Visual brain areas in obsessive compulsive disorder : a diffusion tensor imaging approach

Dissertação de mestrado integrado em Psicologia (área de especialização em Psicologia Clínica)A Perturbação Obsessivo-Compulsiva (POC) é uma condição psiquiátrica pertencente ao espectro das perturbações de ansiedade, sendo caracterizada por obsessões e compulsões. Obsessões são definidas como pensamentos, imagens, ideias ou impulsos recorrentes cujo conteúdo causam um elevado grau de ansiedade no indivíduo, levando-o a executar ações especificas ou rituais mentais de modo a reduzir a ansiedade, i.e. compulsões, (DSM-IV-TR, APA, 2000). A POC é uma psicopatologia bastante debilitante com uma taxa de prevalência de 1 a 2,5% na população adulta, com diversas facetas no que diz respeito às suas características clínicas: comportamentais, emocionais e neurocognitivas. Com especial atenção, défices ao nível do processamento visual e um viés atencional são descritos como uma significante manifestação desta perturbação, desempenhando um papel importante na ineficiente apreensão de estímulos sociais, um importante característica desta perturbação. Em concordância, alterações cerebrais estruturais e funcionais têm sido associadas a este fenótipo. Deste modo, o principal objectivo é analisar a integridade da microestrutura de substância branca em pacientes com POC, através de técnicas de Imagiologia por Tensor de Difusão (do inglês Diffusion Tensor Imaging), usando uma metodologia baseada na segmentação e tractografia, de modo a estabelecer uma relação entre estes padrões de conexão cerebral e a sua sintomatologia clínica. Considerando os défices cognitivos e alterações cerebrais da POC, nomeadamente ao nível das áreas frontais (orbitofrontal e dorsolateral) e occipitais, pretendemos continuar investigações prévias da nossa equipa de investigação e examinar a integridade da substância branca dos feixes da circunvolução frontal inferior (CFI), lobo occipital e área V1, regiões cerebrais relacionadas com o processamento visuo-perceptivo, que hipotetizamos estarem alteradas na população com POC (Gonçalves et al., 2010). Recorrendo a uma inovadora técnica de imagiologia (DTI), foram avaliadas as medidas de integridade dos feixes de substância branca (FA, MD, AD e RD) das áreas da CFI, lobo occipital e V1 devido ao seu papel no processamento visual e perceptivo. Catorze pacientes com POC (idade média,M=32,64±11,41) e dez participantes no grupo controlo (idade média M=30,70±9,73), emparelhados em idade, sexo e lateralidade, participaram neste estudo. Os nosso resultados demonstraram diferenças entre pacientes e controlos em três medidas de DTI nas regiões occipitais e V1. Especificamente, o grupo com POC apresentou menor integridade dos feixes de substância branca nestas áreas cerebrais que estão estritamente relacionadas com o processamento visual. No entanto, não foram encontradas diferenças de grupo no que diz respeito às medidas de integridade da matéria branca no feixe da CFI. Os resultados sugerem que feixes de substância branca envolvidas no processamento precoce de estímulos visuais podem estar associadas às manifestações clínicas da POC, nomeadamente o viés de processamento de estímulos emocionais.Obsessive Compulsive Disorder (OCD) is a psychiatric disorder classified within the spectrum of anxiety disorders, being characterized by obsessions and compulsions. Obsessions are defined as thoughts, images, ideas or recurrent impulses which content causes an elevated degree of anxiety on the individual, impelling him to execute specific actions or mental rituals in order to reduce anxiety, i.e. compulsions, (DSM-IV-TR, APA, 2000). OCD is a very disabling psychopathology with a prevalence rate of 1 to 2,5% in the adult population, with several facets concerning its clinical features: behavioral, emotional and neurocognitive. Of special note, visual processing deficits and an attentional bias has been described as a significant manifestation of this disorder, playing an important role in their inefficient social stimuli aprehension, a important characteristic of this disorder. In agreement, structural and functional brain alterations in the occipital, parietal and other visual areas have been associated with this phenotype. Therefore, the main objective of the present study is to analyze white matter microstructure in OCD patients through the use of Diffusion Tensor Imaging (DTI) techniques, using a segmentation and tractography based approach, in order to establish a relation between connectivity patterns of these visual brain and OCD’ clinical symptomatology. Considering their neurocognitive phenotype and specific brain abnormalities in OCD, namely in frontal (orbitofrontal and dorsolateral) and occipital areas, we now aim to follow our team previous research and investigate the integrity of the Inferior Frontal Gyrus (IFG), occipital lobe and V1 area, as are related with visuo-perceptive processing, which we hypothesize to be abnormal in OCD population (Gonçalves et al., 2010). Using this innovative imaging technique (DTI) we evaluated white matter DTI-derived measures (FA, MD, AD and RD) of the IFG, occipital and V1 areas taking into account their role on visual processing and perception. Fourteen patients with OCD (Mean age=32,64 ± 11,41) and ten comparison controls (Mean age=30,70 ± 9,73), matched on age, sex and handedness, participated in this study. Our results reported group differences in three DTI indexes (MD, AD and RD) in occipital and V1. Specifically, OCD group displayed decreased integrity of these white matter tracts which are strictly related with visual processing. Nevertheless, we did not find group differences regarding the integrity of the IFG white matter tract. Results suggest that brain fiber tracts enrolled in early steges of visual processing may be associated with the clinical features of OCD, specifically the bias in processing for emotional stimuli

Maternal self-efficacy in newborn care: influence of maternal variables

Aim: To analyze the influence of sociodemographic, obstetric, childbirth, and breastfeeding variables on maternal self-efficacy in newborn care. Design: Descriptive cross-sectional study. Methods: The study was conducted in three hospital units in the Northern region of Portugal, with a non-probabilistic sample composed of 340 women recruited at postnatal wards on the day of hospital discharge. A questionnaire including the mother’s sociodemographic, obstetric, childbirth, and breastfeeding data was used. For the analysis of maternal self-efficacy in newborn care, the Scale of Perceived Parental Self-Efficacy in Child Care was used. The scale is a 20-item self-report instrument developed to identify women with low levels of self-efficacy in newborn care. Descriptive and inferential statistics were used for data analysis. Results: Significant differences concerning maternal self-efficacy in newborn care were found with regard to level of education and parity, with multiparous women and women with lower levels of education presenting higher levels of self-efficacy in newborn care. Conclusion: The analysis of these variables could be valuable in building new knowledge to support the development of an action model that would allow at-risk women to be highly confident in their parenting role.info:eu-repo/semantics/publishedVersio

Fluoxetine Removal from Aqueous Solutions Using a Lignocellulosic Substrate Colonized by the White-Rot Fungus Pleurotus ostreatus

One of the main challenges in both the design of new wastewater treatment plants and the expansion and improvement of existing ones is the removal of emerging pollutants. Therefore, the search for economic and sustainable treatments is needed to enhance the removal of pharmaceuticals. The potential of a lignocellulosic substrate colonized by Pleurotus ostreatus, a waste from mushroom production, to remove fluoxetine from aqueous solutions was studied. Batch assays were performed to remove 600 µg∙L−1 fluoxetine from aqueous solutions using the colonized mushroom substrate (CMS) and crude enzyme extracts. The removal efficiencies achieved were, respectively, ≥83.1% and 19.6% in 10 min. Batch assays with sterilized CMS and 1-aminobenzotriazole (to inhibit cytochrome P450 enzymes) showed that the higher removal efficiencies achieved in the CMS assays may be attributed to the synergistic contribution of biosorption onto the CMS and lignin modifying enzymes activity, namely laccase activity. A column assay was performed with the CMS, fed with 750 µg∙L−1 fluoxetine aqueous solution. The removal efficiency was 100% during 30 min, decreasing to a final value of 70% after 8 h of operation. The results suggested that CMS can be a promising eco-friendly alternative to remove fluoxetine from aqueous solutionsThis research was funded by the Associate Laboratory for Green Chemistry-LAQV, which received financial support from UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020 by the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e En sino Superior (MCTES) through national funds. This research was also funded by the EU and FCT/UEFISCDI/FORMAS, in the frame of the collaborative international consortium REWATER— “Sustainable and safe water management in agriculture: increasing the efficiency of water reuse for crop growth while protecting ecosystems, services and citizens’ welfare” (WaterJPI/0007/2016), which was financed under the ERA-NET Cofund WaterWorks2015 Call, as an integral part of the 2016 Joint Activities developed by the Water Challenges for a Changing World Joint Program Initiative (Wa ter JPI). The research was funded also by the ERA-NET Cofund BiodivRestore—DivRestore/002/2020, BioReset—“Biodiversity restoration and conservation of inland water ecosystems for environmental and human well-being”, BiodivRestore 2020–2021 Call. A.D.M. Silva would like to thank FCT for her Ph.D. Grant SFRH/BD/138/780/2018. The authors are greatly indebted to all financing sourcesinfo:eu-repo/semantics/publishedVersio

A structural equation model of self-regulation and healthy habits as an individual protective tool in the context of epidemics evidence from COVID-19

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.Objective: The present study aims to explore the mediation role of self-regulation on health-related behaviors adoption or maintenance, mental health, and well-being during the COVID-19 confinement in a sample of adults in Portugal. Design: One-hundred fifty individuals (118 females, 32 males; Mage = 33.57 year; SD = 12.71) filled an online survey to assess self-regulation, healthy behaviors, mental health, and well-being perception, during the early months of the pandemic (June–August, 2020). Main Outcome Measures: Self-regulation capacity, adoption or maintenance of healthy habits, mental health, including stress management, and the perception of one’s well-being were evaluated using a structural equation model (SEM). Results: Self-regulation had direct effects on healthy habits and mental health and indirect effects on well-being and mental health mediated by healthy habits. In specific, a positive direct effect on healthy habits (β = 0.497, p < 0.001) and a negative direct effect on mental health (β = −0.428, p < 0.001); and a positive indirect effect on well-being perception, mediated by healthy behaviors and mental health (β = 0.253, p = 0.003), and a negative indirect effect on mental health, mediated by healthy habits (β = −0.208, p = 0.003). Additionally, healthy habits exerted direct effects on well-being perception and mental health. A positive direct effect on well-being perception (β = 0.254, p = 0.012), and a negative direct effect on mental health (β = −0.418, p < 0.001) were further observed. No direct effect of mental health was observed in well-being perception (β = −0.199, p = 0.068). Finally, a negative correlation was observed between self-regulation and weeks of confinement (r = −0.208, p = 0.021). Conclusion: Self-regulation seems to be a good indicator of adopting a healthy lifestyle and better mental health and well-being in the context of the COVID-19 pandemic. Future preventive actions and interventions to build long-term global preparedness for future health emergencies, such as COVID-19, should explore the importance of self-regulation as an important individual and collective protective factor.This study was conducted at the Psychology Research Center (PSI/01662), School of Psychology, University of Minho, and supported by the Portuguese Foundation for Science and Technology (FCT) through the Portuguese State Budget (UIDB/PSI/01662/2020). This study was also supported by the project 2018-1-PT01-KA201-047417, funded by the ERASMUS+ Education and Training National Agency. SS was supported by the project PTDC/PSI-ESP/28228/2017, funded by the Portuguese Foundation for Science and Technology (FCT) and the European Regional Development Fund (FEDER). AS-F was supported by FCT and the Portuguese Ministry of Science, Technology and Higher Education, through the national funds, within the scope of the Transitory Disposition of the Decree No. 57/2016, 29th of August, amended by Law No. 57/2017 of 19 July. MF was supported by the UMINHO/BIM-CNCG/2021/29 Research Fellowship funded by the Portuguese Foundation for Science and Technology (FCT). SC acknowledges the Psychology for Positive Development Research Center (PSI/04375), Lusíada University of Porto, Porto, Portugal, supported by national funds through the Portuguese Foundation for Science and Technology, I.P., and the Portuguese Ministry of Science, Technology and Higher Education (UID/PSI/04375/2019)

Técnica de ligadura e resseção para a exérese de uma lesão pseudo-pediculada volumosa no cólon ascendente

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The role of marketing in LGBT tourism: an exploratory contribution in the Portuguese context

Considerando o impacto económico no turismo e a visibilidade social crescente da comunidade LGBT no Mundo, considera-se imprescindível desenvolver o sector turístico com base na investigação e segmentação do mercado de forma a tornar um destino turístico mais competitivo. O turismo LGBT é um turismo de segmentos que tem vindo a assumir uma importância crescente no setor turístico. Neste sentido, o objetivo do presente estudo consistiu em examinar o papel do marketing turístico e qual a sua importância no que se refere às especificidades desta comunidade. Pretendeu-se, igualmente, traçar o perfil do turista LGBT, a procura e a oferta turística existente em contextos nacionais e internacionais. Foi apresentado e discutido um modelo conceptual, a testar empiricamente, por forma a melhor compreender a importância de algumas variáveis do marketing numa ótica de comportamento do consumidor do segmento LGBT. Apesar da oferta existente, este segmento, ainda está pouco explorado em Portugal no ano de 2018. No final, procede-se a uma reflexão sobre o tema com a explicitação de um modelo e discutem-se linhas de investigação futura.According to the economic impact on tourism and the social increase of visibility in the world of the LGBT community, it is considered essential to develop this tourism sector based on the research and the market segmentation in order to create a more competitive tourist destination. LGBT tourism is a niche tourism that has been growing in importance in the tourism sector. In this sense, the objective of the present study consists in the examination of the characteristics of this community, concretely develop the profile of the LGBT tourist, the demand and the existent tourist offer, both internationally and nationally. For that conclusion, a set of methodological research procedures was carried out: a literature review as well as a survey of tourist destinations that ensure this segmentation of the market. Despite of the existing offer, this segment is still not enough explored in Portugal. Sexuality is a sensitive subject and LGBT tourism is not always seen with good eyes, which makes difficult the communication and investigation of this market and the real impact that this segment could have in Portugal. ompreender a importância de algumas variáveis do marketing numa ótica de comportamento do consumidor do segmento LGBT

Aplicação multimédia sobre a Ria Formosa e seus fins educacionais (ForDid)

Na atualidade torna-se inquestionável a necessidade de integrar a aprendizagem com as novas tecnologias de modo a cativar e facilitar a compreensão dos temas abordados através de aplicações didáticas. Durante a última década o Centro de Investigação Marinha e Ambiental (CIMA) assumiu a responsabilidade de criar meios eficazes de comunicação entre o público em geral e a comunidade científica, através de plataformas multimédia interativas. Foram objecto destas aplicações didáticas as várias vertentes do património natural do Algarve. Após o sucesso das primeiras aplicações GuaDid e MonDid visando o Estuário do Rio Guadiana e a Serra de Monchique respectivamente, o desafio de criar e inovar foi acrescido, resultando numa nova aplicação – ForDid, visando a divulgação do importante sistema lagunar Ria Formosa.info:eu-repo/semantics/publishedVersio

Holocene history of Ria Formosa coastal lagoon system (Southern Portugal): borehole evidence and threedimensional paleotopography

A paleotopographic model of Ria Formosa is presented based on two borehole campaigns and a systematic comparison with previous works, revealing the existence of a complex network of fluvial valleys. Vertical sediment profiles showed a mosaic of changing depositional environments, resulting from local hydrodynamics, sedimentary sources and, to an extent, by the structurally inherited accommodation space. Sedimentological, geochemical and micropaleontological data were put in the context of an age model obtained from 14C datings, pointing to the existence of an estuarine environment subjected to a rapid coastal flooding from ca. 10000 to 7500 cal. years B.P., followed by a period of infilling in an increasingly confined coastal lagoon environment.info:eu-repo/semantics/publishedVersio

Fluoxetine Removal from Aqueous Solutions Using a Lignocellulosic Substrate Colonized by the White-Rot Fungus Pleurotus ostreatus

One of the main challenges in both the design of new wastewater treatment plants and the expansion and improvement of existing ones is the removal of emerging pollutants. Therefore, the search for economic and sustainable treatments is needed to enhance the removal of pharmaceuticals. The potential of a lignocellulosic substrate colonized by Pleurotus ostreatus, a waste from mushroom production, to remove fluoxetine from aqueous solutions was studied. Batch assays were performed to remove 600 µg∙L−1 fluoxetine from aqueous solutions using the colonized mushroom substrate (CMS) and crude enzyme extracts. The removal efficiencies achieved were, respectively, ≥83.1% and 19.6% in 10 min. Batch assays with sterilized CMS and 1-aminobenzotriazole (to inhibit cytochrome P450 enzymes) showed that the higher removal efficiencies achieved in the CMS assays may be attributed to the synergistic contribution of biosorption onto the CMS and lignin modifying enzymes activity, namely laccase activity. A column assay was performed with the CMS, fed with 750 µg∙L−1 fluoxetine aqueous solution. The removal efficiency was 100% during 30 min, decreasing to a final value of 70% after 8 h of operation. The results suggested that CMS can be a promising eco-friendly alternative to remove fluoxetine from aqueous solutions