SPATIAL ANALYSIS OF SOIL FERTILITY MANAGEMENT USING INTEGRATED HOUSEHOLD AND GIS DATA FROM SMALLHOLDER KENYAN FARMS

Although soil fertility is recognized as a primary constraint to agricultural production in developing countries, use of fertilizer in Sub-Saharan Africa is declining. Smallholder farmers still rely heavily on livestock manure for soil fertility management. To explore the determinants of soil fertility management practices, including both the use of cattle manure and inorganic fertilizer, data are used from a sample of 3,330 geo-referenced farm households across Central and Western Kenya. A bivariate probit model is applied to jointly examine the use of the two technologies. Particular attention is given to measures of location related to market access and agroclimate, which in the adoption literature have typically been addressed using crude proxies. To avoid such proxies, GIS-derived variables are integrated into the household decision model. Their use also allows the spatial prediction of uptake based on parameter estimates. The results show clearly the derived-demand nature of soil fertility services, based on markets for farm outputs. They also illustrate that supply of manure for soil fertility amendments is conditioned by demand for livestock products, especially milk. The integration of GIS-derived variables is shown to better estimate the effects of location than the usual measures employed, and offers scope to wider use in technology adoption research.spatial analysis, soil fertility, market access, technology adoption., Farm Management, Land Economics/Use, Q12, Q16,

Olfactomedin 4 Serves as a Marker for Disease Severity in Pediatric Respiratory Syncytial Virus (RSV) Infection

Funding: Statement of financial support: The study was financially supported by the VIRGO consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative and partially funded by the Dutch Government (BSIK 03012). The authors have indicated they have no personal financial relationships relevant to this article to disclose. Data Availability Statement: The data is accessible at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE69606.Peer reviewedPublisher PD

Challenges in predicting the change in the cumulative exposure of new tobacco and related products based on emissions and toxicity dose–response data

Funding: This work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, the Netherlands. Project number 9.7.1Many novel tobacco products have been developed in recent years. Although many may emit lower levels of several toxicants, their risk in the long term remains unclear. We previously published a method for the exposure assessment of mixtures that can be used to compare the changes in cumulative exposure to carcinogens among tobacco products. While further developing this method by including more carcinogens or to explore its application to non-cancer endpoints, we encountered a lack of data that are required for better-substantiated conclusions regarding differences in exposure between products. In this special communication, we argue the case for more data on adverse health effects, as well as more data on the composition of the emissions from tobacco products. Such information can be used to identify significant changes in relevance to health using the cumulative exposure method with different products and to substantiate regulatory decisions.Publisher PDFPeer reviewe

Dying to be born again: Mortality, immortality and the fashion model

The primary focus of this thesis is limited to the relationship between sartorial fashion and the fashion model within the world of representation. This includes the forms of fashion display and dissemination that existed prior to the establishment of the modern fashion system—fashion dolls, fashion plates and illustration and the mannequin de monde—as well as the fields where the fashion model as a modern phenomenon came into being—fashion photography and the fashion parade. While the portrait of feminine beauty and ideals in the fashion image betrays the imprint of the representation of the female body in art, pornography and the entertainment industries, this thesis argues for a reading of the fashion image and the fashion model specifically through the prism of fashion which, as a quasi-autonomous system, operates according to its own rules and has its own mode of being. Since its inception, fashion has frustrated its critics and delighted its proponents with a nonchalant rejection of the creations it had hitherto enthroned as essential. This dedication to perpetual change and the ephemeral—the ‘death-wish’ that ensures the continuation of fashion as a structure even as individual fashions are discarded—has fascinated both those who have seriously contemplated fashion and those who document the vicissitudes of fashion’s creations. For its critics, the sin fashion commits in refusing to manifest itself in a permanent form of beauty is compounded by its perceived attacks upon the body, cloaking it in a layer of artifice that distorts it into ‘unnatural’ forms. This imposition by fashion on the body made from flesh and blood is never fully realised. Rather it is only on the body in representation that fashion can begin to escape the limitations imposed upon it by the human form and give full reign to its creative impulse. In the fashion image the fundamental principles of fashion—change and artifice—are metaphorically expressed by the interplay of mortality and immortality on the body of the model which, ultimately, serves as the blank canvas where fashion is free to invent its imaginary self

Individual human serum differs in the amount of antibodies with affinity for pig fetal ventral mesencephalic cells and the ability to lyse these cells by complement activation

Xenografting pig fetal ventral mesencephalic (pfVM) cells to repair the dopamine deficit in patients with Parkinson's disease is the focus of both experimental and clinical investigations. Although there have been marked advances in the experimental and even clinical application of these xenogeneic transplantations, questions regarding the host's xenospecific immune response remain unanswered. It has been shown that human serum is able to lyse pfVM tissue by both anti-gal-gal and non-anti-gal-gal antibodies by complement activation. The aim of this study was to investigate whether interindividual differences exist in the levels of pfVM cell-specific IgM and IgG subclass antibodies, their ability to lyse pfVM cells in vitro and the relationship between both. Pig fetal VM cells were incubated with heat-inactivated serum from 10 different individuals and binding of IgM antibodies and IgG subclass antibodies to pfVM cells was analyzed by flow cytometry. The ability to lyse pfVM cells was analyzed exposing Cr-51-labeled pfVM cells to fresh serum or isolated IgM and IgG from the same individuals and subsequent determination of released Cr-51 from lysed cells. Strong differences were found between individuals in the levels of pfVM cell-specific IgM antibodies: antibody levels differed up to 40-fold. pfVM-specific IgG1 and IgG2 levels were only detectable in a few individuals. The ability to lyse pfVM cells ranged from negligible lysis up to 66.5% specific lysis. There was a strong correlation between the levels of individual pfVM-specific IgM antibodies and the ability to lyse pfVM cells in vitro. Isolated IgM, but not IgG, was able to lyse pfVM cells in the presence of complement. In conclusion, the interindividual differences in the levels of IgM with affinity for pfVM cells and their ability to lyse pfVM cells in vitro are considerable. Only few individuals possessed IgG1 and IgG2 subclass antibodies with affinity for pfVM. These findings may influence patient selection for porcine transplants and chances of graft survival in individual patients