lobid – Dateninfrastruktur für Bibliotheken

lobid ist der zentrale Anlaufpunkt für die Linked-Open-Data-Dienste des Hochschulbibliothekszentrums des Landes Nordrhein-Westfalen (hbz). Das Akronym „lobid" steht für „Linking Open Bibliographic Data“. lobid umfasst Rechercheoberflächen für Anwender und Web-APIs.Die lobid-Dienste bieten Zugriff auf die Titeldaten des hbz-Verbundkatalogs, Beschreibungen von bibliothekarischen Organisationen und anderen Gedächtnisinstitutionen aus dem Sigelverzeichnis und der Deutschen Bibliotheksstatistik (DBS) sowie auf die Gemeinsame Normdatei (GND). Die Datensets können so in verschiedenen Kontexten einheitlich (JSON-LD über HTTP) genutzt und eingebunden werden. Vielfältige Möglichkeiten der Datenabfrage werden unterstützt.Der Artikel beschreibt zunächst die technischen Hintergründe der Bereitstellung von lobid und die Erfahrungen, die bei der Transformation verschiedener Datensets nach JSON-LD gemacht wurden. Vorgestellt wird auch der Entwicklungsprozess und die Art und Weise der Dokumentation der Dienste

lobid-gnd – Eine Schnittstelle zur Gemeinsamen Normdatei für Mensch und Maschine

Mit lobid-gnd bietet das Hochschulbibliothekszentrum des Landes Nordrhein-Westfalen (hbz) eine Schnittstelle zur Gemeinsamen Normdatei (GND) für Mensch und Maschine an. In diesem Beitrag werden detailliert die Nutzungsmöglichkeiten von lobid-gnd beleuchtet. Vorgestellt werden die graphische Nutzeroberfläche, Möglichkeiten komplexer Abfragen gegen die Web-API und die Integration in OpenRefine. Darüber hinaus beschreiben wir den Prozess der Datengenerierung auf Basis des Linked-Data-Angebots der Deutschen Nationalbibliothek (DNB)

CD4+ Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo

Studies in malaria patients indicate that higher frequencies of peripheral blood CD4+ Foxp3+ CD25+ regulatory T (Treg) cells correlate with increased blood parasitemia. This observation implies that Treg cells impair pathogen clearance and thus may be detrimental to the host during infection. In C57BL/6 mice infected with Plasmodium berghei ANKA, depletion of Foxp3+ cells did not improve parasite control or disease outcome. In contrast, elevating frequencies of natural Treg cells in vivo using IL-2/anti-IL-2 complexes resulted in complete protection against severe disease. This protection was entirely dependent upon Foxp3+ cells and resulted in lower parasite biomass, impaired antigen-specific CD4+ T and CD8+ T cell responses that would normally promote parasite tissue sequestration in this model, and reduced recruitment of conventional T cells to the brain. Furthermore, Foxp3+ cell-mediated protection was dependent upon CTLA-4 but not IL-10. These data show that T cell-mediated parasite tissue sequestration can be reduced by regulatory T cells in a mouse model of malaria, thereby limiting malaria-induced immune pathology

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework. METHODS: In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilation modality (four phenotypes), and death (three phenotypes). We constructed patient trajectories illustrating transition frequency and duration between phenotypes. Analyses were stratified by pandemic waves and vaccination status. FINDINGS: Among 57 032 174 individuals included in the cohort, 13 990 423 COVID-19 events were identified in 7 244 925 individuals, equating to an infection rate of 12·7% during the study period. Of 7 244 925 individuals, 460 737 (6·4%) were admitted to hospital and 158 020 (2·2%) died. Of 460 737 individuals who were admitted to hospital, 48 847 (10·6%) were admitted to the intensive care unit (ICU), 69 090 (15·0%) received non-invasive ventilation, and 25 928 (5·6%) received invasive ventilation. Among 384 135 patients who were admitted to hospital but did not require ventilation, mortality was higher in wave 1 (23 485 [30·4%] of 77 202 patients) than wave 2 (44 220 [23·1%] of 191 528 patients), but remained unchanged for patients admitted to the ICU. Mortality was highest among patients who received ventilatory support outside of the ICU in wave 1 (2569 [50·7%] of 5063 patients). 15 486 (9·8%) of 158 020 COVID-19-related deaths occurred within 28 days of the first COVID-19 event without a COVID-19 diagnoses on the death certificate. 10 884 (6·9%) of 158 020 deaths were identified exclusively from mortality data with no previous COVID-19 phenotype recorded. We observed longer patient trajectories in wave 2 than wave 1. INTERPRETATION: Our analyses illustrate the wide spectrum of disease trajectories as shown by differences in incidence, survival, and clinical pathways. We have provided a modular analytical framework that can be used to monitor the impact of the pandemic and generate evidence of clinical and policy relevance using multiple EHR sources. FUNDING: British Heart Foundation Data Science Centre, led by Health Data Research UK

URLs von Webseiten mit Typ Bibliothek aus Lobid.org

<p>List of 5292 URLs. Most are supposed to belong to German libraries. Data originates from Lobid.org on May, 4th 2016. Generated via:</p> <p>curl "http://beta.lobid.org/organisations/search?q=type:Library+AND+url:*&size=6000" > libs-with-urls.json</p> <p>cat libs-with-urls.json | grep \"url\" | cut -d '"' -f4 > urls.txt</p> <p>Only a few minor corrections were made (for example <em>http://</em> instead of <em>http//:</em>).</p> <p> </p

Digital Tracking Control for Machine Tool Feed Drives

106 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.The use of linear motor direct drives as feed drives enables higher feed rates and accelerations, eliminates problems with backlash, and reduces power waste due to friction. Servo controller design of those feed drives becomes more challenging due to dynamic interaction between the servo control and cutting process. A simplified end milling cutting process model is used in a structured singular value based uncertainty analysis to predict the cutting conditions for which the machining process will remain stable. Experimental results from machining aluminum on a linear motor X-Y table validate this approach.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

A Framework for Distributed Preservation Workflows: Paper - iPRES 2009 - San Francisco

The Planets project is developing a service-oriented environment for the definition and evaluation of preservation strategies for human- centric data. It focuses on the question of logically preserving digital materials, as opposed to the physical preservation of content bit-streams. This includes the development of preservation tools for the automated characterization, migration, and comparison of different types of digital objects as well as the emulation of their original runtime environment in order to ensure longtime access and interpretability. The Planets integrated environment provides a number of end-user applications that allow data curators to execute and scientifically evaluate preservation experiments based on composable preservation services. In this paper, we focus on the middleware and programming model and show how it can be utilized in order to create complex preservation workflows