Internal Corporate Governance and the Financial Crisis: Lessons for Banks, Regulators and Supervisors

This paper aims to highlight the importance of banks’ Internal Corporate Governance (ICG),viewed as an operational mitigation instrument, in a context where banks enjoy a high degree oforganisational flexibility due to principle-based regulatory and risk-based supervisory approaches.The recent crisis has shown, on the one hand, that financial mitigations (i.e. capital requirements) are,per se, not sufficient to ensure the stability of the banks (which underpins the soundness of the entirefinancial system) and, on the other hand, the failure of the light-touch supervisory approach. The mainresearch question is whether the improvement of ICG, involving proper protection for stakeholdersand the switch to a more intrusive supervisory model, will be able to offset the failures of marketdiscipline revealed by the crisis and, together with Basel 3’s reinforced capital adequacy regime,strengthen the resilience of the financial system, without the reintroduction of structural reforms. In theEuropean Union, the new European Systemic Risk Board (ESRB) and, above all, the three newEuropean Supervisory Authorities (ESAs) will play a crucial role in this process

Analysis of Narrow-Leaf Lupin Proteins in Lupin-Enriched Pasta by Untargeted and Targeted Mass Spectrometry

The supplementation of different food items with grain legumes and, in particular, with lupin has been demonstrated to provide useful health benefits, especially in the area of cardiovascular disease prevention. In this work, label free quantitative untargeted and targeted approaches based on liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) for investigating the protein profile of three pasta samples containing different percentages of narrow-leaf lupin flour were carried out. The untargeted method permitted the identification of the main acidic globulins (\u3b1-conglutin, \u3b2-conglutin, and \u3b4-conglutin) and the comparison of their profile with raw lupin flour. The targeted method, based on High-performance liquid chromatography electrospray ionization tandem mass spectrometry HPLC-Chip-Multiple Reaction Monitoring (MRM) mode, allowed the quantification of \u3b3-conglutin, the main hypoglycemic component of lupin protein: its concentration was around 2.25 mg/g in sample A, 2.16 mg/g in sample D, and 0.57 mg/g in sample F

The Grizzly, April 23, 2020

Keeping up in the Quarantine • The Career and Post-Graduate Development Office Adjusts to Online Campus • New UCSG President Elected • Student Literary Magazine, The Lantern, Launches Online • Tiger King and the Spectacle of the Redneck • Now Batting for the Ursinus College Bears, Number 21, Alex Mummehttps://digitalcommons.ursinus.edu/grizzlynews/1963/thumbnail.jp

Terapie combinate plurime per prolungare la sopravvivenza delle fistole arterovenose native

La Fistola Arterovenosa Nativa rappresenta a tutt'oggi il gold standard degli accessi vascolari in emodialisi. Tuttavia essa non è applicabile a tutti i pazienti. Le protesi rappresentano una seconda scelta percorribile in alternativa al Catetere Venoso centrale a permanenza, ma sono gravate da maggiori complicanze, hanno una durata inferiore e richiedono un'adeguata sorveglianza e manutenzione. I due casi clinici qui presentati, illustrano come strategie combinate plurime, chirurgiche ed endovascolari, perfettamente complementari e sinergiche, possano garantirne la pervietà a lungo termine e ridurre il ricorso all'uso dei CVC

Optimal cut-off criteria for duplex ultrasound for the diagnosis of restenosis in stented carotid arteries: Review and protocol for a diagnostic study

Background: Carotid angioplasty with stenting is a relatively new, increasingly used, less-invasive treatment for the treatment of symptomatic carotid artery stenosis. It is being evaluated in ongoing and nearly finished randomized trials. An important factor in the evaluation of stents is the occurrence of in-stent restenosis. An un-stented carotid artery is likely to have a more elastic vessel wall than a stented one, even if stenosis is present. Therefore, duplex ultrasound cut-off criteria for the degrees of an in-stent stenosis, based on blood velocity parameters, are probably different from the established cut-offs used for un-stented arteries. Routine criteria can not be applied to stented arteries but new criteria need to be established for this particular purpose. Methods/Design: Current literature was systematically reviewed. From the selected studies, the following data were extracted: publication year, population size, whether the study was prospective, which reference test was used, and if there was an indication for selection bias and for verification bias in particular. Previous studies often were retrospective, or the reference test (DSA or CTA) was carried out only when a patient was suspected of having restenosis at DUS, which may result in verification bias. Results: In general, the cut-off values are higher than those reported for unstented arteries. Previous studies often were retrospective, or the reference test (DSA or CTA) was carried out only when a patient was suspected of having restenosis at DUS, which may result in verification bias. Discussion: To address the deficiencies of the existing studies, we propose a prospective cohort study nested within the International Carotid Stenting Study (ICSS), an international multi-centre trial in which over 1,700 patients have been randomised between stenting and CEA. In this cohort we will enrol a minimum of 300 patients treated with a stent. All patients undergo regular DUS examination at the yearly follow-up visit according to the ICSS protocol. To avoid verification bias, an additional computed tomography angiography (CTA) will be performed as a reference test in all consecutive patients, regardless of the degree of stenosis on the initial DUS test

Gene therapy: the end of the rainbow?

The increased understanding of the molecular basis of oral cancer has led to expectations that correction of the genetic defects will lead to improved treatments. Nevertheless, the first clinical trials for gene therapy of oral cancer occurred 20 years ago, and routine treatment is still not available. The major difficulty is that genes are usually delivered by virus vectors whose effects are weak and temporary. Viruses that replicate would be better, and the field includes many approaches in that direction. If any of these are effective in patients, then gene therapy will become available in the next few years. Without significant advances, however, the treatment of oral cancer by gene therapy will remain as remote as the legendary pot of gold at the end of the rainbow

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services