Variability of the Southwestern Patagonia (51°S) Winds in the Recent (1980–2020) Period: Implications for Past Wind Reconstructions

The Southern Hemisphere Westerly Winds (SWW) control the amount and latitudinal distribution of rainfall in southwestern Patagonia. Recent studies have shown that SWW has intensified in the last decades, but their past behavior is not yet well understood. To understand this behavior, it is necessary to analyze climatic data from meteorological stations and reconstruct their variability through paleoclimatic evidence, such as lake cores. Nevertheless, Patagonia is an austral region characterized by its complex topography and quasi lack of a meteorological network. In this work, three reanalyses are studied (MERRA-2, ERA5, and GLDAS) and compared with the Cerro Castillo and Teniente Gallardo stations (~51°S), with the aim of simulating the winds in the past. The results indicate that ERA5 and MERRA-2 simulate well the wind variability in the study region, while GLDAS is less reliable. Therefore, the first two reanalyses could be used to extend the time series of the meteorological station and calibrate a new wind proxy based on the abundance and size of the aeolian particles, reconstructing in a direct way the intensity of the SWW in the past over southwestern Patagonia

Water content of limestones submitted to realistic wet deposition: a CIME2 chamber simulation

International audienceAn experimental chamber (CIME2) has been specially designed to simulate wet atmospheric deposition on limestones used inParis cultural heritage. This instrument is a complementary tool to CIME, a previously developed chamber dedicated to thesimulation of dry atmospheric deposition on monuments and artifacts. The aim of this paper is to describe CIME2 and characterizethe wet deposits produced inside it. Mist (fog), drizzle, and rainfall are differentiated in order to document their ability tosaturate the limestones most currently used in Paris monuments: The Saint-Maximin’s limestone, the Liais of Saint-Maximin, andthe Chauvigny’s limestone are tested. The comparison between normalized and environmental petrophysical data shows that inthe wet deposition simulations, limestones are not systematically water-saturated. Moreover, the realistic experimental conditionschosen favor a more rapid evaporation of the stone water. The quantification of the non-saturation state is a first step that has to betaken into account to improve the geochemical models used to predict the alteration

Amantadine use in the French prospective NS-Park cohort

International audienceObjective: To assess amantadine use and associated factors in the patients with Parkinson's disease (PD).Background: Immediate-release amantadine is approved for the treatment of PD and is largely used in clinical practice to treat "levodopa-induced dyskinesia (LIDs). Its use varies according to countries and PD stages. The prospective NS-Park cohort collects features of PD patients followed by 26 French PD Expert Centres.Methods: Variables used for the analyses included demographics, motor and non-motor PD symptoms and motor complications [motor fluctuations (MFs), LIDs)], antiparkinsonian pharmacological classes and levodopa equivalent daily dose (LEDD). We evaluated: (i) prevalence of amantadine use and compared clinical features of amantadine users vs. non-users (cross-sectional analysis); (ii) factors associated with amantadine initiation (longitudinal analysis); (iii) amantadine effect on LIDs, MFs, apathy, impulse control disorders and freezing of gait (Fog) (longitudinal analysis).Results: Amantadine use prevalence was 12.6% (1,585/12,542, median dose = 200 mg). Amantadine users were significantly younger, with longer and more severe PD symptoms, greater LEDD and more frequent use of device-aided/surgical treatment. Factors independently associated with amantadine initiation were younger age, longer PD duration, more frequent LIDs, MFs and FoG, higher LEDD and better cognitive function. 9 of the 658 patients on amantadine had stopped it at the following visit, after 12-18 months (1.3%). New users of amantadine presented a higher improvement in LIDs and MF compared to amantadine never users.Conclusions: About 12% of PD patients within the French NS-Park cohort used amantadine, mostly those with younger age and more severe PD. Amantadine initiation was associated with a subsequent reduction in LIDs and MFs