2,383 research outputs found

    Application of a system modification technique to dynamic tuning of a spinning rotor blade

    Get PDF
    An important consideration in the development of modern helicopters is the vibratory response of the main rotor blade. One way to minimize vibration levels is to ensure that natural frequencies of the spinning main rotor blade are well removed from integer multiples of the rotor speed. A technique for dynamically tuning a finite-element model of a rotor blade to accomplish that end is demonstrated. A brief overview is given of the general purpose finite element system known as Engineering Analysis Language (EAL) which was used in this work. A description of the EAL System Modification (SM) processor is then given along with an explanation of special algorithms developed to be used in conjunction with SM. Finally, this technique is demonstrated by dynamically tuning a model of an advanced composite rotor blade

    Geometrical and structural properties of an Aeroelastic Research Wing (ARW-2)

    Get PDF
    Transonic steady and unsteady pressure tests were conducted on a large elastic wing known as the DAST ARW-2 wing. The wing has a supercritical airfoil, an aspect ratio of 10.3, a leading edge sweepback angle of 28.8 deg and is equipped with two inboard and one outboard trailing edge control surfaces. The geometrical and structural characteristics are presented of this elastic wing, using a combination of measured and calculated data, to permit future analyst to compare the experimental surface pressure data with theoretical predictions

    Experimental transonic flutter characteristics of two 72 deg-sweep delta-wing models

    Get PDF
    Transonic flutter boundaries are presented for two simple, 72 deg. sweep, low-aspect-ratio wing models. One model was an aspect-ratio 0.65 delta wing; the other model was an aspect-ratio 0.54 clipped-delta wing. Flutter boundaries for the delta wing are presented for the Mach number range of 0.56 to 1.22. Flutter boundaries for the clipped-delta wing are presented for the Mach number range of 0.72 to 0.95. Selected vibration characteristics of the models are also presented

    Purification and characterization of retrovirally transduced hematopoietic stem cells.

    Full text link

    The application of active controls technology to a generic hypersonic aircraft configuration

    Get PDF
    Analytical methods are described for the prediction of aerothermoelastic stability of hypersonic aircraft including active control systems. Thermal loads due to aerodynamic heating were applied to the finite element model of the aircraft structure and the thermal effects on flutter were determined. An iterative static aeroelastic trim analysis procedure was developed including thermal effects. And active control technology was assessed for flutter suppression, ride quality improvement, and gust load alleviation to overcome any potential adverse aeroelastic stability or response problems due to aerodynamic heating. A generic hypersonic aircraft configuration was selected which incorporates wing flaps, ailerons, and all moveable fins to be used for active control purposes. The active control system would use onboard sensors in a feedback loop through the aircraft flight control computers to move the surfaces for improved structural dynamic response as the aircraft encounters atmospheric turbulence

    Roach infestation optimization

    Get PDF
    Abstract only availableThere are many function optimization algorithms based on the collective behavior of natural systems — Particle Swarm Optimization (PSO) and Ant Colony Optimization (ACO) are two of the most popular. This poster presents a new adaptation of the PSO algorithm, entitled Roach Infestation Optimization (RIO), which is inspired by recent discoveries in the social behavior of cockroaches. We present the development of the simple behaviors of the individual agents, which emulate some of the discovered cockroach social behaviors. We also describe a "hungry" version of the PSO and RIO, which we aptly call Hungry PSO and Hungry RIO. Comparisons with standard PSO show that Hungry PSO, RIO, and Hungry RIO are all more effective at finding the global optima of a suite of test functions.College of Engineering Undergraduate Research Optio

    Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition

    Get PDF
    Soft micellar nanoparticles can be prepared from DNA conjugates designed to assemble via base pairing such that strands containing a polymer corona and a cholesterol tail generate controlled supramolecular architecture. Functionalization of one DNA conjugate strand with a biorecognition ligand results in shielding of the ligand when in the micelle, while encoding of the DNA sequences with overhangs allows supramolecular unpacking by addition of a complementary strand and sequence-specific unshielding of the ligand. The molecular assembly/disassembly and ‘on–off’ switch of the recognition signal is visualized by FRET pair signalling, PAGE and a facile turbidimetric binding assay, allowing direct and amplified readout of nucleic acid sequence recognition

    Medium-chain fatty acids released from polymeric electrospun patches inhibit Candida albicans growth and reduce the biofilm viability

    Get PDF
    Oral candidiasis is a very common oral condition among susceptible individuals, with the main causative organism being the fungus Candida albicans. Current drug delivery systems to the oral mucosa are often ineffective because of short drug/tissue contact times as well as increased prevalence of drug-resistant Candida strains. We evaluated the potency of saturated fatty acids as antifungal agents and investigated their delivery by novel electrospun mucoadhesive oral patches using agar disk diffusion and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the most effective at inhibiting C. albicans growth on disk diffusion assays, both in solution or when released from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100) electrospun patches. In contrast, dodecanoic acid (C12) displayed the most potent antifungal activity against pre-existing C. albicans biofilms in solution or when released by PCL or PVP/RS100 patches. Both free and patch-released saturated fatty acids displayed a significant toxicity to wild-type and azole-resistant strains of C. albicans. These data not only provide evidence that certain saturated fatty acids have the potential to be used as antifungal agents but also demonstrate that this therapy could be delivered directly to Candida-infected sites using electrospun mucoadhesive patches, demonstrating a potential new therapeutic approach to treat oral thrush

    Mucoadhesive electrospun fibre-based technologies for oral medicine

    Get PDF
    Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future
    • …
    corecore