Goldberry and Galadriel: The Quality of Joy

Argues the importance of joy, or eucatastrophe, in The Lord of the Rings. Sees the figures of Goldberry, Bombadil, and especially Galadriel as personifications of that joy arising unexpectedly

Goldberry and Galadriel: The Quality of Joy

Argues the importance of joy, or eucatastrophe, in The Lord of the Rings. Sees the figures of Goldberry, Bombadil, and especially Galadriel as personifications of that joy arising unexpectedly

Impact of changing computer technology on hydrologic and water resource modeling

The increasing availability of substantial computer power at relatively low costs and the increasing ease of using computer graphics, of communicating with other computers and data bases, and of programming using high-level problem-oriented computer languages, is providing new opportunities and challenges for those developing and using hydrologic and water resources models. This paper reviews some of the progress made towards the development and application of computer support systems designed to aid those involved in analyzing hydrologic data and in operating, managing, or planning water resource facilities. Such systems of hardware and software are being designed to allow direct and easy access to a broad and heterogeneous group of users. These systems often combine data-base management; simulation and optimization techniques; symbolic colored displays; heuristic, qualitative approaches; and possibly artificial intelligence methods in an interactive, user-controlled, easily accessible interface. Individuals involved in the use of such systems are not only those with technical training, but also those representing different interest groups and having non-technical backgrounds. The essential difference between what is happening now and the more traditional off-line, non-interactive approaches is that instead of generating solutions to specific problems, model developers are now beginning to deliver, in a much more useful and user-friendly form, computer-based turnkey systems for exploring, analyzing and synthesizing plans or policies. Such tools permit the user to evaluate alternative solutions based on his or her own objectives and subjective judgments in an interactive learning and decision-making process

Inhibition of stat3 protein as an approach to sensitizing ovarian cancer cells to cisplatin

Many human tumors harbor persistently-active Signal Transducer and Activator of Transcription (ST AT)3 protein. There is substantial evidence that aberrantly-active STAT3 is a master regulator of events that promote carcinogenesis and human tumor formation. Abnormal STAT3 activity induces uncontrolled growth and survival of cells, thereby contributing to neoplastic transformation and progression. Cisplatin is a major chemotherapeutic modality for ovarian cancer, but is frequently challenged by drug resistance. Given that STAT3 is aberrantly-active in many human tumors, including ovarian cancer, there is the potential that it contributes to the development of Cisplatin resistance, a problem ripe for investigation. This study was conducted to explore the potential that the aberrant STAT3 present in ovarian cancer cells contributes to the decreased sensitivity to Cisplatin observed for ovarian cancer cells. The investigation revealed that STAT3 is aberrantly activated in cancer cell lines resistant to Cisplatin, but not in sensitive cells. Inhibition of aberrant STAT3 activity by the small-molecule STAT3 inhibitor, NSC 74859, increased growth inhibition induced by Cisplatin in resistant ovarian cancer cells. Furthermore, NSC 74859 enhanced apoptosis induced by Cisplatin in resistant cells in vitro by nearly 52%. Collectively, these observations indicate that inhibition of hyperactive STAT3 increases Cisplatin sensitivity, and therefore effectiveness, in resistant cells. Thus, STAT3 represents a viable target for enhancing the sensitivity of ovarian cancer cells to Cisplatin

Two-phase, two-dimensional numerical simulation of individual well problems

A new numerical simulation method was developed to solve two-dimensional reservoir problems of the type encountered in drilling and producing activities of a single well. The method includes more variables and is more generally applicable than any available method designed for individual well problems. Emphasis was placed on simulating reservoir behavior in the vicinity of the wellbore. To achieve accuracy in computing pressures and saturations close to the wellbore, very small flow cells were used. A fully implicit finite-difference scheme was developed to obtain numerical stability. ..

A comparison of the determinism of Mark Twain and Theodore Dreiser

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Not availabl

An investigation of the displacement of oil by a miscible slug followed by water

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Not availabl

Two-phase, two-dimensional numerical simulation of individual well problems

A new numerical simulation method was developed to solve two-dimensional reservoir problems of the type encountered in drilling and producing activities of a single well. The method includes more variables and is more generally applicable than any available method designed for individual well problems. Emphasis was placed on simulating reservoir behavior in the vicinity of the wellbore. To achieve accuracy in computing pressures and saturations close to the wellbore, very small flow cells were used. A fully implicit finite-difference scheme was developed to obtain numerical stability. ..