Electrospinning of 2-hydroxypropyl-β-cyclodextrin aqueous solutions with added salts

It has been proposed that hydrogen bonding plays a role in promoting the electrospinnability of some materials. In this study, the role of non-covalent interactions in the electrospinnability of 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) was investigated by varying the physical-chemical properties the solvents. The rheological behaviour of a peroxide-aqueous/acetone-ethanol/NaHCO3 solution and an aqueous urea solution, as a function of aqueous 2HP-β-CD concentration, was compared. The rheological behaviour of 2HP-β-CD solutions was characterized by a frequency-independent stress relaxation plateau such as that observed in cross-linked polymer networks and reversible polymer gels with non-linear viscoelasticity. We conclude that the electrospinnability of 2HP-β-CD is, as evidenced by the changes in the morphology of the electrospun 2HP-β-CD materials, in agreement with other related studies on the electrospinning of Cyclodextrins. Also, the electrospinnability of 2HP-β-CD does appear to be related to the physical-chemical properties of the solvent systems

CLIP and complementary methods

RNA molecules start assembling into ribonucleoprotein (RNP) complexes during transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA, coordinates all processes in which the RNA is involved. To identify the sites bound by a specific RNA-binding protein on endogenous RNAs, cross-linking and immunoprecipitation (CLIP) and complementary, proximity-based methods have been developed. In this Primer, we discuss the main variants of these protein-centric methods and the strategies for their optimization and quality assessment, as well as RNA-centric methods that identify the protein partners of a specific RNA. We summarize the main challenges of computational CLIP data analysis, how to handle various sources of background and how to identify functionally relevant binding regions. We outline the various applications of CLIP and available databases for data sharing. We discuss the prospect of integrating data obtained by CLIP with complementary methods to gain a comprehensive view of RNP assembly and remodelling, unravel the spatial and temporal dynamics of RNPs in specific cell types and subcellular compartments and understand how defects in RNPs can lead to disease. Finally, we present open questions in the field and give directions for further development and applications

Addendum to the Calcined Waste Storage at the Idaho Nuclear Technology Center

This report is an addendum to the report Calcined Waste Storage at the Idaho Nuclear Technology and Engineering Center, INEEL/EXT-98-00455 Rev. 1, June 2003. The original report provided a summary description of the Calcined Solids Storage Facilities (CSSFs). It also contained dozens of pages of detailed data tables documenting the volume and composition (chemical content and radionuclide activity) of the calcine stored in the CSSFs and the liquid waste from which the calcine was derived. This addendum report compiles the calcine composition data from the original report. It presents the compiled data in a graphical format with units (weight percent, curies per cubic meter, and nanocuries per gram) that are commonly used in regulatory and waste acceptance criteria documents. The compiled data are easier to use and understand when comparing the composition of the calcine with potential regulatory or waste acceptance criteria. This addendum report also provides detailed explanations for the large variability in the calcine composition among the CSSFs. The calcine composition varies as a result of reprocessing different types of fuel that had different cladding materials. Different chemicals were used to dissolve the various types of fuel, extract the uranium, and calcine the resulting waste. This resulted in calcine with variable compositions. This addendum report also identifies a few trace chemicals and radionuclides for which the accuracy of the amounts estimated to be in the calcine could be improved by making adjustments to the assumptions and methods used in making the estimates

Ursinus College Alumni Journal, July 1958

Dr. Helfferich succeeds Dr. McClure as President of Ursinus College • Bachelor\u27s degrees awarded to 154 • Robert G. Dunlop addresses seniors at graduation • Three faculty additions announced for Fall • Meistersingers tour N. E. • Ursinus Summer School • The Dean looks at 1958 • The Ursinus Evening School meets 1958 • Note from the Admissions Office • Six million books for Ursinus • Outstanding season for forum programs • Library bequests • St. Andrew\u27s Society award • 48% active membership in Alumni Association • Class of 1958 picks permanent officers • Alumni election results • Regional group meetings • Ursinus Woman\u27s Club program • Alumni Day 1958 • Special report: American higher education 1958 • News about ourselves • Weddings • Births • Necrology • Ursinus completes Spring sports seasonhttps://digitalcommons.ursinus.edu/alumnijournal/1062/thumbnail.jp

Ursinus College Alumni Journal, November 1957

Gulf Oil program to aid education • Letters to the editor • Autumn report from the Admissions Office • Early acceptance policy announced • Evening School continues growth • Messiah • The faculty cornered • Young Ursinus missionaries • Note from the Dean\u27s Office • I. C. G. Society looking for lost members • Attention classes 1944-1950 • Famous Ursinus player • G. E. corporate alumnus program extended • Old Timers\u27 Day has excellent alumni turnout • Ursinus teachers meet during Schoolmen\u27s Week • Fall meeting for Washington alumni • Alumni senior banquet • Curtain Club presents Ten Little Indians • Salmon River expedition, part of the International Geophysical Year • Four years of alumni sponsorship completed: 1957 Loyalty Fund report • Glenn Eshbach to head Loyalty Fund Committee • Alfred Gemmell scholarship fund • Contributors for the 1957 Loyalty Fund campaign • Alumnae hockey • Varsity football report • Tentative varsity and junior varsity basketball schedule, 1957-8 • Tentative varsity wrestling schedule, 1958 • Ursinus appoints new court coach • Women\u27s basketball schedule, 1958 • Coull appointed grid aid • News about ourselves • Weddings • Births • Cornelius Weygandt dies • Reunion \u2743 • Necrologyhttps://digitalcommons.ursinus.edu/alumnijournal/1060/thumbnail.jp

Ursinus College Alumni Journal, July 1959

President\u27s page • D. L. Helfferich received LL.D. • 172 graduate at 90th commencement • Dr. Paul Miller commencement speaker • Dr. Sieb Pancoast resigns as Ursinus Dean of Men • Admissions office expects 250 freshmen in \u2763 class • Mr. Wilcox received doctorate from Penn • Rev. Jerry William Trexler speaker at Baccalaureate • Dean Camilla B. Stahr retires - Dean of Women since 1938 • Ralph Strassburger leaves half of his estate to charity • Ruth H. Rothenberger, \u2736 - new Dean of Women • Ursinus College has outstanding Loyalty Fund record • Rev. Richard Schellhase \u2745 - new Alumni Exec. Sec. • Festive Alumni Day brings large crowd • Paul I. Guest reelected alumni president • New York regional alumni elect new officers • The Collegeville Summer Assembly • May Day • Overseas job opportunities • Ursinus Women\u27s Club activities • Class \u2759 elects permanent officers • Old Timer\u27s Day Saturday November 7 • College teachers recognized • Baseball 1959 • 1959 track season • Ursinus girls complete undefeated spring • Lacrosse • National honors for Crosley • Softball • Tennis • News about ourselves • Weddings • Birthshttps://digitalcommons.ursinus.edu/alumnijournal/1064/thumbnail.jp

Ursinus College Alumni Journal, March 1959

President\u27s page • Radioactivity detection in civil defense course • From the Dean\u27s office • University of the Air • From the Office of Admissions • The library • Industrial gift trend is up • G. E. corporate alumnus program • duPont renews $4000 grant •$2000 Esso education foundation grant • Regional groups plan meetings • Philadelphia alumni install 1959 officers • South Jersey alumni plan supper party • New York alumni plan spring dinner • Washington D.C. alumni plan annual dinner • York alumni elect new officers for 1959 • Ursinus Woman\u27s Club plans spring card party • Alumni Day, Saturday, June 6 • Donald Schultz, \u2750 wilderness medic • 1901 schoolgirl driver Rhea Duryea Johnson \u2708 • International educator, scholar and editor, Jacob Foose \u2732 • January 1959 mid year report of the Loyalty Fund Campaign • Mid campaign report • Alumni elections: Watch for your ballot in April • Requests • Football 1958 • Wrestling 1959 • Alumnae hockey 1958 • Alumnae finish undefeated for second year • Proposed amended constitution • News about ourselves • Weddings • Births • Necrology • Chase Manhattan Bank employee gift matching • Saturday, June 6, 1959: Alumni festivalhttps://digitalcommons.ursinus.edu/alumnijournal/1067/thumbnail.jp

Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning

The BAF chromatin remodeling complex plays an essential role in brain development. However its function in postnatal neurogenesis in hippocampus is still unknown. Here, we show that in postnatal dentate gyrus (DG), the BAF170 subunit of the complex is expressed in radial glial-like (RGL) progenitors and in cell types involved in subsequent steps of adult neurogenesis including mature astrocytes. Conditional deletion of BAF170 during cortical late neurogenesis as well as during adult brain neurogenesis depletes the pool of RGL cells in DG, and promotes terminal astrocyte differentiation. These derangements are accompanied by distinct behavioral deficits, as reflected by an impaired accuracy of place responding in the Morris water maze test, during both hidden platform as well as reversal learning. Inducible deletion of BAF170 in DG during adult brain neurogenesis resulted in mild spatial learning deficits, having a more pronounced effect on spatial learning during the reversal test. These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis and cognition and suggest a specific role of adult neurogenesis in DG in adaptive behavior