13 research outputs found

    Ultrasonic diagnostic in porous media and suspensions

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    An apparatus has been constructed to characterize transient fluid displacements in porous media, and probe sedimenting suspensions. The technique used is to propagate an ultrasonic wave in the sample. Both ultrasonic attenuation and velocity are related to the static and hydrodynamic properties of the medium. The system was built so as to perform array imaging (mapping) and tested with different fluids and suspensions. It is suggested that the ultrasonic technique can be suitable whenever transient, low cost and safe saturation and concentration measurements are to be performed.Nous avons rĂ©alisĂ© un appareil pour Ă©tudier l'Ă©volution temporelle des Ă©coulements en milieux poreux et au cours de la sĂ©dimentation des suspensions. La technique employĂ©e utilise la propagation d'une onde ultrasonore dans l'Ă©chantillon. L'attĂ©nuation et la vitesse ultrasonores sont toutes deux reliĂ©es aux propriĂ©tĂ©s statique et dynamique du mileu. Le systĂšme d'imagerie acoustique permet une cartographie à deux dimensions de l'Ă©chantillon , ce systĂšme a Ă©tĂ© testĂ© avec diffĂ©rents fluides et suspensions. Notre Ă©tude montre que la technique ultrasonore est bien adaptĂ©e à la dĂ©termination de la dĂ©pendance temporelle de la concentration et de la saturation dans des conditions de sĂ©curitĂ© et de coĂ»t optimales

    Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study

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    International audienceBackground: Head-to-head comparisons of combinations of more than one non-opioid analgesic (NOA) with morphine alone, for postoperative analgesia, are lacking. The objective of this multicentre, randomised, double-blind controlled trial was to compare the morphine-sparing effects of different combinations of three NOAs-paracetamol (P), nefopam (N), and ketoprofen (K)-for postoperative analgesia. Methods: Patients from 10 hospitals were randomised to one of eight groups: control (C) received saline as placebo, P, N, K, PN, PK, NK, and PNK. Treatments were given intravenously four times a day during the first 48 h after surgery, and morphine patient-controlled analgesia was used as rescue analgesia. The outcome measures were morphine consumption, pain scores, and morphine-related side-effects evaluated 24 and 48 h after surgery. Results: Two hundred and thirty-seven patients undergoing a major surgical procedure were included between July 2013 and November 2016. Despite a failure to reach a calculated sample size, 24 h morphine consumption [median (interquartile range)] was significantly reduced in the PNK group [5 (1-11) mg] compared with either the C group [27 (11-42) mg; P<0.05] or the N group [21 (12-29) mg; P<0.05]. Results were similar 48 h after surgery. Patients experienced less pain in the PNK group compared with the C, N, and P groups. No difference was observed in the incidence of morphine-related side-effects. Conclusions: Combining three NOAs with morphine allows a significant morphine sparing for 48 h after surgery associated with superior analgesia the first 24 h when compared with morphine alone
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