Assessing risk and protective factors in clinical and judicial child-to-parent violence cases

Child-to-parent violence takes different forms (physical, psychological or economic) and can be addressed in the judicial system or in clinical practice. The current paper compares 61 clinical and 30 judicialized cases that were evaluated using the Child-to-Parent Violence Risk assessment tool (CPVR). Results showed a higher prevalence of risk factors in the judicialsample. This group of aggressors had worse profiles of violence (bidirectionality of the parent/child violence, violenceother than CPV, and more CPV complaints), more psychological issues (low frustration tolerance, little anger management, narcissism, and violent attitudes) and, most notably, more dysfunctional families (violence between parents, cohabitationproblems, inversion of the hierarchy, non-violent conflicts, and even criminal history of the parents). Logistic regressionshowed that narcissism, attitudes justifying violence, violence between parents, and problems of parents themselves(such mental disorders or drug abuse) allowed for correct classification of 89.4% of cases. Total CPVR scores differedbetween groups (25.8 vs. 14.2), and classification was good for both type of group (AUC = .830) and injuries to mother (AUC= .764). A cut-off score between 22 and 23 showed the best results in prediction of group and injuries to mother. Utility ofthe CPVR, and next steps in its development are discussed

Marginal Bone Loss and Pink Esthetic Evaluation of Narrow-Diameter Dental Implants for Single Crowns: 1-Year Prospective Clinical Study

Purpose: The aims of this study were: (1) to quantify the marginal bone loss (MBL) of 3.3-mm narrow-diameter, bone-level, titanium-zirconia (Ti-Zr) implants with two different surfaces in single restorations after a 1-year follow-up; (2) to analyze the combinations of different variables that may influence MBL; and (3) to record the Pink Esthetic Score (PES) value and its correlation with MBL. Materials and Methods: This is a prospective longitudinal clinical study with a 1-year follow-up after crown placement. Two different implant surfaces (sandblasted acid-etched and modified sandblasted acid-etched) were used. All bone-level and bone level-tapered implants had a diameter of 3.3 mm. Different healing and prosthetic abutments were used. Clinical, radiographic, and photographic records were taken 6 months and 1 year after placement of the restorations, and the survival rate, MBL, PES, clinical parameters, and biologic and/or mechanical complications were assessed. The correlations between the variables and MBL were verified. Results: A total of 30 narrow-diameter implants were placed in 30 patients; 18 implants had a sandblasted acid-etched surface, and 12 implants had a modified sandblasted acid-etched surface. The measured MBL at 1 year after implant function had a mean value of-0.36 mm, ranging from 0 mm to-1.77 mm. There was no implant loss. A statistically significant relationship was observed between implant shape (design and length), implant placement level, healing abutment, prosthetic abutment size, gingival thickness, and MBL. The mean PES values recorded at the beginning and end of the study were 7.58 and 11.37, respectively. Conclusion: Narrow-diameter implants showed reduced MBL values, with the surrounding tissues remaining stable after 1 year of follow-up. The MBL did not show different values on two implant surfaces. MBL does not seem to influence esthetic outcome. Int.Oral Maxillofaciallmplants2022;37::515-524. doi: 10.11607/jomi.905

Dirac fields in the background of a magnetic flux string and spectral boundary conditions

We study the problem of a Dirac field in the background of an Aharonov-Bohm flux string. We exclude the origin by imposing spectral boundary conditions at a finite radius then shrinked to zero. Thus, we obtain a behaviour of eigenfunctions which is compatible with the self-adjointness of the radial Hamiltonian and the invariance under integer translations of the reduced flux. After confining the theory to a finite region, we check the consistency with the index theorem, and evaluate its vacuum fermionic number and Casimir energy.Comment: 9 pages, 1 figure Two references added To be published in International Journal of Modern Physics

Oxaliplatin toxicity presenting as a liver nodule - case report

BACKGROUND: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging. This is the third reported case of this complication of oxaliplatin toxicity, in which resection was performed and pathological diagnosis confirmed. CASE PRESENTATION: We report the case of a 59 year old man with stage III colon cancer who underwent sigmoidectomy followed by adjuvant chemotherapy with oxaliplatin. One year after surgery a liver nodule was detected and the patient underwent right hepatectomy. Pathology showed no liver nodule and diagnosed sinusoidal obstruction syndrome. CONCLUSION: We describe the third reported case of a liver lesion mimicking a liver metastasis after oxaliplatin-based chemotherapy for colon cancer. We suggest that in patients heavily treated with oxaliplatin with de novo liver nodules, this differential diagnosis should be considered. In particular, in this population of patients an intense imagiologic evaluation and even a preoperative biopsy should be pursued to confirm the diagnosis of malignancy and avoid overtreatment.info:eu-repo/semantics/publishedVersio

2BAD: an application to estimate the parental contributions during two independent admixture events

Several approaches have been developed to calculate the relative contributions of parental populations in single admixture event scenarios, including Bayesian methods. In many breeds and populations, it may be more realistic to consider multiple admixture events. However, no approach has been developed to date to estimate admixture in such cases. This report describes a program application, 2BAD (for 2-event Bayesian ADmixture), which allows the consideration of up to two independent admixture events involving two or three parental populations and a single admixed population, depending on the number of populations sampled. For each of these models, it is possible to estimate several parameters (admixture, effective sizes, etc.) using an approximate Bayesian computation approach. In addition, the program allows comparing pairs of admixture models, determining which is the most likely given data. The application was tested through simulations and was found to provide good estimates for the contribution of the populations at the two admixture events. We were also able to determine whether an admixture model was more likely than a simple split model

Parental health literacy and the use of pediatric emergency services

A literacia em saúde pode ser definida, entre outras, como o nível da capacidade dos indivíduos para obter, processar e perceber informação de saúde básica e os serviços necessários para realizar decisões apropriadas sobre a sua saúde. Neste sentido, o objetivo deste estudo é identificar qual a literacia em saúde dos pais e cuidadores das crianças utilizadoras dos serviços de urgência pediátrica (SUP). Para tal, realizou-se uma revisão integrativa da literatura nas bases de dados CINAHL, MEDLINE e PUBMED, para artigos com menos de cinco anos, com a seguinte equação de pesquisa: [(health literacy OR parental education OR caregiver education) AND (child* OR adolesc* OR paediatric) AND (emergency department OR emergency room OR emergency unit)]. Após aplicação dos critérios de inclusão e exclusão obteve-se uma amostra final de sete artigos. Da análise realizada verificou-se uma elevada prevalência de baixa literacia em saúde, representando em média 63,71% dos inquiridos, com IC 95% ]61-66[. Outros determinantes sociais da saúde, como o nível de rendimento, a etnia e o tipo de seguro de saúde estão também descritos como fatores adjacentes à reduzida literacia em saúde. A baixa literacia em saúde está presente em grande parte dos cuidadores das crianças utilizadores do SUP sendo que esta problemática pode influenciar fenómenos como a recorrência aos serviços de saúde e/ou a incorreta compreensão do tratamento necessário.info:eu-repo/semantics/publishedVersio

Mentalizing in an economic games context is associated with enhanced activation and connectivity in the left temporoparietal junction.

Prior studies in Social Neuroeconomics have consistently reported activation in social cognition regions during interactive economic games, suggesting mentalizing during economic choice. Such mentalizing occurs during active participation in the game, as well as during passive observation of others' interactions. We designed a novel version of the classic false-belief task (FBT) in which participants read vignettes about interactions between agents in the ultimatum and trust games and were subsequently asked to infer the agents' beliefs. We compared activation patterns during the economic games FBT to those during the classic FBT using conjunction analyses. We find significant overlap in the left temporoparietal junction (TPJ) and dorsal medial prefrontal cortex, as well as the temporal pole (TP) during two task phases: belief formation and belief inference. Moreover, generalized Psychophysiological Interaction (gPPI) analyses show that during belief formation, the right TPJ is a target of both the left TPJ and the right TP seed regions, whereas during belief inferences all seed regions show interconnectivity with each other. These results indicate that across different task types and phases, mentalizing is associated with activation and connectivity across central nodes of the social cognition network. Importantly, this is the case for both the novel economic games and the classic FBTs

Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis

Haemangiomas are common focal liver lesions, generally detected in the work-up of asymptomatic patients. From the pathological point of view, they can be classified as small (capillary) or large, with cavernous vascular spaces that may show thrombosis, calcifications and hyalinisation. The polymorphic imaging appearance of haemangiomas depends on their histological features and flow pattern. The widespread use of cross-sectional imaging has allowed an increased detection rate and a better characterisation of this benign tumour. Recent developments of ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) providing high spatial and temporal resolution, together with the use of new contrast agents and/or pulse sequences has broadened the spectrum of imaging findings, contributing to diagnostic refinement in difficult cases. The scope of the present article is to provide an overview of the range of appearances of haemangiomas, explored with recent cross-sectional imaging modalities, emphasising its atypical findings as explored by temporally resolved contrast-enhanced imaging

T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection

AIM: To investigate the role of glutathione S-transferase T1 donor-specific T lymphocytes in plasma cell-rich rejection of liver allografts. METHODS: The study group included 22 liver transplant patients. Among them, 18 patients were mismatched for the glutathione S-transferase T1 (GSTT1) alleles (don+/rec-), and 4 were matched (don+/rec+). Seven of the mismatched patients produced anti-GSTT1 antibodies and developed plasma cell-rich rejection (former de novo immune hepatitis). For the detection of specific T lymphocytes, peripheral blood mononuclear cells were collected and stored in liquid nitrogen. The memory T cell response was studied by adding to the cell cultures to a mix of 39 custom-made, 15-mer overlapping peptides, which covered the entire GSTT1 amino acid sequence. The specific cellular response to peptides was analyzed by flow cytometry using the markers CD8, CD4, IL-4 and IFNγ. RESULTS: Activation of CD8+ T cells with different peptides was observed exclusively in the group of patients with plasma-cell rich rejection (3 out of 7), with production of IL-4 and/or IFNγ at a rate of 1%-4.92% depending on the peptides. The CD4+ response was most common and not exclusive for patients with the disease, where 5 out of 7 showed percentages of activated cells from 1.24% to 31.34%. Additionally, two patients without the disease but with the mismatch had cells that became stimulated with some peptides (1.45%-5.18%). Highly unexpected was the finding of a double positive CD4+CD8low T cell population that showed the highest degree of activation with some of the peptides in 7 patients with the mismatch, in 4 patients with plasma cell-rich rejection and in 3 patients without the disease. Unfortunately, CD4+CD8low cells represent 1% of the total number of lymphocytes, and stimulation could not be analyzed in 9 patients due to the low number of gated cells. Cells from the 4 patients included as controls did not show activation with any of the peptides. CONCLUSION: Patients with GSTT1 mismatch can develop a specific T-cell response, but the potential role of this response in the pathogenesis of plasma cell-rich rejection is unknown