Day

Contribution for a publication by Nico Dockx & Clara Meister entitled, 'A Poem A Day'. "When in 2012, Nico and I talked about utopias and the upcoming Utopia Station exhibition, our conversation quickly turned towards his poster A Poem a Day (2003). Very soon our verbal exchange turned into an idea, into a plan, into an open invitation to friends, asking them to respond to this idea of a poem for every day of the year. Open in the sense that poetry—especially in daily situations—an happen at every moment and in all possible forms and disguises. Our daily hustle and bustle is often too loud and too fast for subtle observations or quiet thoughts. It assigned strolling and whispering the role of their poor cousins of everyday life. But it is exactly their shyness and elegance that may turn a moment of attention into a lasting impression. When a neon light is reflected in a puddle, when crumpled pages are opened and read aloud, when a saying is drawn as a witty sketch, or when a note becomes a song. Then you may pause for a while for all these forms of poetry around you. And so the invitation turned into poems, turned into a calendar, turned into a performance, and now turned into this exhibition. A poem a day keeps indifference away." - Clara Meister This short text is part of 'The Outlands' a long-term, collaborative creative critical writing project with Ola Ståhl and occasionally other invited collaborators. The Outlands seeks to explore writing primarily as a collaborative process and has generated several outputs (chapbooks, artist books, published essays and performances) that define a twisting trajectory in which, beyond all the ruptures and disjunctures, environments and characters, artefacts and objects, turns of phrase and concepts appear, disappear and reappear in a continuous movement

Egypt\u27s Information Society Strategy: A Critical Lexicography

The development of ICT policies within developing countries in the past ten years has opened up a new area for study. These documents chart the ambitions of the countries for the use of ICT to promote rapid development. As such they are intercultural documents, developing at the interface between the culture of the country and western economic culture. This paper develops a critical approach to understanding these documents and studying their message. The approach involves the preparation of a critical dictionary which identifies relevant terms within the ICT policy document and reflects on their multiple meanings. The approach was applied to an Egyptian ICT policy document, Building Digital Bridges. A dictionary of thirty seven entries was developed. The dictionary, presented in full in an appendix, was used to identify critical themes in the document

Developing Responsible Research and Innovation for Robots

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.This paper develops a framework for responsible research and innovation (RRI) in robot design for roboticists from a study of the processes involved in the design and engineering of a range of robots including standard manufacturing robots, humanoid robots, environmental scanning robots and robot swarms. The importance of an iterative approach to design, the nature of transitions between design phases, and issues of uncertainty and complexity are examined for their ethical content. A cycle of RRI thinking based on reconnoitre, realisation, reflection, response and review is described which aligns with the general characterisation of robot engineering processes. Additionally the importance of supporting communities, knowledge bases and tools for assessment and analysis is noted

Development and emancipation: The information society and decision support systems in local authorities in Egypt.

The published version of this article can be found at Emerald publishing http://www.emeraldinsight.com/Insight/menuNavigation.do?hdAction=InsightHomePurpose – The purpose of this paper is to investigate the emancipatory promises and realities of information and communication technology (ICT) in Egypt. Design/methodology/approach – The combination of Habermasian and Foucauldian ideas implemented by a critical discourse analysis of the Egyptian Information Society Policy and interviews with employees of local decision support systems employees. Promises and rhetoric are contrasted with findings and questioned with regards to their validity. Findings – On the policy level, analysis shows that the emancipating rhetoric of ICT is not followed through. ICT is mostly seen as a means of attracting foreign direct investment. Neither political participation nor educational benefits are promoted seriously. On the local level, culture and organisational realities prevent individuals from exploiting the emancipatory potential of the technology. Originality/value – The combination of the Habermasian and Foucauldian approach exposes the problems of ICT use in developing countries. It shows that emancipation is used to legitimise ICT policies but is not taken seriously on a policy level in Egypt. Local implementations also fail to deliver on their promise. In order to have emancipatory effects, ICT policy and use will need to be reconsidered

Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications

Radical changes are needed for transformations to a good Anthropocene

The scale, pace, and intensity of human activity on the planet demands radical departures from the status quo to remain within planetary boundaries and achieve sustainability. The steering arms of society including embedded financial, legal, political, and governance systems must be radically realigned and recognize the connectivity among social, ecological, and technological domains of urban systems to deliver more just, equitable, sustainable, and resilient futures. We present five key principles requiring fundamental cognitive, behavioral, and cultural shifts including rethinking growth, rethinking efficiency, rethinking the state, rethinking the commons, and rethinking justice needed together to radically transform neighborhoods, cities, and regions.Peer reviewe

Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

OBJECTIVES: The ALIGN study (NCT01061723) evaluated the efficacy and safety of sarilumab, the first fully human monoclonal antibody against interleukin-6 receptor-alpha (IL-6Ralpha), in patients with ankylosing spondylitis (AS). METHODS: Patients with active AS despite conventional treatment were randomised to placebo, or one of five subcutaneous dose regimens of sarilumab (100, 150 or 200 mg every other week, or 100 or 150 mg every week), for 12 weeks. The primary efficacy end point was the percentage of patients achieving the Axial SpondyloArthritis international Society (ASAS) 20 response criteria at week 12. Secondary endpoints included ASAS40 response, ASAS partial remission, AS Disease Activity Score, high-sensitivity C-reactive protein (hs-CRP) value, and safety. RESULTS: Baseline demographic and disease characteristics of the 301 patients enrolled were similar across treatment groups. At week 12, there was no statistically significant difference in ASAS20 response rate between placebo (ASAS20 = 24.0%) and any sarilumab dose group. A significantly greater reduction in hs-CRP value was achieved with the higher sarilumab doses versus placebo. No other statistically significant differences were evident for secondary efficacy endpoints.The most common treatment-emergent adverse events reported for sarilumab included infections (non-serious), neutropenia, and increase in alanine aminotransferase. No cases of tuberculosis, opportunistic, or fungal infections, or bowel perforations were reported. Seven patients experienced a treatment-emergent serious adverse event (all in sarilumab treatment groups). No deaths occurred. CONCLUSIONS: The ALIGN study shows that IL-6Ralpha blockade with sarilumab was not an effective treatment for AS. Sarilumab was generally well tolerated with a manageable safety profile

The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison

BACKGROUND Care for people with amyotrophic lateral sclerosis (ALS) has altered at King's College Hospital over the last 20 years. The clinic has been a multidisciplinary, specialist, tertiary referral centre since 1995 with a large team with integrated palliative and respiratory care since 2006. We hypothesised that these changes would improve survival. METHODS In this retrospective observational study, patients diagnosed with El Escorial definite, probable and possible ALS between 1995-1998 and 2008-2011 were followed up. The primary outcome measure was a chi-square test for the proportion of each cohort surviving. Kaplan-Meier survival analysis and Cox multivariate regression were secondary analyses. RESULTS There was low reporting of some interventions. Five hundred and forty-seven people were included. Survival between the cohorts was significantly different (p = 0.022) with a higher proportion surviving during 2008-2011. Survival time was 21.6 (95% CI 19.2-24.0) months in the 2008-2011 cohort compared to 19.2 years (15.6-21.6) in the 1995-1998 cohort (log rank p = 0.018). Four hundred and ninety-three cases were included in the Cox regression. Diagnostic cohort was a significant predictor variable (HR 0.79 (0.64-0.97) p = 0.023). CONCLUSIONS These results support the hypothesis that integrated specialist clinics with multidisciplinary input improve survival in ALS

A Genetic Risk Score Distinguishes Different Types of Autoantibody-Mediated Membranous Nephropathy

INTRODUCTION: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults and is characterized by detectable autoantibodies against glomerular antigens, most commonly phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 domain containing 7A (THSD7A). In Europeans, genetic variation in at least five loci, PLA2R1, HLA-DRB1, HLA-DQA1, IRF4, and NFKB1, affects the risk of disease. Here, we investigated the genetic risk differences between different autoantibody states. METHODS: 1,409 MN individuals were genotyped genome-wide with a dense SNV array. The genetic risk score (GRS) was calculated utilizing the previously identified European MN loci, and results were compared with 4,929 healthy controls and 422 individuals with steroid-sensitive nephrotic syndrome. RESULTS: GRS was calculated in the 759 MN individuals in whom antibody status was known. The GRS for MN was elevated in the anti-PLA2R1 antibody-positive (N = 372) compared with both the unaffected control (N = 4,929) and anti-THSD7A-positive (N = 31) groups (p < 0.0001 for both comparisons), suggesting that this GRS reflects anti-PLA2R1 MN. Among PLA2R1-positive patients, GRS was inversely correlated with age of disease onset (p = 0.009). Further, the GRS in the dual antibody-negative group (N = 355) was intermediate between controls and the PLA2R1-positive group (p < 0.0001). CONCLUSION: We demonstrate that the genetic risk factors for PLA2R1- and THSD7A-antibody-associated MN are different. A higher GRS is associated with younger age of onset of disease. Further, a proportion of antibody-negative MN cases have an elevated GRS similar to PLA2R1-positive disease. This suggests that in some individuals with negative serology the disease is driven by autoimmunity against PLA2R1

Humanity’s Best Friend: A Dog-Centric Approach to Addressing Global Challenges

No other animal has a closer mutualistic relationship with humans than the dog (Canis familiaris). Domesticated from the Eurasian grey wolf (Canis lupus), dogs have evolved alongside humans over millennia in a relationship that has transformed dogs and the environments in which humans and dogs have co-inhabited. The story of the dog is the story of recent humanity, in all its biological and cultural complexity. By exploring human-dog-environment interactions throughout time and space, it is possible not only to understand vital elements of global history, but also to critically assess our present-day relationship with the natural world, and to begin to mitigate future global challenges. In this paper, co-authored by researchers from across the natural and social sciences, arts and humanities, we argue that a dog-centric approach provides a new model for future academic enquiry and engagement with both the public and the global environmental agenda