Concerns with AED conversion: comparison of patient and physician perspectives.

When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clinician's perspective of patient concerns. Findings of a literature review of articles that report patient-expressed concerns regarding their epilepsy and treatment were also reviewed. Results showed that the specialist panel appropriately identified patient-reported concerns of driving ability, medication cost, seizure control, and medication side effects. Additionally, patient-reported concerns of independence, employment issues, social stigma, medication dependence, and undesirable cognitive effects are important to address when considering and initiating AED conversion

An Investigation of the Large-scale Variability of the Apparently Single Wolf-Rayet Star WR 1

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with the existence of an unseen (collapsed?) companion or of spatially extended wind structures as potential candidates. We present observations of WR 1 which highlight the unusual character of the variations in this object. Our narrowband photometric observations reveal a gradual increase of the stellar continuum flux amounting to Delta v = 0.09 mag followed by a decline on about the same timescale (3-4 days). Only marginal evidence for variability is found during the 11 following nights. Strong, daily line-profile variations are also observed but they cannot be easily linked to the photometric variations. Similarly to the continuum flux variations, coherent time-dependent changes are observed in 1996 in the centroid, equivalent width, and skewness of He II 4686. Despite the generally coherent nature of the variations, we do not find evidence in our data for the periods claimed in previous studies. While the issue of a cyclical pattern of variability in WR 1 is still controversial, it is clear that this object might constitute in the future a cornerstone for our understanding of the mechanisms leading to the formation of largely anisotropic outflows in Wolf-Rayet stars.Comment: 11 pages, 9 figures, accepted for publication in Astronomy & Astrophysic

Turbulence observations in a buoyant hydrothermal plume on the East Pacific Rise

Author Posting. © The Oceanography Society, 2012. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 25, no. 1 (2012): 180–181, doi:10.5670/oceanog.2012.15.Hot vent fluid enters the ocean at high-temperature hydrothermal vents, also known as black smokers. Because of the large temperature difference between the vent fluid and oceanic near-bottom waters, the hydrothermal effluent initially rises as a buoyant plume through the water column. During its rise, the plume engulfs and mixes with background ocean water. This process, called entrainment, gradually reduces the density of the rising plume until it reaches its level of neutral buoyancy, where the plume density equals that of the background water, and it begins to spread along a surface of constant density.The data presented here were collected in the context of National Science Foundation grants OCE-0425361 and OCE-0728766

Twitter Informatics: Tracking and Understanding Public Reaction during the 2009 Swine Flu Pandemic

Much attention has been focused on Twitter because it serves as a central hub for the publishing, dissemination, and discovery of online media. This is true for both traditional news outlets and user generated content, both of which can vary widely in their journalistic and scientific quality. The recent Swine Flu pandemic of 2009 highlighted this aspect perfectly, global events that created a large online buzz, with some dubious medical facts leaking into public opinion. This paper presents an investigation into how online resources relating to Swine Flu were discussed on Twitter, with a focus on identifying and analyzing the popularity of trusted information sources (e.g. from quality news outlets and official health agencies). Our findings indicate that reputable sources are more popular than untrusted ones, but that information with poor scientific merit can still leak into to the network and potentially cause harm

La P3 dans l'apprentissage explicite des catégories

La catégorisation consiste en la capacité\ud de classer les stimuli en des catégories\ud discrètes, selon une règle de catégorisation\ud (Harnad, 2005).\ud Une étude en électroencéphalographie\ud de St-Louis et Harnad (en prép.) révèle\ud une positivité tardive (P3b) dans une\ud tâche consistant à trouver une règle\ud permettant de différencier 2 images

Model-Based Interpretation of Time-Varying Medical Data

Temporal concepts are critical is medical therapy-planning. If given early enough, specific therapeutic choices may abort or suppress evolving undesired changes in a patient’s clinical status. Effective medical decision making demands recognition and interpretation of complex temporal changes that permeate the medical record. This paper presents a methodology for representing and using medical knowledge about temporal relationships to infer the presence of clinically relevant events, and describes a program, called TOPAZ, that uses this methodology to generate a narrative summary of such events. A unique feature of TOPAZ is the use of numeric and symbolic modeling techniques to perform temporal reasoning tasks that would be difficult to encode and perform using only one modeling methodology

Follow #eHealth2011: Measuring the Role and Effectiveness of Online and Social Media in Increasing the Outreach of a Scientific Conference

BACKGROUND: Social media promotion is increasingly adopted by organizers of industry and academic events; however, the success of social media strategies is rarely questioned or the real impact scientifically analyzed. Objective: We propose a framework that defines and analyses the impact, outreach, and effectiveness of social media for event promotion and research dissemination to participants of a scientific event as well as to the virtual audience through the Web. METHODS: Online communication channels Twitter, Facebook, Flickr, and a Liveblog were trialed and their impact measured on outreach during five phases of an eHealth conference: the setup, active and last-minute promotion phases before the conference, the actual event, and after the conference. RESULTS: Planned outreach through online channels and social media before and during the event reached an audience several magnitudes larger in size than would have been possible using traditional means. In the particular case of eHealth 2011, the outreach using traditional means would have been 74 attendees plus 23 extra as sold proceedings and the number of downloaded articles from the online proceedings (4107 until October 2013). The audience for the conference reached via online channels and social media was estimated at more than 5300 in total during the event. The role of Twitter for promotion before the event was complemented by an increased usage of the website and Facebook during the event followed by a sharp increase of views of posters on Flickr after the event. CONCLUSIONS: Although our case study is focused on a particular audience around eHealth 2011, our framework provides a template for redefining “audience” and outreach of events, merging traditional physical and virtual communities and providing an outline on how these could be successfully reached in clearly defined event phases

Community based booster seat promotion programs: baseline results of a direct observation survey

Includes bibliographical references (p. 7-8)Final report. Oct. 1, 2004-Sept. 30, 2005This study reports the results of a baseline survey of restraint use by 4 to 8 year old children in Grand Rapids, Kalamazoo, Sturgis, and Coldwater, Michigan. The study, conducted between June 19 and July 1, 2005, focused on low income areas of Grand Rapids and the Hispanic population of Sturgis. Two control cities were chosen to observe booster seat use in cities similar to the experimental cities. Kalamazoo was the control city for Grand Rapids, and Coldwater was the control city for Sturgis. A follow-up survey to be conducted next year will provide comparison data and will be discussed in a separate report. Together, these survey waves will provide an assessment of the booster seat promotion programs implemented in Grand Rapids and Sturgis, Michigan. In this study, 4 to 8 year old children were observed traveling in passenger cars, vans/minivans, sport-utility vehicles, and pickup trucks. Each city was analyzed separately to obtain a booster seat use rate for each sample area. Booster seat use rates were: Grand Rapids 19.0 ± 10.3 percent, Kalamazoo 9.7 ± 11.3 percent, Sturgis 9.7 ± 5.0 percent, and Coldwater 18.2 ± 5.2 percent.Michigan Department of Community Health, LansingCenters for Disease Control and Prevention, Atlanta, Ga.http://deepblue.lib.umich.edu/bitstream/2027.42/13899/2/99236.pd

The Effects of Probiotic Therapy on Stress Coping Styles of Triploid Juvenile Farmed Chinook Salmon, Oncorhynchus tshawytscha

Triploid salmon – fish with three sets of chromosomes – are regularly used in aquaculture as they are functionally sterile and therefore avoid the decline in flesh quality associated with sexual maturation. However, triploid fish exhibit many immune, behavioural, and physiological drawbacks which reduce their condition and survival in aquaculture environments. My research examines the effects of probiotic treatment to promote behavioural and stress-related (termed ‘coping styles’) traits more suited for aquaculture environments in triploid fish with the ultimate goal of increasing fish yield. In this study, Chinook salmon (Oncorhynchus tshawytscha) crosses were developed in a 3x3 and 3x2 design, with each family’s eggs split so that one half remained diploid (2N) and the other underwent triploidization (3N). At the alevin (exogenously feeding) stage, fish were reared under four treatment groups: 2N probiotic or regular feed, and 3N probiotic or regular feed. Juveniles were tested eight months postfertilization and individually assayed for behaviours to test for activity, exploration, predator responsiveness, and sociality. Fish were then terminally sampled for plasma cortisol concentrations as a measure of stress-induced response to aquaculture stressors. Subsets of fish were also sampled for baseline cortisol, as a measure of energetic demand, and for maximum cortisol, as an acute cortisol response. Triploid individuals exhibited marginally increased activity and neophobia, and showed reduced baseline, maximum, and behavioural stress-induced cortisol concentrations. Probiotics had an effect in increasing boldness and exploration behaviours, as well as reducing maximum cortisol concentrations. We also observed independent ploidy, behavioural, and physiological effects on mass, and interactive effects between behaviour and physiology, and physiology and feed on mass as well. Findings from this study may contribute to increasing yield in finfish aquaculture production by increasingbeneficial behaviours and reduce stressor responsiveness, thereby resulting in increased growth

Phytoplankton-Fluorescence-Lifetime Vertical Profiler

A battery-operated optoelectronic instrument is designed to be lowered into the ocean to measure the intensity and lifetime of fluorescence of chlorophyll A in marine phytoplankton as a function of depth from 0 to 300 m. Fluorescence lifetimes are especially useful as robust measures of photosynthetic productivity of phytoplankton and of physical and chemical mechanisms that affect photosynthesis. The knowledge of photosynthesis in phytoplankton gained by use of this and related instruments is expected to contribute to understanding of global processes that control the time-varying fluxes of carbon and associated biogenic elements in the ocean. The concentration of chlorophyll in the ocean presents a major detection challenge because in order to obtain accurate values of photosynthetic parameters, the intensity of light used to excite fluorescence must be kept very low so as not to disturb the photosynthetic system. Several innovations in fluorometric instrumentation were made in order to make it possible to reach the required low detection limit. These innovations include a highly efficient optical assembly with an integrated flow-through sample interface, and a high-gain, low-noise electronic detection subsystem. The instrument also incorporates means for self-calibration during operation, and electronic hardware and software for control, acquisition and analysis of data, and communications. The electronic circuitry is highly miniaturized and designed to minimize power demand. The instrument is housed in a package that can withstand the water pressure at the maximum depth of 300 m. A light-emitting diode excites fluorescence in the sample flow cell, which is placed at one focal point of an ellipsoidal reflector. A photomultiplier tube is placed at the other focal point. This optical arrangement enables highly efficient collection of fluorescence emitted over all polar directions. Fluorescence lifetime is measured indirectly, by use of a technique based on the same principle as the one described in "Fluorometer for Analysis of Photosynthesis in Phytoplankton" (SSC-00110), NASA Tech Briefs, Vol. 24, No. 1 (November 2000), page 79. The excitation is modulated at a frequency of 70 MHz, and the phase shift between the excitation light and the emitted fluorescence is measured by a detection method in which the 70 MHz signal is down-converted to a 400 Hz signal. The fluorescence lifetime can be computed from the known relationship among the fluorescence lifetime, phase shift, and modulation frequenc