‘Next-Generation’ surveillance: an epidemiologists’ perspective on the use of molecular information in food safety and animal health decision-making

Advances in the availability and affordability of molecular and genomic data are transforming human health care. Surveillance aimed at supporting and improving food safety and animal health is likely to undergo a similar transformation. We propose a definition of ‘molecular surveillance’ in this context and argue that molecular data are an adjunct to rather than a substitute for sound epidemiological study and surveillance design. Specific considerations with regard to sample collection are raised, as is the importance of the relation between the molecular clock speed of genetic markers and the spatiotemporal scale of the surveillance activity, which can be control- or strategy-focused. Development of standards for study design and assessment of molecular surveillance system attributes is needed, together with development of an interdisciplinary skills base covering both molecular and epidemiological principles

A Complete Axiomatization of the Three valued Completion of Logic Programs

We prove the completeness of extended SLDNF-resolution for the new class of e-programs with respect to the three-valued completion of a logic program. Not only the class of allowed programs but also the class of definite programs are contained in the class of ε-programs. To understand better the three-valued completion of a logic program we introduce a formal system for three-valued logic in which one can derive exactly the three-valued consequences of the completion of a logic program. The system is proof theoretically interesting, since it is a fragment of Gentzen's sequent calculus L

Economic aspects of food borne disease surveillance

The presence of food-borne disease in food systems creates direct and indirect economic impacts. These include the losses caused by the negative effects of disease itself when people are ill or die leading to reduced productivity, loss of income, and human suffering. In animal populations, similar losses occur when animals are ill or die leading to production losses and/or animal welfare issues. To avoid such losses, efforts to prevent, control or eradicate disease can be undertaken but in return also generate economic costs. Economic analyses in this context investigate how resources are allocated to activities and how to balance direct losses against expenditure to reduce the impact of disease

Sentinel surveillance systems with special focus on vector-borne diseases

In the past few decades, vector-borne diseases have been spreading into countries previously free of these agents. It is necessary for a surveillance method to be tailored to the biology of these agents in order to detect their incursion. Using a sentinel herd system, it is possible to target high-risk areas where occurrence is most probably due to vector presence. Since the 1970s, diseases such as Akabane, vesicular stomatitis and Bluetongue disease have successfully been monitored using cattle herds as sentinels in many countries such as Saudi Arabia, Australia, China, Indonesia, Sultanate of Oman and most recently in countries in Western Europe. This paper reviews the strengths and weaknesses of sentinel herd surveillance systems in general. In order to determine their efficacy, the following criteria were found to be essential: the choice of sentinel locations, sentinel animal, seasonality of sampling and diagnostic testing methods. We conclude that due to its ability to focus on a specific disease, sentinel herd systems have been successful in the early detection of the spread of a targeted agent. This review is used as a basis for recommendations for the development of future sentinel herd system

The influence of distraction on speech processing: How selective is selective attention?

-* indicates shared first authorship - The present study investigated the effects of selective attention on the processing of morphosyntactic errors in unattended parts of speech. Two groups of German native (L1) speakers participated in the present study. Participants listened to sentences in which irregular verbs were manipulated in three different conditions (correct, incorrect but attested ablaut pattern, incorrect and crosslinguistically unattested ablaut pattern). In order to track fast dynamic neural reactions to the stimuli, electroencephalography was used. After each sentence, participants in Experiment 1 performed a semantic judgement task, which deliberately distracted the participants from the syntactic manipulations and directed their attention to the semantic content of the sentence. In Experiment 2, participants carried out a syntactic judgement task, which put their attention on the critical stimuli. The use of two different attentional tasks allowed for investigating the impact of selective attention on speech processing and whether morphosyntactic processing steps are performed automatically. In Experiment 2, the incorrect attested condition elicited a larger N400 component compared to the correct condition, whereas in Experiment 1 no differences between conditions were found. These results suggest that the processing of morphosyntactic violations in irregular verbs is not entirely automatic but seems to be strongly affected by selective attention