1,445 research outputs found

    Measuring the energy intensity of domestic activities from smart meter data

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    Household electricity consumption can be broken down to appliance end-use through a variety of methods such as modelling, sub-metering, load disaggregation or non-intrusive appliance load monitoring (NILM). We advance and complement this important field of energy research through an innovative methodology that characterises the energy consumption of domestic life by making the linkages between appliance end-use and activities through an ontology built from qualitative data about the household and NILM data. We use activities as a descriptive term for the common ways households spend their time at home. These activities, such as cooking or laundering, are meaningful to households’ own lived experience. Thus, besides strictly technical algorithmic approaches for processing quantitative smart meter data, we also draw on social science time use approaches and interview and ethnography data. Our method disaggregates a households total electricity load down to appliance level and provides the start time, duration, and total electricity consumption for each occurrence of appliance usage. We then make inferences about activities occurring in the home by combining these disaggregated data with an ontology that formally specifies the relationships between electricity-using appliances and activities. We also propose two novel standardised metrics to enable easy quantifiable comparison within and across households of the energy intensity and routine of activities of interest. Finally, we demonstrate our results over a sample of ten households with an in-depth analysis of which activities can be inferred with the qualitative and quantitative data available for each household at any time, and the level of accuracy with which each activity can be inferred, unique to each household. This work has important applications from providing meaningful energy feedback to households to comparing the energy efficiency of households’ daily activities, and exploring the potential to shift the timing of activities for demand management

    High-accuracy real-time microseismic analysis platform : case study based on the super-sauze mud-based landslide

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    Understanding the evolution of landslide and other subsurface processes via microseismic monitoring and analysis is of paramount importance in predicting or even avoiding an imminent slope failure (via an early warning system). Microseismic monitoring recordings are often continuous, noisy and consist of signals emitted by various sources. Automated analysis of landslide processes comprises detection, localization and classification of microseismic events (with magnitude <2 richter scale). Previous research has mainly focused on manually tuning signal processing methods for detecting and classifying microseismic signals based on the signal waveform and its spectrum, which is time-consuming especially for long-term monitoring and big datasets. This paper proposes an automatic analysis platform that performs event detection and classification, after suitable feature selection, in near realtime. The platform is evaluated using seismology data from the Super-Sauze mud-based landslide, which islocated in the southwestern French Alps, and features earthquake, slidequake and tremor type events

    Understanding usage patterns of electric kettle and energy saving potential

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    The availability of smart metering and smart appliances enables detecting and characterising appliance use in a household, quantifying energy savings through efficient appliance use and predicting appliance-specific demand from load measurements is possible. With growing electric kettle ownership and usage, lack of any efficiency labelling guidelines for the kettle, slow technological progress in improving kettle efficiency relative to other domestic appliances, and current consumer attitudes, urgent investigation into consumer kettle usage patterns is warranted. From an efficiency point of view, little can be done about the kettle, which is more efficient than other methods of heating water such as the stove top kettle. However, since a majority households use the kettle inefficiently by overfilling, in order to meet energy targets, it is imperative to quantify inefficient usage and predict demand. For the purposes of scalability, we propose tools that depend only on load measurement data for quantifying and visualizing kettle usage and energy consumption, assessing energy wastage through overfilling via our proposed electric kettle model, and predicting kettle-specific demand, from which we can estimate potential energy savings in a household and across a housing stock. This is demonstrated using data from a longitudinal study across a sample of 14 UK households for a two-year period

    Animal Models in Peritoneal Dialysis

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    Over the last decades peritoneal dialysis (PD) has become a successful and widely used treatment for endstage  renal disease patients worldwide. Together with the increasing number of uremic patients successfully  treated with PD has grown an interest in physiological, pathophysiological and clinical aspects of this  therapeutic method. This article provides an overview of the current status on animal models used in studying  the histology and physiology of the peritoneum, as well as the process of peritoneal dialysis itself. We  discuss species of experimental animals, methods of peritoneal access, sampling for histology, different  techniques and methodologies, and complications of experimental models of PD.

    Comment on ``Two Time Scales and Violation of the Fluctuation-Dissipation Theorem in a Finite Dimensional Model for Structural Glasses''

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    In cond-mat/0002074 Ricci-Tersenghi et al. find two linear regimes in the fluctuation-dissipation relation between density-density correlations and associated responses of the Frustrated Ising Lattice Gas. Here we show that this result does not seem to correspond to the equilibrium quantities of the model, by measuring the overlap distribution P(q) of the density and comparing the FDR expected on the ground of the P(q) with the one measured in the off-equilibrium experiments.Comment: RevTeX, 1 page, 2 eps figures, Comment on F. Ricci-Tersenghi et al., Phys. Rev. Lett. 84, 4473 (2000

    On the Schwarzschild-de Sitter metric of nonlocal de Sitter gravity

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    Earlier constructed a simple nonlocal de Sitter gravity model has a cosmological solution in a very good agreement with astronomical observations. In this paper, we continue the investigation of the nonlocal de Sitter model of gravity, focusing on finding an appropriate solution for the Schwarzschild-de Sitter metric. We succeeded to solve the equations of motion in a certain approximation. The obtained approximate solution is of particular interest for examining the possible role of non-local de Sitter gravity in describing the effects in galactic dynamics that are usually attributed to dark matter.Comment: 10 page

    Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients

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    © 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes and fibroblasts) derived from FA patients of the FA-D2 complementation group, which provides a more accurate physiological assessment than is possible with transformed cells or animal models. Results: We analyzed telomere length, telomere dysfunction-induced foci (TIFs), sister chromatid exchanges (SCE), telomere sister chromatid exchanges (T-SCE), apoptosis and expression of shelterin components TRF1 and TRF2. FANCD2 lymphocytes exhibited multiple types of telomeric abnormalities, including premature telomere shortening, increase in telomeric recombination and aberrant telomeric structures ranging from fragile to long-string extended telomeres. The baseline incidence of SCE in FANCD2 lymphocytes was reduced when compared to control, but in response to diepoxybutane (DEB) the 2-fold higher rate of SCE was observed. In contrast, control lymphocytes showed decreased SCE incidence in response to DEB treatment. FANCD2 fibroblasts revealed a high percentage of TIFs, decreased expression of TRF1 and invariable expression of TRF2. The percentage of TIFs inversely correlated with telomere length, emphasizing that telomere shortening is the major reason for the loss of telomere capping function. Upon irradiation, a significant decrease of TIFs was observed at all recovery times. Surprisingly, a considerable percentage of TIF positive cells disappeared at the same time when incidence of γ-H2AX foci was maximal. Both FANCD2 leucocytes and fibroblasts appeared to die spontaneously at higher rate than control. This trend was more evident upon irradiation; the percentage of leucocytes underwent apoptosis was 2.59- fold higher than that in control, while fibroblasts exhibited a 2- h delay before entering apoptosis. Conclusion: The results of our study showed that primary cells originating from FA-D2 patients display shorten telomeres, elevated incidence of T-SCEs and high frequency of TIFs. Disappearance of TIFs in early response to irradiation represent distinctive feature of FANCD2 cells that should be examined further.This article is made available through the Brunel Open Access Publishing Fund. This work was supported by the Ministry of Education and Science of the Republic of Serbia (Project No.173046)

    The First Implementation of Respiratory Triggered 4DCBCT on a Linear Accelerator

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    Four Dimensional Cone Beam Computed Tomography (4DCBCT) is an image guidance strategy used for patient positioning in radiotherapy. In conventional implementations of 4DCBCT, a constant gantry speed and a constant projection pulse rate are used. Unfortunately, this leads to higher imaging doses than are necessary because a large number of redundant projections are acquired. In theoretical studies, we have previously demonstrated that by suppressing redundant projections the imaging dose can be reduced by 40-50% for a majority of patients with little reduction in image quality. The aim of this study was to experimentally realise the projection suppression technique, which we have called Respiratory Triggered 4DCBCT (RT-4DCBCT). A real-time control system was developed that takes the respiratory signal as input and computes whether to acquire, or suppress, the next projection trigger during 4DCBCT acquisition. The CIRS dynamic thorax phantom was programmed with a 2cm peak-to-peak motion and periods ranging from 2 to 8 seconds. Image quality was assessed by computing the edge response width of a 3cm imaging insert placed in the phantom as well as the signal to noise ratio of the phantoms tissue and the contrast to noise ratio between the phantoms lung and tissue. The standard deviation in the Superior-Inferior direction of the 3cm imaging insert was used to assess intra-phase bin displacement variations with a higher standard deviation implying more motion blur. The 4DCBCT imaging dose was reduced by 8.6%, 41%, 54%, 70% and 77% for patients with 2, 3, 4, 6 and 8 second breathing periods respectively when compared to conventional 4DCBCT. The standard deviation of the intra-phase bin displacement variation of the 3cm imaging insert was reduced by between 13% and 43% indicating a more consistent position for the projections within respiratory phases. For the 4 second breathing period, the edge response width was reduced by 39% (0.8mm) with only a 6-7% decrease in the signal to noise and contrast to noise ratios. RT-4DCBCT has been experimentally realised and reduced to practice on a linear accelerator with a measurable imaging dose reductions over conventional 4DCBCT and little degradation in image quality
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