Disfluency on Speech Production Made by English Department Students of IAIN Salatiga Based on Their Length of Study

This present research deals with the disfluency on speech production made by English Department of IAIN Salatiga based on their length of study. The objectives of this research are to identify the types of disfluency, the dominant type of disfluency, and the difference and similarity of disfluency made by English Department students of IAIN Salatiga. The type of this research is qualitative research. The data of this research are utterances containing disfluencies taken from the second and the fourth semester students. In collecting data, the researcher listens to the audio record carefully, writes the scripts of the audios, gives questionnaire, then identifies the data, and selects the data deals with the types of dislfuency. The researcher uses the theory of Clark and Wasow, Shriberg, Levelt, and Fox Tree to analyze the disfluencies. The results indicate that there are three types of disfluencies made by English Department students of IAIN Salatiga are hesitation, repetition, and overt repair. They are analyzed by their length of study that is taken from second and fourth semester students. The dominant type of disfluency which is made by the students is hesitation. Then, the difference is the total number of disfluencies that are produced by second and fourth semester students. The similarities of disfluency that found by the researcher are first the types of disfluencies which are hesitation, repetition, and overt repair. Second, the dominant of disfluency made by students is hesitation. Keywords: Disfluency, Speech Production, English Speech Productio

Mislocalization of the exitatory amino-acid transporters (EAATs) in human astrocytoma and non-astrocytoma cancer cells: effect of the cell confluence

<p>Abstract</p> <p>Background</p> <p>Astrocytomas are cancers of the brain in which high levels of extracellular glutamate plays a critical role in tumor growth and resistance to conventional treatments. This is due for part to a decrease in the activity of the glutamate transporters, i.e. the Excitatory Amino Acid Transporters or EAATs, in relation to their nuclear mislocalization in astrocytoma cells. Although non-astrocytoma cancers express EAATs, the localization of EAATs and the handling of L-glutamate in that case have not been investigated.</p> <p>Methods</p> <p>We looked at the cellular localization and activity of EAATs in human astrocytoma and non-astrocytoma cancer cells by immunofluorescence, cell fractionation and L-glutamate transport studies.</p> <p>Results</p> <p>We demonstrated that the nuclear mislocalization of EAATs was not restricted to astrocytoma and happened in all sub-confluent non-astrocytoma cancer cells we tested. In addition, we found that cell-cell contact caused the relocalization of EAATs from the nuclei to the plasma membrane in all human cancer cells tested, except astrocytoma.</p> <p>Conclusions</p> <p>Taken together, our results demonstrated that the mislocalization of the EAATs and its associated altered handling of glutamate are not restricted to astrocytomas but were also found in human non-astrocytoma cancers. Importantly, we found that a cell contact-dependent signal caused the relocalization of EAATs at the plasma membrane at least in human non-astrocytoma cancer cells, resulting in the correction of the altered transport of glutamate in such cancer cells but not in astrocytoma.</p

ARDL METHOD: Forecasting Data Curah Hujan Harian NTB

Penelitian ini berisi tentang prediksi atau forecasting data iklim di Nusa Tenggara Barat (NTB) tahun 2011, yakni jumlah hari terjadinya hujan dengan menggunakan metode Autoregressive Distributed Lag (ARDL). Data yang digunakan yaitu data iklim di Nusa Tenggara Barat (NTB) dari tahun 2006 -2010, dengan menggunakan beberapa parameter error seperti Mean Absolute Deviation (MAD), Mean Squared Error (MSE), Root Mean Squared Error (RMSE) dan Mean Absolute Percentage Error (MAPE). Berdasarkan hasil simulasi data iklim di Nusa Tenggara Barat (NTB) tersebut, diperoleh prediksi jumlah hari terjadinya curah hujan pada tahun 2011 sebesar 226 hari dengan nilai MAD 20,8069, MSE 3,5569, RMSE 1,88597, dan MAPE 11,9297 . Dan prediksi jumlah hari terjadinya hujan pada tahun 2011 sebanyak 225,928 hari atau jika di bulatkan menjadi 226 hari dengan nilai parameter error MAD sebesar 20,8069, sehingga dapat disimpulkan pada tahun 2011 terjadi peningkatan jumlah hari terjadinya hujan di Nusa Tenggara Barat (NTB)

Quality of life among Patients with Acute Coronary Syndrome in Malaysia

Objectives This study’s objectives were to estimate the quality of life (QOL) of Malaysian patients with acute coronary syndrome (ACS) during admission and at 12 months, to explore the factors associated with the QOL, and to compare utility scores derived from tariffs from local and foreign populations. Methods Data collected from patients with ACS between 2008 and 2009 for a study on cardiac rehabilitation at the Sarawak General Hospital were used for this study. QOL data were obtained using a validated version of the EuroQol five-dimensional questionnaire at baseline and at 12 months. Health utility scores were calculated using visual analogue scale scores and utility tariffs from Malaysia and the United Kingdom. Results Data from 104 subjects from the earlier study was used. The mean age was 56.1 years, with 88.5% being men. The mean hospitalization duration was 6.3 days. The mean utility score was 0.75 at baseline and 0.82 at 12 months. There was a statistically significant improvement in utility from baseline to 12 months based on the Malaysian tariff (P = 0.014) but not with the UK tariff (P = 0.086). The QOL of patients was associated with sex and diagnosis of ST-segment elevation myocardial infarction. Conclusions Our results showed that there was a significant improvement in the QOL from baseline to 12 months. Only sex and diagnosis affected the QOL score at baseline because of limited variables available for testing. It also reconfirms the importance of applying the appropriate, country-specific utility tariffs in QOL studies. Despite limitations, the study is useful toward describing QOL among a group of Malaysian patients with ACS

A real‐world study to assess the association of cardiovascular adverse events (CVAEs) with ibrutinib as first‐line (1L) treatment for patients with chronic lymphocytic leukaemia (CLL) in the United States

Abstract Ibrutinib, a Bruton's tyrosine kinase inhibitor, is often used as first‐line (1L) treatment of chronic lymphocytic leukaemia (CLL); however, it is associated with an increased risk for cardiovascular adverse events (CVAEs). This real‐world study adds to existing literature by simultaneously investigating the correlation between pre‐existing CV risk factors and the relative cardiotoxicity of ibrutinib vs other therapies in CLL/small lymphocytic lymphoma (SLL). Using a real‐world database, the risk of subsequent CVAEs (any CVAE, atrial fibrillation [AF], or hypertension) were compared among patients who received 1L ibrutinib monotherapy or another type of non‐ibrutinib therapy, grouped as intensive (IT) or non‐intensive therapy (NIT). Each patient's baseline CV risk was estimated using the Framingham risk score. Inverse probability treatment weighting was incorporated into a logistic regression model to reduce baseline imbalance. Results showed ibrutinib was significantly associated with higher risk of CVAEs regardless of baseline CV risk. Compared with IT, odds ratios of any CVAE, hypertension, or AF were 2.61, 3.66, and 3.02, respectively vs 1.88, 2.13, and 2.46, respectively, with NIT. Sensitivity analyses confirmed the findings were robust. These results suggest clinical caution should be taken when selecting ibrutinib for patients with CLL/SLL, especially in those with high baseline CV risk

Assessing the burden of pneumonia using administrative data from Malaysia, Indonesia, and the Philippines

Objectives: To describe the incidence, mortality, cost, and length of stay (LOS) of hospitalized community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) in three Southeast Asian countries: Malaysia, Indonesia, and the Philippines. Methods: Using Casemix system data from contributing hospitals, patients with International Classification of Diseases 10th revision (ICD-10) codes identifying pneumonia were categorized into CAP or HAP using a logical algorithm. The incidence among hospitalized patients, case fatality rates (CFR), mean LOS, and cost of admission were calculated. The population incidence was calculated based on Malaysian data. Results: For every 100 000 discharges, CAP and HAP incidences were 14 245 and 5615 cases, respectively, in the Philippines, 4205 and 2187, respectively, in Malaysia, and 988 and 538, respectively, in Indonesia. The impact was greatest in the young and the elderly. The CFR varied from 1.4% to 4.2% for CAP and from 9.1% and 25.5% for HAP. The mean LOS was 6.1–8.6 days for CAP and 6.9–10.2 days for HAP. The cost of hospitalization was between USD 254 and USD 1208 for CAP and between USD 275 and USD 1482 for HAP. Conclusions: The burden of CAP and HAP is high. Results varied between the three countries, likely due to differences in socio-economic conditions, health system differences, and ICD-coding practices