Jeunes et la lecture de la presse quotidienne d\u27information politique et générale (Les)

Face à la concurrence des autres médias (internet, gratuits, magazines) propositions pour le développement de la lecture de la presse chez les collégiens, lycéens et étudiants

An Exceptional Nation: Why the United States Lacks Universal Health Insurance

Senior Project submitted to The Division of Social Studies of Bard College

Etats généraux de la presse écrite - Livre vert

Les Etats généraux de la presse écrite, lancés par le président de la République le 2 octobre 2008, ont eu pour mission d\u27apporter des réponses aux difficultés économiques que rencontre la presse écrite, notamment face au développement de l\u27internet et des journaux gratuits. Coordonnées par le ministère de la culture et de la communication, les réunions thématiques des quatre pôles de réflexions, respectivement consacrés aux métiers du journalisme, au processus industriel de la presse, à l\u27impact d\u27internet et aux questions de société ont eu pour objectif d\u27établir un diagnostic complet. Plus de 150 professionnels y ont participé durant trois mois. A l\u27issue de 70 heures d\u27auditions et de débats, les chefs de pôles ont émis des propositions qui ont permis d\u27élaborer ce Livre vert présentant plus de 90 recommandations

Assessment of Vaginal Lactobacillary Flora in Wet Mount and Fresh or Delayed Gram's Stain

Objective: The assessment of the vaginal lactobacillary flora helps to direct further diagnostic microbiologic investigations in genital infectious disease and seems to represent a powerful tool in predicting infectious morbidity and preterm labor during pregnancy. In the absence of a “gold standard,” we studied the variations in assessing lactobacillary morphotypes according to the method used

Ab Initio Study of Hybrid b-bar-gb Mesons

Hybrid b-bar-gb molecules in which the heavy b-bar-b pair is bound together by the excited gluon field g are studied using the Born-Oppenheimer expansion and numerical simulations. The consistency of results from the two approaches reveals a simple and compelling physical picture for heavy hybrid states.Comment: 4 pages, 3 figures, uses REVTeX and epsf, final published versio

Core Values that Influence the Patient—Healthcare Professional Power Dynamic: Steering Interaction towards Partnership

Healthcare has long been marked by the authoritative-physician–passive-patient interaction, with patients seeking help and physicians seeking to restore patients back to health. However, lobalisation, social movements, and technological advancements are transforming the nature of this relationship. We aim to identify core values that influence the power dynamic betweenpatients and healthcare professionals, and determine how to steer these interactions towards partnership, a more suitable approach to current healthcare needs. Patients with physical chronic diseases (10 men, 18 women) and healthcare professionals (11 men, 12 women) were interviewed, sessions transcribed, and the framework method used to thematically analyse the data. Validation was done through analyst triangulation and member check recheck. Core values identified as influencing the patient-healthcare professional power dynamic include: (A) values that empower patients (acceptance of diagnosis and autonomy); (B) values unique to healthcare professionals (HCPs) (acknowledging patients experiential knowledge and including patients in the therapeutic process); and (C) shared capitals related to their interactions (communication, information sharing and exchange, collaboration, and mutual commitment). These interdependent core values can be considered prerequisites to the implementation of the patient-as-partner approach in healthcare. Partnership would imply a paradigm shift such that stakeholders systematically examine each other’s perspective, motivations, capabilities, and goals, and then adapt their interactions in this accord, for optimal outcome

Frequency of GAA-FGF14 Ataxia in a Large Cohort of Brazilian Patients With Unsolved Adult-Onset Cerebellar Ataxia

OBJECTIVES: Intronic FGF14 GAA repeat expansions have recently been found to be a common cause of hereditary ataxia (GAA-FGF14 ataxia; SCA27B). The global epidemiology and regional prevalence of this newly reported disorder remain to be established. In this study, we investigated the frequency of GAA-FGF14 ataxia in a large cohort of Brazilian patients with unsolved adult-onset ataxia. METHODS: We recruited 93 index patients with genetically unsolved adult-onset ataxia despite extensive genetic investigation and genotyped the FGF14 repeat locus. Patients were recruited across 4 different regions of Brazil. RESULTS: Of the 93 index patients, 8 (9%) carried an FGF14 (GAA)≥250 expansion. The expansion was also identified in 1 affected relative. Seven patients were of European descent, 1 was of African descent, and 1was of admixed American ancestry. One patient carrying a (GAA)376 expansion developed ataxia at age 28 years, confirming that GAA-FGF14 ataxia can occur before the age of 30 years. One patient displayed episodic symptoms, while none had downbeat nystagmus. Cerebellar atrophy was observed on brain MRI in 7 of 8 patients (87%). DISCUSSION: Our results suggest that GAA-FGF14 ataxia is a common cause of adult-onset ataxia in the Brazilian population, although larger studies are needed to fully define its epidemiology

The Pion-Nucleon sigma-Term with Dynamical Wilson Fermions

We calculate connected and disconnected contributions to the flavour singlet scalar density amplitude of the nucleon in a full QCD lattice simulation with $n_f=2$ dynamical Wilson fermions at $\beta=5.6$ on a $16^3 \times 32$ lattice. We find that both contributions are of similar size at the light quark mass. We arrive at the estimate $\sigma_{\pi N} = 18(5)$MeV. Its smallness is directly related to the apparent decrease of $u$, $d$ quark masses when unquenching QCD lattice simulations. The $y$ parameter can be estimated from a semi-quenched analysis, in which there are no strange quarks in the sea, the result being $y=0.59(13)$.}Comment: Final version, accepted for publication in Phys. Rev. D, minor changes to the text, 1 new figure, 17 page

A Novel Epigenetic Phenotype Associated With the Most Aggressive Pathway of Bladder Tumor Progression

International audienceBackground: Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.Methods: We searched for chromosomal regions affected by epigenetic silencing in cancer by using Affymetrix microarrays and real-time quantitative polymerase chain reaction to analyze RNA from 57 bladder tumors compared with normal urothelium. Epigenetic silencing was verified by gene re-expression following treatment of bladder cell lines with 5-aza-deoxycytidine, a DNA demethylating agent, and trichostatin A, a histone deacetylase inhibitor. DNA methylation was studied by bisulfite sequencing and histone methylation and acetylation by chromatin immunoprecipitation. Clustering was used to distinguish tumors with multiple regional epigenetic silencing (MRES) from those without and to analyze the association of this phenotype with histopathologic and molecular types of bladder cancer. The results were confirmed with a second panel of 40 tumor samples and extended in vitro with seven bladder cancer cell lines. All statistical tests were two-sided.Results: We identified seven chromosomal regions of contiguous genes that were silenced by an epigenetic mechanism. Epigenetic silencing was not associated with DNA methylation but was associated with histone H3K9 and H3K27 methylation and histone H3K9 hypoacetylation. All seven regions were concordantly silenced in a subgroup of 26 tumors, defining an MRES phenotype. MRES tumors exhibited a carcinoma in situ-associated gene expression signature (25 of 26 MRES tumors vs 0 of 31 non-MRES tumors, P < 10⁻¹⁴), rarely carried FGFR3 mutations (one of 26 vs 22 of 31 non-MRES tumors, P < 10⁻¹⁶), and contained 25 of 33 (76%) of the muscle-invasive tumors. Cell lines derived from aggressive bladder tumors presented epigenetic silencing of the same regions.Conclusions: We have identified an MRES phenotype characterized by the concomitant epigenetic silencing of several chromosomal regions, which, in bladder cancer, is specifically associated with the carcinoma in situ gene expression signature