19,781 research outputs found
New Crop Testing Nutritional and Organoleptic Analysis
Final Poster for New Crop Testing Nutritional and Organoleptic Analysi
The Gut Microbiome in Neuromyelitis Optica.
Neuromyelitis optica (NMO) is a rare, disabling, sometimes fatal central nervous system inflammatory demyelinating disease that is associated with antibodies ("NMO IgG") that target the water channel protein aquaporin-4 (AQP4) expressed on astrocytes. There is considerable interest in identifying environmental triggers that may elicit production of NMO IgG by AQP4-reactive B cells. Although NMO is considered principally a humoral autoimmune disease, antibodies of NMO IgG are IgG1, a T-cell-dependent immunoglobulin subclass, indicating that AQP4-reactive T cells have a pivotal role in NMO pathogenesis. When AQP4-specific proliferative T cells were first identified in patients with NMO it was discovered that T cells recognizing the dominant AQP4 T-cell epitope exhibited a T helper 17 (Th17) phenotype and displayed cross-reactivity to a homologous peptide sequence within a protein of Clostridium perfringens, a commensal bacterium found in human gut flora. The initial analysis of gut microbiota in NMO demonstrated that, in comparison to healthy controls (HC) and patients with multiple sclerosis, the microbiome of NMO is distinct. Remarkably, C. perfringens was the second most significantly enriched taxon in NMO, and among bacteria identified at the species level, C. perfringens was the one most highly associated with NMO. Those discoveries, along with evidence that certain Clostridia in the gut can regulate the balance between regulatory T cells and Th17 cells, indicate that gut microbiota, and possibly C. perfringens itself, could participate in NMO pathogenesis. Collectively, the evidence linking microbiota to humoral and cellular immunity in NMO underscores the importance for further investigating this relationship
Coordination and Sustainability of River Observing Activities in the Arctic
To understand and respond to changes in the world’s northern regions, we need a coordinated system of long-term Arctic observations. River networks naturally integrate across landscapes and link the terrestrial and ocean domains. Changes in river discharge reflect changes in the terrestrial water balance, whereas changes in water chemistry are linked to changes in biogeochemical processes and water flow paths. Sustained measurements of river water discharge and water chemistry are therefore essential components of an Arctic observing network. As we strive to establish and sustain long-term observations in the Arctic, these two measurements must be coupled. Although river discharge and chemistry measurements are already coupled to some extent within national boundaries, this is not done in a consistent and coordinated fashion across the pan-Arctic domain. As a consequence, data quality and availability vary widely among regions. International coordination of river discharge and chemistry measurements in the Arctic would be greatly facilitated by formal commitments to maintain a set of core sites and associated measurements that are mutually agreed upon among pan-Arctic nations. Involvement of the agencies currently operating river discharge gauges around the Arctic and establishment of an overarching coordination entity to implement shared protocols, track data quality, and manage data streams would be essential in this endeavor. Focused studies addressing scale-dependent relationships between watershed characteristics and water chemistry, in-stream processes, and estuarine and coastal dynamics are also needed to support interpretation and application of Arctic river observing data as they relate to land and ocean change
Genome scan of Diabrotica virgifera virgifera for genetic variation associated with crop rotation tolerance
Crop rotation has been a valuable technique for control of Diabrotica virgifera virgifera for almost a century. However, during the last two decades, crop rotation has ceased to be effective in an expanding area of the US corn belt. This failure appears to be due to a change in the insect's oviposition behaviour, which, in all probability, has an underlying genetic basis. A preliminary genome scan using 253 amplified fragment-length polymorphism (AFLP) markers sought to identify genetic variation associated with the circumvention of crop rotation. Samples of D. v. virgifera from east-central Illinois, where crop rotation is ineffective, were compared with samples from Iowa at locations that the behavioural variant has yet to reach. A single AFLP marker showed signs of having been influenced by selection for the circumvention of crop rotation. However, this marker was not diagnostic. The lack of markers strongly associated with the trait may be due to an insufficient density of marker coverage throughout the genome. A weak but significant general heterogeneity was observed between the Illinois and Iowa samples at microsatellite loci and AFLP markers. This has not been detected in previous population genetic studies of D. v. virgifera and may indicate a reduction in gene flow between variant and wild-type beetles
A Robust Numerical Method for Integration of Point-Vortex Trajectories in Two Dimensions
The venerable 2D point-vortex model plays an important role as a simplified
version of many disparate physical systems, including superfluids,
Bose-Einstein condensates, certain plasma configurations, and inviscid
turbulence. This system is also a veritable mathematical playground, touching
upon many different disciplines from topology to dynamic systems theory.
Point-vortex dynamics are described by a relatively simple system of nonlinear
ODEs which can easily be integrated numerically using an appropriate adaptive
time stepping method. As the separation between a pair of vortices relative to
all other inter-vortex length scales decreases, however, the computational time
required diverges. Accuracy is usually the most discouraging casualty when
trying to account for such vortex motion, though the varying energy of this
ostensibly Hamiltonian system is a potentially more serious problem. We solve
these problems by a series of coordinate transformations: We first transform to
action-angle coordinates, which, to lowest order, treat the close pair as a
single vortex amongst all others with an internal degree of freedom. We next,
and most importantly, apply Lie transform perturbation theory to remove the
higher-order correction terms in succession. The overall transformation
drastically increases the numerical efficiency and ensures that the total
energy remains constant to high accuracy.Comment: 21 pages, 4 figure
Acute effects of Hibiscus sabdariffa calyces on postprandial blood pressure, vascular function, blood lipids, biomarkers of insulin resistance and inflammation in humans
The acute impact of Hibiscus sabdariffa calyces (HSC) extract on postprandial vascular function and other cardiometabolic risk factors have not been studied previously. This study investigated the acute impact of HSC extract consumption on blood pressure (BP), vascular function and other cardiometabolic risk markers. Twenty-five men with 1% to 10% cardiovascular disease (CVD) risk (determined by QRISK 2) were randomised to consume either 250 mL of the aqueous extract of HSC or water with breakfast in a randomised, controlled, single-blinded, 2-meal cross-over study (ClinicalTrials.gov, NTC02165553) with a two weeks washout period between study days. BP was measured at baseline and hourly for 4 h. Flow mediated dilatation (FMD) of the branchial artery was measured at baseline, 2 and 4 h post intervention drink consumption. Acute consumption of aqueous extract of HSC caused a significant increase in % FMD ( < 0.001), a non-significant decrease in systolic BP (SBP) and diastolic BP (DBP); non-significant increase in urinary and plasma nitric oxide (NOx) and reduced response of serum glucose, plasma insulin, serum triacylglycerol and C-reactive protein (CRP) levels; significant ( = 0.026) improvement in the area under systemic antioxidant response curve (0 to 2 h); no significant changes in arterial stiffness following the acute consumption of the extract of HSC. Gallic acid, 4-O-methylgallic acid, 3-O-methylgallic acid and hippuric acid reached a maximum plasma concentration at 1 to 2 h post consumption of the extract of HSC. The extract of HSC improved postprandial vascular function and may be a useful dietary strategy to reduce endothelial dysfunction and CVD risk, although this requires confirmation
The symbiotic star CH Cygni. III. A precessing radio jet
VLA, MERLIN and Hubble Space Telescope imaging observations of the extended
regions of the symbiotic system CH Cygni are analysed. These extensions are
evidence of a strong collimation mechanism, probably an accretion disk
surrounding the hot component of the system. Over 16 years (between 1985 and
2001) the general trend is that these jets are seen to precess. Fitting a
simple ballistic model of matter ejection to the geometry of the extended
regions suggests a period of 6520 +/- 150 days, with a precession cone opening
angle of 35 +/- 1 degrees. This period is of the same order as that proposed
for the orbital period of the outer giant in the system, suggesting a possible
link between the two. Anomalous knots in the emission, not explained by the
simple model, are believed to be the result of older, slower moving ejecta, or
possibly jet material that has become disrupted through sideways interaction
with the surrounding medium.Comment: 9 pages, 4 figure
The inner radio jet region and the complex environment of SS433
We present multi-frequency VLBA+VLA observations of SS433 at 1.6, 5 and 15
GHz. These observations provide the highest angular resolution radio spectral
index maps ever made for this object. Motion of the components of SS433 during
the observation is detected. In addition to the usual VLBI jet structure, we
detect two radio components in the system at an anomalous position angle. These
newly discovered radio emitting regions might be related to a wind-like
equatorial outflow or to an extension of the accretion disk. We show that the
radio core component is bifurcated with a clear gap between the eastern and
western wings of emission. Modelfitting of the precessing jets and the moving
knots of SS433 shows that the kinematic centre -- i.e. the binary -- is in the
gap between the western and eastern radio core components. Spectral properties
and observed core position shifts suggest that we see a combined effect of
synchrotron self-absorption and external free-free absorption in the innermost
AU-scale region of the source. The spatial distribution of the ionized matter
is probably not spherically symmetric around the binary, but could be
disk-like.Comment: Accepted for publication by Astronomy and Astrophysic
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