57 research outputs found

    Multimedia Chinese Web Search Engines: A Survey

    Get PDF
    The objective of this paper is to explore the state of multimedia search functionality on major general and dedicated Web search engines in Chinese language. The authors studied: a) how many Chinese Web search engines presently make use of multimedia searching, and b) the type of multimedia search functionality available. Specifically, the following were examined: a) multimedia features - features allowing multimedia search; and b) extent of personalization - the extent to which a search engine Web site allows users to control multimedia search. Overall, Chinese Web search engines offer limited multimedia searching functionality. The significance of the study is based on two factors: a) little research has been conducted on Chinese Web search engines, and b) the instrument used in the study and the results obtained by this research could help users, Web designers, and Web search engine developers. By large, general Web search engines support more multimedia features than specialized one

    Mapping recent information behavior research: an analysis of co-authorship and cocitation networks

    Get PDF
    There has been an increase in research published on information behavior in recent years, and this has been accompanied by an increase in its diversity and interaction with other fields, particularly information retrieval (HR). The aims of this study are to determine which researchers have contributed to producing the current body of knowledge on this subject, and to describe its intellectual basis. A bibliometric and network analysis was applied to authorship and co-authorship as well as citation and co-citation. According to these analyses, there is a small number of authors who can be considered to be the most productive and who publish regularly, and a large number of transient ones. Other findings reveal a marked predominance of theoretical works, some examples of qualitative methodology that originate in other areas of social science, and a high incidence of research focused on the user interaction with information retrieval systems and the information behavior of doctors

    The Wnt-dependent signaling pathways as target in oncology drug discovery

    Get PDF
    Our current understanding of the Wnt-dependent signaling pathways is mainly based on studies performed in a number of model organisms including, Xenopus, Drosophila melanogaster, Caenorhabditis elegans and mammals. These studies clearly indicate that the Wnt-dependent signaling pathways are conserved through evolution and control many events during embryonic development. Wnt pathways have been shown to regulate cell proliferation, morphology, motility as well as cell fate. The increasing interest of the scientific community, over the last decade, in the Wnt-dependent signaling pathways is supported by the documented importance of these pathways in a broad range of physiological conditions and disease states. For instance, it has been shown that inappropriate regulation and activation of these pathways is associated with several pathological disorders including cancer, retinopathy, tetra-amelia and bone and cartilage disease such as arthritis. In addition, several components of the Wnt-dependent signaling pathways appear to play important roles in diseases such as Alzheimer’s disease, schizophrenia, bipolar disorder and in the emerging field of stem cell research. In this review, we wish to present a focused overview of the function of the Wnt-dependent signaling pathways and their role in oncogenesis and cancer development. We also want to provide information on a selection of potential drug targets within these pathways for oncology drug discovery, and summarize current data on approaches, including the development of small-molecule inhibitors, that have shown relevant effects on the Wnt-dependent signaling pathways

    A self-renewal assay for cancer stem cells

    Full text link
    Cancers of epithelial origin are responsible for the majority of cancer-related deaths in the USA. Unfortunately, although chemotherapy and/or radiation therapy can sometimes shrink tumors, metastatic cancers of epithelial origin are essentially incurable. It is clear that new approaches are needed to treat these diseases. Although cancer cell lines provide invaluable information, their biological properties often differ in crucial ways from de novo cancer cells. Our laboratory has developed a novel mouse model that reliably permits individual cancer cells isolated directly from patients’ tumors to be assayed. This will allow the characterization of crucial signaling pathways involved in processes such as self-renewal that are critical for tumor formation by the cancer cells within de novo tumors. These tools should lead to new insights into the cellular and molecular mechanisms that drive human breast cancer growth and invasion.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46932/1/280_2005_Article_97.pd

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

    Get PDF

    Multimedia search capabilities of Chinese language search engines

    No full text
    This paper reports results from a study exploring the multimedia search functionality of Chinese language search engines. Web searching in Chinese (Mandarin) is a growing research area and a technical challenge for popular commercial Web search engines. Few studies have been conducted on Chinese language search engines. We investigate two research questions: which Chinese language search engines provide multimedia searching, and what multimedia search functionalities are available in Chinese language Web search engines. Specifically, we examine each Web search engine's (1) features permitting Chinese language multimedia searches, (2) extent of search personalization and user control of multimedia search variables, and (3) the relationships between Web search engines and their features in the Chinese context. Key findings show that Chinese language Web search engines offer limited multimedia search functionality, and general search engines provide a wider range of features than specialized multimedia search engines. Study results have implications for Chinese Web users, Website designers and Web search engine developers. © 2009 Elsevier Ltd. All rights reserved

    Web Searching: A Quality Measurement Perspective

    Get PDF
    The purpose of this paper is to describe various quality measures for search engines and to ask whether these are suitable. We especially focus on user needs and their use of web search engines. The paper presents an extensive literature review and a first quality measurement model, as well. Findings include that search engine quality can not be measured by just retrieval effectiveness (the quality of the results), but should also consider index quality, the quality of the search features and search engine usability. For each of these sections, empirical results from studies conducted in the past, as well as from our own research are presented. These results have implications for the evaluation of search engines and for the development of better search systems that give the user the best possible search experience

    Spanish Web Searching Tools: An Exploratory Study

    No full text

    Search Engines' Help Systems

    No full text
    • 

    corecore