181 research outputs found
Putative fishery-induced changes in biomass and population size structures of demersal deep-sea fishes in ICES Sub-area VII, Northeast Atlantic Ocean
This work was supported by a series of NERC grants to the principal investigators including NE/C512961/1. The results of the early joint SAMS and IOS surveys were digitized with support from EU MAST Contract MAS2-CT920033 1993–1995, and data analyses was supported by EU FP7 Projects HERMES and HERMIONE. We thank Alain Zuur from Highland Statistics Ltd. for advice with the statistical analyses and Odd Aksel Bergstad for valuable comments that helped to improve the manuscript. We thank the ships’ companies of the RRS Challenger and RRS Discovery.Peer reviewedPublisher PD
Magnetocaloric properties of (RE)GaO (RE=Tb,Gd,Nd,Dy)
We report the characteristic magnetic properties of several members of the
rare earth garnet family, GdGaO (GGG), DyGaO
(DGG), TbGaO (TGG), and NdGaO (NGG), and compare
their relative potential utility for magnetocaloric cooling, including their
minimal adiabatic demagnetisation refrigeration (ADR) temperatures and relative
cooling parameters. A main objective of this work was to find potential
improvements over the magnetocaloric properties of GGG for use in low
temperature ADR cryostats. Using Tb and Dy in the RE-site offers
in principle higher saturation magnetisation and Nd gives a lower de
Gennes factor and therefore potentially low transition temperature. Our results
show that DyGaO yields an optimal relative cooling parameter
() at low applied fields and a low transition temperature, which would
allow for the design of more efficient ADR cryostats.Comment: 10 pages, 10 figures, submitted to Physical Review Applie
Plant Pattern-Recognition Receptor FLS2 Is Directed for Degradation by the Bacterial Ubiquitin Ligase AvrPtoB
Are Estimates of Wind Characteristics Based on Measurements with Pitot Tubes and GNSS Receivers Mounted on Consumer-grade Unmanned Aerial Vehicles Applicable in Meteorological Studies?
The objective of this paper is to empirically show that estimates of wind speed and wind direction based on measurements carried out using the Pitot tubes and GNSS receivers, mounted on consumer-grade unmanned aerial vehicles (UAVs), may accurately approximate true wind parameters. The motivation for the study is that a growing number of commercial and scientific UAV operations may soon become a new source of data on wind speed and wind direction, with unprecedented spatial and temporal resolution. The feasibility study was carried out within an isolated mountain meadow of Polana Izerska located in the Izera Mountains (SW Poland) during an experiment which aimed to compare wind characteristics measured by several instruments: three UAVs (swinglet CAM, eBee, Maja) equipped with the Pitot tubes and GNSS receivers, wind speed and direction meters mounted at 2.5 m and 10 m (mast), conventional weather station and vertical sodar. The three UAVs performed seven missions along spiral-like trajectories, most reaching 130 m above take-off location. The estimates of wind speed and wind direction were found to agree between UAVs. The time series of wind speed measured at 10 m were extrapolated to flight altitudes recorded at a given time so that a comparison was made feasible. It was found that the wind speed estimates provided by the UAVs on a basis of the Pitot tube/GNSS data are in agreement with measurements carried out using dedicated meteorological instruments. The discrepancies were recorded in the first and last phases of UAV flights
Nova estratègia diagnòstica per la Tuberculosi : sí, però amb matisos
La realització de nous tests per diagnosticar la Infecció Latent per M.tuberculosi (ITBL), els TIGRAs, basats en la detecció d'una citosina relacionada amb la Resposta Immunològica Cel·lular que es desencadena contra el bacil tuberculós, sembla aportar noves llums al tractament de la infecció: són més sensibles i específics que el tractament estàndard de la Tuberculina (TST). Tot i així, encara es desconeix si la seva utilització posterior a un TST influeix en els resultats finals. Per això, i per ampliar aquesta línia d'investigació, un estudi de seguiment immunològic, dut a terme a la Unitat de Tuberculosi Experimental de l'hospital "Germans Trias i Pujol", ha obtingut uns resultats que demostren la necessitat d'aprofundir sobre aquest tema, malgrat alguns països valoren la possibilitat d'utilitzar-los seqüencialment
Breast cancer genetic counseling among Dutch patients from Turkish and Moroccan descent: participation determinants and perspectives of patients and healthcare professionals
Migrant breast cancer patients and their participation in genetic counseling: results from a registry-based study
Stillbirth differences according to regions of origin: an analysis of the German perinatal database, 2004-2007
Reeske A, Kutschmann M, Razum O, Spallek J. Stillbirth differences according to regions of origin: an analysis of the German perinatal database, 2004-2007. BMC Pregnancy and Childbirth. 2011;11(1): 63.Background: Stillbirth is a sensitive indicator for access to, and quality of health care and social services in a society. If a particular population group e. g. migrants experiences higher rates of stillbirth, this might be an indication of social deprivation or barriers to health care. This study examines differences in risk of stillbirth for women of different regions of origin compared to women from Germany in order to identify high risk groups/target groups for prevention strategies. Methods: We used the BQS dataset routinely compiled to examine perinatal outcomes in Germany nationwide. Participation of hospitals and completeness of data has been about 98% in recent years. Data on all live births and stillbirths were obtained for the period 2004 to 2007 (N = 2,670,048). We calculated crude and stratified mortality rates as well as corresponding relative mortality risks. Results: A significantly elevated stillbirth rate was found for women from the Middle East and North Africa (incl. Turkey) (RR 1.34, CI 1.22-1.55). The risk was slightly attenuated for low SES. An elevated risk was also found for women from Asia (RR 1.18, CI 1.02-1.65) and from Mediterranean countries (RR 1.14, CI 0.93-1.28). No considerable differences either in use and timing of antenatal care or preterm birth and low birthweight were observed between migrant and non-migrant women. After stratification for light for gestational age, the relative risk of stillbirth for women from the Middle East/North Africa increased to 1.63 (95% CI 1.25-2.13). When adjusted for preterm births with low birthweight, women from Eastern Europe and the Middle East/North Africa experienced a 26% (43%) higher risk compared with women from Germany. Conclusions: We found differences in risk of stillbirth among women from Middle East/North Africa, especially in association with low SES and low birthweight for gestational age. Our findings suggest a need for developing and evaluating socially and culturally sensitive health promotion and prevention programmes for this group. The findings should also stimulate discussion about the quality and appropriateness of antenatal and perinatal care of pregnant women and newborns with migrant backgrounds
Social and health epidemiology of immigrants in Germany: past, present and future
Razum O, Wenner J. Social and health epidemiology of immigrants in Germany: past, present and future. Public Health Reviews. 2016;37(1): 4.Germany has experienced different forms of immigration for many decades. At the end of and after the Second World War, refugees, displaced persons and German resettlers constituted the largest immigrant group. In the 1950s, labor migration started, followed by family reunification. There has been a constant migration of refugees and asylum seekers reaching peaks in the early 1990s as well as today. Epidemiological research has increasingly considered the health, and the access to health care, of immigrants and people with migration background. In this narrative review we discuss the current knowledge on health of immigrants in Germany. The paper is based on a selective literature research with a focus on studies using representative data from the health reporting system. Our review shows that immigrants in Germany do not suffer from different diseases than non-immigrants, but they differ in their risk for certain diseases, in the resources to cope with theses risk and regarding access to treatment. We also identified the need for differentiation within the immigrant population, considering among others social and legal status, country of origin and duration of stay. Though most of the studies acknowledge the need for differentiation, the lack of data currently rules out analyses accounting for the existing diversity and thus a full understanding of health inequalities related to migration to Germany
The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma
Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with dependency on the ubiquitin proteasome system and identified OTUD6B as an oncogene that drives the G1/S-transition. LIN28B, a suppressor of microRNA biogenesis, is specified as a bona fide cell cycle-specific substrate of OTUD6B. Stabilization of LIN28B drives MYC expression at G1/S, which in turn allows for rapid S-phase entry. Silencing OTUD6B or LIN28B inhibits multiple myeloma outgrowth in vivo and high OTUD6B expression evolves in patients that progress to symptomatic multiple myeloma and results in an adverse outcome of the disease. Thus, we link proteolytic ubiquitylation with post-transcriptional regulation and nominate OTUD6B as a potential mediator of the MGUS-multiple myeloma transition, a central regulator of MYC, and an actionable vulnerability in multiple myeloma and other tumors with an activated OTUD6B-LIN28B axis
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