Granular cell ameloblastoma of jaw: report of a case with an emphasis on its characterization

Ameloblastoma is a neoplasm of odontogenic epithelium, especially of enamel organ-type tissue that has not under gone differentiation to the point of hard tissue formation. It accounts for approximately 10% of all tumors originating from gnathic bones. It exhibits diverse microscopic patterns which occurs either singly or in combination with other patterns. Granular cell ameloblastoma is a rare condition, accounting for 3.5% of all ameloblastoma cases that shows marked transformation in the cytoplasm of tumor cells, which are usually stellate reticulum like cells. The transformed cells possess very coarse, granular, eosinophilic cytoplasm. The 'granular change' is thought to be due to a dysfunctional status of neoplastic cells, and the pathogenesis of this tumour seems to be age-related. Ultrastructural, histochemical, and immunohitochemical studies have revealed that cytoplasmic granularity is caused by overload; however the mechanism ivolved remains poorly understood. This article describes a case of granular cell variant of ameloblastoma affecting a 55-year old femal

Pigmented intramucosal nevus of gingiva with a special insight on its pathophysiology: Report of a rare entity

Oral melanotic nevi can be characterized as developmental malformations or melanocytic tumors. Nevi are benign in nature originating from proliferating malfunctioning melanoblasts of the neural crest cells either in the epithelium or in connective tissue. It is an infrequent oral lesion triggering focal pigmentation. Considerable debate exists in the literature with respect to their origin, development, maturation, and their association to oral melanocytes. Nevi present in the mucous membrane have been documented to ensure the risk of malignant transformation. Hence, it is appropriate to cautiously diagnose all pigmented lesions of the oral cavity. Here, we report a case of intramucosal nevus with unusually large size in maxillary anterior gingival mucosa

Nevoid basal cell carcinoma syndrome: A case report

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant inherited condition that exhibits high penetrance and variable expressivity. The syndrome is caused by mutations in patch (PTCH), a tumor suppressor gene that has been mapped to chromosome 9q22.3-q31. NBCCS is characterized by basal cell carcinomas (BCCs), odontogenic keratocysts of the jaws, pits of the palms and soles, ectopic calcification particularly of the falx cerebri, and skeletal anomalies. Other features, including ovarian fibromas, medulloblastoma, ocular anomalies, and neurological defects, are also associated with this syndrome. It arises in all races with equal sexual predilection. It is a rare syndrome and incidence rate is 5%. In this report, we present a case of NBCCS in a 30-year-old male patient