Приватизация государственной собственности в агропромышленном комплексе Республике Беларусь

Материалы межвуз. науч. конф. студентов, магистрантов и аспирантов, Гомель, 15 мая 2008 г

COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis

Background: The detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is challenging, particularly in post-mortem human tissues. However, there is increasing evidence for viral SARS-CoV-2 manifestation in non-respiratory tissues. In this context, it is a current matter of debate, whether SARS-CoV-2 shows hepatotropism. Case presentation: Here, we report a case of an 88-year-old women with massive SARS-CoV-2 viremia, severe jaundice and clinical signs of an acute hepatitis, who died within a few days from an acute liver failure without showing any clinical signs of pneumonia. Autopsy revealed a severe chronic and acute liver damage with bile duct infestation by SARS-CoV-2 that was accompanied by higher expressions of angiotensin-converting enzyme-2 (ACE2), Cathepsin L and transmembrane serine protease 2 (TMPRSS2). Conclusion: Our findings indicate an enhanced biliary susceptibility to viral infection with SARS-CoV-2, that might have resulted from pre-existing severe liver damage. Furthermore, our findings emphasize the differential diagnosis of coronavirus disease 2019 (COVID-19)-associated liver failure in the clinical setting of an inexplicable jaundice

A many-analysts approach to the relation between religiosity and well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β=0.120). For the second research question, this was the case for 65% of the teams (median reported β=0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

A Many-analysts Approach to the Relation Between Religiosity and Well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N = 10, 535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β = 0.120). For the second research question, this was the case for 65% of the teams (median reported β = 0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

Flicka i nöd – metabolomisk utvärdering av effekter hos flicksländelarver exponerade föravloppsvatten

Aquatic organisms, such as aquatic invertebrates, are exposed to anthropogenic pollutants through their environment. These pollutants, despite their low levels, can adversely affect exposed individuals or even entire ecosystems, especially when present in complex mixtures. The aim of this thesis was to assess the effects of a specific group of complex mixtures of pollutants, wastewater effluent, on damselfly larvae, a common, ecologically relevant invertebrate species. Metabolomics, i.e., the comprehensive analysis of an organism’s metabolites, was explored as a tool to show the sub-lethal effects of wastewater effluent exposure. A set of multi-platform mass spectrometry-based metabolomics methods was developed. These methods were used to measure and identify which damselfly metabolites are responsive to wastewater exposure and thus could potentially be used as early warning tools for anthropogenic pollution. In addition, key behavioural traits of damselfly larvae were assessed after wastewater exposure to investigate whether a change of metabolites would also be reflected at a higher level of biological organisation. The effects of wastewater effluents treated with different treatment methods on the fatty acid metabolites (oxylipins) of exposed damselfly larvae were assessed (paper I). Oxylipins were affected by wastewater exposure and these effects depended on the degree of wastewater treatment. Using a similar set-up, the effect-based removal of a conventional wastewater treatment plant and an additional ozonation step was evaluated on-site at a wastewater treatment facility (paper II). Oxylipins were affected by the exposure in this study, however fewer effects were observed when compared to the previous paper. In a separate series of experiments, damselflies were lab-reared to different developmental stages and a subset of the larvae were exposed to wastewater effluent. In these larvae, oxylipins (paper III) as well as other metabolites (paper IV) were measured to establish metabolite baseline levels and developmental variations as well as variation in their responses to the exposure. Metabolite variations as well as the metabolites affected by the exposure depended greatly on the life stage of the damselflies. In another study, damselfly larvae were exposed to dilutions of conventionally treated effluent and behavioural alterations and metabolite profiles were investigated in the larvae (paper V). Individual metabolites as well as behavioural traits important for damselfly survival and reproduction were altered by exposure to undiluted effluent; however, few effects were observed in the diluted effluents. In conclusion, both metabolomic endpoints and behavioural traits measured on the damselfly larvae were responsive to wastewater effluent exposure. The metabolites affected by exposure mainly play a role in fatty acid metabolism, including oxylipins, and in amino acid metabolism. The individual metabolites that were affected differed across the studies. These observed variations might be due to differences in exposure conditions or differences in larval stages across the studies. The studies presented in this thesis pave the way for metabolomics to be used as a novel tool to monitor sub-lethal effects of anthropogenic pollution in the environment. However, more research is needed on, for example, the ecological implications of the affected metabolites for both the individual and the population before it can be implemented in environmental risk assessments

Flicka i nöd – metabolomisk utvärdering av effekter hos flicksländelarver exponerade föravloppsvatten

Aquatic organisms, such as aquatic invertebrates, are exposed to anthropogenic pollutants through their environment. These pollutants, despite their low levels, can adversely affect exposed individuals or even entire ecosystems, especially when present in complex mixtures. The aim of this thesis was to assess the effects of a specific group of complex mixtures of pollutants, wastewater effluent, on damselfly larvae, a common, ecologically relevant invertebrate species. Metabolomics, i.e., the comprehensive analysis of an organism’s metabolites, was explored as a tool to show the sub-lethal effects of wastewater effluent exposure. A set of multi-platform mass spectrometry-based metabolomics methods was developed. These methods were used to measure and identify which damselfly metabolites are responsive to wastewater exposure and thus could potentially be used as early warning tools for anthropogenic pollution. In addition, key behavioural traits of damselfly larvae were assessed after wastewater exposure to investigate whether a change of metabolites would also be reflected at a higher level of biological organisation. The effects of wastewater effluents treated with different treatment methods on the fatty acid metabolites (oxylipins) of exposed damselfly larvae were assessed (paper I). Oxylipins were affected by wastewater exposure and these effects depended on the degree of wastewater treatment. Using a similar set-up, the effect-based removal of a conventional wastewater treatment plant and an additional ozonation step was evaluated on-site at a wastewater treatment facility (paper II). Oxylipins were affected by the exposure in this study, however fewer effects were observed when compared to the previous paper. In a separate series of experiments, damselflies were lab-reared to different developmental stages and a subset of the larvae were exposed to wastewater effluent. In these larvae, oxylipins (paper III) as well as other metabolites (paper IV) were measured to establish metabolite baseline levels and developmental variations as well as variation in their responses to the exposure. Metabolite variations as well as the metabolites affected by the exposure depended greatly on the life stage of the damselflies. In another study, damselfly larvae were exposed to dilutions of conventionally treated effluent and behavioural alterations and metabolite profiles were investigated in the larvae (paper V). Individual metabolites as well as behavioural traits important for damselfly survival and reproduction were altered by exposure to undiluted effluent; however, few effects were observed in the diluted effluents. In conclusion, both metabolomic endpoints and behavioural traits measured on the damselfly larvae were responsive to wastewater effluent exposure. The metabolites affected by exposure mainly play a role in fatty acid metabolism, including oxylipins, and in amino acid metabolism. The individual metabolites that were affected differed across the studies. These observed variations might be due to differences in exposure conditions or differences in larval stages across the studies. The studies presented in this thesis pave the way for metabolomics to be used as a novel tool to monitor sub-lethal effects of anthropogenic pollution in the environment. However, more research is needed on, for example, the ecological implications of the affected metabolites for both the individual and the population before it can be implemented in environmental risk assessments

Internationale Tagung, Universität Regensburg, 12.-14. Oktober 2023

Nouveaux savoirs du monde/Savoirs du Nouveau Monde : encyclopédisme, processus de traduction et réorganisations du savoir au siècle des Lumières Neue(s) Welt-Wissen: Enzyklopädismus, Übersetzungsprozesse und Wissensneuordnungen im Aufklärungszeitalter Organisation: Susanne Greilich (Regensburg), Hans-Jürgen Lüsebrink (Universität Saarbrücken) Geographischem und anthropologischem Wissen über die außereuropäische Welt kam im 18. Jahrhundert eine besondere Bedeutung zu. Enzyklopädische Wi..

Auf ein Wort mit Enrica Fantino

Übersetzung ist eine allgegenwärtige Tätigkeit, die in jeglichem Bereich begegnet. Über dieses Thema kann man also mit den unterschiedlichsten Gesprächspartner:innen diskutieren. Die Möglichkeit, fachliche Kontakte außerhalb meiner Disziplinen zu knüpfen und die Sicht anderer Fächer über Übersetzungsphänomene zu erfahren, reizt und erfüllt mich immer wieder aufs Neue. Enrica Fantino ist wissenschaftliche Mitarbeiterin am Lehrstuhl für Griechische Philologie der Universität Leipzig. Sie leite..