ASPECTOS CLÍNICOS DA LEISHMANIOSE VISCERAL CANINA NA CIDADE DE FORTALEZA, CE

Visceral leishmaniasis is an infectious zoonosis with high importance in Brazil. The purpose of the present study was to evaluate the clinical findings of 21 dogs naturally infected by visceral leishmaniasis, in Fortaleza, Ceará, Brazil. The diagnosis was based on serology. Most of the dogs showed skin abnormalities, weight loss, decreased appetite, lymphadenomegaly and apathy. It were also observed ocular signs, splenomegaly, arthritis, onychogryphosis, emesis, myositis, dehydration, epistaxis, and involvement of the urinary system. A leishmaniose visceral é uma antropozoonose muito importante no Brasil. O presente trabalho teve como objetivo realizar a descrição clínica de 21 cães naturalmente acometidos por leishmaniose visceral na cidade de Fortaleza, Ceará. O diagnóstico de leishmaniose visceral foi realizado por meio de exames sorológicos. As alterações mais freqüentes foram as dermatológicas, seguidas por emaciação, hiporexia, linfadenomegalia e apatia. Também foram observadas alterações oculares, esplenomegalia, artrite, onicogrifose, emese, miosite, desidratação, epistaxe e comprometimento do sistema urinário

VALORES DE REFERÊNCIA PARA O PERFIL ELETROFORÉTICO DE PROTEÍNAS SÉRICAS EM CABRAS

Electrophoretic profiles of serum proteins can help on the diagnosis of several pathologies. However, the establishment of local reference values is important for accurate interpretation of this laboratory assay, since those values may be variable depending on local conditions. Thus, the aim of the present research work was to determine the reference values for eletrophoretic separation of serum proteins in goats from Rio Grande do Norte State (RN) Brazil farms. Blood samples were collected from 22 adult goats, negative for caprine arthritis and encephalitis virus, from farms at Afonso Bezerra city. Serum levels of total proteins were assayed and separation of gobulins performed by electrophoresis. The following results were found: Total proteins, 70.0 g/L, albumin, 37.0 g/ L, a- globulins, 7.63 g/L, b1 globulins, 10.4 g/l, b2- globulins, 10.2 g/L, g-globulins, 4.76 g/L, and albumin/ globulins ratio 1.16. Thus, data from this research work may be useful as a tool on the diagnosis of goat diseases.O perfil eletroforético de proteínas séricas é uma ferramenta que pode ser utilizada como auxílio ao diagnóstico de diversas patologias. No entanto, para adequada interpretação deste exame, é necessário o estabelecimento dos valores de referência locais, uma vez que estes podem divergir daqueles obtidos em outras condições. Assim, o objetivo do presente trabalho foi determinar valores de referência para o exame eletroforético de proteínas séricas em caprinos criados no estado do Rio Grande do Norte. Foram coletadas amostras de sangue de 22 caprinos adultos negativos para o vírus da artrite e encefalite caprinas, de propriedades localizadas no município de Afonso Bezerra, RN. Foram determinados os níveis séricos de proteínas totais e das diferentes frações de proteínas separadas por eletroforese. Os resultados obtidos foram: proteínas totais - 70,0g/L; albumina - 37,0g/L; a- globulinas - 7,63g/L; b1-globulinas - 10,4g/L; b2- globulinas - 10,2g/L; g-globulinas - 4,76g/L e relação albumina/globulinas - 1,16. Assim, os resultados obtidos poderão ser utilizados no auxílio ao diagnóstico de doenças em caprinos

Testing the Parentâ Adolescent Acculturation Discrepancy Hypothesis: A Fiveâ Wave Longitudinal Study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134121/1/jora12214.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134121/2/jora12214_am.pd

Longitudinal Trajectories of Family Functioning Among Recent Immigrant Adolescents and Parents: Links With Adolescent and Parent Cultural Stress, Emotional Wellâ Being, and Behavioral Health

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148234/1/cdev12914.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148234/2/cdev12914_am.pd

Elucidating the neuropathologic mechanisms of SARS-CoV-2 infection

Acknowledgements We want to express our gratitude to the Union Medical University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer's disease and made our research possible. This work is dedicated to the memory of Professor Dr. José Raúl Mena López†.Peer reviewedPublisher PD

A conceptual framework for crop-based agri-food supply chain characterization under uncertainty

[EN] Crop-based Agri-food Supply Chains (AFSCs) are complex systems that face multiple sources of uncertainty that can cause a significant imbalance between supply and demand in terms of product varieties, quantities, qualities, customer requirements, times and prices, all of which greatly complicate their management. Poor management of these sources of uncertainty in these AFSCs can have negative impact on quality, safety, and sustainability by reducing the logistic efficiency and increasing the waste. Therefore, it becomes crucial to develop models in order to deal with the key sources of uncertainty. For this purpose, it is necessary to precisely understand and define the problem under study. Even, the characterisation process of this domains is also a difficult and time-consuming task, especially when the right directions and standards are not in place. In this chapter, a Conceptual Framework is proposed that systematically collects those aspects that are relevant for an adequate crop-based AFSC management under uncertainty.Authors of this publication acknowledge the contribution of the Project 691249, RUC-APS "Enhancing and implementing Knowledge based ICT solutions within high Risk and Uncertain Conditions for Agriculture Production Systems" (www.ruc-aps.eu), funded by the European Union under their funding scheme H2020-MSCA-RISE-2015Alemany Díaz, MDM.; Esteso, A.; Ortiz Bas, Á.; Hernández Hormazabal, JE.; Fernández, A.; Garrido, A.; Martin, J.... (2021). A conceptual framework for crop-based agri-food supply chain characterization under uncertainty. Studies in Systems, Decision and Control. 280:19-33. https://doi.org/10.1007/978-3-030-51047-3_2S1933280Taylor, D.H., Fearne, A.: Towards a framework for improvement in the management of demand in agri-food supply chains. Supply Chain Manage. 11, 379–384 (2006)Matopoulos, A., Vlachopoulou, M., Manthou, V., Manos, B.: A conceptual framework for supply chain collaboration: empirical evidence from the agri-food industry. Supply Chain Manage. 12, 177–186 (2007)Ahumada, O., Villalobos, J.R.: Application of planning models in the agri-food supply chain: a review. Eur. J. Oper. Res. 196, 1–20 (2009)Iakovou, E., Vlachos, D., Achillas, C., Anastasiadis, F.: A methodological framework for the design of green supply chains for the agrifood sector. Paper presented at the 2nd international conference on supply chains, Katerini, 5–7 Oct 2012Manzini, R., Accorsi, R.: The new conceptual framework for food supply chain assessment. J. Food Eng. 115, 251–263 (2013)Shukla, M., Jharkharia, S.: Agri-fresh produce supply chain management: a state-of-the-art literature review. Int. J. Oper. Prod. Manage. 33, 114–158 (2013)Lemma, Y., Kitaw, D., Gatew, G.: Loss in perishable food supply chain: an optimization approach literature review. Int. J. Sci. Eng. Res. 5, 302–311 (2014)Tsolakis, N.K., Keramydas, C.A., Toka, A.K., Aidonis, D.A., Iakovou, E.T.: Agrifood supply chain management: a comprehensive hierarchical decision-making framework and a critical taxonomy. Biosyst. Eng. 120, 47–64 (2014)Van der Vorst, J.G., Da Silva, C.A., Trienekens, J.H.: Agro-industrial Supply Chain Management: Concepts and Applications. FAO (2007)Hernandez, J., Mortimer, M., Patelli, E., Liu, S., Drummond, C., Kehr, E., Calabrese, N., Iannacone, R., Kacprzyk, J., Alemany, M.M.E., Gardner, D.: RUC-APS: enhancing and implementing knowledge based ICT solutions within high risk and uncertain conditions for agriculture production systems. In: 11th International Conference on Industrial Engineering and Industrial Management, Valencia, Spain (2017)Miles, M.B., Huberman, A.M.: Qualitative Data Analysis: An Expanded Sourcebook. Sage Publications, Thousand Oaks (1994)Alemany, M.M.E., Alarcón, F., Lario, F.C., Boj, J.J.: An application to support the temporal and spatial distributed decision-making process in supply chain collaborative planning. Comput. Ind. 62, 519–540 (2011)Teimoury, E., Nedaei, H., Ansari, S., Sabbaghi, M.: A multi-objective analysis for import quota policy making in a perishable fruit and vegetable supply chain: a system dynamics approach. Comput. Electron. Agric. 93, 37–45 (2013)Kusumastuti, R.D., van Donk, D.P., Teunter, R.: Crop-related harvesting and processing planning: a review. Int. J. Prod. Econ. 174, 76–92 (2016)Zhang, W., Wilhelm, W.E.: OR/MS decision support models for the specialty crops industry: a literature review. Ann. Oper. Res. 190, 131–148 (2011)Grillo, H., Alemany, M.M.E., Ortiz, A.: A review of mathematical models for supporting the order promising process under lack of homogeneity in product and other sources of uncertainty. Comput. Ind. Eng. 91, 239–261 (2016)Blanco, A.M., Masini, G., Petracci, N., Bandoni, J.A.: Operations management of a packaging plant in the fruit industry. J. Food Eng. 70, 299–307 (2005)Grillo, H., Alemany, M.M.E., Ortiz, A., Fuertes-Miquel, V.S.: Mathematical modelling of the order-promising process for fruit supply chains considering the perishability and subtypes of products. Appl. Math. Model. 49, 255–278 (2017)Verdouw, C.N., Beulens, A.J.M., Trienekens, J.H., Wolferta, J.: Process modelling in demand-driven supply chains: a reference model for the fruit industry. Comput. Electron. Agric. 73, 174–187 (2010)Amorim, P., Günther, H., Almada-Lobo, B.: Multi-objective integrated production and distribution planning of perishable products. Int. J. Prod. Econ. 138, 89–101 (2012)Nahmias, S.: Perishable inventory theory: a review. Oper. Res. 30, 680–708 (1982)Mowat, A., Collins, R.: Consumer behavior and fruit quality: supply chain management in an emerging industry. Supply Chain Manage. 5, 45–54 (2000)Kazaz, B., Webster, S.: The impact of yield-dependent trading costs on pricing and production planning under supply uncertainty. M&SOM Manuf. Serv. Oper. Manage. 13, 404–417 (2011)Van der Vorst, J.G.: Effective food supply chains: generating, modelling and evaluating supply chain scenarios (2000)Fuertes-Miquel, V.S., Cuenca, L., Boza, A., Guyon, C., Alemany, M.M.E.: Conceptual framework for the characterization of vegetable breton supply chain sustainability in an uncertain context. In: 12th International Conference on Industrial Engineering and Industrial Management, XXII Congreso de Ingeniería de Organización, Girona, Spain, 12–13 July 2018Kummu, M., de Moel, H., Porkka, M., Siebert, S., Varis, O., Ward, P.J.: Lost food, wasted resources: global food supply chain losses and their impacts on freshwater, cropland, and fertiliser use. Sci. Total Environ. 438, 477–489 (2012)Hoekstra, S., Romme, J.: Integral Logistic Structures: Developing Customer-Oriented Goods Flow. Industrial Press Inc., New York (1992)Borodin, V., Bourtembourg, J., Hnaien, F., Labadie, N.: Handling uncertainty in agricultural supply chain management: a state of the art. Eur. J. Oper. Res. 254, 348–359 (2016)Handayati, Y., Simatupang, T.M., Perdana, T.: Agri-food supply chain coordination: the state-of-the-art and recent developments. Logist. Res. 8, 1–15 (2015)Mintzberg, H.: The Structuring of Organisations. Prentice-Hall, Upper Saddle River (1979)Keuning, D.: Grondslagen Van Het Management. Stenfert Kroese, Houten (1995) (in Dutch)Esteso, A., Alemany, M.M.E., Ortiz, A.: Conceptual framework for designing agri-food supply chains under uncertainty by mathematical programming models. Int. J. Prod. Res. (2018)Backus, G.B.C., Eidman, V.R., Dijkhuizen, A.A.: Farm decision making under risk and uncertainty. Neth. J. Agr. Sci. 45, 307–328 (1997)Esteso, A., Alemany, M.M.E., Ortiz, A.: Conceptual framework for managing uncertainty in a collaborative agri-food supply chain context. In: IFIP Advances in Information and Communication Technology, vol. 506, pp. 715–724 (2017)Mundi, I., Alemany, M.M.E., Poler, R., Fuertes-Miquel, V.S.: Review of mathematical models for production planning under uncertainty due to lack of homogeneity: proposal of a conceptual model. Int. J. Prod. Res. (2019)Grillo, H., Alemany, M.M.E., Ortiz, A., De Baets, B.: Possibilistic compositions and state functions: application to the order promising process for perishables. Int. J. Prod. Res. (2019)Soto-Silva, W.E., Nadal-Roig, E., González-Araya, M.C., Pla-Aragones, L.M.: Operational research models applied to the fresh fruit supply chain. Eur. J. Oper. Res. 251, 345–355 (2016)Farahani, R.Z., Rezapour, S., Drezner, T., Fallah, S.: Competitive supply chain network design: an overview of classifications, models, solution techniques and applications. Omega 45, 92–118 (2014)Banasik, A., Bloemhof-Ruwaard, J.M., Kanellopoulos, A., Claassen, G.D.H., van der Vorst, J.G.: Multi-criteria decision making approaches for green supply chains: a review. Flex. Serv. Manuf. J. 1–31 (2016)Paam, P., Berretta, R., Heydar, M., Middleton, R.H., García-Flores, R., Juliano, P.: Planning models to optimize the agri-fresh food supply chain for loss minimization: a review. In: Reference Module in Food Science (2016)Soysal, M., Bloemhof-Ruwaard, J.M., Meuwissen, M.P., van der Vorst, J.G.: A review on quantitative models for sustainable food logistics management. Int. J. Food Syst. Dyn. 3, 136–155 (2012

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria for risk of hereditary nonpolyposis colorectal cancer. These individuals had mismatch repair-proficient tumors and each carried nonsense variant in the FANCD2/FANCI-associated nuclease 1 gene (FAN1), which encodes a nuclease involved in DNA inter-strand cross-link repair. We sequenced FAN1 in 176 additional families with histories of colorectal cancer and performed in vitro functional analyses of the mutant forms of FAN1 identified. We detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutations. These findings link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway, supporting the connection between genome integrity and cancer risk