Characteristics of Low-Aspect-Ratio Wings at Supercritical Mach Numbers

The separation of the flow over wings precipitated by the compression shock that forms as speeds are increased into the supercritical Mach number range has imposed serious difficulties in the improvement of aircraft performance. Three difficulties rise principally as a consequence of the rapid drag rise and the loss of lift that causes serious stability changes when the wing shock-stalls. Favorable relieving effects due to the three-dimensional flow around the tips were obtained and these effects were of such magnitude that it is indicated that low-aspect-ratio wings offer a possible solution of the problems encountered

Tests of N-85, N-86 and N-87 airfoil sections in the 11-inch high speed wind tunnel

Three airfoils, the N-85, the N-86, and the N-87, were tested at the request of the Bureau of Aeronautics, Navy Department, to determine the suitability of these sections for use as propeller-blade sections. Further tests of the NACA 0009-64 airfoil were also made to measure the aerodynamic effect of thickening the trailing edge in accordance with current propeller practice. The N-86 and the N-87 airfoils appear to be nearly equivalent aerodynamically and both are superior to the N-85 airfoil. Comparison of those airfoils with the previously developed NACA 2409-34 airfoils indicate that the NACA 2409-34 is superior, particularly at high speeds. Thickening the trailing edge appears to have a detrimental effect, although the effect may be small if the trailing-edge radius is less than 0.5 percent of the cord. The N-86 and the N-87 airfoils appear to be nearly equivalent

The Compressibility Burble and the Effect of Compressibility on Pressures and Forces Acting on a Airfoil

Simultaneous air-flow photographs and pressure-distribution measurements were made of the NACA 4412 airfoil at high speeds to determine the physical nature of the compressibility burble. The tests were conducted in the NACA 24-inch high-speed wind tunnel. The flow photographs were obtained by the Schlieren method and the pressures were simultaneously measured for 54 stations in the 5-inch-chord airfoil by means of a multiple-tube manometer. Following the general program, a few measurements of total-pressure loss in the wake of the airfoil at high speeds were made to illustrate the magnitude of the losses involved and the extent of the disturbed region; and, finally, in order to relate this work to earlier force-test data, a force test of a 5-inch-chord NACA 4412 airfoil was made. The results show the general nature of the phenomenon known as the compressibility burble. The source of the increased drag is shown to be a compression shock that occurs on the airfoil as its speed approaches the speed of sound. Finally, it is indicated that considerable experimentation is needed in order to understand the phenomenon completely

Confinement and the analytic structure of the one body propagator in Scalar QED

We investigate the behavior of the one body propagator in SQED. The self energy is calculated using three different methods: i) the simple bubble summation, ii) the Dyson-Schwinger equation, and iii) the Feynman-Schwinger represantation. The Feynman-Schwinger representation allows an {\em exact} analytical result. It is shown that, while the exact result produces a real mass pole for all couplings, the bubble sum and the Dyson-Schwinger approach in rainbow approximation leads to complex mass poles beyond a certain critical coupling. The model exhibits confinement, yet the exact solution still has one body propagators with {\it real} mass poles.Comment: 5 pages 2 figures, accepted for publication in Phys. Rev.

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

peer-reviewedThe gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism. Despite this, drugs of this nature are currently limited to intramuscular administration routes due to intestinal degradation. The aim of this study was to design a recombinant microbial delivery vector for a GLP-1 analogue and assess the efficacy of the therapeutic in improving host glucose, lipid and cholesterol metabolism in diet induced obese rodents. Diet-induced obese animals received either Lactobacillus paracasei NFBC 338 transformed to express a long-acting analogue of GLP-1 or the isogenic control microbe which solely harbored the pNZ44 plasmid. Short-term GLP-1 microbe intervention in rats reduced serum low-density lipoprotein cholesterol, triglycerides and triglyceride-rich lipoprotein cholesterol substantially. Conversely, extended GLP-1 microbe intervention improved glucose-dependent insulin secretion, glucose metabolism and cholesterol metabolism, compared to the high-fat control group. Interestingly, the microbe significantly attenuated the adiposity associated with the model and altered the serum lipidome, independently of GLP-1 secretion. These data indicate that recombinant incretin-secreting microbes may offer a novel and safe means of managing cholesterol metabolism and diet induced dyslipidaemia, as well as insulin sensitivity in metabolic dysfunction

Memory, Conflict and Reconciliation A Half-Day Conference

Join the Steven J. Green School of International and Public Affairs and the Vaclav Havel Program for Human Rights and Diplomacy for a half-day conference exploring the role of memory in conflict and reconciliation. A distinguished group of scholars and practitioners will articulate diverse perspectives on the nature of memory, its role in public discourse, and the ways it can both feed conflict and promote reconciliation. 1:15 PM-1:30 PM I OPENING REMARKS John F. Stack, Jr., Founding Dean, Steven J. Green School of International and Public Affairs Martin Palous, Director, Vaclav Havel Program for Human Rights and Diplomacy 1:30 PM-3:30 PM I PANEL 1: REMEMBRANCE OF THINGS PAST Henrik Syse, Research Professor, Peace Research Institute; Member, Norwegian Nobel Committee, Oslo, Norway Memory as a Means of Reconciliation and Dialogue: Philosophical and Practical Reflections on Memory and Conflict Glenn Hughes, St. Mary\u27s Chair in Catholic Philosophy, St. Mary\u27s University, San Antonio, Texas Uses and Abuses of Memory Aurora Morcillo, Professor, FIU Department of History; Director, Spanish and Mediterranean Studies Program Between Memory and History: A Proustian Intervention Ambassador Michael Zantovsky, Director of Vaclav Havel Library, Prague, the Czech Republic The Responsibility to Remember: Memory as an Attribute of Being 3:00 PM -3:20 PM I COFFEE BREAK 3:20 PM ~ 5:00 PM I PANEL 2: THE CURRENT USES OF MEMORY AND CLOSING REMARKS Marifeli Perez-Stable, Professor, FIU Department of Global & Sociocultural Studies Cuban National Reconciliation Liliana Trevizan, Professor of Modern Languages, State University of New York at Potsdam A Museum and Democratic Performance in Chile Carlos Gonzales, Independent Journalist and Filmmaker; Founder and CEO, Mentora News, Philadelphia Diary of Ukraine\u27s Forgotten War Marie Janouskova and Michal Smid, Representatives ofPostBellum, Prague, Czech Republic The Mission of the Non-Profit Organization Post Bellum Orlando Gutierrez-Boronat, Writer and Educator; Co-founder and Spokesperson, Cuban Democratic Directorate Beyond Narratives: Cuba\u27s Struggle for Memory 5:00 PM-6:00 PM I CLOSING RECEPTIONhttps://digitalcommons.fiu.edu/cri_events/1344/thumbnail.jp

Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes

Glycosaminoglycans (GAGs) are polysaccharides that are typically present in a wide diversity of animal tissue. Most common GAGs are well-characterized and pharmaceutical applications exist for many of these compounds, e.g. heparin and hyaluronan. In addition, also bacterial glycosaminoglycan-like structures exist. Some of these bacterial GAGs have been characterized, but until now no bacterial GAG has been found that possesses the modifications that are characteristic for many of the animal GAGs such as sulfation and C5-epimerization. Nevertheless, the latter conversion may also occur in bacterial and archaeal GAGs, as some prokaryotic polysaccharides have been demonstrated to contain L-iduronic acid. However, experimental evidence for the enzymatic synthesis of L-iduronic acid in prokaryotes is as yet lacking. We therefore performed an in silico screen for D-glucuronyl C5-epimerases in prokaryotes. Multiple candidate C5-epimerases were found, suggesting that many more microorganisms are likely to exist possessing an L-iduronic acid residue as constituent of their cell wall polysaccharides

Low Hesperian P_(CO2) constrained from in situ mineralogical analysis at Gale Crater, Mars

Carbon dioxide is an essential atmospheric component in martian climate models that attempt to reconcile a faint young sun with planetwide evidence of liquid water in the Noachian and Early Hesperian. In this study, we use mineral and contextual sedimentary environmental data measured by the Mars Science Laboratory (MSL) Rover Curiosity to estimate the atmospheric partial pressure of CO_2 (P_(CO2)) coinciding with a long-lived lake system in Gale Crater at ∼3.5 Ga. A reaction–transport model that simulates mineralogy observed within the Sheepbed member at Yellowknife Bay (YKB), by coupling mineral equilibria with carbonate precipitation kinetics and rates of sedimentation, indicates atmospheric P_(CO2) levels in the 10s mbar range. At such low P_(CO2) levels, existing climate models are unable to warm Hesperian Mars anywhere near the freezing point of water, and other gases are required to raise atmospheric pressure to prevent lake waters from being lost to the atmosphere. Thus, either lacustrine features of Gale formed in a cold environment by a mechanism yet to be determined, or the climate models still lack an essential component that would serve to elevate surface temperatures, at least locally, on Hesperian Mars. Our results also impose restrictions on the potential role of atmospheric CO_2 in inferred warmer conditions and valley network formation of the late Noachian

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

Plasmodium falciparum, the causative agent of human malaria, expresses two aminopeptidases, PfM1AAP and PfM17LAP, critical to generating a free amino acid pool used by the intraerythrocytic stage of the parasite for proteins synthesis, growth and development. These exopeptidases are potential targets for the development of a new class of anti-malaria drugs.To define the substrate specificity of recombinant forms of these two malaria aminopeptidases we used a new library consisting of 61 fluorogenic substrates derived both from natural and unnatural amino acids. We obtained a detailed substrate fingerprint for recombinant forms of the enzymes revealing that PfM1AAP exhibits a very broad substrate tolerance, capable of efficiently hydrolyzing neutral and basic amino acids, while PfM17LAP has narrower substrate specificity and preferentially cleaves bulky, hydrophobic amino acids. The substrate library was also exploited to profile the activity of the native aminopeptidases in soluble cell lysates of P. falciparum malaria.This data showed that PfM1AAP and PfM17LAP are responsible for majority of the aminopeptidase activity in these extracts. These studies provide specific substrate and mechanistic information important for understanding the function of these aminopeptidases and could be exploited in the design of new inhibitors to specifically target these for anti-malaria treatment