Contrasting responses of idealised and realistic simulations of shallow cumuli to aerosol perturbations

Shallow clouds remain greatly significant in improving our understanding of the atmosphere. Using the Met Office Unified Model, we compare highly idealised simulations of shallow cumuli with those using more realistic domains, with open lateral boundaries and varying large-scale forcing. We find that the realistic simulations are more capable of representing the cloud field on large spatial scales, and appear to limit the aerosol perturbations leading to impacts on the thermodynamic conditions. Aerosol perturbations lead to changes in the cloud vertical structure, and thermodynamic evolution of the idealised simulations; a central feature of behavior seen previously in idealised simulations. Modelling approaches with open boundaries and time-varying forcing may allow for improved representation of shallow clouds in the atmosphere, and greater understanding of how they may respond to perturbations

Boundary conditions representation can determine simulated aerosol effects on convective cloud fields

Anthropogenic aerosols effect on clouds remains a persistent source of uncertainty in future climate predictions. The evolution of the environmental conditions controlling cloud properties is affected by the clouds themselves. Hence, aerosol-driven modifications of cloud properties can affect the evolution of the environmental thermodynamic conditions, which in turn could feed back to the cloud development. Here, by comparing many different cloud resolving simulations conducted with different models and under different environmental condition, we show that this feedback loop is strongly affected by the representation of the boundary conditions in the model. Specifically, we show that the representation of boundary conditions strongly impacts the magnitude of the simulated response of the environment to aerosol perturbations, both in shallow and deep convective clouds. Our results raise doubts about the significance of previous conclusions of aerosol-cloud feedbacks made based on simulations with idealised boundary conditions

Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Developing strategies to inflame tumors is critical for increasing response to immunotherapy. Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell infiltration and enables responsiveness to combinatorial immunotherapy in an IFN-dependent manner. Treatment efficacy relied upon mobilizing both adaptive and innate immunity and depended on both cytotoxic CD4(+) and CD8(+) T cells. LDRT elicited predominantly CD4(+) cells with features of exhausted effector cytotoxic cells, with a subset expressing NKG2D and exhibiting proliferative capacity, as well as a unique subset of activated dendritic cells expressing the NKG2D ligand RAE1. We translated these findings to a phase I clinical trial administering LDRT, low-dose cyclophosphamide, and immune checkpoint blockade to patients with immune-desert tumors. In responsive patients, the combinatorial treatment triggered T-cell infiltration, predominantly of CD4(+) cells with Th1 signatures. Our data support the rational combination of LDRT with immunotherapy for effectively treating low T cell-infiltrated tumors. SIGNIFICANCE: Low-dose radiation reprogrammed the tumor microenvironment of tumors with scarce immune infiltration and together with immunotherapy induced simultaneous mobilization of innate and adaptive immunity, predominantly CD4(+) effector T cells, to achieve tumor control dependent on NKG2D. The combination induced important responses in patients with metastatic immune-cold tumors

Oil Spill Dispersants Induce Formation of Marine Snow by Phytoplankton-Associated Bacteria

Unusually large amounts of marine snow, including Extracellular Polymeric Substances (EPS), were formed during the 2010 Deepwater Horizon oil spill. The marine snow settled with oil and clay minerals as an oily sludge layer on the deep sea floor. This study tested the hypothesis that the unprecedented amount of chemical dispersants applied during high phytoplankton densities in the Gulf of Mexico induced high EPS formation. Two marine phytoplankton species (Dunaliella tertiolecta and Phaeodactylum tricornutum) produced EPS within days when exposed to the dispersant Corexit 9500. Phytoplankton-associated bacteria were shown to be responsible for the formation. The EPS consisted of proteins and to lesser extent polysaccharides. This study reveals an unexpected consequence of the presence of phytoplankton. This emphasizes the need to test the action of dispersants under realistic field conditions, which may seriously alter the fate of oil in the environment via increased marine snow formation