Hemodynamic study in a real intracranial aneurysm: an in vitro and in silico approach

Mestrado de dupla diplomação com o Centro Federal de Educação Tecnológica Celso Suckow da Fonseca - Cefet/RJIntracranial aneurysm (IA) is a cerebrovascular disease with high rates of mortality and morbidity when it ruptures. It is known that changes in the intra-aneurysmal hemodynamic load play a significant factor in the development and rupture of IA. However, these factors are not fully understood. In this sense, the main objective of this work is to study the hemodynamic behavior during the blood analogues flow inside an AI and to determine its influence on the evolution of this pathology. To this end, experimental and numerical studies were carried out, using a real AI model obtained using computerized angiography. In the experimental approach, it was necessary, in the initial phase, to develop and manufacture biomodels from medical images of real aneurysms. Two techniques were used to manufacture the biomodels: rapid prototyping and gravity casting. The materials used to obtain the biomodels were of low cost. After manufacture, the biomodels were compared to each other for their transparency and final structure and proved to be suitable for testing flow visualizations. Numerical studies were performed with the aid of the Ansys Fluent software, using computational fluid dynamics (CFD), using the finite volume method. Subsequently, flow tests were performed experimentally and numerically using flow rates calculated from the velocity curve of a patient's doppler test. The experimental and numerical tests, in steady-state, made it possible to visualize the three-dimensional behavior of the flow inside the aneurysm, identifying the vortex zones created throughout the cardiac cycle. Correlating the results obtained in the two analyzes, it was possible to identify that the areas of vortexes are characterized by low speed and with increasing the fluid flow, the vortexes are positioned closer to the wall. These characteristics are associated with the rupture of an intracranial aneurysm. There was also a good qualitative correlation between numerical and experimental results.O aneurisma intracraniano (AI) é uma patologia cerebrovascular com altas taxas de mortalidade e morbidade quando se rompe. Sabe-se que alterações na carga hemodinâmica intra-aneurismática exerce um fator significativo no desenvolvimento e ruptura de AI, porém, esses fatores não estão totalmente compreendidos. Nesse sentido, o objetivo principal deste trabalho é o de estudar o comportamento hemodinâmico durante o escoamento de fluidos análogos do sangue no interior de um AI e determinar a sua influência na evolução da patologia. Para tal, foram realizados estudos experimentais e numéricos, utilizando um modelo de AI real obtido por meio de uma angiografia computadorizada. Na abordagem experimental foi necessário, na fase inicial, desenvolver e fabricar biomodelos a partir de imagens médicas de um aneurisma real. No fabrico dos biomodelos foram utilizadas duas técnicas: a prototipagem rápida e o vazamento por gravidade. Os materiais utilizados para a obtenção dos biomodelos foram de baixo custo. Após a fabricação, os biomodelos foram comparados entre si quanto à sua transparência e estrutura final e verificou-se serem adequados para testes de visualizações do fluxo. Os estudos numéricos foram realizados com recurso ao software Ansys Fluent, utilizando a dinâmica dos fluidos computacional (CFD), através do método dos volumes finitos. Posteriormente, foram realizados testes de escoamento experimentais e numéricos, utilizando caudais determinados a partir da curva de velocidades do ensaio doppler de um paciente. Os testes experimentais e numéricos, em regime permanente, possibilitaram a visualização do comportamento tridimensional do fluxo no interior do aneurisma, identificando as zonas de vórtices criadas ao longo do ciclo cardíaco. Correlacionando os resultados obtidos nas duas análises, foi possível identificar que as áreas de vórtices são caracterizadas por uma baixa velocidade e com o aumento do caudal os vórtices posicionam-se mais próximos da parede. Essas características apresentadas estão associadas com a ruptura de aneurisma intracraniano. Verificou-se, também, uma boa correlação qualitativa entre os resultados numéricos e experimentais

Characterization of shear strain on PDMS: numerical and experimental approaches

Polydimethylsiloxane (PDMS) is one of the most popular elastomers and has been used in di erent fields, especially in biomechanics research. Among the many interesting features of this material, its hyperelastic behavior stands out, which allows the use of PDMS in various applications, like the ones that mimic soft tissues. However, the hyperelastic behavior is not linear and needs detailed analysis, especially the characterization of shear strain. In this work, two approaches, numerical and experimental, were proposed to characterize the e ect of shear strain on PDMS. The experimental method was implemented as a simple shear testing associated with 3D digital image correlation and was made using two specimens with two thicknesses of PDMS (2 and 4 mm). A finite element software was used to implement the numerical simulations, in which four di erent simulations using the Mooney–Rivlin, Yeoh, Gent, and polynomial hyperelastic constitutive models were performed. These approaches showed that the maximum value of shear strain occurred in the central region of the PDMS, and higher values emerged for the 2 mm PDMS thickness. Qualitatively, in the central area of the specimen, the numerical and experimental results have similar behaviors and the values of shear strain are close. For higher values of displacement and thicknesses, the numerical simulation results move further away from experimental values.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: CIMO UIDB/00690/2020info:eu-repo/semantics/publishedVersio

Numerical characterization of a hyperelastic material to shear stress

In last years, some studies have been proved that there is an association between the wall shear stress with intracranial aneurysm rupture, however, is very difficult to understand the mechanical tissue behaviour when subjected to shear stresses. In this work, it is implemented numerical simulations to characterise the polydimethylsiloxane (PDMS) material when it is subjected to a shear solicitation. For this, it was initially necessary to perform some experimental tests to characterize the mechanical behaviour of the material. Based on these results, several numerical simulations were performed with the most common constitutive models in the simulation of hyperelastic materials by varying numerical factors and parameters of the numerical models.info:eu-repo/semantics/publishedVersio

Fluid flow and structural numerical analysis of a cerebral aneurysm model

Intracranial aneurysms (IA) are dilations of the cerebral arteries and, in most cases, have no symptoms. However, it is a very serious pathology, with a high mortality rate after rupture. Several studies have been focused only on the hemodynamics of the flow within the IA. However, besides the effect of the flow, the development and rupture of the IA are also associated with a combination of other factors such as the wall mechanical behavior. Thus, the objective of this work was to analyze, in addition to the flow behavior, the biomechanical behavior of the aneurysm wall. For this, CFD simulations were performed for different Reynolds numbers (1, 100, 500 and 1000) and for two different rheological models (Newtonian and Carreau). Subsequently, the pressure values of the fluid simulations were exported to the structural simulations in order to qualitatively observe the deformations, strains, normal stresses and shear stress generated in the channel wall. For the structural simulations, a hyperelastic constitutive model (5-parameter Mooney–Rivlin) was used. The results show that with the increase in the Reynolds number (Re), the recirculation phenomenon is more pronounced, which is not seen for Re = 1. The higher the Re, the higher the strain, displacement, normal and shear stresses values.The authors acknowledge the financial support from the project EXPL/EME-EME/0732/2021, funded by the NORTE 2020 Portugal Regional Operational Programme, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and by Fundação para a Ciência e Tecnologia (FCT). This work was also supported by Fundação para a Ciência e a Tecnologia (FCT) under the strategic grants UIDB/04077/2020, UIDB/04436/2020, UIDB/00319/2020 and UIDB/00532/2020. Andrews Souza and Violeta Carvalho also acknowledge the financial support by FCT through the individual research grants 2021.07961.BD and UI/BD/151028/2021, respectively.info:eu-repo/semantics/publishedVersio

Isokinetic torque peak and hamstrings/quadriceps ratios in endurance athletes with anterior cruciate ligament laxity

PURPOSE: To evaluate torque and the hamstring/quadriceps ratio of the knee of athletes with and without anterior cruciate ligament laxity. METHODS: Twenty-eight male athletes, 19 without anterior cruciate ligament laxity and 9 with anterior cruciate ligament laxity, were evaluated with an isokinetic machine model Cybex 770. The peak torque of quadriceps and hamstrings was compared, and the hamstring/quadriceps ratio on the constant angular speed of 60º per second were also compared. RESULTS: In athletes with anterior cruciate ligament laxity, the peak torque values (right and left knees) of flexors (120 ± 15 and 116 ± 15 Nm) and of extensors (218 ± 36 Nm and 207 ± 26 Nm) were not different than those of athletes without laxity (109 ± 21 Nm and 111 ± 22 Nm; 191 ± 5 Nm and 188 ± 35 Nm). The hamstring/quadriceps ratio of athletes with laxity (right: 57 ± 6% and left: 56 ± 8%) did not differ from those without anterior cruciate ligament laxity (right: 58 ± 9% and left: 58 ± 7%). CONCLUSIONS: The anterior cruciate ligament laxity of long distances running athletes did not significantly alter the peak torque of flexors and of extensors or the hamstring/quadriceps ratio.OBJETIVO: Avaliar o torque e a relação de forças entre ísquios-tibiais/quadríceps dos joelhos de atletas corredores de longas distâncias com e sem frouxidão do ligamento cruzado anterior. METODOLOGIA: Vinte e oito atletas do gênero masculino, 19 sem frouxidão do ligamento cruzado anterior e 9 com frouxidão do ligamento cruzado anterior foram avaliados com aparelho isocinético modelo Cybex 770. Comparou-se o pico de torque dos quadríceps e dos ísquios-tibiais e a relação ísquios-tibiais/quadríceps na velocidade angular constante de 60º por segundo. Os dados obtidos foram comparados por meio dos testes t de Student e para dados pareados (membros direito e esquerdo) e o nível de significância estabelecido foi p < 0,05. RESULTADOS: Nos atletas com frouxidão do ligamento cruzado anterior os valores de pico de torque (joelhos direito e esquerdo) dos flexores (120 ± 15 Nm e 116 ± 15 Nm) e dos extensores (218 ± 36 Nm e 207 ± 26 Nm) não diferiram significantemente dos atletas sem frouxidão (109 ± 21 Nm e 111 ± 22 Nm; 191 ± 5 Nm e 188 ± 35 Nm). A relação ísquios-tibiais/quadríceps dos atletas com frouxidão (57 ± 6% e 56 ± 8%) também não diferiu daqueles sem frouxidão do ligamento cruzado anterior (58 ± 9% e 58 ± 7%). CONCLUSÕES: A frouxidão do ligamento cruzado anterior não alterou significantemente o pico de torque dos flexores e extensores e a relação ísquios-tibiais/quadríceps dos joelhos de atletas corredores de longas distâncias

Thermal contact resistance between mold steel and additively manufactured insert for designing conformal channels: an experimental study

The focus of this research is on thermal contact resistance between a mold and its insert, specifically inserts made by additive manufacturing (AM). Using a thermal steady-state system and varying contact pressures (0, 50, 75, and 100 bars), we present experimental results of the thermal contact resistance at the contact interface between steel A (1.2344), obtained from an extruded rod, and steel B (1.2709), produced by laser powder bed fusion. Thermal tests were performed for unbonded and bonded configurations. Results showed that increasing the contact pressure allows the system equilibrium to be reached at lower temperatures. Furthermore, thermal tests showed that in the transition zone of the bonded configuration, a well-defined resistance is not formed between the two steel samples as it occurs in the unbonded configuration. For the unbonded configuration, the thermal contact resistance values decrease with increasing applied contact pressure, improving the system’s heat transfer.This work was financially supported by project PRIDOP (POCI-01-0247-FEDER-040271), co-financed by the European Community Fund FEDER through POCI—Programa Operacional Competitividade e Internacionalização. This work was also supported by FCT—Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/04077/2020 (METRICS Center). Furthermore, this work was supported by Portuguese FCT under the reference project UIDB/04436/2020

Stress Concentration on PDMS: An evaluation of three numerical constitutive models using digital image correlation

The examination of hyperelastic materials’ behavior, such as polydimethylsiloxane (PDMS), is crucial for applications in areas as biomedicine and electronics. However, the limitations of hyperelastic models for specific stress scenarios, with stress concentration, are not well explored on the literature. To address this, firstly, three constitutive models were evaluated (Neo-Hookean, Mooney-Rivlin, and Ogden) using numerical simulations and Digital Image Correlation (DIC) analysis during a uniaxial tensile test. The samples were made of PDMS with stress concentration geometries (center holes, shoulder fillets, and edge notches). Results of ANOVA analysis showed that any of the three models can be chosen for numerical analysis of PDMS since no significant differences in suitability were found. Finally, the Ogen model was chosen to obtain the stress concentration factors for these geometries, a property which characterize how discontinuities change the maximum stress supported by an element. Our study provides new values for variables needed to analyze and design hyperelastic elements and produce a foundation for understanding PDMS stress-strain behavior.The authors acknowledge the projects EXPL/EME-EME/0732/2021 and 2022.06207.PTDC for the financial support, through national funds (OE), within the scope of the Scientific Research and Technological Development Projects (IC&DT) program in all scientific domains (PTDC), PORTUGAL 2020 Partnership Agreement, European Regional Development Fund (FEDER), via the Foundation for Science and Technology, I.P. (FCT, I.P) and the R&D Units projects (UIDB/00690/2020 and UIDP/00690/2020) (CIMO), SusTEC (LA/P/0007/2020), UIDB/ 04077/2020, UIDP/04077/2020, UIDB/04436/2020 and UIDB/00532/ 2020. Andrews Souza acknowledges FCT for the Ph.D. scholarship 2021.07961.BD.info:eu-repo/semantics/publishedVersio

Discovering Local Binary Pattern Equation for Foreground Object Removal in Videos

Designing a novel Local Binary Pattern (LBP) process usually relies heavily on human experts' knowledge and experience in the area. Even experts are often left with tedious episodes of trial and error until they identify an optimal LBP for a particular dataset. To address this problem, we present a novel symbolic regression able to automatically discover LBP formulas to remove the moving parts of a scene by segmenting it into a background and a foreground. Experimental results conducted on real videos of outdoor urban scenes under various conditions show that the LBPs discovered by the proposed approach significantly outperform the previous state-of-the-art LBP descriptors both qualitatively and quantitatively. Our source code and data will be available online.Comment: arXiv admin note: substantial text overlap with arXiv:2104.0863

In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review

Cardiovascular diseases are one of the leading causes of death globally and the most common pathological process is atherosclerosis. Over the years, these cardiovascular complications have been extensively studied by applying in vivo, in vitro and numerical methods (in silico). In vivo studies represent more accurately the physiological conditions and provide the most realistic data. Nevertheless, these approaches are expensive, and it is complex to control several physiological variables. Hence, the continuous effort to find reliable alternative methods has been growing. In the last decades, numerical simulations have been widely used to assess the blood flow behavior in stenotic arteries and, consequently, providing insights into the cardiovascular disease condition, its progression and therapeutic optimization. However, it is necessary to ensure its accuracy and reliability by comparing the numerical simulations with clinical and experimental data. For this reason, with the progress of the in vitro flow measurement techniques and rapid prototyping, experimental investigation of hemodynamics has gained widespread attention. The present work reviews state-of-the-art in vitro macro-scale arterial stenotic biomodels for flow measurements, summarizing the different fabrication methods, blood analogues and highlighting advantages and limitations of the most used techniques.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/00319/2020, UIDB/04077/2020, UIDB/00690/2020, UIDB/04436/2020 and NORTE-01-0145-FEDER-030171, NORTE-01-0145-FEDER-029394 funded by COMPETE2020, NORTE 2020, PORTUGAL 2020, Lisb@2020 and FEDER.info:eu-repo/semantics/publishedVersio

Construídas no feminino: Relações histórico-culturais no corpo e no gênero das travestis

Este artigo é um desdobramento de uma dissertação de mestrado que centrou-se na compreensão do desenvolvimento das travestis que moram na cidade de Manaus, partindo da perspectiva da psicologia histórico-cultural proposta por Vygotsky. Partimos da prerrogativa que o desenvolvimento da identidade de gênero terá forte influência dos aspectos sociais, históricos e culturais. O objetivo deste trabalho é analisar as relações histórico-culturais no desenvolvimento identitário das travestis que moram na cidade de Manaus. Como metodologia, escolhemos a pesquisa qualitativa, que tem como instrumento a entrevista semiestruturada, os dados coletados foram transcritos e então submetidos à análise dos núcleos de significação. Os resultados a partir das falas das participantes indicaram que em seus desenvolvimentos, elas são fortemente marcadas por concepções presentes na cultura ocidental, tais como idealizações de gênero, aspectos políticos, econômicos e socioculturais