Room to Flourish: Lessons for Canadian Grantmaking Foundations from Sweden, Germany and the Netherlands

While Canada has experienced a long and successful history of encouraging social participation and community activity through its grantmaking foundation sector, this article argues that Canada’s historic and present-day regulatory restrictions have limited the extent to which its foundation sector has been allowed to innovate and flourish. To exemplify the types of tractable regulatory schemes that have allowed grantmaking foundation sectors in comparative contexts to prosper, the evolution of the grantmaking foundation sectors in Sweden, Germany, and the Netherlands is examined within the context of social origins theory. One important contribution of this article is to compare their regulatory frameworks to the Canadian context. It concludes with lessons learned for the Canadian grantmaking foundation sector and for public officials to consider.Bien que le secteur des fondations subventionnaires au Canada ait connu une longue histoire de réussites dans l’encouragement de la participation sociale et de l’activité communautaire, cet article soutient qu’une réglementation restrictive autant dans le passé qu’au présent a limité l’innovation et l’épanouissement dans le secteur. Afin de montrer comment une réglementation plus souple pourrait permettre aux fondations canadiennes de prospérer davantage, cet article recourt à la théorie des origines sociales pour examiner le secteur en Suède, en Allemagne et aux Pays-Bas. Une contribution importante de cet article consiste ainsi à comparer les contextes réglementaires dans ces pays à celui du Canada. En conclusion, il fait des recommandations pour les fondations subventionnaires et le secteur public canadiens

Software for the frontiers of quantum chemistry:An overview of developments in the Q-Chem 5 package

This article summarizes technical advances contained in the fifth major release of the Q-Chem quantum chemistry program package, covering developments since 2015. A comprehensive library of exchange–correlation functionals, along with a suite of correlated many-body methods, continues to be a hallmark of the Q-Chem software. The many-body methods include novel variants of both coupled-cluster and configuration-interaction approaches along with methods based on the algebraic diagrammatic construction and variational reduced density-matrix methods. Methods highlighted in Q-Chem 5 include a suite of tools for modeling core-level spectroscopy, methods for describing metastable resonances, methods for computing vibronic spectra, the nuclear–electronic orbital method, and several different energy decomposition analysis techniques. High-performance capabilities including multithreaded parallelism and support for calculations on graphics processing units are described. Q-Chem boasts a community of well over 100 active academic developers, and the continuing evolution of the software is supported by an “open teamware” model and an increasingly modular design

Resident participation in non-profit housing

Bibliography: p. 110-11

Effect of Rootstock on Vineyard Establishment Using Green-Growing Benchgrafts

Demand for vine plant material has increased drastically due to the ongoing expansion of viticulture, and recent widespread replanting efforts. Nurseries and growers are turning to green-grafted vines to meet demand. Unfortunately, most vineyard establishment studies have centered around dormant benchgrafted vines. Thus, little is known regarding the specific establishment trends of green-growing benchgrafts. This study aimed to explore the role rootstock selection has in green-growing benchgraft establishment and development over the first four years post-planting. Vitis vinifera L. cv. Sauvignon blanc was grafted onto multiple rootstocks of varying parentage, including ‘101-14MGT’ (V. riparia × V. rupestris), ‘1103P’ (V. berlandieri × V. rupestris), ‘110R’ (V. berlandieri × V. rupestris), ‘420A MGT’ (V. berlandieri × V. riparia), and ‘Teleki 5C’ (V. berlandieri × V. riparia). The experimental site was organized using a completely randomized design (n = 12) with all vines managed to industry-standard cultural practices. Vines grafted onto 1103P had the largest average trunk diameter (p = 0.0012) and circumference (p p p = 0.0008). The larger trunk size and more extensive carbohydrate reserves suggest that green-growing benchgrafts using 110R or 1103P have a higher capacity and likelihood of establishment success

XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia

Francisella tularensis is the causative agent for the potentially fatal disease tularemia. The lipoprotein Flpp3 has been identified as a virulence determinant of tularemia with no sequence homology outside the Francisella genus. We report a room temperature structure of Flpp3 determined by serial femtosecond crystallography that exists in a significantly different conformation than previously described by the NMR-determined structure. Furthermore, we investigated the conformational space and energy barriers between these two structures by molecular dynamics umbrella sampling and identified three low-energy intermediate states, transitions between which readily occur at room temperature. We have also begun to investigate organic compounds in silico that may act as inhibitors to Flpp3. This work paves the road to developing targeted therapeutics against tularemia and aides in our understanding of the disease mechanisms of tularemia