661 research outputs found
Keratin hydrolysates obtained from sheep wool from the leather industry
This work presents experiments in making biopolymer-based materials with smart functionalities from renewable resources in the leather industry, applicable in various areas. Keratin hydrolysates were obtained by alkaline hydrolysis in the presence of NaOH and CaO. The physico-chemical characterization, DLS and FT-IR analysis of keratin hydrolysates highlighted the rich content in protein and total nitrogen. The recovery of wool by-products from the leather industry leads to less waste and helps prevent environmental pollution
Analysis of CGF biomolecules, structure and cell population: Characterization of the stemness features of CGF cells and osteogenic potential
Concentrated Growth Factors (CGF) represent new autologous (blood-derived biomaterial), attracting growing interest in the field of regenerative medicine. In this study, the chemical, structural, and biological characterization of CGF was carried out. CGF molecular characterization was performed by GC/MS to quantify small metabolites and by ELISA to measure growth factors and matrix metalloproteinases (MMPs) release; structural CGF characterization was carried out by SEM analysis and immunohistochemistry; CGF has been cultured, and its primary cells were isolated for the identification of their surface markers by flow cytometry, Western blot, and real-time PCR; finally, the osteogenic differentiation of CGF primary cells was evaluated through matrix mineralization by alizarin red staining and through mRNA quantification of osteogenic differentiation markers by real-time PCR. We found that CGF has a complex inner structure capable of influencing the release of growth factors, metabolites, and cells. These cells, which could regulate the production and release of the CGF growth factors, show stem features and are able to differentiate into osteoblasts producing a mineralized matrix. These data, taken together, highlight interesting new perspectives for the use of CGF in regenerative medicine
Evolution of cooperation driven by zealots
Recent experimental results with humans involved in social dilemma games
suggest that cooperation may be a contagious phenomenon and that the selection
pressure operating on evolutionary dynamics (i.e., mimicry) is relatively weak.
I propose an evolutionary dynamics model that links these experimental findings
and evolution of cooperation. By assuming a small fraction of (imperfect)
zealous cooperators, I show that a large fraction of cooperation emerges in
evolutionary dynamics of social dilemma games. Even if defection is more
lucrative than cooperation for most individuals, they often mimic cooperation
of fellows unless the selection pressure is very strong. Then, zealous
cooperators can transform the population to be even fully cooperative under
standard evolutionary dynamics.Comment: 5 figure
The LBNO long-baseline oscillation sensitivities with two conventional neutrino beams at different baselines
The proposed Long Baseline Neutrino Observatory (LBNO) initially consists of
kton liquid double phase TPC complemented by a magnetised iron
calorimeter, to be installed at the Pyh\"asalmi mine, at a distance of 2300 km
from CERN. The conventional neutrino beam is produced by 400 GeV protons
accelerated at the SPS accelerator delivering 700 kW of power. The long
baseline provides a unique opportunity to study neutrino flavour oscillations
over their 1st and 2nd oscillation maxima exploring the behaviour, and
distinguishing effects arising from and matter. In this paper we
show how this comprehensive physics case can be further enhanced and
complemented if a neutrino beam produced at the Protvino IHEP accelerator
complex, at a distance of 1160 km, and with modest power of 450 kW is aimed
towards the same far detectors. We show that the coupling of two independent
sub-MW conventional neutrino and antineutrino beams at different baselines from
CERN and Protvino will allow to measure CP violation in the leptonic sector at
a confidence level of at least for 50\% of the true values of
with a 20 kton detector. With a far detector of 70 kton, the
combination allows a sensitivity for 75\% of the true values of
after 10 years of running. Running two independent neutrino
beams, each at a power below 1 MW, is more within today's state of the art than
the long-term operation of a new single high-energy multi-MW facility, which
has several technical challenges and will likely require a learning curve.Comment: 21 pages, 12 figure
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