Determinants of Mortality and Disease Progression of Kaposi Sarcoma in a Primary care ART Programme in Khayelitsha, South Africa

CROI 200

Failure time and microcrack nucleation

The failure time of samples of heterogeneous materials (wood, fiberglass) is studied as a function of the applied stress. It is shown that in these materials the failure time is predicted with a good accuracy by a model of microcrack nucleation proposed by Pomeau. It is also shown that the crack growth process presents critical features when the failure time is approached.Comment: 13 pages, 4 figures, submitted to Europhysics Letter

Co-management and adaptive co-management: Two modes of governance in a Honduran marine protected area

Selecting the best mode of governance for marine protected areas (MPAs) especially in developing countries has generated considerable controversy in the academic and policy literature during the last 20 years. In this article, two modes - co-management (CM) and adaptive co-management (ACM) - are analysed in detail, and an examination is made of an attempt to put these modes sequentially into practice in the first (2003-2009) and second (2008-2013) management plans, respectively, of the Cayos Cochinos MPA (CCMPA) in Honduras. Extensive fieldwork was carried out during 2006-2010 in three communities dependent on the CCMPA (Rio Esteban, Nueva Armenia, and Chachahuate) including key informant interviews, focus group meetings, household surveys, and participant observation. The paper's findings are (1) that while the first plan implemented some CM principles (such as sharing responsibility between government, stakeholders and NGOs) it failed to deliver other CM principles (such as transparency and accountability); and (2) that while the second plan increased participation and transparency, and used a more adaptive approach, it still left many stakeholders out of the decision-making process, and its processes of experimentation, monitoring and social learning were very limited. The fact is that CM and ACM are laudable objectives, but very difficult to implement in full

UK physiotherapists delivering physical activity advice: what are the challenges and possible solutions? A qualitative study

Objectives Despite the known health benefits of physical activity (PA), PA levels are in decline. Healthcare professionals, including physiotherapists, have been identified as ideal conduits to promote PA, yet their knowledge and awareness of PA guidelines are poor. The aims of this study were to explore current knowledge of PA guidelines among UK physiotherapists and identify barriers and possible solutions to delivering PA advice. Design A qualitative approach using semistructured interviews that took place between March and May 2021. Data were analysed with a thematic approach using Braun and Clarke’s six steps. Setting Various inpatient and outpatient clinical settings across six UK regions. Participants Eighteen UK-based physiotherapists managing National Health Service patients were recruited through volunteer sampling in March 2021. Results Five themes and 16 subthemes (shown in parenthesis) were identified as barriers and solutions to delivering PA advice: physiotherapist intrinsic barriers (knowledge, fear/confidence); a lack of emphasis and priority given to PA (time constraints, minimal educational and staff training); patient barriers (compliance, expectations and fear of doing PA); increasing awareness of the PA guidelines (staff training, signposting awareness, use of social media and television campaigns); and optimising delivery (use of visual resources, good communication and approaches involving being individualised and gradual for patients with chronic conditions). Conclusions In this study, physiotherapist participants seemed to have limited awareness of the PA guidelines despite recent updates and were faced with similar barriers to those previously reported in the literature. The solutions suggested could guide strategies to support physiotherapists being able to deliver PA advice. Further research is needed to evaluate the efficiency of any implemented solutions supporting the delivery of PA advice

Designing for the End of Life of IoT Objects

The Internet of Things (IoT) and ubiquitous computing are leading to an increase in objects with a short lifespan - either through breakage, “bricking” by the manufacturer, or discontinued use by the owner. This leads to a surplus of material and e-waste that cannot or is not readily recycled, upcycled or otherwise reused, aggravating material scarcity. In part, this is due to custom-built hardware, and use of unrecyclable materials. However, it is also due to the limited value people place on these objects (e.g., sentimental and environmental). This one-day workshop will explore how the configuration of values designed into IoT objects influences the end-user practices of disposal, recycling and upcycling. Through this lens, we will collectively consider potential design strategies that can be instilled during the process of design, to support the continuity of the material life of IoT objects after their “death”

Lessons from history of socioeconomic improvements: a new approach to treating multi-drug-resistant tuberculosis

Summary This study investigated the trends in tuberculosis mortality through time in Switzerland. Information on the decline in mortality before chemotherapies were introduced may be useful in developing countries where drug-resistant tuberculosis is now becoming a major problem. Swiss data were collected from historical records and comparative data were obtained from the literature for England and Wales, New York, Japan, Brazil and Sierra Leone. Logistic curves were fitted to examine the rate of decline before introduction of pharmacotherapies and these show that the decline would have continued without the introduction of chemical therapies, including antibiotics. In Switzerland, England and Wales and New York, the decline had occurred long before the introduction of specific anti-tuberculosis agents. In Brazil and Japan, chemical therapy was co-incident with the decline in tuberculosis mortality rates. Overall, it is suggested that the effective control of tuberculosis can be achieved through a combination of chemical interventions, conservative therapy (rest, good nutrition, ventilation, etc.) as well as public health interventions addressing hygiene, nutrition, reducing exposure to infections and educating the population about tuberculosis

Mouth rinsing with a sweet solution increases energy expenditure and decreases appetite during 60 minutes of self-regulated walking exercise

Carbohydrate mouth rinsing can improve endurance exercise performance and is most ergogenic when exercise is completed in the fasted state. This strategy may also be beneficial to increase exercise capacity and the energy deficit achieved during moderate intensity exercise relevant to weight control when performed after an overnight fast. Eighteen healthy men (mean(SD); age 23(4)years, body mass index 23.1(2.4)kg.m-2 ) completed a familiarisation trial and three experimental trials. After an overnight fast, participants performed 60-minutes of treadmill walking at a speed that equated to a rating of perceived exertion of 13 (“fairly hard”). Participants manually adjusted the treadmill speed to maintain this exertion. Mouth rinses for the experimental trials contained either a 6.4% maltodextrin solution with sweetener (CHO), a taste-matched placebo (PLA) or water (WAT). Appetite ratings were collected using visual analogue scales and exercise energy expenditure and substrate oxidation were calculated from online gas analysis. Increased walking distance during CHO and PLA induced greater energy expenditure compared with WAT (mean difference (90% CI); 79(60)kJ; P=0.035; d=0.24 and 90(63)kJ; P=0.024; d=0.27, respectively). Appetite area under the curve was lower in CHO and PLA than WAT (8(6)mm; P=0.042; d=0.43 and 6(8)mm; P=0.201; d=0.32, respectively). Carbohydrate oxidation was higher in CHO than PLA and WAT (7.3(6.7)g; P=0.078; d=0.47 and 10.1(6.5)g; P=0.015; d=0.81, respectively). This study provides novel evidence that mouth rinsing with a sweetened solution may promote a greater energy deficit during moderate exertion walking exercise by increasing energy expenditure and decreasing appetite. A placebo effect may have contributed to these benefits

Exploration of the nurse shark (Ginglymostoma cirratum) plasma immunoproteome using high-resolution LC-MS/MS

Funding Information: FKB was supported by a BBSRC-funded EASTBIO Doctoral Training Partnership studentship (grant number BB/M010996/1) awarded to HD. HM is supported by NIH-NIAID predoctoral fellowship F31AI147532. DM received institutional strategic funding from the BBSRC (grants: BBS/E/D/10002071 and BBS/E/D/20002174). For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. Funding Information: We thank Professor Sam Martin (University of Aberdeen) for supporting the supervision of FKB during her PhD. Our thanks also to Luke Tallon and Lisa Sadzewicz at UMBs Institute for Genome Sciences for helpful advice and sharing their expertise during sequencing of the nurse shark transcriptome. Publisher Copyright: Copyright © 2022 Bakke, Gundappa, Matz, Stead, Macqueen and Dooley.Peer reviewedPublisher PD