The Collins-Roscoe mechanism and D-spaces

We prove that if a space X is well ordered $(\alpha A)$, or linearly semi-stratifiable, or elastic then X is a D-space

Exploring Audience Perceptions of, and Preferences for, Online News Videos

Journalism professionals and media experts have traditionally used normatively formed criteria to evaluate news quality. Although the digital news media environment has enabled journalists to respond at unprecedented speed to audience consumption patterns, little academic research has systematically addressed how audiences themselves perceive and evaluate news, and even less has focused on audio-visual news. To help fill this research gap, we conducted in-depth group interviews with 22 online news video consumers in the UK to explore their perceptions of online news videos—an increasingly popular news format. Thematic analyses suggest audiences evaluate online news videos using a complex and interwoven set of criteria, which we group under four headings: antecedents of perceptions, emotional impacts, news and editorial values and production characteristics. Some of these criteria can be positioned clearly in relation to the literature on news quality in general, while our documentation of the others contributes new, format-specific knowledge. Our findings offer journalists practical insights into how audiences perceive and evaluate a host of characteristics of online news videos, while our conceptual framework provides a foundation for further academic research on audience evaluations of online news videos, and even audio-visual news more generally

Poverty in Perspective: A typology of poverty in Scotland

The report sets out 13 different ‘types’ of poverty in Scotland, spread across three pre-determined life stages: families with children, working age households without children, and pensioner households

Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition

Acknowledgments This work was funded in part by the William and Melinda Gates Foundation, award 42917 to JPN and OCS; US National Institutes of Health grants 5R01HG005220 to HCB, 5R01HG004885 to MP; US National Science Foundation Graduate Research Fellowship award DGE0750616 to JNP; AWW and JP are funded by The Wellcome Trust (Grant No. WT098051).Peer reviewedPublisher PD

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution. ccRCC can be grouped into seven evolutionary subtypes, ranging from tumors characterized by early fixation of multiple mutational and copy number drivers and rapid metastases to highly branched tumors with >10 subclonal drivers and extensive parallel evolution associated with attenuated progression. We identify genetic diversity and chromosomal complexity as determinants of patient outcome. Our insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance

Religion and the public ethics of stem-cell research: Attitudes in Europe, Canada and the United States

We examine international public opinion towards stem-cell research during the period when the issue was at its most contentious. We draw upon representative sample surveys in Europe and North America, fielded in 2005 and find that the majority of people in Europe, Canada and the United States supported stem-cell research, providing it was tightly regulated, but that there were key differences between the geographical regions in the relative importance of different types of ethical position. In the U.S., moral acceptability was more influential as a driver of support for stem-cell research; in Europe the perceived benefit to society carried more weight; and in Canada the two were almost equally important. We also find that public opinion on stem-cell research was more strongly associated with religious convictions in the U.S. than in Canada and Europe, although many strongly religious citizens in all regions approved of stem-cell research. We conclude that if anything public opinion or 'public ethics' are likely to play an increasingly important role in framing policy and regulatory regimes for sensitive technologies in the future