Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

The DUNE far detector vertical drift technology. Technical design report

DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals

Calibration of surface roughness standards

The key comparison EURAMET.L-K8.2009 on roughness was carried out in the framework of a EURAMET project starting in 2009 and ending in 2011. It involved the participation of 14 National Metrology Institutes from Europe, North America, Central America, South America and Africa representing three regional metrology organisations. Four surface texture standards of different type were circulated and on each of the standards several roughness parameters according to the standard ISO 4287 had to be determined. 27 out of 171 individual results were not consistent with the reference value. After some corrective actions the number of inconsistent results could be reduced to 24, which correspond to about 14% of the total. In addition to the material standards, two soft-gauges were circulated, which allow to test the software of the instruments used in the comparison. The comparison results help to support the calibraton and measurement capabilities (CMCs) of the laboratories involved in the CIPM MRA. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</jats:p

Search for resonances in events with photon and jet final states in proton-proton collisions at √s=13 TeV

A search for resonances in events with the gamma+jet final state has been performed using proton-proton collision data collected at root s = 13 TeV by the CMS experiment at the LHC. The total data analyzed correspond to an integrated luminosity of 138 fb(-1). Models of excited quarks and quantum black holes are considered. Using a wide-jet reconstruction for the candidate jet, the gamma +jet invariant mass spectrum measured in data is examined for the presence of resonances over the standard model continuum background. The background is estimated by fitting this mass distribution with a functional form. The data exhibit no statistically significant deviations from the expected standard model background. Exclusion limits at 95% confidence level on the resonance mass and other parameters are set. Excited light-flavor quarks (excited bottom quarks) are excluded up to a mass of 6.0 (3.8) TeV. Quantum black hole production is excluded for masses up to 7.5 (5.2) TeV in the ArkaniHamed-Dimopoulos-Dvali (Randall-Sundrum) model. These lower mass bounds are the most stringent to date among those obtained in the gamma +jet final state

Proton reconstruction with the CMS-TOTEM Precision Proton Spectrometer

The Precision Proton Spectrometer (PPS) of the CMS and TOTEM experiments collected 107.7 fb-1 in proton-proton (pp) collisions at the LHC at 13 TeV (Run 2). This paper describes the key features of the PPS alignment and optics calibrations, the proton reconstruction procedure, as well as the detector efficiency and the performance of the PPS simulation. The reconstruction and simulation are validated using a sample of (semi)exclusive dilepton events. The performance of PPS has proven the feasibility of continuously operating a near-beam proton spectrometer at a high luminosity hadron collider

Observation of the Ξb−​ → ψ(2S) Ξ− decay and studies of the Ξb∗0 baryon in proton-proton collisions at sqrt(s)= 13 TeV

The first observation of the decay Formula Presented and measurement of the branching ratio of Formula Presented to Formula Presented are presented. The Formula Presented and Formula Presented mesons are reconstructed using their dimuon decay modes. The results are based on proton-proton colliding beam data from the LHC collected by the CMS experiment at Formula Presented in 2016-2018, corresponding to an integrated luminosity of Formula Presented. The branching fraction ratio is measured to be Formula Presented, where the last uncertainty comes from the uncertainties in the branching fractions of the charmonium states. New measurements of the Formula Presented baryon mass and natural width are also presented, using the Formula Presented final state, where the Formula Presented baryon is reconstructed through the decays Formula Presented, Formula Presented, Formula Presented, and Formula Presented. Finally, the fraction of Formula Presented baryons produced from Formula Presented decays is determined

Search for dark QCD with emerging jets in proton-proton collisions at sqrt{s} = 13 TeV

A search for ``emerging jets'' produced in proton-proton collisions at a center-of-mass energy of 13 TeV is performed using data collected by the CMS experiment corresponding to an integrated luminosity of 138 fb−1. This search examines a hypothetical dark quantum chromodynamics (QCD) sector that couples to the standard model (SM) through a scalar mediator. The scalar mediator decays into an SM quark and a dark sector quark. As the dark sector quark showers and hadronizes, it produces long-lived dark mesons that subsequently decay into SM particles, resulting in a jet, known as an emerging jet, with multiple displaced vertices. This search looks for pair production of the scalar mediator at the LHC, which yields events with two SM jets and two emerging jets at leading order. The results are interpreted using two dark sector models with different flavor structures, and exclude mediator masses up to 1950 (1950) GeV for an unflavored (flavor-aligned) dark QCD model. The unflavored results surpass a previous search for emerging jets by setting the most stringent mediator mass exclusion limits to date, while the flavor-aligned results provide the first direct mediator mass exclusion limits to date

Search for the decay of the Higgs boson to a pair of light pseudoscalar bosons in the final state with four bottom quarks in proton-proton collisions at s \sqrt{\textrm{s}} = 13 TeV

Abstract A search is presented for the decay of the 125 GeV Higgs boson (H) to a pair of new light pseudoscalar bosons (a), followed by the prompt decay of each a boson to a bottom quark-antiquark pair, H → aa → b b ¯ b b ¯ $$\textrm{H}\to \textrm{aa}\to \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}}$$ . The analysis is performed using a data sample of proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb −1. To reduce the background from standard model processes, the search requires the Higgs boson to be produced in association with a leptonically decaying W or Z boson. The analysis probes the production of new light bosons in a 15 < m a < 60 GeV mass range. Assuming the standard model predictions for the Higgs boson production cross sections for pp → WH and ZH, model independent upper limits at 95% confidence level are derived for the branching fraction B H → aa → b b ¯ b b ¯ $$\mathcal{B}\left(\textrm{H}\to \textrm{aa}\to \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}}\right)$$ . The combined WH and ZH observed upper limit on the branching fraction ranges from 1.10 for m a = 20 GeV to 0.36 for m a = 60 GeV, complementing other measurements in the μμττ, ττττ and bbℓℓ (ℓ = μ, τ) channels

Search for ZZZZ and ZHZH production in the bbˉbbˉ final state using proton-proton collisions at sqrt(s)=13 TeV

: A search for ZZ and ZH production in the bb ̄bb ̄ final state is presented, where H is the standard model (SM) Higgs boson. The search uses an event sample of proton-proton collisions corresponding to an integrated luminosity of 133 fb-1 collected at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The analysis introduces several novel techniques for deriving and validating a multi-dimensional background model based on control samples in data. A multiclass multivariate classifier customized for the bb ̄bb ̄ final state is developed to derive the background model and extract the signal. The data are found to be consistent, within uncertainties, with the SM predictions. The observed (expected) upper limits at 95% confidence level are found to be 3.8 (3.8) and 5.0 (2.9) times the SM prediction for the ZZ and ZH production cross sections, respectively