Electron scattering and neutrino physics

A thorough understanding of neutrino–nucleus scattering physics is crucial for the successful execution of the entire US neutrino physics program. Neutrino– nucleus interaction constitutes one of the biggest systematic uncertainties in neutrino experiments—both at intermediate energies affecting long-baseline deep underground neutrino experiment, as well as at low energies affecting coherent scattering neutrino program—and could well be the difference between achieving or missing discovery level precision. To this end, electron– nucleus scattering experiments provide vital information to test, assess and validate different nuclear models and event generators intended to test, assessThe authors acknowledge the support of the U.S. Department of Energy (DOE) Office of Science, U.S. National Science Foundation (NSF), the Deutsche Forschungsgemeinschaft (DFG) through the Cluster of Excellence 'Precision Physics, Fundamental Interactions,U.S. Department of Energy (DOE) Office of Science, U.S. National Science Foundation (NSF) PRISMA+ EXC 2118/1German Research Foundation (DFG)FWO PID2019-107564GB-I00Spanish Ministerio de Economa y Competitividad (SEIDI-MINECO)CERCA program of the Generalitat de Cataluny

Nogo, myelin and axonal regeneration

El sistema nerviós dels mamífers té una baixa capacitat de reparació axonal després d'una lesió. En els últims anys, diversos estudis han demostrat que els axons lesionats no poden recréixer a causa de la presència d'un gran nombre de molècules inhibitòries. Les molècules associades a la mielina limiten el creixement axonal i el seu bloqueig afavoreix la regeneració de diverses connexions. Tres d'aquestes proteïnes, Nogo, MAG i OMgp, comparteixen un mateix receptor: NgR. El clonatge recent de Nogo ha obert noves vies per estudiar la regeneració axonal. No obstant això, molts dels elements involucrats en la via inhibitòria de la mielina són desconeguts, i els primers estudis amb animals knockout són, a més, contradictoris. Per aquesta raó, Nogo i el seu receptor han de caracteritzar-se abans de desenvolupar noves tècniques per promoure regeneració axonal.Adult mammalian central nervous system (CNS) axons have very limited capacity of regrowth after injury. In recent years, advances in the field of axonal regeneration have proved that neurons do not regenerate, mainly because of the presence of inhibitory molecules. Myelin-associated proteins limit axonal outgrowth and their blockage improves the regeneration of damaged fiber tracts. Three of these proteins, Nogo, MAG and OMgp, share a common neuronal receptor (NgR), and together represent one of the main hindrances to neuronal regeneration. The recent molecular cloning of Nogo and its receptors opened a new door to the study of axon regeneration. However, many of the elements involved in the myelin inhibitory pathway are still unknown, and the preliminary experiments with knockout mice are rather contradictory. Because of this complexity, Nogo and NgR need to be characterized before precise strategies to promote axon regeneration in the CNS can be designed

The Self-Seeding of Anthemis arvensis L. for Cover Crop in Olive Groves under Intense Rabbit Grazing

Cover crops can be an effective means to protect soil and reduce risks of erosion in olive groves. However, for this protection to be significant, the vegetation must attain a significant amount of ground cover, which is estimated to be at least 30% during the rainy season. In olive groves on degraded soils, which occupy large surface areas in the olive-growing areas of the Mediterranean region, the establishment of cover crops may be an arduous challenge, particularly in areas with a high density of rabbits. In this study, we have selected two olive orchards with scarce natural vegetation located in Andalusia (southern Spain), in which rabbit populations intensively forage the cover crops, to test whether the self-seeding of an unpalatable species corn chamomile (Anthemis arvensis L.; A. arvensis for short) could achieve sufficient coverage for soil protection, in the year following that in which the broadcast-seeding was carried out for the implementation of cover crops. The hand broadcast-seeding of A. arvensis was carried out on sixteen elementary plots in the lanes of the two olive orchards in the autumn of 2015, and seed germination in the subsequent self-seeding took place in the autumn of 2016. The plant height and A. arvensis ground cover in these plots were measured throughout the two growth cycles, and aerial biomass was measured at maturity. The results showed that there were no significant differences in the maximum plant height between the two growth cycles (mean ± SD of 21.2 ± 1.6 cm), while the ground cover was significantly greater in the case of self-seeding, especially during the winter (37.2 ± 8.1 and 9.3 ± 6.7% for self-seeding and broadcast-seeding, respectively), and aerial biomass at maturity had more than doubled (99.7 and 43.9 g m−2, respectively). These data suggest that this unpalatable species could establish an effective herbaceous cover by means of self-seeding in olive groves on degraded soils that are being overgrazed owing to the high pressure of rabbits. Despite the poor establishment in the broadcast-seeding year, our findings indicate that A. arvensis might be an alternative cover crop that could help the sustainability of these threatened olive groves. Its high seed production (2000 to 4000 seeds per plant), and an early emergence just after the first autumn rains, should result in an increased ground cover by A. arvensis during the rainy season in the subsequent years of self-seeding. This, therefore, could contribute to soil conservation, in addition to providing other benefits of increased biodiversity and improvement for agricultural landscapes

Editorial: Management of right ventricular failure: pathophysiology, medical treatment and use of ventricular assist devices

Left ventricular assist device; Advanced heart failure; Right ventricular failureDispositiu d'assistència ventricular esquerre; Insuficiència cardíaca avançada; Insuficiència del ventricle dretDispositivo de asistencia ventricular izquierda; Insuficiencia cardíaca avanzada; Insuficiencia del ventrículo derech

An Optical Engine Used as a Physical Model for Studies of the Combustion Process Applying a Two-Color Pyrometry Technique

[EN] This work describes an experimental installation for the investigation of the combustion and injection processes. This installation is based on a two-stroke direct injection diesel engine with a total displacement of 3 L and a cylinder head equipped with three quartz windows. The windows are optical accesses that allow studying the process of injection, the atomization and evaporation of the fuel jet in an inert atmosphere (nitrogen), and the combustion process in a reactive atmosphere (ambient air). Additionally, the application of a two-color pyrometry technique to measure soot formation in this facility is presented. A methodological study is carried out regarding the influence of the dynamic range of the detectors and the wavelengths used. Maps of KL2C, flame temperature, and error probability are presented. The use of cameras with high dynamic range provides better results since the system seems to be less sensitive to measurement noise, and fewer points are obtained with a non-physical solution. Moreover, an appropriate combination of interference filters can improve the reliability of the solution. The greater the difference between the wavelengths of both interference filters, the fewer points with a non-physical solution, which improves the reliability of results.This research was funded by Castilla-La Mancha Government to the project grant number ASUAV Ref. SBPLY/19/180501/000116.Corral-Gómez, L.; Armas, O.; Soriano, JA.; Pastor, JV.; García-Oliver, JM.; Micó, C. (2022). An Optical Engine Used as a Physical Model for Studies of the Combustion Process Applying a Two-Color Pyrometry Technique. Energies. 15(13):1-17. https://doi.org/10.3390/en15134717117151

Automatic detection of e-commerce availability from web data

Resumen de la ponencia[EN] In the transition to the digital economy, the implementation of e-commerce strategies contributes to foster economic growth and obtain competitive advantages. Indeed, national and supranational statistics offices monitor the adoption of e-commerce solutions by conducting periodic surveys to businesses. However, the information about e-commerce adoption is often available online in each company corporate website, which is usually public and suitable for being automatically retrieved and processed.In this context, this work proposes and develops an intelligent system for automatically detecting and monitoring e-commerce availability by analyzing data retrieved from corporate websites. This system combines web scraping techniques with some learning methods for Big Data, and has been evaluated with a data set consisting of 426 corporate websites of manufacturing firms based in France and Spain.Results show that the proposed model reaches a classification precision of about 85% in the test set. A more detailed analysis evidences that websites with e-commerce tend to include some specific keywords and have a private area. Our proposal opens up the opportunity to monitor e-commerce adoption at a large scale, with highly granular information that otherwise would have required every firm to complete a survey.Blázquez Soriano, MD.; Domenech, J.; Gil, JA.; Pont Sanjuan, A. (2016). Automatic detection of e-commerce availability from web data. En CARMA 2016: 1st International Conference on Advanced Research Methods in Analytics. Editorial Universitat Politècnica de València. 121-121. https://doi.org/10.4995/CARMA2016.2016.3603OCS12112

An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer

Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this review, we provide a general overview about recent research on the implications of quadruplex structures in cancer, firstly gathering together DNA G-quadruplexes, RNA G-quadruplexes as well as DNA i-Motifs.3TR, IMI2 H2020-JTI538 IMI2-2018Instituto de Salud Carlos III AC18/00008Government of Spain FPU16/0582

Pollutant emissions from Euro 6 light duty vehicle tested under steady state and transient operation on a roller test bench with hydrogenated paraffinic and biodiesel fuels

[EN] The effort to implement more environmental-friendly fuels has been enhanced not only by the desire to reduce the greenhouse effects but also for public health issues. This paper studies the effects on pollutant emissions from a light-duty Euro 6 vehicle with four types of fuel: diesel (fossil origin, used as reference), biodiesel (renewable origin), Gas-to-Liquid (fossil origin) and farnesane (renewable origin). Both stationary engine and real-world driving cycles are studied. First, each fuel was tested in stationary modes in a vehicle test-bench and then tested in a realistic driving cycle with the same vehicle. This allows the separation the transient effects of the driving cycle from stationary results. Stationary tests lead to engine emission maps and driving cycle tests allow weighting the importance of each stationary condition during a realistic route. Instantaneous and cumulative CO, THC (total hydrocarbon), NOx and PN (particle number) emissions on route were obtained. The fuel that presented a highest level of emissions at stationary conditions was, for CO, diesel, for THC, diesel, for NOx, biodiesel and for PN, diesel. The behaviour of fuels during the driving cycles, from less pollutant to more pollutant, was: for CO, diesel, farnesane, GTL and biodiesel; for THC, GTL, farnesane, biodiesel, diesel. For NOx, farnesane and diesel (very similar values), GTL and biodiesel; for PN, GTL, biodiesel, farnesane and diesel.The authors would like to thank the funding provided by the Spanish Ministry of Science for RECUPERA project (Ref. RTI2018-095923-B-C21) and infrastructure (Ref. EQC2019-005675-P) , the donation of Farnesane fuel by AMYRIS, the donation of GTL fuel by SASOL and the discount provided by REPSOL in the purchase of diesel and biodiesel fuels.Fernández-Yáñez, P.; Soriano, JA.; Soto, F.; Armas, O.; Pla Moreno, B.; Bermúdez, V. (2022). Pollutant emissions from Euro 6 light duty vehicle tested under steady state and transient operation on a roller test bench with hydrogenated paraffinic and biodiesel fuels. Fuel. 323:1-12. https://doi.org/10.1016/j.fuel.2022.12417311232

A simple and accurate analytical model of the Stark profile and its application to plasma characterization

Optical Emission Spectroscopy techniques are among the most employed to perform the characterization of laboratory plasmas. The analysis of the obtained data is based on the convolution of three different types of profiles: Lorentzians, Gaussians and Starks. While analytic expressions are available for the first two types, the Stark profile has been traditionally obtained through theoretical calculations using different models. In this paper, we propose is a simple and accurate analytical function that can be employed as approximation of a Stark profile. The application of this new model may simplify the analysis of plasmas