Solar radius and luminosity variations induced by the internal dynamo magnetic fields

Although the occurrence of solar irradiance variations induced by magnetic surface features (e.g., sunspots, faculae, magnetic network) is generally accepted, the existence of intrinsic luminosity changes due to the internal magnetic fields is still controversial. This additional contribution is expected to be accompanied by radius variations, and to be potentially significant for the climate of the Earth. We aim to constrain theoretically the radius and luminosity variations of the Sun that are due to the effect of the variable magnetic fields in its interior associated with the dynamo cycle. We have extended a one-dimensional stellar evolution code to include several effects of the magnetic fields on the interior structure. We investigate different magnetic configurations, based on both observational constraints and on the output of state-of-the-art mean field dynamo models. We explore both step-like and simply periodic time dependences of the magnetic field peak strength. We find that the luminosity and radius variations are in anti-phase and in phase, respectively, with the magnetic field strength. For peak magnetic field strengths of the order of tens of kilogauss, luminosity variations ranging between 10^{-6} and 10^{-3} (in modulus) and radius variations between 10^{-6} and 10^{-5} are obtained. Modest but significant radius variations (up to 10^{-5} in relative terms) are obtained for magnetic fields of realistic strength and geometry, providing a potentially observable signature of the intrinsic variations. Establishing their existence in addition to the accepted surface effects would have very important implications for the understanding of solar-induced long-term trends on climate.Comment: 18 pages, 7 figures; accepted for publication in Astronomische Nachrichte

Power Density Spectra of Gamma-Ray Bursts in the Internal Shock Model

We simulate Gamma-Ray Bursts arising from internal shocks in relativistic winds, calculate their power density spectrum (PDS), and identify the factors to which the PDS is most sensitive: the wind ejection features, which determine the wind dynamics and its optical thickness, and the energy release parameters, which give the pulse 50-300 keV radiative efficiency. For certain combinations of ejection features and wind parameters the resulting PDS exhibits the features observed in real bursts. We found that the upper limit on the efficiency of conversion of wind kinetic energy into 50-300 keV photons is $\sim$ 1%. Winds with a modulated Lorentz factor distribution of the ejecta yield PDSs in accord with current observations and have efficiencies closer to $10^{-3}$, while winds with a random, uniform Lorentz factor ejection must be optically thick to the short duration pulses to produce correct PDSs, and have an overall efficiency around $10^{-4}$.Comment: 6 pages, 4 figures, Latex, submitted to The Astrophysical Journal (05/04/99

Angular momentum transport efficiency in post-main sequence low-mass stars

Context. Using asteroseismic techniques, it has recently become possible to probe the internal rotation profile of low-mass (~1.1-1.5 Msun) subgiant and red giant stars. Under the assumption of local angular momentum conservation, the core contraction and envelope expansion occurring at the end of the main sequence would result in a much larger internal differential rotation than observed. This suggests that angular momentum redistribution must be taking place in the interior of these stars. Aims. We investigate the physical nature of the angular momentum redistribution mechanisms operating in stellar interiors by constraining the efficiency of post-main sequence rotational coupling. Methods. We model the rotational evolution of a 1.25 Msun star using the Yale Rotational stellar Evolution Code. Our models take into account the magnetic wind braking occurring at the surface of the star and the angular momentum transport in the interior, with an efficiency dependent on the degree of internal differential rotation. Results. We find that models including a dependence of the angular momentum transport efficiency on the radial rotational shear reproduce very well the observations. The best fit of the data is obtained with an angular momentum transport coefficient scaling with the ratio of the rotation rate of the radiative interior over that of the convective envelope of the star as a power law of exponent ~3. This scaling is consistent with the predictions of recent numerical simulations of the Azimuthal Magneto-Rotational Instability. Conclusions. We show that an angular momentum transport process whose efficiency varies during the stellar evolution through a dependence on the level of internal differential rotation is required to explain the observed post-main sequence rotational evolution of low-mass stars.Comment: 8 pages, 6 figures; accepted for publication in Astronomy & Astrophysic

Analysis of Temporal Features of Gamma Ray Bursts in the Internal Shock Model

In a recent paper we have calculated the power density spectrum of Gamma-Ray Bursts arising from multiple shocks in a relativistic wind. The wind optical thickness is one of the factors to which the power spectrum is most sensitive, therefore we have further developed our model by taking into account the photon down-scattering on the cold electrons in the wind. For an almost optically thick wind we identify a combination of ejection features and wind parameters that yield bursts with an average power spectrum in agreement with the observations, and with an efficiency of converting the wind kinetic energy in 50-300 keV emission of order 1%. For the same set of model features the interval time between peaks and pulse fluences have distributions consistent with the log-normal distribution observed in real bursts.Comment: ApJ in press, 2000; with slight revisions; 12 pag, 6 fi

Creep, Relaxation and Viscosity Properties for Basic Fractional Models in Rheology

The purpose of this paper is twofold: from one side we provide a general survey to the viscoelastic models constructed via fractional calculus and from the other side we intend to analyze the basic fractional models as far as their creep, relaxation and viscosity properties are considered. The basic models are those that generalize via derivatives of fractional order the classical mechanical models characterized by two, three and four parameters, that we refer to as Kelvin-Voigt, Maxwell, Zener, anti-Zener and Burgers. For each fractional model we provide plots of the creep compliance, relaxation modulus and effective viscosity in non dimensional form in terms of a suitable time scale for different values of the order of fractional derivative. We also discuss the role of the order of fractional derivative in modifying the properties of the classical models.Comment: 41 pages, 8 figure

Efficiency and spectrum of internal gamma-ray burst shocks

We present an analysis of the Internal Shock Model of GRBs, where gamma-rays are produced by internal shocks within a relativistic wind. We show that observed GRB characteristics impose stringent constraints on wind and source parameters. We find that a significant fraction, of order 20 %, of the wind kinetic energy can be converted to radiation, provided the distribution of Lorentz factors within the wind has a large variance and provided the minimum Lorentz factor is higher than 10^(2.5)L_(52)^(2/9), where L=10^(52)L_(52)erg/s is the wind luminosity. For a high, >10 %, efficiency wind, spectral energy breaks in the 0.1 to 1 MeV range are obtained for sources with dynamical time R/c < 1 ms, suggesting a possible explanation for the observed clustering of spectral break energies in this range. The lower limit to wind Lorenz factor and the upper limit, around (R/10^7 cm)^(-5/6) MeV to observed break energies are set by Thomson optical depth due to electron positron pairs produced by synchrotron photons. Natural consequences of the model are absence of bursts with peak emission energy significantly exceeding 1 MeV, and existence of low luminosity bursts with low, 1 keV to 10 keV, break energies.Comment: 10 pages, 5 ps-figures. Expanded discussion of magnetic field and electron energy fraction. Accepted for publication in Astrophysical Journa

Hepatocellular carcinoma in children: Hepatic resection and liver transplantation

Hepatocellular carcinoma (HCC) is a rare malignancy in children and at the time of diagnosis up to 80% of pediatric HCC are unresectable due to large and multiple lesions. The majority of pediatric HCC occurs on a background of normal liver, and consequently the absence of concomitant chronic liver disease generally allows tolerating pre-and post-operative chemotherapy. Based on the large experiences of adult HCC and pediatric hepatoblastoma, in the last years a multidisciplinary aggressive treatment composed of surgical resection and chemotherapy (based on cisplatin and doxorubicin) has been proposed, improving patient outcomes and recurrence rate in children with HCC. However, the overall survival rate in children with HCC is not satisfactory yet; while the 5-year survival rate may achieve up to 70-80% in non-metastatic resectable HCC, it remains &lt;20% in children with unresectable HCC. The mainstay of the pediatric HCC therapeutic strategy is the radical tumor resection, weather by hepatic resection or liver transplantation, nevertheless the best surgical approaches as well as the optimal neoadjuvant and adjuvant treatment are still under debate. Different strategies have been explored to convert unresectable HCC into resectable tumors by extending criteria for surgical treatment and/or associating multi-modal treatments, such as systemic and local-regional therapy, but universal recommendation needs to be defined yet. The purpose of this review is to outline the role of different surgical approaches, including hepatic resection and liver transplantation, in pediatric HCC with or without underlying chronic liver disease

The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.

Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7). Deletion of SGF73 dramatically extends replicative lifespan (RLS) in yeast. To further define the basis for Sgf73-mediated RLS extension, we performed ChIP-Seq, identified 388 unique genomic regions occupied by Sgf73, and noted enrichment in promoters of ribosomal protein (RP)-encoding genes. Of 388 Sgf73 binding sites, 33 correspond to 5' regions of genes implicated in RLS extension, including 20 genes encoding RPs. Furthermore, half of Sgf73-occupied, RLS-linked RP genes displayed significantly reduced expression in sgf73Δ mutants, and double null strains lacking SGF73 and a Sgf73-regulated, RLS-linked RP gene exhibited no further increase in replicative lifespan. We also found that sgf73Δ mutants display altered acetylation of Ifh1, an important regulator of RP gene transcription. These findings implicate altered ribosomal protein expression in sgf73Δ yeast RLS and highlight altered acetylation as a pathway of relevance for SCA7 neurodegeneration

hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

Human Mena (hMENA), an actin regulatory protein of the ENA/VASP family, cooperates with ErbB receptor family signaling in breast cancer. It is overexpressed in high-risk preneoplastic lesions and in primary breast tumors where it correlates with HER2 overexpression and an activated status of AKT and MAPK. The concomitant overexpression of hMENA and HER2 in breast cancer patients is indicative of a worse prognosis. hMENA is expressed along with alternatively expressed isoforms, hMENA11a and hMENAΔv6 with opposite functions. A novel role for the epithelial-associated hMENA11a isoform in sustaining HER3 activation and pro-survival pathways in HER2-overexpressing breast cancer cells has been identified by reverse phase protein array and validated in vivo in a series of breast cancer tissues. As HER3 activation is crucial in mechanisms of cell resistance to PI3K inhibitors, we explored whether hMENA11a is involved in these resistance mechanisms. The specific hMENA11a depletion switched off the HER3-related pathway activated by PI3K inhibitors and impaired the nuclear accumulation of HER3 transcription factor FOXO3a induced by PI3K inhibitors, whereas PI3K inhibitors activated hMENA11a phosphorylation and affected its localization. At the functional level, we found that hMENA11a sustains cell proliferation and survival in response to PI3K inhibitor treatment, whereas hMENA11a silencing increases molecules involved in cancer cell apoptosis. As shown in three-dimensional cultures, hMENA11a contributes to resistance to PI3K inhibition because its depletion drastically reduced cell viability upon treatment with PI3K inhibitor BEZ235. Altogether, these results indicate that hMENA11a in HER2-overexpressing breast cancer cells sustains HER3/AKT axis activation and contributes to HER3-mediated resistance mechanisms to PI3K inhibitors. Thus, hMENA11a expression can be proposed as a marker of HER3 activation and resistance to PI3K inhibition therapies, to select patients who may benefit from these combined targeted treatments. hMENA11a activity could represent a new target for antiproliferative therapies in breast cancer