Mental health and developmental disorders in infancy and early childhood. The PDM-2

We provide a general introduction to the theoretical and empirical sources informing the development of the Infancy and Early Childhood Section (IEC) of the second edition of the Psychodynamic Diagnostic Manual (PDM-2). We offer a brief exploration of the evolution of developmental psychoanalysis and its applications to infant mental health, along with an example of applying the IEC framework to clinical and developmental data from a longitudinal study based on developmental and psychodynamic principles. This article illustrates the evolution of theory in the context of interdisciplinary integration and explores its implications for diagnosis and clinical formulatio

Does the Danube exist? Versions of reality given by various regional climate models and climatological datasets

We present an intercomparison and verification analysis of several regional climate models (RCMs) nested into the same run of the same Atmospheric Global Circulation Model (AGCM) regarding their representation of the statistical properties of the hydrological balance of the Danube river basin for 1961-1990. We also consider the datasets produced by the driving AGCM, from the ECMWF and NCEP-NCAR reanalyses. The hydrological balance is computed by integrating the precipitation and evaporation fields over the area of interest. Large discrepancies exist among RCMs for the monthly climatology as well as for the mean and variability of the annual balances, and only few datasets are consistent with the observed discharge values of the Danube at its Delta, even if the driving AGCM provides itself an excellent estimate. Since the considered approach relies on the mass conservation principle and bypasses the details of the air-land interface modeling, we propose that the atmospheric components of RCMs still face difficulties in representing the water balance even on a relatively large scale. Their reliability on smaller river basins may be even more problematic. Moreover, since for some models the hydrological balance estimates obtained with the runoff fields do not agree with those obtained via precipitation and evaporation, some deficiencies of the land models are also apparent. NCEP-NCAR and ERA-40 reanalyses result to be largely inadequate for representing the hydrology of the Danube river basin, both for the reconstruction of the long-term averages and of the seasonal cycle, and cannot in any sense be used as verification. We suggest that these results should be carefully considered in the perspective of auditing climate models and assessing their ability to simulate future climate changes.Comment: 25 pages 8 figures, 5 table

Isotropic-nematic phase equilibria of polydisperse hard rods: The effect of fat tails in the length distribution

We study the phase behaviour of hard rods with length polydispersity, treated within a simplified version of the Onsager model. We give a detailed description of the unusual phase behaviour of the system when the rod length distribution has a "fat" (e.g. log-normal) tail up to some finite cutoff. The relatively large number of long rods in the system strongly influences the phase behaviour: the isotropic cloud curve, which defines the where a nematic phase first occurs as density is increased, exhibits a kink; at this point the properties of the coexisting nematic shadow phase change discontinuously. A narrow three-phase isotropic-nematic-nematic coexistence region exists near the kink in the cloud curve, even though the length distribution is unimodal. A theoretical derivation of the isotropic cloud curve and nematic shadow curve, in the limit of large cutoff, is also given. The two curves are shown to collapse onto each other in the limit. The coexisting isotropic and nematic phases are essentially identical, the only difference being that the nematic contains a larger number of the longest rods; the longer rods are also the only ones that show any significant nematic ordering. Numerical results for finite but large cutoff support the theoretical predictions for the asymptotic scaling of all quantities with the cutoff length.Comment: 21 pages, 13 figure

Extreme events in the Mediterranean area: A mixed deterministic-statistical approach

Statistical inference suffers for severe limitations when applied to extreme meteo-climatic events. A fundamental theorem proposes a constructive theory for a “universal” distribution law (the Generalized Extreme Value distribution) of extremes. Use of this theorem and of its derivations is nowadays quite common. However, when applying it, the selected events should be real extremes. In practical applications a major source of errors is the fact that there is no strict criterion for selecting extremes and, in order to “fatten” the statistical sample very “mild” selection criteria are often used. The theorem in question applies to stationary processes. When a trend is introduced, inference becomes even more problematic. Experience shows that any available a priori knowledge concerning the system can play a fundamental role in the analysis, in particular if it lowers the dimensionality of the parameter space to be explored. The inference procedures serve, then, the purpose of testing the reliability of inductive hypothesis, rather than proving them. Within the above general context, analysis of the hypothesis that the frequency and/or intensity of extreme weather events in the Mediterranean area may be changing is proposed. The analysis is based on a combined deterministic-statistical approach: dynamical analysis of intense perturbations is combined with statistical techniques in order to try to formulate the problem in such a way that meaningful conclusion may be achieved

Zinc transporter 8 and MAP3865c homologous epitopes are recognized at T1D onset in Sardinian children

Our group has recently demonstrated that Mycobacterium avium subspecies paratuberculosis (MAP) infection significantly associates with T1D in Sardinian adult patients. Due to the potential role played by MAP in T1D pathogenesis, it is relevant to better characterize the prevalence of anti-MAP antibodies (Abs) in the Sardinian population, studying newly diagnosed T1D children. Therefore, we investigated the seroreactivity against epitopes derived from the ZnT8 autoantigen involved in children at T1D onset and their homologous sequences of the MAP3865c protein. Moreover, sera from all individuals were tested for the presence of Abs against: the corresponding ZnT8 C-terminal region, the MAP specific protein MptD, the T1D autoantigen GAD65 and the T1D unrelated Acetylcholine Receptor. The novel MAP3865c281–287 epitope emerges here as the major C-terminal epitope recognized. Intriguingly ZnT8186–194 immunodominant peptide was cross-reactive with the homologous sequences MAP3865c133–141, strengthening the hypothesis that MAP could be an environmental trigger of T1D through a molecular mimicry mechanism. All eight epitopes were recognized by circulating Abs in T1D children in comparison to healthy controls, suggesting that these Abs could be biomarkers of T1D. It would be relevant to investigate larger cohorts of children, followed over time, to elucidate whether Ab titers against these MAP/Znt8 epitopes wane after diagnosis

The Vehicle Routing Problem with Divisible Deliveries and Pickups

The vehicle routing problem with divisible deliveries and pickups is a new and interesting model within reverse logistics. Each customer may have a pickup and delivery demand that have to be served with capacitated vehicles. The pickup and the delivery quantities may be served, if beneficial, in two separate visits. The model is placed in the context of other delivery and pickup problems and formulated as a mixed-integer linear programming problem. In this paper, we study the savings that can be achieved by allowing the pickup and delivery quantities to be served separately with respect to the case where the quantities have to be served simultaneously. Both exact and heuristic results are analysed in depth for a better understanding of the problem structure and an average estimation of the savings due to the possibility of serving pickup and delivery quantities separately

Baroclinic instability of a symmetric, rotating, stratified flow: a study of the nonlinear stabilisation mechanisms in the presence of viscosity

This paper presents the analysis of symmetric circulations of a rotating baroclinic flow, forced by a steady thermal wind and dissipated by Laplacian friction. The analysis is performed with numerical time-integration. Symmetric flows, vertically bound by horizontal walls and subject to either periodic or vertical wall lateral boundary conditions, are investigated in the region of parameter-space where unstable small amplitude modes evolve into stable stationary nonlinear solutions. The distribution of solutions in parameter-space is analysed up to the threshold of chaotic behaviour and the physical nature of the nonlinear interaction operating on the finite amplitude unstable modes is investigated. In particular, analysis of time-dependent energy-conversions allows understanding of the physical mechanisms operating from the initial phase of linear instability to the finite amplitude stable state. Vertical shear of the basic flow is shown to play a direct role in injecting energy into symmetric flow since the stage of linear growth. Dissipation proves essential not only in limiting the energy of linearly unstable modes, but also in selecting their dominant space-scales in the finite amplitude stage

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