. CTE and PTE do not require analytical identification of transformation products and mixture components but instead prompt two key questions: is the chemical or mixture toxic, and is this toxicity persistent or can it be attenuated by environmental degradation? Taken together, the proposed hazard indicators CTE and PTE have the potential to integrate P, B/M and T assessment into one high-throughput experimental workflow that sidesteps the need for analytical measurements and will support the Chemicals Strategy for Sustainability of the European Union
The obesityâlinked human lncRNA AATBC stimulates mitochondrial function in adipocytes
Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark of obesityâassociated disorders, thermogenic adipocytes are linked to cardiometabolic health. As adipocytes dynamically adapt to environmental cues by functionally switching between white and thermogenic phenotypes, a molecular understanding of this plasticity could help improving metabolism. Here, we show that the lncRNA Apoptosis associated transcript in bladder cancer (AATBC) is a humanâspecific regulator of adipocyte plasticity. Comparing transcriptional profiles of human adipose tissues and cultured adipocytes we discovered that AATBC was enriched in thermogenic conditions. Using primary and immortalized human adipocytes we found that AATBC enhanced the thermogenic phenotype, which was linked to increased respiration and a more fragmented mitochondrial network. Expression of AATBC in adipose tissue of mice led to lower plasma leptin levels. Interestingly, this association was also present in human subjects, as AATBC in adipose tissue was inversely correlated with plasma leptin levels, BMI, and other measures of metabolic health. In conclusion, AATBC is a novel obesityâlinked regulator of adipocyte plasticity and mitochondrial function in humans
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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF â„5%) and nine low-frequency or rare (MAF <5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants
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