Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists

The chemokine receptor CCR5 has been implicated in the pathogenesis of cancers and AIDS. A series of novel piperidine derivatives were designed, synthesized, and evaluated as CCR5 antagonists. The ability of the new ligands to inhibit the increment of intracellular calcium level stimulated by endogenous ligand CCL5 was measured in the calcium mobilization assay as an indication of its CCR5 receptor antagonism. The anti-proliferation assay was performed to measure the ability of these new compounds to inhibit the proliferation of prostate cancer cell lines, PC-3 and M12. A new lead compound has been identified which showed micromolar level of inhibition to PC-3 cell line proliferation as well as calcium mobilization. These studies are the beginning of a thorough analysis of the CCR5 receptor antagonist binding pocket in the CCR5 receptor. Further examination may help identify next generation lead to develop highly selective CCR5 receptor antagonists and anti prostate cancer agents

Analysis of Growth, Phenotypic characteristics and Expression of STRO1 and CD106, in Dental Pulp Stem Cells and Stem cells from Human Exfoliated Deciduous teeth: A Cell culture study

In this study we successfully isolated and cultured five Dental Pulp Stem Cells (DPSC) from twelve samples of permanent teeth and six Stem cells from Human Exfoliated Deciduous teeth (SHED) from nine deciduous teeth. We compared the growth characteristics and the phenotype of both the cell populations. We also evaluated the immuno histochemical expression of STRO1 and CD 106 on these cells. • Estimation of growth curve and its derivatives revealed that the doubling time of DPSCs ranged from 37 hours to 144 hours. This long population doubling time indicate their loss of proliferation and entering the process of differentiation. SHED also had similar doubling time ranging from 13 hours to 246 hours. • The subpopulation analysis of both DPSCs and SHED revealed no statistically significant difference between the two groups. (p>0.05). • The seeding efficiency of DPSCs ranged from 37 to 112% but that of SHED ranged from 42.6 to 119.4. • Both DPSCs and SHED had higher proportion of F2 subpopulation, indicating slow proliferation. • The morphologically characterized DPSCs and SHED did not express the early mesenchymal markers, like STRO1 and VCAM. • Further study using a larger panel of antibodies is required to better localize and characterizethe stem cell niches of DPSCs and SHED apart from their perivascular locations. • Given the easy accessibility of pulp stem cell the molecular studies of DPSC and SHED with more number of samples should be done. • In future such characterization would improve the scope and utility of these cells in clinical dentistry and therapeutics

Arivumathi and Dravidianism

Superstitions, rituals, religion, and godly principles that arose from the emergence of the Dravidian movement and the rise of the Dravidian race are enslaving the people. It was through this that those human beings created ups and downs among themselves and locked up the slave animals for themselves. Untouchability was an act of demeaning a man. This atrocity of untouchability was seen in restaurants, art halls, buses, and even schools, with separate cups, separate seats, and separate sections. In addition to demeaning women, there were many oppressive policies in Tamil Nadu, such as that a woman is a slave to a man, home, and society. The Dravidian movement was a movement that emerged to rescue the people from many more such forms of oppression. Even Tamil, the oldest language of the Dravidian languages, began to lose its uniqueness at some point. In order to bring the Tamil language out of this decline, the speakers of the Dravidian movement like Thanthai Periyar, Anna, and Kalaignar promoted Tamil through their self-conscious speeches. Similarly, many poets of the Dravidian movement, like Bharathidasan, Suradha, Vanithasan, etc., through their writings, worked hard to make the Tamil language flourish on our soil again. Arivumathi is one of those who have been attracted by such principles and who is now a poet of the Dravidian movement. The Dravidian thoughts found in his poems can be seen in poems such as his unique Tamil principles, his attachment to race, the restoration of slavery, and his concept of untouchability

Extracting Patterns of Semantic Roles from Accident Narratives

Accident databases are filled with rich information about accidents. Analyzing these datasets can reveal useful information which can be used to prevent similar accidents in the future. Policy makers, and safety management organizations can design appropriate measures based on the analysis done to prevent accidents. Besides structured data, crash reports include natural language narratives which contain valuable accident-related information which is otherwise not present in the structured data. Using natural language processing (NLP) techniques one can analyze these narratives and mine hidden patterns of accidents from them. The thesis focuses on developing an algorithm to extract common patterns of semantic role labels from the narratives of accidents. These patterns capture frequently occurring sequences of verbs and their arguments. In this work, the developed algorithm was applied to accident narratives and the resulting patterns were assessed for their accident-related information

Familial Case of Cherubism from South India: Differential Diagnosis and Report of 2 Cases

Cherubism is a rare familial multilocular cystic lesion of the jaws. The condition clinically appears as a bilateral symmetric swelling of the cheeks in children and is the primary reason for referral. It is a rare lesion of the jaws that has a dominant pattern of inheritance. We report two cases of cherubism, that of a boy and his mother suggestive of a strong familial incidence. A variety of lesions of the jaw mimic this condition and hence the differential diagnosis has been emphasised

Comparative study between Intravenous 50% Magnesium Sulphate and Dexmedetomidine for attenuation of cardiovascular stress response during laryngoscopy and endotracheal intubation

BACKGROUND: Direct laryngoscopy and endotracheal intubation frequently induces a cardiovascular stress response due to reflex sympathetic stimulation. This response may be hazardous in patients with hypertension, coronary artery disease, myocardial disease, cerebrovascular disease. Numerous agents have therefore been utilized to blunt this response. OBJECTIVES: The present study was undertaken to compare effectiveness of intravenous Magnesium sulphate and Dexmedetomidine in suppressing the cardiovascular stress response. METHODS: 60 Patients were divided in to two groups of 30 patients each. Group-M received 30mg/kg of Magnesium sulphate and Group-D received 1 mcg/kg Dexmedetomidine ten minutes before intubation. Both the groups were observed for changes in hemodynamic parameters i.e. heart rate (HR) systolic and diastolic blood pressure ,mean rterial blood pressure at 0, 1, 3, 5, 10 minutes post intubation and level of sedation during recovery using ramsay sedation score scale and for adverse effects. RESULTS: Comparison of parameters was done using One‐Way ANOVA and categorical data was compared by using Chi‐square test. p Value < 0.05 was considered as statistically significant. It was observed that both magnesium sulphate and dexmedetomidine attenuated the rise in systolic , diastolic blood pressure and mean arterial blood pressure, but magnesium failed to attenuate increase in the heart rate which is less than 10 beats/ min. Sedation score was statistically significant in dexmedetomidine group compared to magnesium group. CONCLUSION: Intravenously administered Magnesium sulfate 30mg/kg given before intubation is equally effective as Dexmedetomidine 1 mcg/kg for attenuation of the cardiovascular stress responses to laryngoscopy and endotracheal intubatio

Magical Realism and Myth in Divakaruni’s Novels

The aim of the study is to portray that Magical realism acts an important factor because of its alternative belief system. Women are the crucial part of society, since their life depends upon someone else to run their life, they are fictional worlds and hence the Women Writers make him to enter into “real” world. Some familiar writers like Garcia Marquez\u27s Macondo were one among them. It is said that the Magic comes naturally, as a simple, everyday occurrence. Magical realism is about mixing up things like ordinary with extraordinary, Fantasy with reality, reel with real. Hence Magical realism engages belief systems. It sets Magical events in realistic contexts about ‘Real\u27 and how it is exposed. It undermines our limitations we accept with or without any explanations. Hence Magical realist fiction is not “either/or but “both at once”

Automatic Demand Draft Withdrawal Machine Using Micro controller

At present, intelligent automation has stepped its presence in every field all over the world. This paper is an intelligent automation for issuing the demand drafts in automated way. In present scenario, demand draft was taken manually. Without the help of human source, it is highly impossible to take DD. To take DD the customer has to go for bank and wait for an hour. Initially the customer will be provided DD form, after filling the complete details it will be forwarded to the next level, this process is followed in existing system and DD will be taken only on bank working hours. In order to overcome such kind of difficulties an idea is introduced which allows the customer to take DD automatically. To make the work easier, faster and automated a domain called embedded system is used. In this automated system, the customer has to insert their currency in the rupee slot and have to wait for few seconds to accept it. Then within next few seconds they have to feed the required details in the PC instead of writing in a form. This is then generated and the sum of amount which has been inserted will be added in the softcopy. Then they have to verify once and have to give print .Thus the Demand Draft will be generated in few seconds instead of standing for hours. Thus, this system eliminates the drawbacks of the existing set-up. It is placed in the bank branches similar to that of ATM. In proposed system, image processing is used to count the currency. With this automation, issuing of demand draft is made easier by feeding the inputs in the input module. In our project we designed the hardware for taking the currency notes from the input slot and software is designed to generate the demand draft. The objective of this project is to design a simple, easy to install, microcontroller-based circuit to control and PC or laptop interface for generating the demand draft

Role of Jaloukavacharana in the management of Cicatricle Alopecia – A Case Report

Introduction: Cicatricial alopecia is a disease of scalp in which the major clinical feature is patchy loss of hair accompanied with scarring. Cicatricial alopecia is caused by diverse group of hair disorders in which healthy tissue is replaced by scar tissue and causes permanent hair loss. It affects both men and women, most commonly adults. It can be correlated to Indralupta a type of Kapalagta Roga by Vagbhata. The basic pathophysiology of Indralupta is the vitiated Tridosha and Rakta affecting the scalp. The pathology also reveals the blockage of hair follicles with aggravated Rakta and Kapha which further prevents regrowth of hairs. This is the case report of 22 year old male who complained of patchy loss of hair at the left parital region of scalp, associated with pus discharge and swelling since 4 years. Materials and Methods: The subject who approached Shalakya Tantra OPD of Government Ayurveda Medical College, Bengaluru with symptoms of patchy hair loss at left parietal region since 4 years was systemically reviewed and Rakthamokshana, Lepa and Rasayana line of treatment is adopted. Results: The subject showed marked improvement as depicted in the photographs taken at different levels of treatment. Discussion: Idralupta is a Kshudraroga affecting scalp and involving Pitta, Vata Dusti, later Kapha and Rakta blocking the Romakupa. By adopting the holistic approach with both internal and external treatment modalities an attempt is made to bring about satisfactory results