Religion And Sex A Look At Sexual Frequency As It Relates To Religious Affiliation, Religious Attendance, And Subjective Religiosity

This research addresses the relationship between sexual activity and religion. In particular, the analysis focuses on the impact of religious affiliation, religious public participation and subjective religiosity on the frequency of sexual activity. Religious categories are operationalized as conservative Protestants, moderate Protestants, liberal Protestants, black Protestants, Catholics, Jews, non-affiliates, no religious preference, and other Protestants. The results of the analysis indicate that conservative Protestants and black Protestants are more sexually active than other religious categories. Attendance at religious services has a negative effect on the frequency of sex activity. Subjective religiosity is not related to sexual frequency. Conclusions and directions for future research are discussed

Antimycobacterial activity of diospyrin and its derivatives against Mycobacterium aurum

The objective of this study was to determine the antimycobacterial activity of diospyrin (D1) and four of its derivatives (D2, D5, D7 and D17) against the non-pathogenic Mycobacterium aurum. The effect of these compounds was determined on growth parameters and drug efflux pumping activity. Diospyrin was shown to be the most active in inhibiting the growth of M. aurum whilst D2 was inactive. D17 was found to have the lowest MIC of < 0.1 µg/ml, while the MIC of other compounds were found to be as follows: D1= 0.1 µg/ml, D5= 0.39 µg/ml, D7= 0.78 µg/ml and D2 =3.13 µg/ml, in order of potency. The compounds were bacteriostatic rather than bactericidal as the MBCs were greater than 50 µg/ml. The compounds were potent efflux pump inhibitors as D5 enhanced ciprofloxacin accumulation by 160 %, D17 by 58 %, D7 by 41 %, D1 by 37 % when compared with the standard efflux pump inhibitor, reserpine, which enhanced accumulation by 51 %. D2 had no effect on drug efflux pumping activity. The modifications of diospyrin enhanced the activity of D17 and D5 by decreasing the MIC and enhancing accumulation of ciprofloxacin, respectively. In contrast, activity decreased significantly for D2 in the growth and accumulation assays. Diospyrin and its derivatives are potential antimycobacterial agents and drug efflux inhibitors and could be used to enhance the activity of known antimycobacterial agents that are actively effluxed from M. tuberculosis

A probabilistic model to evaluate population dietary recommendations.

Food-based dietary recommendations (FBR) play an essential role in promoting a healthy diet. To support the process of formulating a set of population-specific FBR, a probabilistic model was developed specifically to predict the changes in the percentage of a population at risk of inadequate nutrient intakes after the adoption of alternative sets of FBR. The model simulates the distribution of the number of servings per week from food groups or food items at baseline and after the hypothetical successful adoption of alternative sets of FBR, while ensuring that the population's energy intake distribution remains similar. The simulated changes from baseline in median nutrient intakes and the percentage of the population at risk of inadequate nutrient intakes are calculated and compared across the alternative sets of FBR. The model was illustrated using a hypothetical population of 12- to 18-month-old breast-feeding children consuming a cereal-based diet low in animal source foods

Analysis of Observed Contamination Through SAGE III's First Year on Orbit

SAGE III is a payload on the International Space Station that conducts measurements of ozone and other atmospheric constituents through the use of a moderate resolution spectrometer with an operating wavelength range of 290 nm to 1550 nm. Because of the optically sensitive nature of the payload, a suite of eight Thermoelectric Quartz Crystal Microbalances (TQCMs) were included to monitor the operating environment. During the rst year of operation, the SAGE III TQCMs were instrumental in detecting several periods of higher contamination and localizing their sources. A clear window made from quartz crystal covers the instrument assembly's aperture. Under nominal operating conditions, this window is only open during science gathering activities. However, if the rates of contamination accumulation are detected to be above the background rate, the window will be kept closed during science gathering to protect the optically sensitive instrument mirror. An analysis of the signal transmissions through the window for the wavelengths of 290 nm to 1550 nm has been conducted to determine any possible degradation of the window and potential in uence on science data collected to date, and established a baseline for future analysis

Assessing impacts of alternative livestock management practices: raging debates and a role for science

Grazing of domestic livestock is the most pervasive and persistent human impact on the grasslands and shrublands of the Colorado Plateau. Impacts on ecosystem function and biological diversity arc thought to be great, but few studies have attempted to characterize such effects and compare the impacts of alternative livestock management practices. The dearth of pertinent, defensible information has contributed to the polarization of ranching and environmental interests, and has exacerbated what is one of the most contentious social issues in the southwestern USA. We discuss the role of ecological science in deriving and disseminating information that will help focus and perhaps resolve the impasse over grazing impacts and other natural resource issues. Specifically, we describe results of our involvement in "management teams" that include ranchers, environmentalists, public servants, and interested citizens, and how this collaborative process has helped shape an experimental research program that would be impossible to execute without the involvement of divergent interests in the grazing debate. Claims of various interest groups are reformulated as testable hypotheses, and a research design is presented

Lipidomics analysis of juveniles' blue mussels (Mytilus edulis L. 1758), a key economic and ecological species

Blue mussels (Mytilus edulis L. 1758) are important components of coastal ecosystems and in the economy of rural and coastal areas. The understanding of their physiological processes at key life stages is important both within food production systems and in the management of wild populations. Lipids are crucial molecules for bivalve growth, but their diversity and roles have not been fully characterized. In this study, traditional lipid profiling techniques, such as fatty acid (FA) and lipid class analysis, are combined to un-targeted lipidomics to elucidate the lipid metabolism in newly settled spat fed on a range of diets. The evaluated diets included single strains treatments (Cylindrotheca fusiformis CCAP 1017/2 –CYL, Isochrysis galbana CCAP 927/1– ISO, Monodopsis subterranean CCAP 848/1 –MONO, Nannochloropsis oceanica CCAP 849/10– NANNO) and a commercial algae paste (SP). Spat growth was influenced by the diets, which, according to their efficacy were ranked as follows: ISO>NANNO/CYL>SP>MONO. A higher triacylglycerols (TG) content, ranging from 4.23±0.82 μg mgashfree Dry weight (DW)-1 at the beginning of the trial (T0) to 51±15.3 μg mgashfreeDW-1 in ISO, characterised significant growth in the spat, whereas, a reduction of TG (0.3±0.08 μg mgashfreeDW-1 in MONO), mono unsaturated FA–MUFA (from 8.52±1.02 μg mgFAashfreeDW-1 at T0 to 2.81±1.02 μg mgFAashfreeDW-1 in MONO) and polyunsaturated FA–PUFA (from 17.57±2.24 μg mgFAashfreeDW-1 at T0 to 6.19±2.49 μg mgFAashfreeDW-1 in MONO) content characterised poor performing groups. Untargeted lipidomics evidenced how the availability of dietary essential PUFA did not influence only neutral lipids but also the membrane lipids, with changes in lipid molecular species in relation to the essential PUFA provided via the diet. Such changes have the potential to affect spat production cycle and their ability to respond to the surrounding environment. This study evidenced the advantages of coupling different lipid analysis techniques, as each technique disclosed relevant information on nutritional requirements of M. edulis juveniles, expanding the existing knowledge on the physiology of this important species

Social Work Research in the UK: A View through the Lens of REF2021

The Research Assessment Exercise was introduced in 1986 to measure research quality and to determine the allocation of higher education funding. The renamed Research Excellence Framework (REF) has become an important barometer of research capacity and calibre across academic disciplines in UK universities. Based on the expert insights of REF sub-panel members for Unit of Assessment 20 (UOA20), Social Work and Social Policy, this article contributes to understanding of the current state of UK social work research. It documents the process of research quality assessment and reports on the current social work research landscape, including impact. Given its growing vigour, increased engagement with theory and conceptual frameworks, policy and practice and its methodological diversity, it is evident that social work research has achieved considerable consolidation and growth in its activity and knowledge base. Whilst Russell Group and older universities cluster at the top of the REF rankings, this cannot be taken for granted as some newer institutions performed well in REF2021. The article argues that the discipline’s embeddedness in interdisciplinary research, its quest for social justice and its applied nature align well with the REF framework where interdisciplinarity, equality, diversity and inclusion and impact constitute core principles

A novel retinoblastoma therapy from genomic and epigenetic analyses.

Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low; RB1 was the only known cancer gene mutated. We then evaluated the role of RB1 in genome stability and considered non-genetic mechanisms of cancer pathway deregulation. For example, the proto-oncogene SYK is upregulated in retinoblastoma and is required for tumour cell survival. Targeting SYK with a small-molecule inhibitor induced retinoblastoma tumour cell death in vitro and in vivo. Thus, retinoblastomas may develop quickly as a result of the epigenetic deregulation of key cancer pathways as a direct or indirect result of RB1 loss

Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression

peer-reviewedWe tested the hypothesis that dietary whey protein isolate (WPI) affects the intestinal mechanisms related to energy absorption and that the resulting energy deficit is compensated by changes in energy balance to support growth. C57BL/6 mice were provided a diet enriched with WPI with varied sucrose content, and the impact on energy balance-related parameters was investigated. As part of a high-sucrose diet, WPI reduced the hypothalamic expression of pro-opiomelanocortin gene expression and increased energy intake. The energy expenditure was unaffected, but epididymal weight was reduced, indicating an energy loss. Notably, there was a reduction in the ileum gene expression for amino acid transporter SLC6a19, glucose transporter 2, and fatty acid transporter 4. The composition of the gut microbiota also changed, where Firmicutes were reduced. The above changes indicated reduced energy absorption through the intestine. We propose that this mobilized energy in the adipose tissue and caused hypothalamic changes that increased energy intake, acting to counteract the energy deficit arising in the intestine. Lowering the sucrose content in the WPI diet increased energy expenditure. This further reduced epididymal weight and plasma leptin, whereupon hypothalamic ghrelin gene expression and the intestinal weight were both increased. These data suggest that when the intestine-adipose-hypothalamic pathway is subjected to an additional energy loss (now in the adipose tissue), compensatory changes attempt to assimilate more energy. Notably, WPI and sucrose content interact to enable the component mechanisms of this pathway

Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data.

BackgroundAlthough studies involving preterm infants ≤34 weeks gestation report a decreased incidence of patent ductus arteriosus after antenatal betamethasone, studies involving younger gestation infants report conflicting results.MethodsWe used preterm baboons, mice, and humans (≤276/7 weeks gestation) to examine betamethasone's effects on ductus gene expression and constriction both in vitro and in vivo.ResultsIn mice, betamethasone increased the sensitivity of the premature ductus to the contractile effects of oxygen without altering the effects of other contractile or vasodilatory stimuli. Betamethasone's effects on oxygen sensitivity could be eliminated by inhibiting endogenous prostaglandin/nitric oxide signaling. In mice and baboons, betamethasone increased the expression of several developmentally regulated genes that mediate oxygen-induced constriction (K+ channels) and inhibit vasodilator signaling (phosphodiesterases). In human infants, betamethasone increased the rate of ductus constriction at all gestational ages. However, in infants born ≤256/7 weeks gestation, betamethasone's contractile effects were only apparent when prostaglandin signaling was inhibited, whereas at 26-27 weeks gestation, betamethasone's contractile effects were apparent even in the absence of prostaglandin inhibitors.ConclusionsWe speculate that betamethasone's contractile effects may be mediated through genes that are developmentally regulated. This could explain why betamethasone's effects vary according to the infant's developmental age at birth