Quality of Living Perceived of the Young People of the Vale do Sinos / RS/Brazil

The objective of this study was to identify the Quality of Life level of young people from Vale do Sinos / RS. The methodology was observational, descriptive and transversal. The sample had 391 young people. The data collection instruments were the WHOQOL-Bref and a socioeconomic questionnaire. Resulting in a total average score of 52.37 points, the highest for the Social Relations Domain and the lowest for the Environment. When compared to the variables "Sex", "Income" and "Age", the one with the highest statistically significant association among the domains was "Income", followed by "Sex" and "Age". It was concluded that the QoL of young people is smaller when compared with other studies, being relevant investments in public policies

Alpinia

Species of the genus Alpinia are widely used by the population and have many described biological activities, including activity against insects. In this paper, we describe the bioactivity of the essential oil of two species of Alpinia genus, A. zerumbet and A. vittata, against Rhodnius nasutus, a vector of Chagas disease. The essential oils of these two species were obtained by hydrodistillation and analyzed by GC-MS. The main constituent of A. zerumbet essential oil (OLALPZER) was terpinen-4-ol, which represented 19.7% of the total components identified. In the essential oil of A. vittata (OLALPVIT) the monoterpene β-pinene (35.3%) was the main constituent. The essential oils and their main constituents were topically applied on R. nasutus fifth-instar nymphs. In the first 10 min of application, OLALPVIT and OLALPZER at 125 μg/mL provoked 73.3% and 83.3% of mortality, respectively. Terpinen-4-ol at 25 μg/mL and β-pinene at 44 μg/mL provoked 100% of mortality. The monitoring of resistant insects showed that both essential oils exhibited antifeedant activity. These results suggest the potential use of A. zerumbet and A. vittata essential oils and their major constituents to control R. nasutus population

Antiprotozoal activity of the cyclopalladated complexes against leishmania amazonensis and trypanosoma cruzi

The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(μ-Cl)]2, [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N3)(isn)] and [Pd(dmba)(μ-NCO)]2, (dmba: N,N'-dimethylbenzylamine and isn: isonicotinamide), against the diseases leishmaniasis (Leishmania amazonensis and Leishmania infantum), Chagas disease (Trypanosoma cruzi) and human African trypanosomiasis (Trypanosoma brucei). [Pd(dmba)(μ-NCO)]2 exhibited good leishmanicidal and trypanocidal activities against L. amazonensis and T. cruzi intracellular amastigote forms, with a 50% inhibitory concentration (IC50) value of less than 9 µM and selectivity indexes of 14.47 and 28.42, respectively. Stability essays were conducted in phosphate buffer saline (PBS) pH 7.0 and showed that [Pd(dmba)(μ-NCO)]2 is the most stable molecule. These findings indicate that this compound presented higher selectivity for these parasites than the other tested compounds. The data presented here suggest that this compound should be considered in the development of new and more potent drugs for the treatment of leishmaniasis and Chagas disease27610321039COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPSem informação201308248-

Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice

Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration has been shown to improve lipid profile in humans. We evaluated the effect of macadamia oil supplementation on insulin sensitivity, inflammation, lipid profile, and adipocyte size in high-fat diet (HF) induced obesity in mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD supplemented with macadamia oil by gavage at 2g/Kg of body weight, three times per week, for 12 weeks (CD + MO), and (d) HF diet supplemented with macadamia oil (HF + MO). CD and HF mice were supplemented with water. HF mice showed hypercholesterolemia and decreased insulin sensitivity as also previously shown. HF induced inflammation in adipose tissue and peritoneal macrophages, as well as adipocyte hypertrophy. Macadamia oil supplementation attenuated hypertrophy of adipocytes and inflammation in the adipose tissue and macrophages.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Dept Biol Celular & Desenvolvimento, BR-05508000 São Paulo, BrazilUniv Estadual Paulista, UNESP, Dept Educ Fis, Programa Posgrad Ciencia Motricidad, BR-13506900 Rio Claro, SP, BrazilUniv São Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508000 São Paulo, BrazilUniv Sao Judas Tadeu, Dept Ciencias Biol, Lab Movimento Humano, BR-05503001 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023901 São Paulo, BrazilUniv São Paulo, Inst Biociencias, Dept Fisiol Geral, BR-05508090 São Paulo, BrazilUniv Cruzeiro Sul, Inst Ciencias Atividade Fis & Esporte, Programa Posgrad Ciencia Movimento Humano, BR-01506000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023901 São Paulo, BrazilWeb of Scienc

Alinhamento frontal estático do joelho e cargas plantares durante a marcha de adultos jovens assintomáticos

In physical therapy practice, it is assumed that lower-limb posture changes may influence other complexes' biomechanics or function during movement. However, literature on the relationship between static knee alignment and possible dynamic changes is still scarce and inconclusive. This study assessed the effect of static frontal knee alignment on plantar pressure distribution during gait. At first 44 young asymptomatic adults were evaluated. Front knee angles were measured by digital photogrammetry and classified as normal (170° to 175°), valgus ;175°. Given the low number of valgus found, two groups were analysed: normal knees (n=18) and varus knees (n=23). Plantar pressure distribution was measured during gait in five plantar surface areas. Groups were found to be statistically similar in all kinetic variables assessed in all plantar surface areas. Normal knees showed significant correlation with the contact time at lateral forefoot and midfoot. Varus knees showed correlation with contact area and time at respectively two and three plantar areas, and with full pressure at lateral forefoot. Results thus show that a 3° frontal knee malalignment, though with moderate correlation, does not influence pressure distribution on plantar surface during gait. It is hence suggested that clinical evaluation should not be limited to static knee assessment, but rather include dynamic activities.Na prática fisioterapêutica, pressupõe-se que alterações posturais do membro inferior influenciem a biomecânica e função dos demais complexos durante o movimento. No entanto, a literatura sobre a relação entre desalinhamentos estáticos do joelho e possíveis alterações dinâmicas ainda é escassa e inconclusiva. Assim, buscou-se avaliar o efeito do alinhamento frontal estático do joelho sobre a distribuição da pressão plantar durante a marcha. Foram avaliados inicialmente 44 adultos jovens assintomáticos. Por fotogrametria digital, mediu-se o ângulo frontal do joelho, classificado como normal (170° a 175°), valgo ;175°. Dado o baixo número de valgos, foram analisados dois grupos: de joelhos normais (n=18) e de joelhos varos (n=23). A distribuição da pressão plantar foi avaliada durante a marcha em cinco áreas. Os grupos mostraram-se estatistica-mente semelhantes em todas as variáveis cinéticas avaliadas em todas as áreas plantares. Joelhos normais apresentaram significativa correlação com o tempo de contato no antepé lateral e médio-pé; e os varos, correlação com a área e tempo de contato em duas e três áreas plantares, e com a pressão integral no antepé lateral. Os resultados mostraram que o desalinhamento frontal de 3° do joelho, embora com moderada correlação, não influencia a distribuição de cargas na superfície plantar durante a marcha. Sugere-se pois que a avaliação clínica não se limite à avaliação articular estática do joelho, mas inclua atividades dinâmicas

INDICADORES FECAIS DE BOVINOS NELORE ALIMENTADOS COM DIETAS DE ALTA PROPORÇÃO DE CONCENTRADO

O presente trabalho teve como objetivo avaliar os efeitos de dietas de alta proporção de concentrado sobre características fecais em 20 bovinos Nelore machos com idade de 28 meses, em delineamento inteiramente casualizado. Os tratamentos foram constituídos de dieta total mais bagaço in natura - DT+BIN (54,52% de sorgo moído, 10,94% de caroço de algodão, 18% de casca de soja, 2,54% de farelo de soja, 10% bagaço de cana in natura e 4% de núcleo farelado), milho grão inteiro - MGI (75% de milho grão inteiro, 10% de casca de soja e 15% de núcleo peletizado) e dieta total - DT (44,44% de sorgo moído, 16,70% de caroço de algodão, 28,86% de casca de soja e 10% de núcleo farelado). Para determinação do pH das fezes e do amido fecal, amostras de fezes foram coletadas do reto de cada bovino nos dias 54, 55, 56 e 57 de experimento no período da manhã. O pH fecal foi determinado após adição de 100 mL de água destilada deionizada em 15 g de fezes frescas úmidas com a introdução da ponta do eletrodo de um peagâmetro microprocessado. O restante da amostra foi colocado em gelo, para depois ser congelado. Com o intuito de avaliar ocorrências de distúrbios gastrintestinais, as fezes frescas dos animais nas baias experimentais individuais foram avaliadas diariamente durante todo o experimento em três períodos. Os valores médios em percentagem do amido fecal, matéria seca fecal, medida de pH para o local de fermentação do amido e consumo de amido/kg não foram influenciados (P>0,05) pelos tratamentos. A FDN das fezes e o escore de consistência fecal foram influenciados pelos tratamentos (P<0,05). A dieta MGI com menor teor de FDNfe apresentou menor escore de fezes e menor percentagem de FDN fecal. Porém, a percentagem de amido e pH fecal, MS fecal e o consumo do amido não foram afetados pelo teor de FDNfe nas rações. A concentração de FDN fecal foi igual para os tratamentos DT+BIN e DT. O menor teor de FDN fecal no tratamento MGI é função do menor consumo de FDN pelos animais e, possivelmente, da maior digestibilidade dessa dieta. Os animais do tratamento MGI apresentaram fezes com consistência mais mole, com o valor de escore de 2,92. As fezes dos bovinos do tratamento DT+BIN foram de consistência mais firme com valor de escore de 3,12, considerada normal, e a dos animais do tratamento DT foram de consistência mais dura com valor de escore de 3,20.  Houve uma relação consistente positiva entre amido fecal e eficiência alimentar e uma tendência de relação positiva entre amido fecal e GMD. Dieta de alta proporção de concentrado com adição de 10% de BIN na matéria seca proporciona maior freqüência de fezes com escore de consistência firme. PALAVRAS-CHAVE: amido; confinamento; fezes; ração

Cytogenotoxicity biomarkers in fat snook Centropomus parallelus from Cananéia and São Vicente estuaries, SP, Brazil

The aquatic environment receives many contaminants that can induce damages at the molecular, biochemical, cellular and physiological levels. Centropomus parallelus, an important food resource for local populations, is a predator fish that feeds on small fishes and benthic invertebrates, thus being vulnerable to the bioconcentration and biomagnification processes. This study aimed to evaluate cytogenotoxic responses in erythrocytes from C. parallelus juveniles collected in the Cananéia and São Vicente estuaries, both in winter and in summer. After anesthesia, blood samples were collected by caudal puncture. Blood smears were prepared on glass slides and stained with May-Grünwald-Giemsa dye. Two thousand cells were analyzed per slide (1000x), and nuclear abnormalities (NA) and micronuclei (MN) were scored. The São Vicente sample showed MN and NA frequencies (%/1000 cells) of 0.325 and 3.575, in winter, and of 0.125 and 2.935 in summer respectively; the Cananéia sample showed frequencies of 0.0325 and 0.03, in winter, and of 0.065 and 0.355 in summer, respectively. The rates found in São Vicente were significantly higher than those found in Cananéia, evidencing that the levels of pollution in that estuary were high enough to induce genetic damages