6,604 research outputs found
Twisted [(R3P)PdX] groups above dicarbaborane ligands: 4-dimethylsulfido-3-iodo-3-triphenylphosphine-closo-3-pallada-1,2-dicarbadodecaborane and 3-dimethylphenylphosphine-3-chloro-4-dimethylsulfido-closo-3-pallada-1,2-dicarbadodecaborane
The structural analyses of [3-(PPh₃)-3-I-4-(SMe₂)-closo-3,1,2-PdC₂B₉H₁₀] or [Pd(C₄H₁₆B₉S)I(C₁₈H₁₅P)], (I), and [3-(PPhMe₂)-3-Cl-4-(SMe₂)-closo-3,1,2-PdC₂B₉H₁₀] or [Pd(C₄H₁₆B₉S)Cl(C₈H₁₁P)], (II), show that in comparison with [3-(PR₃)2-closo-3,1,2-PdC₂B₉H₁₁] the presence of the 4-SMe₂ group causes the [PdX(PR₃)] unit (X = halogen) to twist about an axis passing through the Pd atom and the directly opposite B atom of the carbaborane ligand. The halogen atoms are located almost directly above a C atom in the C₂B₃ face, and the conformations of the [PdX(PR₃)] units above the C₂B₃ faces are not those predicted from molecular orbital calculations of the closo-3,1,2-PdC₂B₉ system. The fact that the variation from the predicted conformation is greater in the case of (I) than in (II) may be ascribed to the greater steric interactions induced by the I atom in (I) compared with the Cl atom in (II)
Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae)
Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This research presents the results of an in vitro study on the anthelmintic tolerance of several isolates of Halicephalobus to thiabendazole and ivermectin using an adaptation of the Micro-Agar Larval Development Test hereby focusing on egg hatching and larval development. Panagrellus redivivus and Panagrolaimus superbus were included as a positive control. The results generally show that the anthelmintic tolerance of Halicephalobus to both thiabendazole and ivermectin was considerably higher than that of the closely related Panagrolaimidae and, comparing to other studies, than that of obligatory equine parasites. Our results further reveal a remarkable trend of increasing tolerance from fully free-living isolates towards horse-associated isolates. In vitro anthelmintic testing with free-living and facultative parasitic nematodes offers the advantage of observing drug effect on the complete lifecycle as opposed to obligatory parasites which can only be followed until the third larval stage. We therefore propose Halicephalobus gingivalis as an experimental tool to deepen our understanding of the biology of anthelmintic tolerance
Candidemia on presentation to the hospital: development and validation of a risk score
Introduction: Candidemia results in substantial morbidity and mortality, especially if initial antifungal therapy is delayed or is inappropriate; however, candidemia is difficult to diagnose because of its nonspecific presentation. Methods: To develop a risk score for identifying hospitalized patients with candidemia, we performed a retrospective analysis of a large database of 176 acute-care hospitals in the United States. We studied 64,019 patients with bloodstream infection (BSI) on presentation from 2000 through 2005 (derivation cohort) and 24,685 from 2006 to 2007 (validation cohort). We used recursive partitioning (RPART) to identify the best discriminators for Candida as the cause of BSI. We compared three sets of models (equal-weight, unequal-weight, vs full model with additional variables from logistic regression model) for sensitivity analysis. Results: The RPART identified 6 variables as the best discriminators: age 0.10, indicating predicted and observed candidemia rates did not differ significant across the 7 risk stratus). The full model with 16 risk factors had slightly higher AUROCs (0.74 versus 0.73 for derivation versus validation); however, 7 variables were no longer significant in the recalibrated model for the validation cohort, indicating that the additional items did not materially enhance the model. Conclusions: A simple equal-weight risk score differentiated patients' risk for candidemia in a graded fashion upon hospital presentation
Simultaneous Water Vapor and Dry Air Optical Path Length Measurements and Compensation with the Large Binocular Telescope Interferometer
The Large Binocular Telescope Interferometer uses a near-infrared camera to
measure the optical path length variations between the two AO-corrected
apertures and provide high-angular resolution observations for all its science
channels (1.5-13 m). There is however a wavelength dependent component to
the atmospheric turbulence, which can introduce optical path length errors when
observing at a wavelength different from that of the fringe sensing camera.
Water vapor in particular is highly dispersive and its effect must be taken
into account for high-precision infrared interferometric observations as
described previously for VLTI/MIDI or the Keck Interferometer Nuller. In this
paper, we describe the new sensing approach that has been developed at the LBT
to measure and monitor the optical path length fluctuations due to dry air and
water vapor separately. After reviewing the current performance of the system
for dry air seeing compensation, we present simultaneous H-, K-, and N-band
observations that illustrate the feasibility of our feedforward approach to
stabilize the path length fluctuations seen by the LBTI nuller.Comment: SPIE conference proceeding
Exoplanet science with the LBTI: instrument status and plans
The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument
of the LBT designed for high-sensitivity, high-contrast, and high-resolution
infrared (1.5-13 m) imaging of nearby planetary systems. To carry out a
wide range of high-spatial resolution observations, it can combine the two
AO-corrected 8.4-m apertures of the LBT in various ways including direct
(non-interferometric) imaging, coronagraphy (APP and AGPM), Fizeau imaging,
non-redundant aperture masking, and nulling interferometry. It also has
broadband, narrowband, and spectrally dispersed capabilities. In this paper, we
review the performance of these modes in terms of exoplanet science
capabilities and describe recent instrumental milestones such as first-light
Fizeau images (with the angular resolution of an equivalent 22.8-m telescope)
and deep interferometric nulling observations.Comment: 12 pages, 6 figures, Proc. SPI
Rotational dynamics and heating of trapped nanovaterite particles
We synthesize, optically trap, and rotate individual nanovaterite crystals with a mean particle radius of 423 nm. Rotation rates of up to 4.9 kHz in heavy water are recorded. Laser-induced heating due to residual absorption of the nanovaterite particle results in the superlinear behavior of the rotation rate as a function of trap power. A finite element method based on the Navier-Stokes model for the system allows us to determine the residual optical absorption coefficient for a trapped nanovaterite particle. This is further confirmed by the theoretical model. Our data show that the translational Stokes drag force and rotational Stokes drag torque need to be modified with appropriate correction factors to account for the power dissipated by the nanoparticle
The HOSTS Survey for Exozodiacal Dust: Preliminary results and future prospects
[abridged] The presence of large amounts of dust in the habitable zones of
nearby stars is a significant obstacle for future exo-Earth imaging missions.
We executed an N band nulling interferometric survey to determine the typical
amount of such exozodiacal dust around a sample of nearby main sequence stars.
The majority of our data have been analyzed and we present here an update of
our ongoing work. We find seven new N band excesses in addition to the high
confidence confirmation of three that were previously known. We find the first
detections around Sun-like stars and around stars without previously known
circumstellar dust. Our overall detection rate is 23%. The inferred occurrence
rate is comparable for early type and Sun-like stars, but decreases from 71%
[+11%/-20%] for stars with previously detected mid- to far-infrared excess to
11% [+9%/-4%] for stars without such excess, confirming earlier results at high
confidence. For completed observations on individual stars, our sensitivity is
five to ten times better than previous results. Assuming a lognormal luminosity
function of the dust, we find upper limits on the median dust level around all
stars without previously known mid to far infrared excess of 11.5 zodis at 95%
confidence level. The corresponding upper limit for Sun-like stars is 16 zodis.
An LBTI vetted target list of Sun-like stars for exo-Earth imaging would have a
corresponding limit of 7.5 zodis. We provide important new insights into the
occurrence rate and typical levels of habitable zone dust around main sequence
stars. Exploiting the full range of capabilities of the LBTI provides a
critical opportunity for the detailed characterization of a sample of
exozodiacal dust disks to understand the origin, distribution, and properties
of the dust.Comment: To appear in SPIE Astronomical Telescopes + Instrumentation 2018
proceedings. Some typos fixed, one reference adde
Structure of the near-injector region of nonevaporating pressure-atomized sprays
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76883/1/AIAA-23315-239.pd
Measurement of the p\bar{p}\sqrt{s}$ = 1.8 TeV
We update the measurement of the top production cross section using the CDF
detector at the Fermilab Tevatron. This measurement uses decays to
the final states +jets and +jets. We search for quarks from
decays via secondary-vertex identification or the identification of
semileptonic decays of the and cascade quarks. The background to the
production is determined primarily through a Monte Carlo simulation.
However, we calibrate the simulation and evaluate its uncertainty using several
independent data samples. For a top mass of 175 , we measure
pb and pb using
the secondary vertex and the lepton tagging algorithms, respectively. Finally,
we combine these results with those from other decay channels and
obtain pb.Comment: The manuscript consists of 130 pages, 35 figures and 42 tables in
RevTex. The manuscript is submitted to Physical Review D. Fixed typo in
author lis
The medical student
The Medical Student was published from 1888-1921 by the students of Boston University School of Medicine
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